Combining Notch inhibition with current therapies for breast cancer treatment

Gamma-secretase inhibitors in solid tumor malignancies

(2014) J.J. Arcaroli et al.   DRUGS OF THE FUTURE

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

(2012) Natalie Cook et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch ligand endocytosis: Mechanistic basis of signaling activity

(2012) Abdiwahab A. Musse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

(2011) K Pandya et al.   BRITISH JOURNAL OF CANCER

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

(2011) Nadia A Rana et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice

(2011) Zhenyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097

(2011) Wei He et al.   Molecular Oncology

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer

(2011) M Kondratyev et al.   ONCOGENE

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

(2011) J. M. Haughian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells

(2011) S. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Lethality through Combined Notch-Epidermal Growth Factor Receptor Pathway Inhibition in Basal-Like Breast Cancer

(2010) Y. Dong et al.   CANCER RESEARCH

Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

(2010) H. Harrison et al.   CANCER RESEARCH

Targeting Notch to Target Cancer Stem Cells

(2010) A. Pannuti et al.   CLINICAL CANCER RESEARCH

Specificity of Notch pathway activation: Twist controls the transcriptional output in adult muscle progenitors

(2010) F. Bernard et al.   DEVELOPMENT

The Notch signaling pathway: Molecular basis of cell context dependency

(2010) Ralf Schwanbeck et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype

(2010) Sarah J Zardawi et al.   HISTOPATHOLOGY

Notch-1 and Notch-4 Receptors as Prognostic Markers in Breast Cancer

(2010) Katharine Yao et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Targeting Breast Cancer Stem Cells

(2010) Suling Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Triple-negative breast cancer: disease entity or title of convenience?

(2010) Lisa Carey et al.   Nature Reviews Clinical Oncology

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

(2010) Kelly L Arnett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

(2010) M. Mazzone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells

(2009) O. Meurette et al.   CANCER RESEARCH

De novo Discovery of a  -Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

(2009) J. W. Watters et al.   CANCER RESEARCH

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis

(2009) Suruchi Mittal et al.   Molecular Cancer

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Mammary development meets cancer genomics

(2009) Aleix Prat et al.   NATURE MEDICINE

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

(2009) Elgene Lim et al.   NATURE MEDICINE

NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells

(2008) N. Yamaguchi et al.   CANCER RESEARCH

Molecular Dependence of Estrogen Receptor-Negative Breast Cancer on a Notch-Survivin Signaling Axis

(2008) C. W. Lee et al.   CANCER RESEARCH

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

(2008) P. Rizzo et al.   CANCER RESEARCH

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a γ-secretase inhibitor

(2008) C Osipo et al.   ONCOGENE

Notch signaling regulates tumor angiogenesis by diverse mechanisms

(2008) J Dufraine et al.   ONCOGENE

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA