Review
Chemistry, Medicinal
Ewa Dudzinska, Andreas M. Grabrucker, Pawel Kwiatkowski, Robert Sitarz, Monika Sienkiewicz
Summary: Visceral stimuli from the digestive tract are transmitted to the brain via nerves, causing overreaction in the brain of irritable bowel syndrome (IBS) patients. Stress and dysbiosis can lead to inflammation and gastrointestinal hypersensitivity. Treating IBS involves reducing visceral hypersensitivity and regulating the intestinal microbiota.
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Neurosciences
Rachel P. Sarnoff, Ravi R. Bhatt, Vadim Osadchiy, Tien Dong, Jennifer S. Labus, Lisa A. Kilpatrick, Zixi Chen, Vishvak Subramanyam, Yurui Zhang, Benjamin M. Ellingson, Bruce Naliboff, Lin Chang, Emeran A. Mayer, Arpana Gupta
Summary: This cross-sectional study characterizes the brain-gut-microbiome system (BGM) in irritable bowel syndrome (IBS) patients with different bowel habits. The study finds that dysbiosis and altered connectivity in brain regions are associated with symptoms in IBS patients. Interestingly, the microbiome and metabolome of IBS-C patients resemble healthy controls, while IBS-D patients show distinct metabolic changes and altered connectivity in brain networks.
Article
Multidisciplinary Sciences
Isabelle A. M. van Thiel, Aimilia A. Stavrou, Auke de Jong, Bart Theelen, Mark Davids, Theodorus B. M. Hakvoort, Iris Admiraal-van den Berg, Isabelle C. M. Weert, Martine A. M. Hesselink-van de Kruijs, Duong Vu, Christine Moissl-Eichinger, Sigrid E. M. Heinsbroek, Daisy M. A. E. Jonkers, Ferry Hagen, Teun Boekhout, Wouter J. de Jonge, Rene M. van den Wijngaard
Summary: Irritable bowel syndrome (IBS) is a common disorder characterized by chronic abdominal pain and changes in bowel movements. Visceral hypersensitivity may be caused by intestinal fungi, but the diversity of fungal communities does not differ between IBS subgroups. The study highlights the importance of conducting strain-specific cause-and-effect studies in IBS research.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Gabriella Yazbeck, Diana Malaeb, Hamid Shaaban, Abir Sarray El Dine, Souheil Hallit, Rabih Hallit
Summary: This study aimed to assess the rate of unidentified IBS among Lebanese adults and investigate the role of socio-demographic factors, anxiety, depression, insomnia, and eating attitudes on IBS diagnosis. A cross-sectional study was conducted using a self-reporting questionnaire distributed via social media. The study found that higher psychological distress and insomnia severity were significantly associated with higher odds of having possible unidentified IBS.
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Review
Gastroenterology & Hepatology
Mariana Brizuela, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This review discusses the underlying causes of chronic visceral pain in patients with IBS, highlighting the role of mediators and receptors that induce itch in the skin acting as gut irritants. Activation of these receptors triggers changes in neuronal excitability, leading to visceral hypersensitivity and pain, suggesting potential therapeutic targets for more effective treatment options.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen
Summary: This bibliometric study provides a comprehensive summary of the research trend and developments in visceral hypersensitivity in Irritable Bowel Syndrome (IBS). The study reveals that China, the United States, and Belgium are the main contributors in this field, focusing on exploring the disease mechanisms and sensitizing factors. Additionally, the study highlights the potential relationship between gut microbiota and visceral hypersensitivity, suggesting probiotics as a promising direction for future research in this area.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuanxia Lv, Jing Wen, Yingying Fang, Haoyuan Zhang, Jianwu Zhang
Summary: CRF is a 41-amino acid polypeptide that coordinates various systems in the body, mediating visceral hypersensitivity like in irritable bowel syndrome. However, the lack of sufficient understanding of the multiple variants of CRF-R1 and CRF-R1 antagonists hinders the successful translation of preclinical studies into clinical trials. Investigating the sites of action of central and peripheral CRF is crucial for accelerating this translation process.
Article
Nutrition & Dietetics
Martyna Wiecek, Paulina Panufnik, Magdalena Kaniewska, Konrad Lewandowski, Grazyna Rydzewska
Summary: The study found that in patients in remission of IBD, a low-FODMAP diet intervention is effective in reducing IBS-like symptoms, regardless of the presence of bacterial overgrowth.
Review
Neurosciences
Yuanzhen Yang, Jiaqi Wang, Chaoyang Zhang, Yi Guo, Meidan Zhao, Man Zhang, Zhongzheng Li, Feifei Gao, Yu Luo, Yiru Wang, Junyi Cao, Mingfang Du, Yuzhe Wang, Xiaowei Lin, Zhifang Xu
Summary: This review explores the central and peripheral analgesic mechanisms of acupuncture in the treatment of Irritable Bowel Syndrome (IBS). Acupuncture can alleviate inflammation and pain, regulate emotional components, and improve pain caused by IBS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Immunology
Pariya Khodabakhsh, Nilgoon Khoie, Ahmad-Reza Dehpour, Alireza Abdollahi, Mahmoud Ghazi-Khansari, Hamed Shafaroodi
Summary: This study evaluated the effects of pharmacological inhibition of CysLT1R on acetic acid-induced D-IBS in rats. The results showed that montelukast can reduce pain responses, decrease stool frequency, and improve depression-like behavior in IBS rats. Furthermore, montelukast decreases inflammatory cytokine levels and histopathological inflammatory injuries while increasing anti-inflammatory cytokine levels. These findings suggest the potential beneficial effects of montelukast in the management of D-IBS symptoms, possibly through modulating CysLT1R-mediated NF-kappa B signaling.
INFLAMMOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Sahar M. El-Haggar, Sahar K. Hegazy, Sherief M. Abd-Elsalam, Mostafa M. Bahaa
Summary: The study suggests that pentoxifylline could be a promising adjuvant anti-inflammatory drug in the treatment of abdominal pain in IBS patients, reducing inflammation and alleviating pain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Microbiology
Enfu Tao, Yuhao Wu, Chenmin Hu, Zhenya Zhu, Diya Ye, Gao Long, Bo Chen, Rui Guo, Xiaoli Shu, Wei Zheng, Ting Zhang, Xinyi Jia, Xiao Du, Marong Fang, Mizu Jiang
Summary: The study demonstrates that maternal separation induces irritable bowel syndrome (IBS) from early life to adulthood in mice. The disrupted intestinal mitochondrial structure and significant dysbiosis of intestinal microbiota in early life may contribute to the initiation and progression of IBS.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Lei Zhang, Ruiyun Wang, Yuhua Chen, Pengcheng Yang, Tao Bai, Jun Song, Xiaohua Hou
Summary: This study found that EphrinB2/epheB2 expression was increased in the enteric nerves, which was correlated with the severity of abdominal pain. In addition, synaptic plasticity was altered in patients with irritable bowel syndrome (IBS), along with increased sensitivity to colorectal distention and enhanced colonic mesenteric afferent activity. These findings suggest that EphrinB2/epheB2 may mediate sustained pain hypersensitivity in the enteric nervous system.
