期刊
ONCOIMMUNOLOGY
卷 5, 期 2, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1078966
关键词
BRAF V600E; Cancer; Cytotoxic T cell; HLA; immune suppression; immunotherapy; interleukin-1; MHC class I; melanoma; oncogene; oncogene targeted therapies
Several studies have demonstrated that oncogenic BRAF((V600E)) promotes T-cell suppression in melanoma by upregulating the transcription of a multitude of immunomodulatory chemokine and cytokine genes. BRAF((V600E)) has now been shown to act even more directly to evade cytotoxic T-cell recognition, by driving rapid internalization of human leukocyte antigen (HLA) class I from the tumor-cell surface and its intracellular sequestration.
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