Review
Engineering, Biomedical
Guy Decante, Joao B. Costa, Joana Silva-Correia, Maurice N. Collins, Rui L. Reis, J. Miguel Oliveira
Summary: Three-dimensional (3D) bioprinting technology has gained significant attention in biomedical engineering and clinical applications, with advancements in bioink development allowing for more precise mimicry of native tissue characteristics and support for biofunctionality.
Article
Engineering, Biomedical
Cyrus W. Beh, Dionis S. Yew, Ruth J. Chai, Sau Yin Chin, Yiqi Seow, Shawn S. Hoon
Summary: The study introduces a hydrogel 3D printer that can print complex structures quickly and continuously, and is capable of multi-material printing. This innovative approach helps address the nutrient supply issue in bioprinting.
Article
Engineering, Manufacturing
Frederik Wulle, Oliver Gorke, Sarah Schmidt, Maximilian Nistler, Gunter E. Tover, Oliver Riedel, Alexanser Verl, Achim Weber, Alexanser Southan
Summary: This paper introduces the potential and advantages of multi-axis 3D printing of hydrogels, and demonstrates through experiments the relative flexibility and water absorbency of 3D printed hydrogels compared to conventional molded hydrogels. The research also highlights related research questions, such as cross-linking chemistry and formulation of hydrogel inks.
ADDITIVE MANUFACTURING
(2022)
Review
Engineering, Multidisciplinary
Xin Ning Zhang, Qiang Zheng, Zi Liang Wu
Summary: This paper reviews the recent progress in 3D printing of tough hydrogels and their applications. It provides an overview of the advantages and requirements of tough hydrogel systems for specific 3D printing technologies, and summarizes the network structures, mechanical performances, toughening mechanisms, and representative applications of the printed tough hydrogels. It also discusses the recent advances in 4D printing of tough hydrogels as a prospective direction for soft actuators and robots.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Polymer Science
Jianghong Huang, Jianyi Xiong, Daping Wang, Jun Zhang, Lei Yang, Shuqing Sun, Yujie Liang
Summary: 3D bioprinting is an emerging technology that allows for personalized therapy strategies in regenerative medicine. Over the last two decades, 3D bioprinting hydrogels have significantly advanced the field of cartilage and bone tissue engineering. This review discusses the development and application of 3D bioprinting, as well as future directions for optimization.
Article
Biotechnology & Applied Microbiology
Matteo Pitton, Andrea Fiorati, Silvia Buscemi, Lucio Melone, Silvia Fare, Nicola Contessi Negrini
Summary: By developing multicomponent bioinks combining pectin with TEMPO-oxidized cellulose nanofibers (TOCNFs), the research optimized the printability of pectin inks, ensuring stability of the printed hydrogels and viability of cell-laden inks.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Polymer Science
Quinten Thijssen, Joseph Toombs, Chi Chung Li, Hayden Taylor, Sandra Van Vlieberghe
Summary: This review comprehensively discusses the potential of volumetric 3D-printing, summarizing the theoretical framework of photopolymerization and highlighting the advancements in light-based 3D-printing techniques. Special attention is given to the subfield of volumetric bioprinting. The review provides important discussions and prospects for those interested in the field of volumetric 3D-printing.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Engineering, Biomedical
Erik Brodin, Melanie Boehmer, Alexandra Prentice, Emily Neff, Kathleen McCoy, Jens Mueller, Justin Saul, Jessica L. Sparks
Summary: Keratins, derived from sources such as human hair, offer desirable characteristics for tissue engineering scaffolds. This study aimed to leverage the rheological properties of keratin hydrogels to develop a strategy for 3D printing keratin bio-inks without the need for exogenous modifiers. By varying the keratose/kerateine ratio and total keratin weight percentage, the rheological properties of keratin hydrogels were tuned. The study found that adjusting these parameters influenced the flow resistance and degradation kinetics of the gels, allowing for enhanced printability and control of scaffold properties.
BIOMEDICAL MATERIALS
(2022)
Article
Polymer Science
Chi Gong, Zhiyuan Kong, Xiaohong Wang
Summary: This study successfully printed composite hydrogels by replacing the pregelatinization effect of gelatin with agarose physical crosslinking. The structures manufactured by agarose pregelatinization are significantly more accurate, stable, and harder than those pregelatined by gelatin. It holds great potential for future organ manufacturing fields with high structural accuracy and stability.
Article
Polymer Science
Izar Gorronogoitia, Uzuri Urtaza, Ana Zubiarrain-Laserna, Ana Alonso-Varona, Ane Miren Zaldua
Summary: Three-dimensional bioprinting combined with natural hydrogels is a promising technology for the treatment of various pathologies and tissue regeneration. This study focuses on the printability and physicochemical properties of alginate-based hydrogels and scaffolds. The results show that the microstructure of alginate has a significant impact on its printability and mechanical properties, emphasizing the importance of controlling the viscoelastic and mechanical properties for obtaining high-resolution and precise structures.
Article
Polymer Science
Hadis Gharacheh, Murat Guvendiren
Summary: Composite hydrogel bioink, formulated by incorporating human allograft bone particles in a methacrylated alginate formulation, enhances osteogenesis of adult human mesenchymal stem cells (hMSCs) for bone tissue engineering. The bioink is suitable for extrusion-based 3D bioprinting, and in vitro studies show significantly enhanced osteogenic differentiation of hMSCs cultured within the bioprinted composite scaffolds.
Article
Biochemistry & Molecular Biology
Kelsey Willson, Anthony Atala, James J. Yoo
Summary: Developing appropriate bioinks is a complex task that depends on the mechanical and biochemical requirements of the final construct and the type of printer used. Different types of tissue printers have different requirements for bioinks, with an emphasis on supporting cellular development. Researchers are increasingly using composite bioinks to take advantage of multiple materials in the development process.
Article
Biochemical Research Methods
Shukufe Amukarimi, Zahra Rezvani, Neda Eghtesadi, Masoud Mozafari
Summary: The development of smart biomaterials has led to enhanced medical facilities in this century. One shining example is the rise of four-dimensional bioprinting technology, which can fabricate stimuli-responsive cell-laden structures that can undergo morphological changes in a pre-planned way.
Review
Materials Science, Multidisciplinary
Amir A. Elhadad, Ana Rosa-Sainz, Raquel Canete, Estela Peralta, Belen Begines, Mario Balbuena, Ana Alcudia, Y. Torres
Summary: This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It provides an overview of various 3D printing techniques and their applications, with a focus on materials such as composites, hybrids, and smart materials. The article also discusses the latest developments in 4D bioprinting technology and outlines present challenges and future regulations.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Bram G. Soliman, Alessia Longoni, Mian Wang, Wanlu Li, Paulina N. Bernal, Alessandro Cianciosi, Gabriella C. J. Lindberg, Jos Malda, Juergen Groll, Tomasz Jungst, Riccardo Levato, Jelena Rnjak-Kovacina, Tim B. F. Woodfield, Yu Shrike Zhang, Khoon S. Lim
Summary: Sacrificial printing involves using 3D-printed sacrificial ink to create open-channels in hydrogel constructs. Traditional sacrificial inks lack the ability to mimic tissue development dynamics. To overcome this, a new class of sacrificial inks was developed with tailorable and programmable delayed dissolution profiles. These inks showed compatibility with various biofabrication technologies and allowed precise control over the introduction of architectural features into cell-laden hydrogel constructs.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biophysics
Audrey C. Ford, Wan Fung Chui, Anne Y. Zeng, Aditya Nandy, Ellen Liebenberg, Carlo Carraro, Galateia Kazakia, Tamara Alliston, Grace D. O'Connell
JOURNAL OF BIOMECHANICS
(2018)
Article
Engineering, Biomedical
Bo Yang, Grace D. O'Connell
ACTA BIOMATERIALIA
(2019)
Article
Biophysics
Minhao Zhou, Semih E. Bezci, Grace D. O'Connell
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Arvin H. Soepriatna, A. Kevin Yeh, Abigail D. Clifford, Semih E. Bezci, Grace D. O'Connell, Craig J. Goergen
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bo Yang, Michael F. Wendland, Grace D. O'Connell
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Multidisciplinary Sciences
Tao Yang, Kevin C. Tran, Anne Y. Zeng, Stephen M. Massa, Frank M. Longo
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Yishu Yan, Hao Fan, Yibin Li, Elias Hoeglinger, Alexander Wiesinger, Alan Barr, Grace D. O'Connell, Carisa Harris-Adamson
Summary: The deep learning model achieved a high accuracy in predicting occupational physical activities, but accuracy varied greatly when predicting complex tasks that combined different occupational physical activities. Further research is needed to improve accuracy in predicting combined occupational physical activities in simulated work tasks.
APPLIED SCIENCES-BASEL
(2021)
Article
Orthopedics
Shiyin Lim, Reece D. Huff, Joanna E. Veres, Divya Satish, Grace D. O'Connell
Summary: Mechanical testing is a valuable tool for assessing intervertebral disc health, but the lack of consistency in disc geometry measurement methods makes it difficult to compare results. This study found that different measurement methods significantly impact reported mechanical properties.
Article
Biochemical Research Methods
Jonathan P. McKinley, Andre R. Montes, Maple N. Wang, Anuya R. Kamath, Gissell Jimenez, Jianhua Lim, Siddharth A. Marathe, Mohammad R. K. Mofrad, Grace D. O'Connell
Summary: Severe lower back pain is the leading cause of disability globally. To tackle this untreated epidemic, researchers investigate intervertebral disc degeneration, the main cause of back pain. They develop a microphysiological device called the flexing annulus-on-a-chip (AoC) to examine the effects of complex multiaxial strains on the annulus fibrosus (AF) cells, a critical tissue in degenerative discs. Through this device, researchers could advance therapies for early-stage degeneration at the cellular level.
Review
Orthopedics
John J. Costi, Eric H. Ledet, Grace D. O'Connell
Summary: Biomechanical testing methodologies for the spine have evolved over the past 50 years, incorporating advanced engineering principles, in vivo measurements, anatomical structure-function relationships, and the scientific method. While some methods have been commonly adopted, a 2019 survey revealed that not all are consistent with scientific evidence, highlighting the need for standardized testing protocols in the field.
Article
Ophthalmology
Jesse J. Jung, Daryle Jason G. Yu, Anne Zeng, Michael H. Chen, Yue Shi, Marco Nassisi, Kenneth M. Marion, Srinivas R. Sadda, Quan Hoang
OPHTHALMOLOGY RETINA
(2020)
Article
Orthopedics
Nicolas Newell, David Rivera Tapia, Tamanna Rahman, Shiyin Lim, Grace D. O'Connell, Timothy P. Holsgrove
Article
Ophthalmology
Anne Zeng, Ron Strauss, Sarah E. Goglin, John Gonzales, Varun K. Pawar, Richard K. Imes, Jesse J. Jung
JOURNAL OF VITREORETINAL DISEASES
(2020)