Clinical translation of RNAi-based treatments for respiratory diseases

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice

(2011) Andrea Beyerle et al.   JOURNAL OF CONTROLLED RELEASE

Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense

(2011) Sterghios A Moschos et al.   MOLECULAR THERAPY

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

Mucoadhesive Nanoparticles May Disrupt the Protective Human Mucus Barrier by Altering Its Microstructure

(2011) Ying-Ying Wang et al.   PLoS One

Blockade of the Wnt/β-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis

(2011) Tae Hyung Kim et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus

(2010) John P. DeVincenzo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

(2010) Martin R. Zamora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Characterization of Particle Translocation through Mucin Hydrogels

(2010) Oliver Lieleg et al.   BIOPHYSICAL JOURNAL

Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

(2010) Erich M Ehlert et al.   BMC NEUROSCIENCE

Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury*

(2010) Mario Perl et al.   CRITICAL CARE MEDICINE

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

(2010) Narendra Vaish et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Efficient Gene Silencing in Lungs and Liver Using Imidazole-Modified Chitosan As a Nanocarrier for Small Interfering RNA

(2010) Bilal Ghosn et al.   OLIGONUCLEOTIDES

Pulmonary Gene Silencing in Transgenic EGFP Mice Using Aerosolised Chitosan/siRNA Nanoparticles

(2010) Ebbe J. B. Nielsen et al.   PHARMACEUTICAL RESEARCH

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice

(2010) Birgitt Gutbier et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis

(2010) T. Senoo et al.   THORAX

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

(2010) Jiu-Cun Wang et al.   ARTHRITIS RESEARCH & THERAPY

Delivery of RNA interference therapeutics using polycation-based nanoparticles

(2009) Kenneth Alan Howard   ADVANCED DRUG DELIVERY REVIEWS

Micro- and macrorheology of mucus

(2009) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

(2009) R. Alvarez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

WT1 gene silencing by aerosol delivery of PEI–RNAi complexes inhibits B16-F10 lung metastases growth

(2009) D E Zamora-Avila et al.   CANCER GENE THERAPY

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Alveolar Macrophages Transport Pathogens to Lung Draining Lymph Nodes

(2009) A. C. Kirby et al.   JOURNAL OF IMMUNOLOGY

Nonviral siRNA Delivery to the Lung: Investigation of PEG−PEI Polyplexes and Their In Vivo Performance

(2009) Olivia M. Merkel et al.   MOLECULAR PHARMACEUTICS

Asymmetric Shorter-duplex siRNA Structures Trigger Efficient Gene Silencing With Reduced Nonspecific Effects

(2009) Chan Il Chang et al.   MOLECULAR THERAPY

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Naked siLNA-Mediated Gene Silencing of Lung Bronchoepithelium EGFP Expression After Intravenous Administration

(2009) Sys Zoffmann Glud et al.   OLIGONUCLEOTIDES

Effective Treatment of Respiratory Alphaherpesvirus Infection Using RNA Interference

(2009) Amy Fulton et al.   PLoS One

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

(2009) W. G. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

(2009) B. C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS

Intrapulmonary Delivery of XCL1-Targeting Small Interfering RNA in Mice Chronically Infected withMycobacterium tuberculosis

(2008) Adrian G. Rosas-Taraco et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

(2008) Ying-Ying Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

(2008) J DEVINCENZO et al.   ANTIVIRAL RESEARCH

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

Inhaled nanoparticles—A current review

(2008) Wei Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNA Interference Inhibits Respiratory Syncytial Virus Replication and Disease Pathogenesis without Inhibiting Priming of the Memory Immune Response

(2008) W. Zhang et al.   JOURNAL OF VIROLOGY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH

Potent RNAi by short RNA triggers

(2008) C.-y. Chu et al.   RNA

Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA

(2007) Gino V. Limmon et al.   FASEB JOURNAL