Review
Biochemistry & Molecular Biology
Karina Akhiiarova, Rita Khusainova, Ildar Minniakhmetov, Natalia Mokrysheva, Anton Tyurin, Giuseppina Storlino
Summary: Peak bone mass refers to the amount of bone tissue formed when a stable skeletal state is achieved at a young age. It plays a crucial role in the prevention of osteoporosis. Factors such as hormonal levels, body composition, physical activity, nutrition, and heredity influence the level of peak bone mass.
Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study aimed to identify nutrient patterns (NPs) and their association with bone mineral density (BMD) categories in postmenopausal women. The results showed that lower consumption of NP1 and NP2 was associated with an increased risk of osteopenia, but not osteoporosis.
Review
Pharmacology & Pharmacy
Jiangbi Li, Yang Sun, Zhuo Chen, Xiaoping Xie, Feng Gu, Songqi Bi, Tiecheng Yu
Summary: This review examined the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women. The study found that bisphosphonates had significant positive effects on bone density and bone markers, as well as reducing the risk of fractures. However, further research is needed to determine their safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Katherine W. Reeves, Gabriela Vieyra, Nydjie P. Grimes, Jaymie Meliker, Rebecca D. Jackson, Jean Wactawski-Wende, Robert Wallace, R. Thomas Zoeller, Carol Bigelow, Susan E. Hankinson, JoAnn E. Manson, Jane A. Cauley, Antonia M. Calafat
Summary: The study found that certain phthalate biomarkers were associated with greater percentage decreases in total hip and femoral neck bone mineral density (BMD), suggesting that phthalate exposure may have clinically significant effects on BMD and potentially increase fracture risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Graziamaria Corbi, Vincenzo Nobile, Valeria Conti, Alessandro Cannavo, Vincenzo Sorrenti, Alessandro Medoro, Giovanni Scapagnini, Sergio Davinelli
Summary: This study aimed to evaluate the effects of equol and resveratrol on bone turnover biomarkers in postmenopausal women. The results showed that the combination of equol and resveratrol significantly improved bone turnover biomarkers and increased bone mineral density, suggesting a potential approach to prevent age-related bone loss in postmenopausal women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Pilar Sanchis, Rafael Maria Prieto, Jadwiga Konieczna, Felix Grases, Itziar Abete, Jordi Salas-Salvado, Vicente Martin, Miguel Ruiz-Canela, Nancy Babio, Jesus Francisco Garcia-Gavilan, Albert Goday, Antonia Costa-Bauza, Jose Alfredo Martinez, Dora Romaguera
Summary: The main objective of this study was to examine the relationship between dietary phytate intake and bone mineral density (BMD) in a Mediterranean population of postmenopausal women. The results showed that phytate intake was positively associated with BMD in Mediterranean postmenopausal women, indicating a potential protective effect on bone. However, further large-scale, long-term, and randomized prospective clinical studies are needed to assess the potential benefits of phytate consumption on BMD in postmenopausal women.
Article
Orthopedics
Jiemei Gu, Hao Zhang, Qingyun Xue, Li Wang, Zhifeng Cheng, Yawei Zhang, Qifu Li, Lingqing Yuan, Yukun Li, Jin Dong, Yanan Huo, Xin Tang, Ling Hu, Xinjia Wang, Fei Hua, Lin Shen, Jinluo Cheng, Huimin Zhou, Youjia Xu, Tao Yang, Chuansuo Wang, Jin Xu, Jie Shen, Ying Zhang, Xiaomei Zhang, Dun Hong, Xiaoling Guan, Xinhua Xiao, Guang Wang, Yonghua Liu, Liujun Fu, Jianting Chen, Xigao Cheng, Yue Ding, Lijun Liu, Qi Yao, Xinchao Zhang, Lixin Li, Panjun Zhang, Chunying Deng, Chengyan Jiang, Li You, Kai Wang, Shimin Zhang, Jianzhong Xiao, Wei Liu, Xiaohong Du, Xianwen Shang, Tianrong Pan, Chen Lei, Shuren Guo, Zhenlin Zhang
Summary: This study assessed the efficacy, safety, pharmacokinetics, and immunogenicity of a denosumab biosimilar (LY06006) in Chinese postmenopausal women with osteoporosis. The results showed that LY06006 significantly increased bone mineral density and reduced bone resorption. The safety and tolerability of LY06006 were comparable to the reference drug Prolia(R).
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Endocrinology & Metabolism
Shanshan Xue, Yuzheng Zhang, Wenjing Qiao, Qianqian Zhao, Dingjie Guo, Binbin Li, Xue Shen, Lijie Feng, Fengyi Huang, Na Wang, Kemal Sherefa Oumer, Charkos Tesfaye Getachew, Shuman Yang
Summary: The study updated BMD T-score references using the most recent NHANES data, finding significant differences in the percentages of individuals classified as having osteoporosis and low bone mass between the updated and existing guidelines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Albert Shieh, Kristine M. Ruppert, Gail A. Greendale, Yinjuan Lian, Jane A. Cauley, Sherri-Ann Burnett-Bowie, Carrie Karvonen-Guttierez, Arun S. Karlamangla
Summary: Years since the final menstrual period (FMP) is more strongly associated with postmenopausal bone mineral density (BMD) than chronological age, and earlier menopause is associated with more fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Mariah Kay Jackson, Laura D. Bilek, Nancy L. Waltman, Jihyun Ma, James R. Hebert, Sherry Price, Laura Graeff-Armas, Jill A. Poole, Lynn R. Mack, Didier Hans, Elizabeth R. Lyden, Corrine Hanson
Summary: Little is known about the relationship between diet and inflammation and its impact on bone health. This cross-sectional study examined the association between diet's inflammatory potential and bone-related outcomes in midwestern post-menopausal women. The results showed that there was no significant association between the inflammatory potential of diet and bone density or structure in this cohort.
Article
Endocrinology & Metabolism
Su-Qin Shi, Shan-Shan Li, Xiao-Ya Zhang, Zhe Wei, Wen-Zhen Fu, Jin-Wei He, Yun-Qiu Hu, Miao Li, Li-Li Zheng, Zhen-Lin Zhang
Summary: This study found that genetic variations of the LGR4 gene are associated with peak bone mineral density, BMI, and trunk fat mass.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Christa Ellis, Herculina S. Kruger, Michelle Viljoen, Joel A. Dave, Marlena C. Kruger
Summary: The study found that changes in bone mineral density and bone resorption markers over two years were minimal in black postmenopausal women living with HIV. Despite a decrease in serum vitamin D, there were small or no changes in BMD and CTx over the 2-year period.
Article
Nutrition & Dietetics
Orlagh Feehan, Pamela Jane Magee, Laura Kirsty Pourshahidi, David John Armstrong, Mary Martina Slevin, Philip James Allsopp, Marie Catherine Conway, J. J. Strain, Emeir Mary McSorley
Summary: The study aimed to investigate the association between n-3 LCPUFA and bone density as well as bone remodeling markers. The results showed no association between n-3 LCPUFA and T-score or BMD, but a significant positive association between total n-3 LCPUFA and femur BMD was observed in women with a low n-6:n-3 ratio. Furthermore, there was a significant inverse association between ALA and urinary DPD/Cr.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study evaluated the association between dietary selenium consumption and bone mineral density in postmenopausal women. The results showed that postmenopausal women with higher selenium consumption were less likely to have osteoporosis.
FRONTIERS IN NUTRITION
(2022)