Article
Chemistry, Multidisciplinary
Rikke Hahn Kofoed, Chinaza Lilian Dibia, Kate Noseworthy, Kristiana Xhima, Nathalie Vacaresse, Kullervo Hynynen, Isabelle Aubert
Summary: Focused ultrasound combined with intravenously injected microbubbles (FUS) can increase the permeability of the blood-brain barrier (BBB) and deliver genes to the brain. The properties of AAV serotypes and targeted brain tissue influence the distribution, diffusion, and transduction of AAVs. Non-invasive contrast-enhanced MR imaging can predict the efficacy of FUS-AAV delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biotechnology & Applied Microbiology
Shuo Zhang, Shuai Zhang, Siyuan Luo, Peng Tang, Mingxi Wan, Daocheng Wu, Wei Gao
Summary: Brain tumors pose a challenge, and effective drug delivery across the blood-brain barrier (BBB) is essential. Ultrasound-assisted brain delivery (UABD) technology combined with nanomedicines shows promise in enhancing therapeutic effects on brain tumors. However, research on UABD nanomedicines is still in its early stages, with unclear mechanisms and material design theories.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaopeng Song, Yaxiong Cui, Yanxiao Wang, Yizhe Zhang, Qi He, Zhenyang Yu, Chengfang Xu, Huimin Ning, Yuying Han, Yunting Cai, Xuan Cheng, Jian Wang, Yan Teng, Xiao Yang, Jun Wang
Summary: In this study, the AAV-BR1-CRISPR system was used to specifically knock out target genes in brain endothelial cells of adult mice, demonstrating its effectiveness in rapidly identifying endothelial genes that regulate blood-brain barrier integrity in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Anita Barzegar-Fallah, Kushan Gandhi, Shakila B. Rizwan, Tania L. Slatter, John N. J. Reynolds
Summary: This article reviews the application of ultrasound in treating brain tumors. Ultrasound can penetrate the skull to safely and reversibly open the blood-brain barrier, allowing for enhanced delivery of chemotherapeutic agents to tumor sites. The article describes the basics of therapeutic ultrasound, ultrasound-based drug delivery strategies, mechanisms of ultrasound in improving brain tumor therapy, and the current ultrasound devices and technologies available for this purpose.
Review
Pharmacology & Pharmacy
Scott Schoen, M. Sait Kilinc, Hohyun Lee, Yutong Guo, F. Levent Degertekin, Graeme F. Woodworth, Costas Arvanitis
Summary: Brain tumors located in the central nervous system (CNS) present a unique challenge due to limited drug access to the brain tumor microenvironment (TME). Recent advancements in microbubble ultrasound contrast agents and ultrasound energy have shown promise in enhancing drug delivery to brain tumors. This technology has the potential to improve the effectiveness of both traditional chemotherapy and novel immunotherapeutic agents. Early clinical studies have demonstrated safety, and ongoing Phase I/II trials are testing the preclinical findings.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Thomas J. Manuel, Michelle K. Sigona, M. Anthony Phipps, Jiro Kusunose, Huiwen Luo, Pai-Feng Yang, Allen T. Newton, John C. Gore, William Grissom, Li Min Chen, Charles F. Caskey
Summary: This study evaluates the performance of a system using focused ultrasound to open the blood-brain barrier. The results show that incorporating grey matter segmentation improves spatial precision and the system can be used to deliver drugs and gene therapy to small brain regions.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
E. 't Hart, J. Bianco, M. A. C. Bruin, M. Derieppe, H. C. Besse, K. Berkhout, L. A. Chin Joe Kie, Y. Su, E. W. Hoving, A. D. R. Huitema, M. G. Ries, D. G. van Vuurden
Summary: Diffuse midline glioma H3K27-altered (DMG) is a pediatric brain tumor with limited treatment options and poor prognosis. This study evaluated the potential of PARP1 inhibition combined with focused ultrasound mediated blood-brain barrier opening (FUS-BBBO) to enhance radiosensitivity in DMG.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Virology
R. Alexander Martino, Qiang Wang, Hao Xu, Gui Hu, Peter Bell, Edgardo. J. J. Arroyo, Joshua. J. J. Sims, James. M. M. Wilson
Summary: Unbiased in vivo selections of diverse capsid libraries can yield engineered capsids that overcome gene therapy delivery challenges, but little is known about the parameters of capsid-receptor interactions that govern their improved activity. In this work, a high-throughput method for quantifying capsid-receptor affinity is developed, and it is demonstrated that efficient central nervous system transduction requires high levels of target receptor expression at the blood-brain barrier. Enhanced receptor affinity leads to reduced transduction of off-target tissues but can negatively impact on-target cellular transduction and penetration of endothelial barriers. This work provides a set of tools for defining vector-receptor affinities and demonstrates how receptor expression and affinity interact to impact the performance of engineered AAV vectors.
JOURNAL OF VIROLOGY
(2023)
Review
Nanoscience & Nanotechnology
SeongHoon Jo, In-Cheol Sun, Cheol-Hee Ahn, Sangmin Lee, Kwangmeyung Kim
Summary: The blood-brain barrier poses a challenge to the delivery of imaging probes and therapeutic agents to the brain. Methods like ultrasound-mediated nano-particle delivery and photoacoustic brain imaging have emerged as potential solutions. Focused ultrasound is a popular means of enhancing drug delivery through temporary opening of the blood-brain barrier, while photoacoustic brain imaging uses light-to-heat conversion and ultrasound detection to visualize brain morphologies or diseases. The versatility of nanoparticles allows for successful brain imaging and treatment through the combined action of ultrasound and nanoparticulate agents.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Chuanshi He, Zhisheng Wu, Min Zhuang, Xiangyu Li, Shunxu Xue, Songjie Xu, Jinshun Xu, Zhe Wu, Man Lu
Summary: In this study, bionic drug delivery microbubbles were developed and their combination with focused ultrasound showed significant inhibitory effects on glioblastoma. The microbubbles successfully penetrated the blood-brain barrier and effectively inhibited glioblastoma growth, providing a new approach for glioblastoma treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhuqing Song, Xiuxian Huang, Jieqiong Wang, Feiyan Cai, Ping Zhao, Fei Yan
Summary: The ultrasound-mediated BBB opening combined with liposomal temozolomide formulation has been successfully applied in the treatment of glioblastoma, significantly inhibiting tumor growth and prolonging animal survival time without significant side effects.
Article
Multidisciplinary Sciences
Carmen Gasca-Salas, Beatriz Fernandez-Rodriguez, Jose A. Pineda-Pardo, Rafael Rodriguez-Rojas, Ignacio Obeso, Frida Hernandez-Fernandez, Marta del Alamo, David Mata, Pasqualina Guida, Carlos Ordas-Bandera, J. Ignacio Montero-Roblas, Raul Martinez-Fernandez, Guglielmo Foffani, Itay Rachmilevitch, Jose A. Obeso
Summary: MRgFUS-BBB opening in PDD is safe, reversible, and can be performed repeatedly. This study provides encouragement for the concept of BBB opening for drug delivery to treat dementia in PD and other neurodegenerative disorders.
NATURE COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Kibeom Kim, Jungmin Lee, Myoung-Hwan Park
Summary: The blood-brain barrier is an important barrier that protects the brain and maintains homeostasis. Traditional drug delivery methods face limitations such as low diversity and efficiency. Microbubble-based drug delivery systems, which utilize ultrasound-induced physical changes, have gained attention in recent years for their ability to enhance drug delivery by disrupting the blood-brain barrier.
Article
Multidisciplinary Sciences
Zachary K. Englander, Hong-Jian Wei, Antonios N. Pouliopoulos, Ethan Bendau, Pavan Upadhyayula, Chia-Ing Jan, Eleanora F. Spinazzi, Nina Yoh, Masih Tazhibi, Nicholas M. McQuillan, Tony J. C. Wang, Jeffrey N. Bruce, Peter Canoll, Neil A. Feldstein, Stergios Zacharoulis, Elisa E. Konofagou, Cheng-Chia Wu
Summary: The study demonstrated that FUS is a safe and feasible technique for opening the BBB and delivering drugs to the brainstem efficiently without causing significant adverse reactions. Furthermore, FUS can significantly increase drug concentration within the tumor, providing a new direction for the treatment of pontine glioma.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Oliver Vince, Sarah Peeters, Vanessa A. Johanssen, Michael Gray, Sean Smart, Nicola R. Sibson, Eleanor Stride
Summary: The study shows that a new formulation of microbubbles containing lysolipids can enhance blood-brain barrier permeability, leading to approximately twofold increase at the highest ultrasound pressure. This modification has the potential to improve drug delivery deep within the brain without the need to increase ultrasound pressure amplitude.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Silke Roovers, Tim Segers, Guillaume Lajoinie, Joke Deprez, Michel Versluis, Stefaan C. De Smedt, Ine Lentacker
Article
Radiology, Nuclear Medicine & Medical Imaging
Shweta Saini, Hannelie Korf, Sayuan Liang, Rein Verbeke, Bella Manshian, Koen Raemdonck, Ine Lentacker, Conny Gysemans, Stefaan C. De Smedt, Uwe Himmelreich
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2019)
Article
Nanoscience & Nanotechnology
Dan Lv, Ruoxue Wang, Guosheng Tang, Zhipeng Mou, Jiandu Lei, Jingquan Han, Stefaan De Smedt, Ranhua Xiong, Chaobo Huang
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Multidisciplinary
Rein Verbeke, Ine Lentacker, Karine Breckpot, Jonas Janssens, Serge Van Calenbergh, Stefaan C. De Smedt, Heleen Dewitte
Review
Pharmacology & Pharmacy
Joke Devoldere, Karen Peynshaert, Stefaan C. De Smedt, Katrien Remaut
DRUG DISCOVERY TODAY
(2019)
Article
Chemistry, Physical
Aranit Harizaj, Olivier Q. De Clercq, Benedicte Descamps, Christian Vanhove, Stefaan C. De Smedt, Dirk Poelman, Ine Lentacker, Kevin Braeckmans
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2019)
Article
Nanoscience & Nanotechnology
Juan C. Fraire, Stephan Stremersch, Davinia Bouckaer, Tinne Monteyne, Thomas De Beer, Pieter Wuytens, Riet De Rycke, Andre G. Skirtach, Koen Raemdonck, Stefaan De Smedt, Kevin Braeckrnans
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Engineering, Biomedical
Silke Roovers, Guillaume Lajoinie, Ine De Cock, Toon Brans, Heleen Dewitte, Kevin Braeckmans, Michel Versluis, Stefaan C. De Smedt, Ine Lentacker
Review
Chemistry, Multidisciplinary
Heyang Zhang, Dawei Hua, Chaobo Huang, Sangram Keshari Samal, Ranhua Xiong, Felix Sauvage, Kevin Braeckmans, Katrien Remaut, Stefaan C. De Smedt
ADVANCED MATERIALS
(2020)
Review
Chemistry, Multidisciplinary
Dawei Hua, Ranhua Xiong, Kevin Braeckmans, Benoit Scheid, Chaobo Huang, Felix Sauvage, Stefaan C. De Smedt
Summary: Concentration gradients play a crucial role in natural phenomena and have significant applications in biomedical and pharmaceutical fields. While generating gradients in solutions is well understood, incorporating them in solid materials remains a challenge. This study reviews methods for generating gradients in both solutions and solid materials, and discusses the potential applications of innovative materials with gradients in biomedicine and pharmacy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Ines De Hoon, Alexandre Barras, Tomasz Swebocki, Bernd Vanmeerhaeghe, Bram Bogaert, Cristina Muntean, Amar Abderrahmani, Rabah Boukherroub, Stefaan De Smedt, Felix Sauvage, Sabine Szunerits
Summary: Topical administration of drugs to the corneal endothelium is challenging in ophthalmology, and diseases at this site can cause corneal blindness. Carbon quantum dots have shown potential for ocular nanomedicine. This study investigated the corneal penetration abilities of differently charged carbon quantum dots and their use as permeation enhancers for drugs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Ranhua Xiong, Felix Sauvage, Juan C. Fraire, Chaobo Huang, Stefaan C. De Smedt, Kevin Braeckmans
Summary: Delivering biological effector molecules in cultured cells is crucial for studying gene expression modulation. However, delivering these molecules across cell membranes while minimizing adverse effects remains challenging.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Juan C. Fraire, Maria Guix, Ana C. Hortelao, Noelia Ruiz-Gonzalez, Anna C. Bakenecker, Pouria Ramezani, Charlotte Hinnekens, Felix Sauvage, Stefaan C. De Smedt, Kevin Braeckmans, Samuel Sanchez
Summary: Nanomotors, powered by enzymes and triggered by laser irradiation, can improve drug delivery efficiency and overcome biological barriers. These nanomotors can collectively displace and disrupt protein fibers in a blocked microchannel. This active motion and mechanical disruption provide a clear advantage for improving therapy.
Review
Medicine, Research & Experimental
Ines De Hoon, Rabah Boukherroub, Stefaan C. C. De Smedt, Sabine Szunerits, Felix Sauvage
Summary: Drug permeation across the cornea poses challenges due to its unique and complex anatomy and physiology. Static barriers and dynamic factors present hurdles for effective ophthalmic drug delivery. Novel drug formulations such as liposomes, nanoemulsions, and nanoparticles have been explored to address these limitations. Reliable in vitro and ex vivo alternatives are needed for corneal drug development, adhering to the principles of the 3Rs, and models such as in vitro cell culture and ex vivo porcine eyes have shown promise in studying corneal permeation.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Subrata Senapati, Ramakanta Naik, Saumya Dash, Ashutosh Mohanty, Kevin Braeckmans, Stefaan C. De Smedt, Sangram Keshari Samal
Summary: Biomass-derived luminescent nitrogen-doped carbon nanosheets were prepared using an eco-friendly and cost-effective green method. The nitrogen-doped carbon nanosheets exhibited intense visible light emission with excitation-dependent behavior, as well as temperature-dependent photoluminescent properties. The nanosheets also showed excitation-dependent emissions in the dispersed state, making them suitable for various biomedical applications. Overall, this study demonstrates the potential of environmentally friendly nitrogen-doped carbon nanosheets for nanoscale temperature sensing, bioimaging, and therapeutic applications.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)