Article
Clinical Neurology
Michael Dietrich, Hans-Peter Hartung, Philipp Albrecht
Summary: 4-aminopyridine is used as a symptomatic therapy in various neurological disorders, with potential neuroprotective features beyond its symptomatic action, particularly in patients with multiple sclerosis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Cecilie Dollerup Skov, Christina Borgen Sorensen, Maria Thorning, Kate Lykke Lambertsen, Lars Henrik Frich, Henrik Boye Jensen, Anders Holsgaard-Larsen, Helle H. Nielsen
Summary: The purpose of this study was to evaluate changes in functional hand and walking measurements in multiple sclerosis patients with walking disability after fampridine treatment. The combination of self-reported walking capacity and walking endurance was found to be the most effective measurement for detecting clinically meaningful improvement after fampridine treatment.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Mona Klara Ros Mueller, Monika Christ, Markus Naumann, Antonios Bayas
Summary: This article reports a case of spinal myoclonus in a patient with multiple sclerosis after cervical myelitis, which significantly improved after treatment with prolonged-release fampridine.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Cell Biology
Ulrike B. S. Hedrich, Stephan Lauxmann, Markus Wolff, Matthis Synofzik, Thomas Bast, Adrian Binelli, Jose M. Serratosa, Pedro Martinez-Ulloa, Nicholas M. Allen, Mary D. King, Kathleen M. Gorman, Bruria Ben Zeev, Michal Tzadok, Lily Wong-Kisiel, Dragan Marjanovic, Guido Rubboli, Sanjay M. Sisodiya, Florian Lutz, Harshad Pannikkaveettil Ashraf, Kirsten Torge, Pu Yan, Christian Bosselmann, Niklas Schwarz, Monika Fudali, Holger Lerche
Summary: Developmental and epileptic encephalopathies are severe disorders characterized by epilepsy, intellectual disability, and other neuropsychiatric symptoms with limited treatment options. Through a precision medicine approach, it was found that the K+ channel blocker 4-aminopyridine could effectively alleviate symptoms in patients with KCNA2-encephalopathy caused by variants in the K(V)1.2 subunit. Results from n-of-1 trials showed that most patients benefited from the treatment with 4-aminopyridine, with well-tolerated dosages up to 2.6 mg/kg per day.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Kryslaine L. Radomski, Xiaomei Zi, Fritz W. Lischka, Mark D. Noble, Zygmunt Galdzicki, Regina C. Armstrong
Summary: 4-aminopyridine (4-AP) treatment has multiple benefits in promoting recovery and reducing pathological hallmarks of axon damage in closed head traumatic brain injury.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ivanka Kostadinova, Boycho Landzhov, Lyubomir Marinov, Lyubomir Vezenkov, Nikolai Danchev
Summary: The study assessed the effects of newly synthesized 4-AP derivatives on a cuprizone-induced mouse model of brain demyelination, with compounds 4b and 4c showing promise in improving memory processes and reversing the effects of cuprizone.
Article
Chemistry, Physical
Derui Liang, Caifeng Xia, Hanhan Huang, Yao Liu, Zequn Ma, Shuang Li, Qian Zhang, Zilin Meng
Summary: In this study, the slow-release of the pesticide MCPA using layered double hydroxides (LDH) was successfully achieved. The release behavior of MCPA/LDH was studied and analyzed under different conditions. The results showed improved weed control effect and potential applications in agricultural production, demonstrating an effective strategy for the efficient utilization of MCPA.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Clinical Neurology
Lyubomir T. Vezenkov, Daniela S. Tsekova, Ivanka Kostadinova, Rositsa Mihaylova, Valentin Lozanov, Nikolay G. Vassilev, Nikolai Danchev, Ivanka Tsakovska, Ilza Pajeva
Summary: This study aimed to obtain new peptide derivatives of 4-aminopyridine with decreased toxicity compared to 4-aminopyridine. The new derivatives containing analogues of the β-secretase inhibitory peptide were synthesized using a consecutive condensation approach. The results showed that the acute toxicity of the new compounds was approximately 150 times lower than that of 4-aminopyridine, and they exhibited negligible growth-inhibitory effects on tumor cells.
CURRENT ALZHEIMER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Chan Soon Park, Jin Joo Park, Hae-Young Lee, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Suk Keun Hong, Joon-Han Shin, Myung-A Kim, Dae-Gyun Park, Eung-ju Kim, Soon-jun Hong, Seok Yeon Kim, Jae-Joong Kim, Dong-Ju Choi
Summary: This study compared the clinical efficacy of once daily slow-release carvedilol with twice daily immediate-release carvedilol in patients with heart failure and reduced ejection fraction. The results showed that once daily slow-release carvedilol was non-inferior to twice daily immediate-release carvedilol in treating heart failure.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sunitha Subhramanian, Ajish Ariyath, Reshma Sabhi, Tessy Xavier, Anandkumar Anandakuttan, Sudheeran Kannoth, Arumugam Thennavan, Kannoth Panicker Sreekumar, Ayalur Kodakara Kochugovindan Unni, Chethampadi Gopi Mohan, Krishnakumar N. Menon
Summary: In the context of gut-brain control of multiple sclerosis (MS), developing therapeutics targeting proinflammatory proteins controlling the gut-brain immunomodulation is promising. One such immunomodulator is glia maturation factor-fi (GMF-fi). We identified an inhibitor, 1H-indazole-4-yl-methanol (GMFBI.1), which blocked GMF-fi-ser-83 phosphorylation critical in EAE suppression.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Clinical Neurology
Sepide Kashefiolasl, Marlies Wagner, Nina Brawanski, Volker Seifert, Stefan Wanderer, Lukas Andereggen, Juergen Konczalla
Summary: By studying experimental data and clinical databases, it was found that statin treatment can reduce the risk of cerebral vasospasm, delayed infarction, and delayed cerebral ischemia in patients with non-aneurysmal subarachnoid hemorrhage. Additionally, statin treatment is significantly associated with favorable clinical outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Deepa Jonnalagadda, Debin Wan, Jerold Chun, Bruce D. Hammock, Yasuyuki Kihara
Summary: sEH inhibitor TPPU showed potential in treating MS in animal models by blocking the production of toxic dihydroxy-FAs and increasing certain EpFA species to reduce neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Bilal Beig, Muhammad Bilal Khan Niazi, Baseer Ullah, Ahmed Nadeem Gondal, Zaib Jahan, Munir Zia, Nouman Ahmad
Summary: This research focuses on the application of zinc oxide as a coating material for urea fertilizer to achieve slow-release performance. Modelling and experimental studies were conducted to understand the nutrient release pattern. The findings suggest that second-order kinetics can accurately describe the nutrient release from zinc-coated urea.
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2023)
Article
Construction & Building Technology
Zhiqiang Zhang, Yinjun Tan, Runlin Hong, Yu Zhao, Heng Zhang, Yuchun Zhang, Zhisheng Li
Summary: A series of model tests were conducted to investigate the smoke movement and influencing factors when a fire occurs in a slowly moving train in a tunnel. The results showed that the piston wind speed generated by the slow moving train increases non-linearly with the train speed, but remains below 10% of the train speed. The main driving force for smoke diffusion is buoyancy. The combustion process in the fire-source carriage can be divided into three stages, with the heat release rate decreasing in the stable combustion stage as the train speed increases. The temperature rising process of the tunnel vault also consists of three stages, with the maximum temperature rise during the fire control stage accounting for 44.2% of the total temperature rise. The smoke accumulation stage is the main period of temperature rise in the tunnel, accounting for over 94% of the total temperature rise when the model train speed reaches 0.6 m/s.
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abdulaziz M. S. Alsaad, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Saleh A. Bakheet, Hatun A. Alomar, Sheikh F. Ahmad
Summary: We assessed the impact of 4-Methylhistamine (4-MeH), a specific agonist for the Histamine H4 Receptor (H4R), on the progression of EAE and found that it promotes the production of pro-inflammatory mediators, exacerbating EAE symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rehabilitation
Cecilie Thrue, Lars G. Hvid, Mads Gamborg, Helen Dawes, Ulrik Dalgas, Martin Langeskov-Christensen
Summary: This study systematically reviewed the psychometric properties of the VO2max test in PD, VO2max levels in pwPD compared to HCs, and reported VO2max associations in PD. The results showed that VO2max was comparable between pwPD and HC as well as between different PD-medication states, and only age, sex, and fatigue were associated with VO2max. However, there was limited evidence on the psychometric properties of the VO2max test.
DISABILITY AND REHABILITATION
(2023)
Review
Clinical Neurology
Mads Gamborg, Lars Grondahl Hvid, Cecilie Thrue, Sverker Johansson, Erika Franzen, Ulrik Dalgas, Martin Langeskov-Christensen
Summary: This study systematically reviewed the literature on mechanical muscle function in people with Parkinson's disease (PwPD). The findings indicate that PwPD have impaired muscle strength, power, and rate of force development compared to healthy controls (HC). Additionally, muscle strength was found to be associated with functional capacity and disease severity.
JOURNAL OF NEUROLOGIC PHYSICAL THERAPY
(2023)
Article
Clinical Neurology
Paolo Preziosa, Maria A. Rocca, Elisabetta Pagani, Paola Valsasina, Maria Pia Amato, Giampaolo Brichetto, Nicolo Bruschi, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Alessandro Meani, Cecilia Meza, Robert W. Motl, Amber Salter, Brian M. Sandroff, Anthony Feinstein, Massimo Filippi
Summary: The study explores the associations among fatigue, dual-task performance and structural and functional abnormalities of frontal cortico-subcortical network in progressive multiple sclerosis (PMS). The results indicate that both structural and functional abnormalities contribute to fatigue and worse dual-task performance in PMS, with different patterns according to the presence of fatigue.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Maria Thorning, Kate Lykke Lambertsen, Cecilie Dollerup Skov, Lars Henrik Frich, Henrik Boye Jensen, Anders Holsgaard-Larsen, Helle Hvilsted Nielsen
Summary: The aim of this study was to investigate whether muscle strain measured by speckle tracking ultrasonography could be a useful quantitative measure of muscle function in patients with multiple sclerosis. The validity of muscle strain was compared to that of validated performance measures of upper and lower extremity function. The findings indicate that muscle strain assessed by speckle tracking ultrasonography is not a valid measure of muscle function in multiple sclerosis.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Clinical Neurology
John Brincks, Ulrik Dalgas, Erika Franzen, Jacob Callesen, Andreas Wallin, Sverker Johansson
Summary: The specific components of balance training interventions in people with multiple sclerosis (PwMS) were systematically analyzed. The frequency, time, and duration of the interventions were well described, while the intensity and progression of training were not reported systematically. The interventions primarily focused on sensory and motor strategies, with little emphasis on reactive motor strategies, vestibular sense, and cognitive dual-tasking.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Francesco Romano, Robert W. Motl, Paola Valsasina, Maria Pia Amato, Giampaolo Brichetto, Nicolo Bruschi, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Amber Salter, Brian M. Sandroff, Anthony Feinstein, Maria A. Rocca, Massimo Filippi, CogEx Res Team CogEx Res Team
Summary: Altered thalamic volumes and resting state functional connectivity are associated with physical activity and cardiorespiratory fitness in people with progressive multiple sclerosis. Thalamic structural and functional alterations are correlated with levels of physical activity and cardiorespiratory fitness in people with progressive multiple sclerosis. People with progressive multiple sclerosis have lower thalamic volumes and abnormal resting state functional connectivity.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
R. Veldkamp, M. D'hooge, B. M. Sandroff, J. DeLuca, D. Kos, A. Salter, A. Feinstein, M. P. Amato, G. Brichetto, J. Chataway, R. Farrell, N. D. Chiaravalloti, U. Dalgas, M. Filippi, J. Freeman, R. W. Motl, C. Meza, M. Inglese, M. A. Rocca, G. Cutter, P. Feys
Summary: Performing cognitive-motor dual tasks can negatively affect walking performance and cognitive function in individuals with progressive multiple sclerosis and cognitive impairment. This study examined the dual task performance in different disability levels and found that it significantly affected walking performance, with similar effects across disability subgroups.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Frederik Bonde Jensen, Ulrik Dalgas, John Brincks, Martin Langeskov-Christensen
Summary: This study investigated the content validity and test-retest reliability of the VO2-max test in persons with Parkinson's disease (pwPD), both in the ON and OFF medication states. The study found that the VO2-max test had acceptable content validity and excellent day-to-day reliability in pwPD, regardless of medication.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Infectious Diseases
Trine Andreasen Leth, Anita Nymark, Fredrikke Christie Knudtzen, Sanne Lokkegaard Larsen, Marianne N. Skov, Thoger Gorm Jensen, Malene Bek-Thomsen, Henrik Boye Jensen, Joppe W. Hovius, Sigurdur Skarphedinsson, Jens Kjolseth Moller, Nanna Skaarup Andersen
Summary: This study aimed to improve the clinical sensitivity of PCR detection of Borrelia burgdorferi sensu lato spirochetes in diagnosing Lyme neuroborreliosis (LNB) by inoculating cerebrospinal fluid directly into culture medium. The results suggest that PCR may be of additional value in selected patients with a limited time from symptom onset to sample collection.
TICKS AND TICK-BORNE DISEASES
(2023)
Article
Sport Sciences
Lisa Urup Tonning, Bjarne Mygind-Klavsen, Troels Kjeldsen, Ulrik Dalgas, John Brincks, Inger Mechlenburg
Summary: Chronic exertional compartment syndrome (CECS) is a common cause of exercise-induced pain in the lower leg. This study compared muscle strength, oxygen saturation, and daily physical activity between patients with CECS and asymptomatic controls. The results showed no differences in muscle strength, oxygen saturation, and daily physical activity levels between the two groups, but patients with CECS experienced significantly higher levels of lower leg pain during running and daily activities. Oxygen saturation was not associated with leg pain.
INTERNATIONAL JOURNAL OF SPORTS PHYSICAL THERAPY
(2023)
Article
Clinical Neurology
Ulrik Dalgas, Morten Riemenschneider, Stefan M. Gold, Alon Kalron, Heleen Beckerman, Vincent de Groot, Rachel Dennett, Thomas Edwards, Lara A. Pilutti, Jenny Freeman
Summary: This paper outlines the work of the 'Study design and methodology' group of the MoXFo initiative, aiming to improve the quality of exercise studies in MS patients. By proposing the MS exercise PICOTS framework, it addresses the challenges and considerations in exercise-specific MS research.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Clinical Neurology
Marcia Finlayson, Peter Feys, Ulrik Dalgas, Daphne Kos
Summary: This study discusses the conceptual and practical issues related to selecting intermediate outcomes for clinical trials of multiple sclerosis (MS) rehabilitation interventions. The overall goal of rehabilitation is optimal functioning, which is a complex biopsychosocial phenomenon that varies with patient priorities and environmental context. Multiple causal pathways and potential intermediate outcomes must be carefully considered in the design of clinical trials aiming to improve functioning in MS rehabilitation, along with practical issues such as the psychometric properties of outcome measures, measure type, and characteristics of the target population, including severity of dysfunction.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Morten Riemenschneider, Lars G. G. Hvid, Thor Petersen, Egon Stenager, Ulrik Dalgas
Summary: This study investigates the effects of exercise on physical function, cognition, and patient-reported measures of disease and fatigue impact in early multiple sclerosis (MS). The results show that supervised aerobic exercise can improve physical function, but does not have a significant impact on cognitive function. However, perception of disease and fatigue impact can be improved through exercise in early MS.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Anders G. Skjerbaek, Ulrik Dalgas, Egon Stenager, Finn Boesen, Lars G. Hvid
Summary: Walking capacity is crucial for individuals with multiple sclerosis. This study compared impairment levels across three commonly used walking capacity outcomes in multiple sclerosis patients. The results showed that patients with multiple sclerosis performed worse than healthy controls in all three outcomes, with differences observed between the different outcomes.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Clinical Neurology
Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W. Motl, Maria A. Rocca, Brian M. Sandroff, CogEx Res Team
Summary: This study investigated the individual and synergistic effects of cognitive rehabilitation and exercise in patients with progressive multiple sclerosis. The results showed that combined cognitive rehabilitation plus exercise did not seem to improve processing speed in these patients.