Review
Biochemistry & Molecular Biology
Antonela Gverovic Antunica, Ljubo Znaor, Mira Ivankovic, Velibor Puzovic, Irena Markovic, Snjezana Kastelan
Summary: Diabetic retinopathy, the most common eye disease complication of diabetes, is associated with hypovitaminosis D. Vitamin D2 and D3 are the main forms of vitamin D, with sunlight being a major source. Vitamin D plays a crucial role not only in maintaining healthy bones and immune system but also in the development of various diseases, including diabetic retinopathy. Diagnosis of vitamin D deficiency, which is prevalent worldwide, is done through measuring serum concentration of 25-hydroxyvitamin D. Supplementation of vitamin D has been proven effective in treating diabetic retinopathy, but under the recommendation and supervision of a doctor to prevent potential negative side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Jeremy Grossman, Jun Fan, Felicia Allard, Jane Moon, Luis A. Marcos
Summary: This article reports a fatal case of S. stercoralis hyperinfection in an immigrant from rural Ecuador and emphasizes the importance of screening for this parasite in the appropriate clinical scenarios. Various diagnostic methods are introduced to make the diagnosis of S. stercoralis more accessible to practitioners.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Parasitology
Lei Deng, Huiyi Tay, Guangneng Peng, Jonathan W. J. Lee, Kevin S. W. Tan
Summary: This study investigated the prevalence and subtype characteristics of Blastocystis in patients with suspicion of C. difficile infection in Singapore. The study found a Blastocystis positivity rate of 10.1%, with the predominant subtype being ST7. Co-infection of Blastocystis and C. difficile was observed in five patients, with subtypes ST7, ST1, and ST3 identified.
PARASITES & VECTORS
(2021)
Article
Nutrition & Dietetics
Pilar Palmrich, Alexandra Thajer, Nawa Schirwani, Christina Haberl, Harald Zeisler, Robin Ristl, Julia Binder
Summary: This study indicates that the majority of pregnant women are deficient in vitamin D during pregnancy, despite the intake of pregnancy vitamins containing vitamin D. Therefore, individualized vitamin D assessment should be considered to ensure adequate supplementation and prevention of hypovitaminosis D.
Article
Multidisciplinary Sciences
Mao Hagihara, Tadashi Ariyoshi, Yasutoshi Kuroki, Shuhei Eguchi, Seiya Higashi, Takeshi Mori, Tsunemasa Nonogaki, Kenta Iwasaki, Makoto Yamashita, Nobuhiro Asai, Yusuke Koizumi, Kentaro Oka, Motomichi Takahashi, Yuka Yamagishi, Hiroshige Mikamo
Summary: CBM 588 enhances the antibacterial activity against C. difficile, reduces colon epithelial damage, and improves immunity through upregulating pathogen specific immunoglobulin A and enhancing gut epithelial barrier function to protect colon tissue from CDI.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Srishti Saha, Kristin Mara, Darrell S. Pardi, Sahil Khanna
Summary: Fecal microbiota transplantation (FMT) is highly effective for treating recurrent Clostridioides difficile infection (CDI) and appears to be safe. Common symptoms during short-term follow-up include diarrhea and constipation, while long-term follow-up revealed new diagnoses that should be further explored in future studies.
Review
Nutrition & Dietetics
Elena Formisano, Elisa Proietti, Consuelo Borgarelli, Livia Pisciotta
Summary: Psoriasis is a chronic immune-dysregulated inflammatory disease and low vitamin D levels are associated with it. This study reviewed the relationship between vitamin D, bone metabolism parameters, and psoriasis, as well as evaluated the effectiveness of oral vitamin D supplementation. The results showed that psoriasis patients had lower levels of 25(OH)D and parathormone compared to controls. However, vitamin D supplementation did not seem to improve clinical manifestations in psoriasis patients.
Review
Immunology
Esraa Menshawey, Rahma Menshawey, Omnia Azmy Nabeh
Summary: Low vitamin D levels in COVID-19 patients are associated with severe disease, ICU admission, and mortality, sharing pathophysiologic mechanisms with diseases such as diabetes and obesity, highlighting the importance of addressing and supplementing deficient individuals.
INFLAMMOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Faruk Ahmed, Hossein Khosravi-Boroujeni, Moududur Rahman Khan, Anjan Kumar Roy, Rubhana Raqib
Summary: This study found that hypovitaminosis D is highly prevalent among pregnant rural Bangladeshi women. Parity and gestational age are common risk factors for vitamin D deficiency and insufficiency, while a husband's occupation and anaemia status may predict vitamin D insufficiency. Younger age and sub-optimal vitamin A status are risk factors for vitamin D deficiency in this population.
Article
Nutrition & Dietetics
Addolorata Corrado, Cinzia Rotondo, Daniela Cici, Stefano Berardi, Francesco Paolo Cantatore
Summary: This study demonstrated that supplementation with calcifediol is more effective and faster than cholecalciferol in increasing 25(OH)D serum levels and improving muscular function in post-menopausal women. Weekly administration of cholecalciferol showed the best results in this regard.
Review
Nutrition & Dietetics
Mauro Lombardo, Alessandra Feraco, Morena Ottaviani, Gianluca Rizzo, Elisabetta Camajani, Massimiliano Caprio, Andrea Armani
Summary: This study, through a systematic literature review, confirms the correlation between vitamin D deficiency and fibromyalgia syndrome (FMS) and chronic widespread musculoskeletal pain (CMP), and suggests that vitamin D supplementation may alleviate pain symptoms.
Article
Nutrition & Dietetics
Vanessa Rosa Retamoso, Fernanda Barbisan, Graziele Meira Moro, Patricia Maurer, Debora Vasquez Rubio, Lauren Flores Viera dos Santos, Lyana Berro Feijoo, Matias Nunes Frizzo, Ivana Beatrice Manica da Cruz, Vanusa Manfredini, Ana Leticia Vargas Barcelos, Jacqueline da Costa Escobar Piccoli
Summary: This study evaluates the effect of the BsmI single nucleotide polymorphism (SNP) of the VDR gene on the expression of VDR, SOD2, and CYP24A1 genes in individuals with low serum vitamin D levels. The results show that the BsmI SNP of the VDR gene leads to overexpression of the CYP24A1 gene and low expression of the SOD2 gene. Therefore, the BsmI SNP of the VDR gene can modulate gene expression without interfering with serum vitamin D levels.
Article
Agriculture, Dairy & Animal Science
Peng Li, Chengao Liu, Junlong Niu, Yuanke Zhang, Changwu Li, Zhengfan Zhang, Shuangshuang Guo, Bingying Ding
Summary: This study investigated the effects of dietary supplementation with vitamin A on the antioxidant and intestinal barrier function of broilers co-infected with coccidia and C. perfringens. The results showed that dietary VA improved the growth performance and the intestinal barrier function but failed to alleviate the negative effects of CCP on the antioxidant function in broilers.
Article
Orthopedics
Matthew T. Weintraub, Jonathan Guntin, JaeWon Yang, Anne DeBenedetti, Vasili Karas, Craig J. Della Valle, Denis Nam
Summary: This randomized controlled trial aimed to investigate the effects of a one-time dose of vitamin D3 prior to total knee arthroplasty. The results showed no significant improvements in functional scores, walking test times, or complications in the early postoperative period when compared to the placebo group.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Pediatrics
Olivia Fahrni, Alexandra Wilhelm-Bals, Klara M. Posfay-Barbe, Noemie Wagner
Summary: Vitamin D deficiency is prevalent among children in Switzerland, with migrant children at higher risk. The majority of children assessed showed hypovitaminosis D, with the highest prevalence in children from Eastern Mediterranean and African regions.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Urology & Nephrology
Lazaros Andronis, Ilias Goranitis, Sarah Pirrie, Ann Pope, Darren Barton, Stuart Collins, Adam Daunton, Duncan McLaren, Joe M. O'Sullivan, Chris Parker, Emilio Porfiri, John Staffurth, Andrew Stanley, James Wylie, Sharon Beesley, Alison Birtle, Janet E. Brown, Prabir Chakraborti, Syed A. Hussain, J. Martin Russell, Lucinda J. Billingham, Nicholas D. James
Article
Oncology
Jennifer A. Locke, Gregory Russell Pond, Guru Sonpavde, Andrea Necchi, Patrizia Giannatempo, Ravi Kumar Paluri, Guenter Niegisch, Peter Albers, Carlo Buonerba, Giuseppe Di Lorenzo, Ulka N. Vaishampayan, Scott A. North, Neeraj Agarwal, Syed A. Hussain, Sumanta Pal, Bernhard J. Eigl
CLINICAL GENITOURINARY CANCER
(2016)
Review
Oncology
Omar M. S. El-Taji, Sameer Alam, Syed A. Hussain
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2016)
Article
Urology & Nephrology
Thomas Powles, Matthew Wheater, Omar Din, Thomas Geldart, Ekaterini Boleti, Andrew Stockdale, Santhanam Sundar, Angus Robinson, Imtiaz Ahmed, Akhila Wimalasingham, Wendy Burke, Shah-Jalal Sarker, Syed Hussain, Christy Ralph
Article
Oncology
Matthew Smith, Johann De Bono, Cora Sternberg, Sylvestre Le Moulec, Stephane Oudard, Ugo De Giorgi, Michael Krainer, Andries Bergman, Wolfgang Hoelzer, Ronald De Wit, Martin Boegemann, Fred Saad, Giorgio Cruciani, Antoine Thiery-Vuillemin, Susan Feyerabend, Kurt Miller, Nadine Houede, Syed Hussain, Elaine Lam, Jonathan Polikoff, Arnulf Stenzl, Paul Mainwaring, David Ramies, Colin Hessel, Aaron Weitzman, Karim Fizazi
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Article
Oncology
Majed Saad Al Fayi, Xiaojun Gou, Shiva S. Forootan, Waseem Al-Jameel, Zhengzheng Bao, Philip R. Rudland, Philip A. Cornford, Syed A. Hussain, Youqiang Ke
Article
Oncology
Farzad S. Forootan, Shiva S. Forootan, Xiaojun Gou, Jin Yang, Bichong Liu, Danqing Chen, Majed Saad Al Fayi, Waseem Al-Jameel, Philip S. Rudland, Syed A. Hussain, Youqiang Ke
Article
Oncology
Nicholas D. James, Sarah J. Pirrie, Ann M. Pope, Darren Barton, Lazaros Andronis, Ilias Goranitis, Stuart Collins, Adam Daunton, Duncan McLaren, Joe O'Sullivan, Christopher Parker, Emilio Porfiri, John Staffurth, Andrew Stanley, James Wylie, Sharon Beesley, Alison Birtle, Janet Brown, Prabir Chakraborti, Syed Hussain, Martin Russell, Lucinda J. Billingham
Article
Oncology
Syed A. Hussain, Daniel H. Palmeri, Wing-Kin Syn, Joseph J. Sacco, Richard M. D. Greensmith, Taha Elmetwali, Vijay Aachi, Bryony H. Lloyd, Puthen V. Jithesh, John Arrand, Darren Barton, Jawaher Ansari, D. Ross Sibson, Nicholas D. James
INTERNATIONAL JOURNAL OF ONCOLOGY
(2017)
Article
Oncology
Sophie Therese Williams, Salma El Badri, Syed Anwer Hussain
Summary: This retrospective case series found that administration of anticancer treatment did not result in an apparent increase in symptomatic COVID-19 infections in urological cancer patients at one centre.
BRITISH JOURNAL OF CANCER
(2021)
Letter
Urology & Nephrology
Syed A. Hussain, Nuria Porta, Emma Hall, Muneeb Qureshi, Rebecca Lewis, Robert Huddart, Nicholas D. James
Article
Multidisciplinary Sciences
Michiel S. van der Heijden, Thomas Powles, Daniel Petrylak, Ronald de Wit, Andrea Necchi, Cora N. Sternberg, Nobuaki Matsubara, Hiroyuki Nishiyama, Daniel Castellano, Syed A. Hussain, Aristotelis Bamias, Georgios Gakis, Jae-Lyun Lee, Scott T. Tagawa, Ulka Vaishampayan, Jeanny B. Aragon-Ching, Bernie J. Eigl, Rebecca R. Hozak, Erik R. Rasmussen, Meng Summer Xia, Ryan Rhodes, Sameera Wijayawardana, Katherine M. Bell-McGuinn, Amit Aggarwal, Alexandra Drakaki
Summary: This study identifies potential predictive biomarkers for survival benefit in patients with platinum-refractory advanced urothelial carcinoma treated with the anti-VEGFR2 monoclonal antibody ramucirumab. Higher PD-L1 IHC and immune pathway scores are associated with greater ramucirumab overall survival (OS) benefit. Basal molecular subtypes show greater OS benefit compared to Luminal subtypes. Patients from East Asia have lower immune/angiogenesis signature scores, correlating with decreased ramucirumab OS benefit. The study highlights the importance of multiple biomarkers in identifying patients who might benefit the most from treatment with ramucirumab.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Valentine M. Macaulay, Simon Lord, Syed Hussain, Jose Pablo Maroto, Robert Hugh Jones, Miguel Angel Climent, Natalie Cook, Chia-Chi Lin, Shian-Shiang Wang, Diletta Bianchini, Mark Bailey, Laura Schlieker, Thomas Bogenrieder, Johann de Bono
Summary: This study evaluated the combination therapy of xentuzumab and enzalutamide in patients with metastatic castrate-resistant prostate cancer. The results showed that the combination treatment had some efficacy in certain patients.
BRITISH JOURNAL OF CANCER
(2023)
Article
Urology & Nephrology
Andrea Necchi, Gregory R. Pond, Marc C. Smaldone, Sumanta K. Pal, Kevin Chan, Yu-Ning Wong, Rosalia Viterbo, Guru Sonpavde, Lauren C. Harshman, Simon Crabb, Ajjai Alva, Simon Chowdhury, Ugo De Giorgi, Sandy Srinivas, Neeraj Agarwal, Aristotelis Bamias, Jack Baniel, Ali-Reza Golshayan, Sylvain Ladoire, Cora N. Sternberg, Linda Cerbone, Evan Y. Yu, Joaquim Bellmunt, Ulka Vaishampayan, Gunter Niegisch, Syed Hussain, Daniel W. Bowles, Rafael Morales-Barrera, Matthew I. Milowsky, Christine Theodore, Dominik R. Berthold, Srikala S. Sridhar, Thomas Powles, Jonathan E. Rosenberg, Matthew D. Galsky
EUROPEAN UROLOGY FOCUS
(2018)
Article
Oncology
Ananya Choudhury, Catharine M. West, Nuria Porta, Emma Hall, Helen Denley, Carey Hendron, Rebecca Lewis, Syed A. Hussain, Robert Huddart, Nicholas James
BRITISH JOURNAL OF CANCER
(2017)