Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1

(2013) Marina Vettraino et al.   ANTI-CANCER DRUGS

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

(2013) Carlotta Granchi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

(2011) J. Chen et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

JNK2-dependent regulation of SIRT1 protein stability

(2011) Jack Ford et al.   CELL CYCLE

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

(2011) Marcella Manerba et al.   ChemMedChem

SIRT1, metabolism and cancer

(2011) John R.P. Knight et al.   CURRENT OPINION IN ONCOLOGY

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells

(2011) G Zhao et al.   GENE THERAPY

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sacrifice for survival

(2011) Nana-Maria Grüning et al.   NATURE

SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53

(2010) Cian J. Lynch et al.   PLoS One

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

(2009) Anne von Heideman et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

(2009) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

(2009) H. Xie et al.   MOLECULAR CANCER THERAPEUTICS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Molecular pathogenesis of bladder cancer

(2008) Margaret A. Knowles   International Journal of Clinical Oncology

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA