Article
Oncology
Joseph M. M. Unger, Michael LeBlanc, Suzanne George, Norman Wolmark, Walter J. J. Curran Jr, Peter J. J. O'Dwyer, Mitchell D. D. Schnall, Robert S. S. Mannel, Sumithra J. J. Mandrekar, Robert J. J. Gray, Fengmin Zhao, Mariama Bah, Riha Vaidya, Charles D. D. Blanke
Summary: The National Cancer Institute National Cancer Clinical Trials Network (NCTN) groups in the United States have conducted publicly funded oncology research for 50 years, but the combined impact of all adult network group trials has never been systematically examined.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Polymer Science
Ei Mon Khaing, Torsak Intaraphairot, Jongjan Mahadlek, Siriporn Okonogi, Wiwat Pichayakorn, Thawatchai Phaechamud
Summary: A rosin/cinnamon oil in situ forming gel (ISG) was developed for the sustainable delivery of imatinib mesylate against colorectal cancer cells. The addition of cinnamon oil increased the viscosity and drug release of the gel, and exhibited cytotoxicity. Therefore, this cinnamon oil-loaded ISG has the potential to be a novel chemotherapy drug delivery system for colorectal cancer.
Article
Chemistry, Multidisciplinary
Shiyi Zhou, Zipeng Zhen, Amy V. Paschall, Lijun Xue, Xueyuan Yang, Anne-Gaelle Bebin Blackwell, Zhengwei Cao, Weizhong Zhang, Mengzhe Wang, Yong Teng, Gang Zhou, Zibo Li, Fikri Y. Avci, Wei Tang, Jin Xie
Summary: This study developed a photodynamic therapy approach using nanoparticles specifically targeting FAP, which efficiently eradicated CAFs in tumors and induced anti-cancer immunity in murine models. Interestingly, the treatment not only elicited cellular immunity against cancer cells, but also stimulated an anti-CAFs immunity, as supported by adoptive cell transfer study.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Oncology
Almudena Callejo, Sara Faouzi, Olivier Bouche, Francois Bertucci, Thomas Chevalier, Nicolas Isambert, Florence Duffaud, Olivier Collard, Nicolas Penel, Philippe Terrier, Olivier Mir, Jean Yves Blay, Axel Le Cesne
Summary: Retrospective analysis suggests that adjuvant imatinib 400 mg daily may benefit high-risk patients with advanced KIT exon 9-mutated GIST. Patients with advanced disease receiving imatinib 400 mg with dose escalation had a similar time to progression as those starting with 800 mg. In this setting, intra-patient dose escalation could be considered as an option.
Review
Chemistry, Multidisciplinary
Meihua Yu, Wei Yang, Wenwen Yue, Yu Chen
Summary: With the advancements in nanoengineering, therapeutic immunostimulators formulated in nanomaterials have shown great potential in cancer treatment. Nanoformulations offer precise regulation of immune activities and can target specific immune cells. This review discusses recent developments in nanoformulations targeting immune cells and highlights the opportunities and challenges in clinical translation for targeted cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Alfonso Garcia-Valverde, Jordi Rosell, Sergi Sayols, David Gomez-Peregrina, Daniel F. Pilco-Janeta, Ivan Olivares-Rivas, Enrique de Alava, Joan Maurel, Jordi Rubio-Casadevall, Anna Esteve, Marta Gut, Claudia Valverde, Jordi Barretina, Joan Carles, George D. Demetri, Jonathan A. Fletcher, Joaquin Arribas, Cesar Serrano
Summary: In most gastrointestinal stromal tumors (GIST), KIT/PDGFRA oncogenic tyrosine kinase signaling is central but GIST cells develop resistance to KIT/PDGFRA suppression. The study found that the E3 ubiquitin ligase Atrogin-1 is critical in GIST adaptive resistance to KIT inhibition, and overexpression of Atrogin-1 enables GIST cells to evade apoptosis through cell quiescence. Targeting both KIT and the ubiquitin pathway may maximize therapeutic response to imatinib treatment.
Article
Immunology
Jingjing Wang, Hui Ren, Wenhui Wu, Qianlin Zeng, Jingyao Chen, Juanjuan Han, Minquan Lin, Changhua Zhang, Yulong He, Mingzhe Li
Summary: The study revealed the relationship between immune infiltration and cancer stem-like properties in patients with gastrointestinal stromal tumor (GIST), with a correlation to tumor purity. The cancer stemness index can serve as a predictive biomarker for tumor metastasis and a target for drug therapy in GIST patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Biomaterials
Chunhui Wu, Jiming Xu, Zhengxin Xie, Honglin Huang, Ningxi Li, Xiaodan Wei, Tingting Li, Hong Yang, Shun Li, Xiang Qin, Yiyao Liu
Summary: The study demonstrated a targeted photo- and immune-active nanoplatform NLG919@HA-Ce6 for combined photodynamic therapy and checkpoint blockade immunotherapy, effectively suppressing triple-negative and poorly immunogenic 4T1 breast cancer model by triggering a potent antitumor immune response.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Goncalo A. Marcelo, David Montpeyo, Joana Galhano, Ramon Martinez-Manez, Jose Luis Capelo-Martinez, Julia Lorenzo, Carlos Lodeiro, Elisabete Oliveira
Summary: In this study, a combinatory antitumoral nanotherapy was developed using magneto-fluorescent nanoparticles as carriers for a combination of two drugs (doxorubicin and ofloxacin) and surface modification with two targeting agents (AZM-SH and Cetuximab). The results showed that the nanoparticles modified with AZM-SH had higher cellular uptake than those modified with Cetuximab, making them more effective for colorectal cancer cells. Furthermore, the oral administration of the nanoparticles with an enteric coating was successfully achieved under extreme conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Dongmei Gao, Guopeng Wang, Honghai Wu, JinHua Wu, Xiaoang Zhao
Summary: This study developed a physiologically based pharmacokinetic (PBPK) model to predict the trough concentration (Ctrough) of imatinib (IMA) and explored the role of free concentration (fup), alpha 1acid glycoprotein (AGP) level, and organic cation transporter 1 (OCT1) activity/expression in clinical efficacy. The PBPK model accurately predicted the Ctrough of IMA in different clinical situations and provided dosing adjustment recommendations. Sensitivity analysis showed that fup and AGP level had a significant influence on plasma Ctrough, while OCT1 activity and expression affected intracellular Ctrough.
Article
Medicine, Research & Experimental
Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang, Cheng Yang, Li Yu
Summary: A novel epigenetic agent named Apigenin-Vorinostat-Conjugate (AVC) showed potential therapeutic effects against acute myeloid leukemia by effectively inhibiting leukemia cell growth and inducing apoptosis, while sparing normal cells. It exhibits a promising next-generation epigenetic drug for clinical therapy against AML.
Article
Chemistry, Physical
Brajesh Narayan, Nicolae-Viorel Buchete, Ron Elber
Summary: This study used atomically detailed simulations within the Milestoning framework to investigate the molecular dissociation mechanism of Gleevec from Abl kinase. The researchers calculated the dissociation free energy profile, mean first passage time for unbinding, and explored the transition state ensemble of conformations. The study revealed that near the transition state, the highly conserved salt bridge between K217 and E286 is transiently broken.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Engineering, Biomedical
Jiaxin Chen, Bingbing Zhao, Junhui Zou, Jiachen Yang, Lifen Yang, Junmei Zhang, Wei Chen, Dechun Huang, Yinan Zhong
Summary: A bombesin-installed nanoplatform combining mitoxantrone (MTO) and nitric oxide (NO) is developed for targeted chemotherapy against prostate cancer. The nanoplatform actively targets and accumulates in tumor sites, and releases NO to induce DNA damage and reactive oxygen species (ROS) generation, enhancing the cytotoxicity of MTO through inhibition of DNA repair and anti-oxidation pathways.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Mei Zhou, Liming Zhang
Summary: This study evaluated the clinical efficacy of imatinib mesylate plus radiotherapy for acute leukemia and its impact on immune function. The results showed that the combination therapy group had better improvement in white blood cell, platelet, red blood cell, and hemoglobin levels compared to the radiotherapy alone group. The absolute values of peripheral blood mature neutrophils increased in the combination therapy group, indicating higher efficacy. Further clinical trials are needed to validate this treatment approach.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Lina Yu, Guanxiong Zhu, Zeyu Zhang, Zidan Xu, Weijie Peng, Liting Zeng, Yang Yu, Siran Wang, Zhongxiao Lin, Xin Zhang, Na Zhou, Lingmin Zhang, Lu Liang
Summary: The use of macrophage membrane-coated Verteporfin-loaded nanoparticles shows potential for effective photodynamic therapy in oral cancer treatment, displaying efficient cellular uptake and cytotoxic effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)