Article
Psychiatry
Ashok Malla, Srividya N. Iyer, Ridha Joober, Thara Rangaswamy, Padmavati Ramachandran, Norbert Schmitz, Aarati Taksal, Greeshma Mohan, Howard C. Margolese
Summary: This study investigated the impact of supervised antipsychotic medication discontinuation on clinical and functional outcomes in first-episode psychosis in two different cultural environments. The results showed that certain cultural environments and patient characteristics may facilitate supervised discontinuation of antipsychotic medication following treatment of a first-episode psychosis without negative consequences.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Review
Psychiatry
Helene Gjervig Hansen, Helene Speyer, Marie Starzer, Nikolai Albert, Carsten Hjorthoj, Lene Falgaard Eplov, Merete Nordentoft
Summary: This study conducted a comprehensive analysis of previous research on individuals with schizophrenia and found a clinical recovery rate of approximately 21%. The study also found that the recovery rate was not significantly influenced by various factors, and there was no significant difference in recovery between early intervention services and other interventions. New initiatives are needed to improve the rate of recovery.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Review
Psychology, Clinical
Nathalia Garrido-Torres, Idalino Rocha-Gonzalez, Luis Alameda, Aurora Rodriguez-Gangoso, Ana Vilches, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla
Summary: Research on drug-naive first-episode of psychosis patients showed a higher prevalence of metabolic syndrome, suggesting cardiovascular risk is underestimated in this population and not solely due to antipsychotic treatments. The study also highlighted the significant impact of ethnicity on metabolic parameters in psychosis patients.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Marissa Wilson, Michael Harris, Marco Pereira, Jessica Buckle, Emily Forshall, Titus Murphy, Andrew Thompson, Gail Kavanagh, Richard Whale
Summary: This study aimed to identify factors influencing clinical outcomes after antipsychotic discontinuation. Results showed that only the type of antipsychotic medication had a significant association with discontinuation, with fewer individuals discontinuing aripiprazole requiring hospital admission. It was also found that individuals who remained symptom-free after discontinuation were most likely to have received clinician support.
SCHIZOPHRENIA RESEARCH
(2023)
Review
Endocrinology & Metabolism
Claudia Aymerich, Borja Pedruzo, Malein Pacho, Marta Laborda, Jon Herrero, Toby Pillinger, Robert A. McCutcheon, Daniel Alonso-Alconada, Marta Bordenave, Maria Martinez-Querol, Ainara Arnaiz, Javier Labad, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres, Ana Catalan
Summary: Alterations in prolactin and cortisol levels have been found in antipsychotic naive patients with first episode psychosis. This study aims to provide estimates for the standardized mean differences and inter-group variability of these hormone levels in this patient group compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychology, Clinical
Akiah Ottesen, W. T. Hegelstad, Inge Joa, Stein E. Opjordsmoen, Bjorn Rishovd Rund, Jan Ivar Rossberg, Erik Simonsen, Jan Olav Johannessen, Tor K. Larsen, Ulrik Helt Haahr, Thomas H. McGlashan, Svein Friis, Ingrid Melle
Summary: This longitudinal study compares symptom trajectories and remission in first-episode psychosis (FEP) with and without a history of childhood interpersonal trauma (CIT) over the first 2 years of treatment. The results indicate that antipsychotic medication is equally beneficial in achieving symptomatic remission, regardless of CIT. However, FEP patients with CIT experience more severe positive, depressive, and excited symptoms throughout the disease.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Raza Sagarwala, Henry A. Nasrallah
Summary: Studies have shown that psychotic patients have differences in white matter microstructure, and antipsychotic medications may improve this condition, particularly effective at remission. However, more controlled trials are needed to validate this conclusion.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Fernanda Talarico, Gabriela Xavier, Vanessa Kiyomi Ota, Leticia M. Spindola, Pawan Kumar Maurya, Priscila Farias Tempaku, Patricia S. Moretti, Ary Gadelha, Mariane Noto, Cristiano Noto, Quirino Cordeiro, Rodrigo A. Bressan, Simone de Jong, Marcos L. Santoro, Gerome Breen, Sintia Belangero
Summary: Schizophrenia patients show altered DNA methylation age (DMA) and longer relative telomere length (RTL), indicating a decelerated aging process. However, no significant association was found between these aging markers and treatment response in antipsychotic-naive patients.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Immunology
V. L. Cropley, M. Kittel, M. Heurich, M. Focking, F. M. Leweke, C. Pantelis
Summary: The study found that alterations in the complement system may be a feature of the early psychosis phenotype. Complement protein levels in blood were higher in individuals with first-episode psychosis and clinical high-risk for psychosis, while levels in cerebrospinal fluid did not differ significantly between groups. Serum protein levels were correlated with symptom severity in first-episode psychosis. Further studies are needed to investigate complement proteins in cerebrospinal fluid and their changes with progression of psychotic illness.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychology, Clinical
Sung Woo Joo, Harin Kim, Young Tak Jo, Young Jae Choi, Soojin Ahn, Jungsun Lee
Summary: This study investigates the relationship between antipsychotic treatment and risk of psychiatric hospitalization in first-episode schizophrenia patients using a population database in South Korea. The findings suggest that long-acting injectable antipsychotics, such as LAI paliperidone and clozapine, are associated with lower treatment discontinuation and better effectiveness in lowering the risk of psychiatric hospitalization.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Pierluigi Selvaggi, Sameer Jauhar, Vasileia Kotoula, Fiona Pepper, Mattia Veronese, Barbara Santangelo, Fernando Zelaya, Federico E. Turkheimer, Mitul A. Mehta, Oliver D. Howes
Summary: This study found significantly lower frontal cortical blood flow in FEP patients before antipsychotic treatment. Additionally, the relative-to-global frontal cerebral blood flow measured before antipsychotic treatment may be associated with treatment response.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Robert A. McCutcheon, David Taylor, Jose Rubio, Joseph Nour, Toby Pillinger, Robin M. Murray, Sameer Jauhar
Summary: This study found that discontinuation of antipsychotic medication is associated with an increased risk of relapse in schizophrenia, which is related to receptor occupancy. Although the rate of discontinuation does not appear to affect relapse, gradual discontinuation strategies may facilitate easier reinstatement of antipsychotic medication in case of symptomatic worsening.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Wei Qi, Zhenfu Wen, Jingyun Chen, Gillian Capichioni, Fumika Ando, Zhe Sage Chen, Jijun Wang, Yuliya Yoncheva, Francisco X. Castellanos, Mohammed Milad, Donald C. Goff
Summary: This study found abnormal functional connectivity in the striatal-pallidal-thalamic pathway in patients with schizophrenia, providing insights into the failure of neurodevelopmental processes in psychosis.
SCHIZOPHRENIA RESEARCH
(2023)
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
