Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ha Mai, Lynette Mc Evoy, Carol Wilson, Lynda Marov, Ayano Kelly, Carlos El Haddad, Danielle Ni Chroinin, Geraldine Hassett, Steven A. Frost
Summary: Frailty is associated with an increased risk of subsequent fracture among older adults with a minimal trauma fracture, highlighting the importance of screening for frailty in this population.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Caitlin McArthur, Ahreum Lee, Hajar Abu Alrob, Jonathan D. Adachi, Lora Giangregorio, Lauren E. Griffith, Suzanne Morin, Lehana Thabane, George Ioannidis, Justin Lee, William D. Leslie, Alexandra Papaioannou
Summary: The study revealed that a majority of community-dwelling older adults at high fracture risk, especially males, are not taking osteoporosis medication, indicating a significant opportunity for enhanced primary fracture prevention in the community.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Geriatrics & Gerontology
Mary E. Walsh, Mari Nerdrum, Tom Fahey, Frank Moriarty
Summary: Initiation of bone-health medication in older patients is associated with factors such as female sex, older age, state-funded health cover, and osteoporosis. High fracture risk for hip and all fractures, previous fracture, rheumatoid arthritis, corticosteroid use, and certain comorbidities are also associated with medication initiation. Undertreatment remains a concern, particularly in older patients with multiple conditions.
Article
Orthopedics
Jacques P. Brown, Jonathan D. Adachi, Emil Schemitsch, Jean-Eric Tarride, Vivien Brown, Alan Bell, Maureen Reiner, Thiago Oliveira, Ponda Motsepe-Ditshego, Natasha Burke, Lubomira Slatkovska
Summary: This study found that the mortality rate was higher in adults aged over 65 after non-hip fractures caused by osteoporosis, especially within the first year post-fracture. The relative risk of mortality was 2.47 in women and 3.22 in men within 1 year post-fracture, with absolute mortality risk of 12.5% in women and 19.5% in men within one year post-fracture.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Tanchanok Chattaris, Gahee Oh, Natalia A. Gouskova, Dae Hyun Kim, Douglas P. Kiel, Sarah D. Berry
Summary: In frail older adults, taking osteoporosis medications for more than 90 days reduces the risk of subsequent fractures. However, treatment rates are particularly low in frail individuals, and clinicians should carefully consider treatment options in this population.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Rheumatology
Beatrice Bouvard, Cedric Annweiler, Erick Legrand
Summary: The incidence of fragility fractures increases with age after 50, particularly in the elderly, leading to serious consequences. Falls and decreased bone mineral density are major factors in fragility fractures in older adults. Despite advancements in osteoporosis diagnosis and treatment, there is still a significant treatment gap in the elderly population.
Article
Medicine, General & Internal
Patrick Pflueger, Felix N. Harder, Karoline Mueller, Lukas Willinger, Peter Biberthaler, Moritz Croenlein
Summary: Trimalleolar ankle fractures predominantly affect younger men and older women, with postmenopausal women having lower bone mineral density and a higher risk of fractures. This study aimed to analyze the association between patient characteristics and cortical bone thickness of the distal tibia in trimalleolar ankle fractures. The results showed that older age and female sex were associated with reduced cortical bone thickness and an increased risk of subsequent osteoporotic fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Sujith Ramachandran, Setareh A. Williams, Richard J. Weiss, Yamei Wang, Yiqiao Zhang, Irene Nsiah, Kaustuv Bhattacharya
Summary: This study found that testing and treatment rates for osteoporosis after fractures are poor in the Medicare fee-for-service population, especially for men compared to women. Receiving appropriate testing and treatment was associated with reduced mortality and risk of composite outcomes.
ADVANCES IN THERAPY
(2021)
Article
Medicine, General & Internal
Yichi Zhang, James M. Wilkins, Lily Gui Bessette, Cassandra York, Vincent Wong, Kueiyu Joshua Lin
Summary: This retrospective cohort study investigated the discontinuation rates and patient characteristics of antipsychotic medications (APMs) used to treat delirium following infection-related hospitalization among older US adults. The study found that the discontinuation rate of haloperidol was significantly higher compared to atypical APMs, and there was an increasing trend in haloperidol discontinuation rates in recent years.
Article
Medicine, General & Internal
Ebony King, Mohsen Bazargan, Nana Entsuah, Sayaka W. W. Tokumitsu, Cheryl Wisseh, Edward K. K. Adinkrah
Summary: This study aimed to investigate the prevalence of potentially inappropriate medication (PIM) use among underserved older Latino adults. The results showed that one-third of the participants had at least one use of PIM, over half of the sample had polypharmacy, and 46% of the sample took drugs to be used with caution. Regression analysis revealed that PIM use was associated with the number of prescription medications, chronic conditions, sleep difficulty, lack of access to primary care, financial strain, and poor self-rated health.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Tanchanok Chattaris, Laiji Yang, Helena Johansson, Shivani Sahni, Elizabeth J. Samelson, Douglas P. Kiel, Sarah D. Berry
Summary: This study compared the performance of FRAX in identifying fracture risk in individuals with and without frailty. It found that FRAX had lower discrimination ability in individuals with frailty, but this improved when bone mineral density (BMD) was included. The study suggests that BMD is an important factor for fracture prediction in frail individuals.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Maria Beatrice Zazzara, Agnese Cangini, Roberto Da Cas, Ilaria Ippoliti, Alessandra Marengoni, Andrea Pierantozzi, Elisabetta Poluzzi, Simona Zito, Graziano Onder
Summary: This study analyzed medication use and costs in Italian adults aged >= 90 years, finding that both use and costs decreased linearly with increasing age. Men had higher utilization and costs compared to women, with antihypertensives, antiplatelet agents, medications for peptic ulcer and gastroesophageal reflux, and lipid-lowering agents being the most frequently used medications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Manav V. Vyas, Jennifer A. Watt, Amy Y. X. Yu, Sharon E. Straus, Moira K. Kapral
Summary: The study found that loneliness in older adults is associated with increased daily use of opioids and benzodiazepines, but not with non-opioid analgesics. Additionally, loneliness is associated with polypharmacy.
Article
Endocrinology & Metabolism
Gregory A. A. Kline, Suzanne N. N. Morin, Lisa M. M. Lix, William D. D. Leslie
Summary: Based on the FLEX study in 2006, a 5-year course of bisphosphonate therapy was found to be sufficient for most women. However, despite the increased risk of atypical femoral fractures associated with long-term use, up to one-third of patients continued to receive bisphosphonate therapy for over 10 years after 2010.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
