Article
Medicine, Research & Experimental
Juliana Sales Rodrigues Costa, Graciene Fernandes Araujo Campos Fonseca, Natielle Cecilia dos Santos Ottone, Patrick Almeida Silva, Romulo Fernandes Antonaccio, Gabriela Silva, Maira da Silva Almeida Rocha, Candido Celso Coimbra, Elizabethe Adriana Esteves, Zachary A. Mang, Fabiano Trigueiro Amorim, Flavio de Castro Magalhaes
Summary: Strength training can improve insulin resistance and glucose tolerance through mitochondrial adaptation in skeletal muscle, increased skeletal muscle Hsp72, and reduced adipocyte size in visceral fat.
Article
Food Science & Technology
Se-Jun Park, Dong-Hyun Shon, Yang-Hwan Ryu, Yong Ko
Summary: Herbal extracts from Ephedra sinica show dual effects on adipocytes, inhibiting adipogenesis in immature cells and promoting browning in mature cells.
Article
Endocrinology & Metabolism
Arthe Raajendiran, Christoph Krisp, David P. De Souza, Geraldine Ooi, Paul R. Burton, Renea A. Taylor, Mark P. Molloy, Matthew J. Watt
Summary: Adipose tissue plays a crucial role in energy balance and metabolism regulation, with differences in protein composition leading to metabolic variation in different regions. Upper-body adipocytes are associated with glycolysis, lipogenesis, and oxidative stress, while lower-body adipocytes show enhanced activation of PPARa and mitochondrial oxidative phosphorylation processes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Physiology
Lu Wang, Xinmeng Liu, Sujuan Liu, Yanmei Niu, Li Fu
Summary: This study reveals the necessity of Sensrin2 in mediating exercise-induced browning of subcutaneous white adipose tissue (scWAT), which affects glucose metabolism and energy expenditure.
Article
Endocrinology & Metabolism
Emily J. King, Simon T. Bond, Christine Yang, Yingying Liu, Anna C. Calkin, Darren C. Henstridge, Brian G. Drew
Summary: This study investigated the impact of muscle-specific deletion of TRIM28 on obesity, glucose tolerance, and insulin resistance. Although alterations in mitochondrial activity and autophagy markers were observed, no major impacts on most metabolic measures were observed.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Cell Biology
Qian Li, Kirsty L. Spalding
Summary: Adipocytes undergo extensive cytoskeletal remodeling to accommodate their dramatic morphological changes. Cell growth-related signaling pathways are activated to meet the increasing cellular needs. Continued expansion of adipocytes can lead to metabolic dysfunction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shiqiao Peng, Xiaoying Zhang, Lili Yu, Yanhong Xu, Yang Zhou, Shengnan Qian, Xinyu Cao, Xiaotong Ye, Jiajun Yang, Weiping Jia, Jianping Ye
Summary: This study investigated the role of the transcription factor nuclear factor of kappa-light-chain-enhancer of activated B cells (NF-kappa B) in brown adipocytes. The findings showed that NF-kappa B activity increased during brown adipocyte differentiation and cold stimulation, protecting the cells from apoptosis by down-regulating the expression of adenine nucleotide translocase 2 (ANT2).
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Endocrinology & Metabolism
Siwen Xue, Derek Lee, Daniel C. Berry
Summary: The ability to generate thermogenic fat cells is a potential targeted therapy for obesity and metabolic health improvement. Brown and beige adipocytes, which regulate energy balance, share certain properties but also display unique features such as origin and regulatory processes. Beige adipocytes are highly plastic, responding to environmental stimuli and converting between different states. However, obese and aged individuals face hurdles in developing beige adipocytes, hindering therapeutic potential. Understanding the mechanisms behind thermogenic fat cells will enhance understanding of energy regulation and enable new targeted therapies. This review discusses recent advances and potential mechanisms for failure in thermogenic fat cell regulation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yukimasa Takeda, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai
Summary: Brown fats specialize in thermogenesis by increasing the utilization of circulating blood glucose and fatty acids, and they prevent the incidence of obesity-associated metabolic diseases and several types of cancers in humans. Mitochondrial energy metabolism in brown/beige adipocytes regulates both uncoupling protein 1 (UCP1)-dependent and -independent thermogenesis, and the mass and activity of human BAT are inversely correlated with the body mass index (BMI) and visceral adiposity. Modulation of obesity-associated repression in human brown fats is a promising strategy to counteract obesity and related metabolic diseases through the activation of thermogenic capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Abhijit Babaji Shinde, Anying Song, Qiong A. Wang
Summary: Brown adipocytes in BAT expend energy through uncoupling, playing important roles in glucose and lipid homeostasis, making them valuable therapeutic targets for metabolic disorders. Recent rediscovery of BAT depots in humans has reignited interest in using them as promising therapeutic interventions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Braud, Maria Pini, Donald F. Stec, Sylvie Manin, Genevieve Derumeaux, David E. Stec, Roberta Foresti, Roberto Motterlini
Summary: The up-regulation of Sirt1 levels specifically in the visceral adipose tissue of Nrf2(-/-) mice is a key adaptive mechanism that mitigates glucose intolerance induced by nutritional stress.
Article
Endocrinology & Metabolism
Zachary Silver, Sam Abbott-Tate, Lindsay Hyland, Frances Sherratt, Barbara Woodside, Alfonso Abizaid
Summary: Chronic exposure to high circulating glucocorticoid or ghrelin concentrations did not have an effect on GHSR signaling in female mice, with no differences observed in weight gain, adiposity, and other metabolic effects compared to male mice.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Shaofeng Xiong, Shumin Yu, Kun Wang, Xiaowei Xiong, Min Xia, Guohua Zeng, Qiren Huang
Summary: In this study, the effects of AP on glycolipid metabolism, browning, and autophagy were investigated using a mouse obesity model and a preadipocyte induction model in vitro. The results showed that AP treatment alleviated body weight, glycolipid metabolic disorder, and insulin resistance through autophagy inhibition and promotion of fat-browning. These findings suggest that autophagy inhibition promotes browning of white adipocytes and highlight the potential of AP in preventing and treating obesity and associated metabolic disorders.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Veronica Marquez, Grisel Ballesteros, Thomas Dobner, Ramon A. Gonzalez
Summary: Human adenovirus 36 (HAdV-D36) infection can induce obesity in animal models and promote adipocyte differentiation. In this study, the researchers explored the replication cycle of HAdV-D36 in preadipocytes and found that only adipocyte-committed cells supported productive viral replication, leading to a greater impact on adipogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mobina Alemi, Angela Oliveira, Sofia C. Tavares, Jose Ricardo Vieira, Marco G. Alves, Pedro F. Oliveira, Isabel Cardoso
Summary: TTR haploinsufficiency (TTR+/-) leads to elevated glucose levels in plasma and primary hepatocyte culture media, as well as reduced expression of glucose transporters GLUT1, GLUT3, and GLUT4. TTR also increases mitochondrial density in the liver and protects against mitochondrial oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Hui Wang, Monja Willershaeuser, Yongguo Li, Tobias Fromme, Katharina Schnabl, Andrea Bast-Habersbrunner, Samira Ramisch, Sabine Mocek, Martin Klingenspor
Summary: While UCP1 is essential for cold-induced thermogenesis, its presence alone does not protect mice from diet-induced obesity. A new mouse model with low UCP1 levels demonstrates that impaired cold-induced thermogenic capacity does not increase susceptibility to diet-induced obesity. Pharmacological activation of brown fat is necessary to promote negative energy balance in diet-induced obese mice.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Andrea Bast-Habersbrunner, Christoph Kiefer, Peter Weber, Tobias Fromme, Anna Schiessl, Petra C. Schwalie, Bart Deplancke, Yongguo Li, Martin Klingenspor
Summary: The nuclear lncRNA Ctcflos plays a crucial role in thermogenic gene expression during brite adipocyte differentiation, by regulating transcriptional recruitment and alternative splicing to drive brite adipogenesis. This highlights the mechanistic versatility of lncRNAs in effectively regulating key differentiation factors at multiple levels of gene expression to direct cell fate and function.
Review
Endocrinology & Metabolism
Katharina Schnabl, Yongguo Li, Mueez U-Din, Martin Klingenspor
Summary: Secretin, as a promising peripheral target for the treatment of obesity, induces meal termination by modulating meal-associated brown fat thermogenesis, making it an attractive option. Further investigation into the potential effects of secretin in different scenarios, as well as the differences between meal-associated thermogenesis and other gut hormones, is crucial for understanding its role in energy balance and weight regulation.
Review
Medicine, Research & Experimental
Magdalena Wit, Jonathan Trujillo-Viera, Akim Strohmeyer, Martin Klingenspor, Mohammed Hankir, Grzegorz Sumara
Summary: Overconsumption of energy-dense foods can lead to increased intestinal nutrient absorption and excessive lipid accumulation, resulting in obesity and obesity-associated diseases. Targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential.
EMBO MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yongguo Li, Tobias Fromme
Summary: Mitochondrial uncoupling protein 1 (UCP1) is crucial for heat production in brown and beige fat. However, UCP1 is constitutively inhibited and inherently inactive without activation. Simply increasing UCP1 abundance does not result in automatic increase in thermogenesis. Understanding the controls of UCP1 activity is important for therapeutic interventions to unlock the energy-expending potential of brown fat.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G. Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad
Summary: The study identifies GPR183/EBI2 as the most highly expressed inhibitory G-protein-coupled receptor in brown adipose tissue, which decreases energy expenditure. Loss of Ebi2 in mice results in increased brown adipocyte energy expenditure in response to cold exposure, providing potential insights into modulating energy expenditure in humans.
COMMUNICATIONS BIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Sebastian Baur, Nicole Belle, Oliver Frank, Sebastian Wurzer, Stefan Alexander Pieczonka, Tobias Fromme, Remco Stam, Hans Hausladen, Thomas Hofmann, Ralph Hueckelhoven, Corinna Dawid
Summary: Plant pathogens pose a threat to food security and new plant protection strategies are needed. A study found that Phytophthora infestans induced metabolic changes in potato foliage and tubers, and identified compounds with antioomycete activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Josef Oeckl, Petra Janovska, Katerina Adamcova, Kristina Bardova, Sarah Brunner, Sebastian Dieckmann, Josef Ecker, Tobias Fromme, Jiri Funda, Thomas Gantert, Piero Giansanti, Maria Soledad Hidrobo, Ondrej Kuda, Bernhard Kuster, Yongguo Li, Radek Pohl, Sabine Schmitt, Sabine Schweizer, Hans Zischka, Petr Zouhar, Jan Kopecky, Martin Klingenspor
Summary: We explore different potential sources of UCP1-independent thermogenesis and identify a futile ATP-consuming triglyceride/fatty acid cycle as the main contributor to cellular heat production in brown adipocytes lacking UCP1. We uncover the mechanism on a molecular level and pinpoint the key enzymes involved using pharmacological and genetic interference.
MOLECULAR METABOLISM
(2022)
Article
Cell Biology
Cecilia Colson, Pierre-Louis Batrow, Sebastian Dieckmann, Laura Contu, Christian H. Roux, Laurence Balas, Claire Vigor, Baptiste Fourmaux, Nadine Gautier, Nathalie Rochet, Nathalie Bernoud-Hubac, Thierry Durand, Dominique Langin, Martin Klingenspor, Ez-Zoubir Amri
Summary: Obesity is a complex disease associated with diet and lifestyle, and it is related to a low amount of thermogenic adipocytes. Recent studies suggest that lipokines, fatty acids and their metabolites, play a role in the control of thermogenesis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Sanna Laurila, Minna Lahesmaa, Eleni Rebelos, Kirsi A. Virtanen, Katharina Schnabl, Martin Klingenspor, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study reveals that secretin can induce satiation by modulating the metabolic communication between brown adipose tissue and the brain. Secretin regulates the brain response to appetite-inducing stimuli and improves inhibitory control, leading to increased feelings of fullness.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Severin Lechner, Raphael R. Steimbach, Longlong Wang, Marshall L. Deline, Yun-Chien Chang, Tobias Fromme, Martin Klingenspor, Patrick Matthias, Aubry K. Miller, Guillaume Medard, Bernhard Kuster
Summary: Lipoic acid is a cofactor in central metabolic pathways and is investigated for its potential as a pharmaceutical in clinical trials. It has been found that lipoic acid inhibits certain histone deacetylases, which explains its various effects on cells.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mueez U-Din, Eleni Rebelos, Teemu Saari, Tarja Niemi, Katharina Kuellmer, Olli Eskola, Tobias Fromme, Johan Rajander, Markku Taittonen, Martin Klingenspor, Pirjo Nuutila, Lauri Nummenmaa, Kirsi A. Virtanen
Summary: The expression of uncoupling protein 1 (UCP-1) in supraclavicular brown adipose tissue (BAT) is directly related to brain metabolism during cold stress. This relationship is observed in various brain regions, such as the hypothalamus, medulla, and frontal lobe. Future research is needed to determine the clinical implications of these findings, particularly in relation to cognitive functions under cold stress.
Meeting Abstract
Endocrinology & Metabolism
M. U-Din, V. de Mello Laaksonen, K. Hanhineva, J. Newman, K. Kristiansen, M. Klingenspor, T. Fromme, T. Niemi, M. Taittonen, T. Saari, J. Raiko, P. Nuutila, K. A. Virtanen
Correction
Endocrinology & Metabolism
Timo D. Mueller, Martin Klingenspor, Matthias H. Tschoep
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)