The application of RNAi-based treatments for inflammatory bowel disease

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Galactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages

(2013) Jing Zhang et al.   BIOMATERIALS

Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles

(2013) Borja Ballarín-González et al.   Molecular Therapy-Nucleic Acids

Classification of inflammatory bowel disease

(2012) Severine Vermeire et al.   CURRENT OPINION IN GASTROENTEROLOGY

Diagnosis and Therapeutic Management of Extra-Intestinal Manifestations of Inflammatory Bowel Disease

(2012) Guru Trikudanathan et al.   DRUGS

Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa

(2012) Eva-Maria Collnot et al.   JOURNAL OF CONTROLLED RELEASE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Antibiotic Exposure and IBD Development Among Children: A Population-Based Cohort Study

(2012) M. P. Kronman et al.   PEDIATRICS

Necessity of phenotypic classification of Inflammatory Bowel Disease

(2011) Edouard Louis et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

From virus to inflammation: Mechanisms of RIG-I-induced IL-1β production

(2011) Hendrik Poeck et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Current immunosuppressive treatment after kidney transplantation

(2011) Marcia Kho et al.   EXPERT OPINION ON PHARMACOTHERAPY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Conventional Medical Management of Inflammatory Bowel Disease

(2011) Daniel Burger et al.   GASTROENTEROLOGY

Epidemiology and Natural History of Inflammatory Bowel Diseases

(2011) Jacques Cosnes et al.   GASTROENTEROLOGY

Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis

(2011) Patricia Lepage et al.   GASTROENTEROLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Current and emerging drugs for the treatment of inflammatory bowel disease

(2011) John Triantafillidis   Drug Design Development and Therapy

Dual TNF-α/Cyclin D1 Gene Silencing With an Oral Polymeric Microparticle System as a Novel Strategy for the Treatment of Inflammatory Bowel Disease

(2011) Christina Kriegel et al.   Clinical and Translational Gastroenterology

Gastrointestinal and liver adverse effects of drugs used for treating IBD

(2010) Gerhard Rogler   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

(2010) Erich M Ehlert et al.   BMC NEUROSCIENCE

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease

(2010) Christina Kriegel et al.   JOURNAL OF CONTROLLED RELEASE

Bioresponsive hyperbranched polymers for siRNA and miRNA delivery

(2010) Ulrik L. Rahbek et al.   JOURNAL OF DRUG TARGETING

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

(2010) Maria B. Laursen et al.   Molecular BioSystems

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

(2010) Narendra Vaish et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

(2010) Isabel Nawroth et al.   RADIOTHERAPY AND ONCOLOGY

Delivery of RNA interference therapeutics using polycation-based nanoparticles

(2009) Kenneth Alan Howard   ADVANCED DRUG DELIVERY REVIEWS

Cyclosporine regulates intestinal epithelial apoptosis via TGF-β-related signaling

(2009) Yuki Satoh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Infliximab and the TNF-α system

(2009) Ellen C. Ebert   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf

(2009) Michael Fisher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

(2009) Svetlana Hamm et al.   IMMUNOBIOLOGY

Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase

(2009) Gro F. Flatekval et al.   IMMUNOLOGY

In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles

(2009) Gregory A. Dissen et al.   METHODS

Asymmetric Shorter-duplex siRNA Structures Trigger Efficient Gene Silencing With Reduced Nonspecific Effects

(2009) Chan Il Chang et al.   MOLECULAR THERAPY

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

(2009) W. G. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Saccharomyces boulardii on Human Colon Cells and Inflammation in Rats with Trinitrobenzene Sulfonic Acid-Induced Colitis

(2008) Sang Kil Lee et al.   DIGESTIVE DISEASES AND SCIENCES

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH

Potent RNAi by short RNA triggers

(2008) C.-y. Chu et al.   RNA

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE

Delivery of siRNA from lyophilized polymeric surfaces

(2007) Morten Ø. Andersen et al.   BIOMATERIALS

Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides

(2007) Ulrik L. Rahbek et al.   JOURNAL OF GENE MEDICINE