Review
Pharmacology & Pharmacy
Wen-Qian Zhu, Hui-Ying Wu, Zhi-Hui Sun, Yi Guo, Tong-Tong Ge, Bing-Jin Li, Xin Li, Ran-Ji Cui
Summary: Depression is a widespread and overlooked mood disorder, and natural Chinese medicine berberine has shown promising antidepressant effects. However, further research is needed to understand its efficacy and mechanism in treating depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Rufus O. Akinyemi, Joseph Yaria, Akin Ojagbemi, Maelenn Guerchet, Njideka Okubadejo, Alfred K. Njamnshi, Fred S. Sarfo, Albert Akpalu, Godwin Ogbole, Temitayo Ayantayo, Thierry Adokonou, Stella-Maria Paddick, David Ndetei, Judith Bosche, Biniyam Ayele, Andrea Damas, Motunrayo Coker, Lingani Mbakile-Mahlanza, Kirti Ranchod, Kirsten Bobrow, Udunna Anazodo, Albertino Damasceno, Sudha Seshadri, Margaret Pericak-Vance, Brian Lawlor, Bruce L. Miller, Mayowa Owolabi, Olusegun Baiyewu, Richard Walker, Oye Gureje, Rajesh N. Kalaria, Adesola Ogunniyi
Summary: The burden of dementia is increasing in Africa due to the aging population. Dementia prevalence and incidence rates vary, with Alzheimer's disease, vascular dementia, and HIV/AIDS-associated neurocognitive disorders being the most common subtypes. Longitudinal studies and genetic research are needed for better understanding of dementia in Africa.
ALZHEIMERS & DEMENTIA
(2022)
Review
Immunology
Yan Sun, Kexin Wang, Weiliang Zhao
Summary: Perioperative neurocognitive disorders (PND) is a common surgical anesthesia complication that impairs memory, attention, language understanding, and social ability, resulting in decreased patient quality of life, prolonged hospitalization, and increased mortality rate. PND has a high incidence rate and has become an important public health issue due to its impact on postoperative recovery, quality of life, and economic burden. Gut microbiota imbalance and the microbiota-gut-brain axis play a role in PND development, while neuroinflammation and immune activation are important mechanisms. Modulating gut microbiota through probiotics or fecal bacteria transplantation can reduce neuroinflammation, suppress abnormal immune activation, and prevent PND. This review provides a basis for the prevention and treatment of PND through an understanding of the relationship between gut microbiota and PND.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Ann-Marie M. Schoos, Bright I. Nwaru, Magnus P. Borres
Summary: This review provides an overview of furry mammal allergens as important sources of allergens, discusses the application of component resolved diagnostics beyond traditional methods, and highlights the clinical utility of CRD in predicting asthma risk and disease severity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Carsten Tschoepe, Enrico Ammirati, Biykem Bozkurt, Alida L. P. Caforio, Leslie T. Cooper, Stephan B. Felix, Joshua M. Hare, Bettina Heidecker, Stephane Heymans, Norbert Huebner, Sebastian Kelle, Karin Klingel, Henrike Maatz, Abdul S. Parwani, Frank Spillmann, Randall C. Starling, Hiroyuki Tsutsui, Petar Seferovic, Sophie Van Linthout
Summary: Inflammatory cardiomyopathy is a disease characterized by inflammatory cell infiltration into the myocardium and is predominantly mediated by viral infection. Despite extensive research, inflammatory cardiomyopathy complicated by left ventricular dysfunction, heart failure or arrhythmia is associated with a poor prognosis. The relative roles of the pathogen, host genomics and environmental factors in disease progression and healing are still under discussion.
NATURE REVIEWS CARDIOLOGY
(2021)
Review
Microbiology
Yao Zhou, Chendan Zhou, Aijun Zhang
Summary: The gut microbiota, which consists of a large number of microorganisms in the human gastrointestinal tract, plays a vital role in various physiological functions and is closely associated with the development of diseases. The interaction between gut microbiota and cancer, particularly acute leukemia (AL), has gained attention. The composition and diversity of gut microbiota significantly influence the complications and prognosis of AL after chemotherapy or hematopoietic stem cell transplantation. Microbial preparations, such as probiotics and fecal microbiota transplantation, show potential in reducing side effects and improving treatment response in leukemia therapy.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Oncology
Hongna Sun, Junnan Xu, Shuang Dai, Yiwen Ma, Tao Sun
Summary: Breast cancer is the most common cancer in women and brain metastasis has a significant impact on patient survival and quality of life. Triple-negative breast cancer and human epidermal growth factor receptor 2-positive breast cancer are more likely to develop brain metastases. Despite advancements in breast cancer treatment, brain metastases remain the leading cause of morbidity and mortality. Lack of clinical research often leads to exclusion of breast cancer patients with brain metastases from clinical trials. Understanding the molecular mechanisms of breast cancer brain metastasis is crucial for effective treatment.
Review
Medicine, General & Internal
Johannes Rotta detto Loria, Steffen Desch, Janine Poess, Katharina Kirsch, Holger Thiele, Marcus Sandri
Summary: This systematic review provides a comprehensive evaluation of the clinical application of percutaneous left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) over the past two decades, including anatomical features, patient selection, procedural planning and execution, complications, medical treatment following the procedure, and contemporary outcome data.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Allergy
J. L. Fauquert, C. Alba-Linero, A. Gherasim, A. Testera-Montes, G. Bentabol-Ramos, R. Saenz de Santa Maria-Garcia, M. J. Torres, I. Eguiluz-Gracia, C. Rondon
Summary: Aeroallergens can trigger respiratory symptoms in both atopic and non-atopic individuals. Nasal, conjunctival, and bronchial allergen challenges are helpful in determining the diagnosis, adjusting management strategies, and improving health outcomes for patients with airway allergy.
Article
Surgery
Jad Abi-Rafeh, Mehrad Jaberi, Leila Cattelan, Albaraa Aljerian, Mirko S. Gilardino
Summary: This article provides a comprehensive synthesis of the latest evidence on different soft-tissue reconstructive strategies for progressive hemifacial atrophy. The study found that serial fat grafting is the main modality for patients with mild soft-tissue atrophy, while microvascular free flaps remain the treatment of choice for reconstruction of large-volume defects. Additionally, graft supplementation to improve fat graft survival and early intervention may help curb disease progression.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Oncology
Despoina E. Kiousi, Antonia Z. Kouroutzidou, Konstantinos Neanidis, Emmanuel Karavanis, Dimitrios Matthaios, Aglaia Pappa, Alex Galanis
Summary: Cancer immunotherapy aims to stimulate the immune response against tumors, and the gut microbiota plays a crucial role in immunity and cancer immunotherapy. Manipulating the gut microbiota through dietary interventions or fecal microbiota transplantation can enhance the efficacy of immunotherapy and lead to personalized treatments.
Review
Oncology
Sirisha Tadimalla, Wei Wang, Annette Haworth
Summary: The use of functional MRI methods for liver radiation therapy planning and adaptation holds great potential in providing more individualized and adaptive treatment options.
Article
Integrative & Complementary Medicine
Jinxin Xie, Huiming Huang, Xingxing Li, Lishan Ouyang, Longyan Wang, Dongxiao Liu, Xuejiao Wei, Peng Tan, Pengfei Tu, Zhongdong Hu
Summary: The tumor microenvironment plays a crucial role in tumor development, and immune checkpoint-targeted drugs have shown unique advantages in cancer treatment. Traditional Chinese medicine has a positive impact on tumor immunotherapy by regulating immune cells, cytokines, and immune checkpoint molecules. Immunomodulatory stimulation with traditional Chinese medicine could be valuable for immunotherapy in patients with non-inflammatory or cold tumors.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Oncology
Leila T. Tchelebi, Cathy Eng, Craig A. Messick, Theodore S. Hong, Ethan B. Ludmir, Lisa A. Kachnic, Nicholas G. Zaorsky
Summary: The treatment of squamous cell carcinoma of the anus has shifted from radical surgery to sphincter-preserving chemoradiation, with chemotherapy using mitomycin-C and 5-fluorouracil found to be essential for cure. Advanced radiation techniques are now considered standard of care, and further studies are exploring the addition of immune checkpoint inhibitors in locally advanced cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Allergy
Feng Lan, Hua Zhong, Nan Zhang, Sebastian L. Johnston, Weiping Wen, Nikos Papadopoulos, Luo Zhang, Claus Bachert
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Claire L. Greiller, Reetika Suri, David A. Jolliffe, Tatiana Kebadze, Aurica G. Hirsman, Christopher J. Griffiths, Sebastian L. Johnston, Adrian R. Martineau
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)
Editorial Material
Respiratory System
Aran Singanayagam, Sebastian L. Johnston
Editorial Material
Critical Care Medicine
Sebastian L. Johnston
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Immunology
Coraline Radermecker, Catherine Sabatel, Celine Vanwinge, Cecilia Ruscitti, Pauline Marechal, Fabienne Perin, Joey Schyns, Natacha Rocks, Marie Toussaint, Didier Cataldo, Sebastian L. Johnston, Fabrice Bureau, Thomas Marichal
Article
Medicine, Research & Experimental
Aleks Guvenel, Agnieszka Jozwik, Stephanie Ascough, Seng Kuong Ung, Suzanna Paterson, Mohini Kalyan, Zoe Gardener, Emma Bergstrom, Satwik Kar, Maximillian S. Habibi, Allan Paras, Jie Zhu, Mirae Park, Jaideep Dhariwal, Mark Almond, Ernie H. C. Wong, Annemarie Sykes, Jerico Del Rosario, Maria-Belen Trujillo-Torralbo, Patrick Mallia, John Sidney, Bjoern Peters, Onn Min Kon, Alessandro Sette, Sebastian L. Johnston, Peter J. Openshaw, Christopher Chiu
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Chemistry, Analytical
Tao Xiong, Mingle Li, Xueze Zhao, Yang Zou, Jianjun Du, Jiangli Fan, Xiaojun Peng
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Editorial Material
Respiratory System
Philip G. Bardin, Sebastian L. Johnston
Editorial Material
Critical Care Medicine
Sebastian L. Johnston
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Editorial Material
Respiratory System
Chloe I. Bloom, Sebastian L. Johnston
Meeting Abstract
Critical Care Medicine
D. J. Wiseman, F. Kamal, L. Finney, A. I. Ritchie, J. Gent, M. R. Edwards, S. L. Johnston, G. C. Donaldson, P. J. Openshaw, J. A. Wedzicha
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
D. P. Potaczek, S. D. Unger, N. Zhang, S. Taka, S. Michel, N. Akdag, F. Lan, M. Helfer, C. Hudemann, M. Eickmann, C. Skevaki, S. Megremis, A. Sadewasser, B. Alashkar Alhamwe, F. Alhamdan, M. Akdis, M. R. Edwards, S. L. Johnston, C. A. Akdis, S. Becker, C. Bachert, N. G. Papadopoulos, H. Garn, H. Renz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
M. J. O'Sullivan, J. Mitchel, Y. A. Bochkov, L. Tan, T. Kebadze, S. L. Johnston, J. E. Gern, J. A. Park
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
L. Finney, P. S. Fenwick, S. Kemp, E. Bakhsoliani, K. B. R. Belchamber, M. R. Edwards, G. C. Donaldson, L. Donnelly, P. Mallia, S. L. Johnston, J. A. Wedzicha
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)