期刊
ONCOIMMUNOLOGY
卷 4, 期 8, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1019198
关键词
Cancer; cross-presentation; dendritic cells; melanoma; tumor immunity
The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin. Two migratory populations defined as CD103(-)XCR1(+) and CD103(+)XCR1(+) efficiently cross-presented melanoma-derived antigen, with the CD103(-)XCR1(+) DCs surprisingly dominating this process. These results are critical for understanding how antitumor CD8(+) T cell immunity is coordinated to tumor antigens present within the skin.
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