Article
Environmental Sciences
Lin Wang, Khaliunaa Bayanbold, Lei Zhao, Yifang Wang, Andrea Adamcakova-Dodd, Peter S. Thorne, Hushan Yang, Bing-Hua Jiang, Ling-Zhi Liu
Summary: This study found that hexavalent chromium (Cr(VI)) treatment can upregulate the expression of Nrf2, and the upregulation of Nrf2 is mediated by the downregulation of KEAP1 in the late stage of exposure. Additionally, the study also revealed that Cr(VI) exposure leads to the inhibition of miR-27a/b, resulting in the upregulation of Nrf2. These findings highlight the important role of redox-sensitive miR-27a/b in the regulation of Nrf2 upon Cr(VI) exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Oncology
Chunfeng Liu, Jun Deng, Songping Wang, Lei Ren
Summary: This study found that hypoxia promotes proliferation, migration, invasion, and the epithelial-mesenchymal transition (EMT) process of lung cancer cells by inhibiting miR-27a expression. NRF2, as a regulator of oxidation/anti-oxidation, is activated under hypoxia conditions, leading to the repression of miR-27a expression.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dun Su, Xingwen Wang, Yan Ma, Jinghua Hao, Jinshen Wang, Yongqu Lu, Yulin Liu, Xingfang Wang, Li Zhang
Summary: This study revealed that the Nrf2/miR-23a-27a-24-2/Bach1/HO-1 regulatory axis promotes the damage repair of intestinal mucosa during the development of inflammatory bowel diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Bo Li, Xiaoyu Huang, Chen Yang, Ting Ge, Leiyun Zhao, Xiaoqiang Zhang, Lintao Tian, Enping Zhang
Summary: This study reveals the mechanism by which miR-27a regulates lipid synthesis in sheep through targeting CPT1B, thereby promoting the formation of lipid droplets. These findings are important for improving the nutritional value of sheep meat.
Article
Biochemistry & Molecular Biology
Kuo Shen, Xujie Wang, Yunwei Wang, Yanhui Jia, Yue Zhang, Kejia Wang, Liang Luo, Weixia Cai, Jin Li, Shaohui Li, Yuting Du, Lixia Zhang, Hao Zhang, Yuxi Chen, Chaolei Xu, Jinxin Zhang, Ruizhi Wang, Xuekang Yang, Yunchuan Wang, Dahai Hu
Summary: This study explored the protective effect and mechanism of ADSCs exosomes on excessive inflammation-induced injury in pulmonary microvascular endothelial cells (PMVECs). ADSCs exosomes reduced ROS accumulation and cell injury in PMVECs by inhibiting excessive inflammatory response. They also alleviated ferroptosis induced by excessive inflammatory response and upregulated GPX4 expression. Furthermore, specific delivery of miR-125b-5p by ADSCs exosomes inhibited Keap1 and alleviated ferroptosis. In a sepsis model, ADSCs exosomes relieved lung tissue injury, reduced the death rate, and alleviated oxidative stress injury and ferroptosis of lung tissue.
Article
Endocrinology & Metabolism
Qiaoli Zeng, Dehua Zou, Na Liu, Yue Wei, Jing Yang, Weibiao Wu, Fengqiong Han, Rongrong He, Runmin Guo
Summary: This study found that the miR-27a rs895819 C allele is associated with an increased risk of gestational diabetes mellitus (GDM) and higher blood glucose levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu, Weiyu Shen
Summary: This study found that circBCAR3 is highly expressed in esophageal cancer and it can promote the tumorigenesis of esophageal cancer by interacting with miR-27a-3p to upregulate TNPO1. The splicing factor QKI was identified as a positive regulator of circBCAR3 and hypoxia upregulates E2F7 to transcriptionally activate QKI.
Article
Cell Biology
Wenyu Li, Qiongbin Zhu, Xiaoyan Xu, Xingyue Hu
Summary: The study found that miR-27a-3p can suppress cerebral ischemia-reperfusion injury by targeting FOXO1. In vitro experiments showed that OGD induced apoptosis and oxidative stress in HT22 cells, along with G1 arrest mediated by FOXO1/p27 Kip1 signaling. MiR-27a-3p mimics reversed these effects, and in vivo studies using a rat model also showed alleviation of CI/R symptoms with miR-27a-3p agomir treatment.
Article
Oncology
Giovannina Barisciano, Manuela Leo, Livio Muccillo, Erica Pranzini, Matteo Parri, Vittorio Colantuoni, Maria Letizia Taddei, Lina Sabatino
Summary: miR-27a regulates mitochondrial biogenesis through FOXJ3, impacting various aspects of mitochondrial function. Cells with high miR-27a and low FOXJ3 levels exhibit reduced mitochondrial activity, potentially inhibiting tumor growth.
Article
Biochemistry & Molecular Biology
Li-Rong Ren, Ru-Bin Yao, Shi-Yong Wang, Xiang-Dong Gong, Ji-Tao Xu, Kai-Shun Yang
Summary: It was found that miR-27a-3p promotes osteoblast differentiation by mediating the CRY2/ERK1/2 axis, suggesting it could be a new target for treating osteoporosis.
MOLECULAR MEDICINE
(2021)
Review
Pathology
Wen Bi, Jingjing Li, Mengqiu Xiong, Bei Pan, Zhongqiu Zhang, Lubanga Nasifu, Bangshun He, Ping Wang
Summary: MicroRNA-27a (miR-27a) is abnormally expressed in cancer patients and can serve as a potential diagnostic and prognostic biomarker. It is a valuable diagnostic biomarker in serum/plasma and can predict poor prognosis in cancer patients. However, its diagnostic value is slightly reduced in tumor tissue samples.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Guohua Lai, Renli Zhao, Weida Zhuang, Zuoxu Hou, Zefeng Yang, Peipei He, Jiachang Wu, Hongxun Sang
Summary: In the bone marrow microenvironment of postmenopausal osteoporosis, BMSC-derived exosomal miRNAs, specifically miR-27a-3p and miR-196b-5p, have been found to play an important regulatory role in bone formation and bone resorption. The study suggests that these miRNAs may have therapeutic potential for the treatment of osteoporosis.
Article
Microbiology
Min Xiao, Song Yang, An Zhou, Tongxin Li, Jingjing Liu, Yang Chen, Ya Luo, Chunfang Qian, Fuping Yang, Bo Tang, Chunhua Li, Na Su, Jing Li, Mingying Jiang, Shiming Yang, Hui Lin
Summary: This study found that miR-27a-3p and miR-30b-5p affect the progression of TB by targeting VDR, and regulate the secretion of proinflammatory cytokines and macrophage differentiation through the NF-kB inflammatory cytokine signaling pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Zihao Wei, Ying Wang, Jiakuan Peng, Honglin Li, Junjie Gu, Ning Ji, Taiwei Li, Xikun Zhou, Xin Zeng, Jing Li, Qianming Chen
Summary: In this study, circRFWD3 was found to be significantly upregulated in HNSCC tissues and cell lines, and it was associated with the aggressiveness of HNSCC cells and lymph node metastasis. Mechanistically, it acts as a miRNAs sponge for miR-27a/27b, leading to the upregulation of PPAR gamma, and then promotes HNSCC metastasis via the NF-kappa B/MMP13 pathway. The study suggests that circRFWD3 may serve as a potential therapeutic target in HNSCC.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Sara Hosseinpor, Bahman Khalvati, Farshad Safari, Ali Mirzaei, Ebrahim Hosseini
Summary: This study investigated the expression of miR-146a, miR-27, miR-149, and miR-34a in the plasma of CAD patients and the control group. The results showed that miR-27 was upregulated in the CAD group compared to the control group, while miR-146a was downregulated in CAD patients. Furthermore, there was a direct correlation between miR-146a and HDL-C, miR-27 and LDL-C, and miR-34a and total cholesterol, and a negative correlation between miR-149 and BMI.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)