Article
Psychology, Biological
Florencia M. Bercum, Maria J. Navarro Gomez, Michael P. Saddoris
Summary: Early life stress (ELS) disrupts typical neural development and makes the prefrontal cortex (PFC) particularly vulnerable. In this study, adult rats with ELS showed lower motivation for rewards in threatening situations and exhibited changes in in vivo PFC signals. This suggests that ELS may contribute to susceptibility to mental health disorders in adulthood.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Samira Ezi, Mahdi Eskandarian Boroujeni, Aysan Khatmi, Kimia Vakili, Mobina Fathi, Mohammad-Amin Abdollahifar, Fakhroddin Aghajanpour, Reza Soltani, Seyed Hamidreza Mirbehbahani, Fariba Khodagholi, Abbas Aliaghaei, Reza Mastery Farahani
Summary: This study aimed to investigate the molecular and histological changes in the cerebellar cortex related to tramadol administration, revealing that tramadol treatment resulted in cerebellar atrophy, microgliosis, neuroinflammation, and activation of apoptotic biomarkers, as well as a significant drop in VEGF level and impaired motor coordination. Several signaling cascades related to neurodegenerative disease and energy metabolism were deregulated in the cerebellum of tramadol-treated rats.
NEUROTOXICITY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Naghmeh Zamani, Laya Takbiri Osgoei, Abbas Aliaghaei, Nasim Zamani, Hossein Hassanian-Moghaddam
Summary: This study found that methadone treatment causes cerebellar atrophy, glial cell activation, astrocyte proliferation, apoptosis, and neuro-inflammation. Methadone also affects motor coordination, locomotor performance, and neuromuscular activity.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Pawan Sharma, Prithvi K. Shah
Summary: This study identified the predominant neural structures activated with cervical epidural stimulation (ES) and highlighted the importance of this information in enhancing our understanding of ES, refining rehabilitative strategies, and constructing neuroprosthetics. The findings pave the way for designing motor rehabilitation strategies that can utilize cervical ES to recover upper limb function following neurological deficits.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Engineering, Biomedical
Nicholas G. Mellor, Sylvia A. Chung, E. Scott Graham, Bryan W. Day, Charles P. Unsworth
Summary: This article establishes a method for stimulating Ca2+ transients in GBM cell-lines, providing a new way to study Ca2+ communication in GBM cells and their networks.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Environmental Sciences
Zainab Sabry Othman Ahmed, Mohamed Abdelaziz Tahon, Randa S. Hasan, Hazem G. M. El-Sayed, Huda O. AbuBaker, Ismaiel M. Ahmed, Yasmine H. Ahmed
Summary: This study aimed to investigate the potential toxic effects of the herbicide Atrazine (ATZ) on the cerebellum, thyroid gland, and liver, as well as the protective effects of Acacia nilotica. The findings showed that ATZ caused degeneration and vacuolation in the examined organs, increased liver enzyme levels and DNA fragmentation, and decreased antioxidant levels. However, Acacia nilotica administration partially protected against these toxic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Critical Care Medicine
Alejandra Jacotte-Simancas, Jason W. Middleton, Zachary F. Stielper, Scott Edwards, Patricia E. Molina, Nicholas W. Gilpin
Summary: TBI produces sex-specific acute effects on BLA neuronal activation, excitability, and synaptic transmission. Females exhibit increased apnea duration and reduced respiratory rate post-TBI relative to males. In both male and female rats, TBI increases c-fos expression in BLA glutamatergic cells and firing rate in BLA pyramidal neurons. In females, TBI also increases spontaneous excitatory and inhibitory postsynaptic current amplitude and sEPSC frequency in BLA neurons.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Neurosciences
Clemence Giere, Yannick Menger, Hannah Illouz, Meggane Melchior, Vincent Lelievre, Pierrick Poisbeau
Summary: Early life adversities can have long-term consequences on the developing nervous system, leading to altered pain processing. This study focuses on the effects of neonatal maternal separation on spinal cord neurons, finding that these neurons exhibit an excessive response to mechanical and thermal stimuli. The reduced inhibitory tone on these neurons may contribute to the observed pain hypersensitivity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Yasmin Fidler, Jose Rosa Gomes
Summary: This study evaluated the effects of radiation on the morphology and MMP-9 expression in the cerebellum. The results showed that radiation caused morphological changes in Purkinje cells and granular cells, along with an increase in MMP-9 expression in the first two weeks after radiation.
Article
Neurosciences
Kathryn R. Przybysz, Meredith E. Gamble, Marvin R. Diaz
Summary: The study reveals that adolescent alcohol exposure may result in long-term sex-dependent effects on BLA physiology and KOR function in adulthood, impacting the modulation of GABAergic and glutamatergic neurotransmission.
Article
Neurosciences
Louis J. Martin, Joseph M. Breza, Suzanne Sollars
Summary: This study demonstrates that early and chronic loss of taste input from the chorda tympani in rats leads to abnormal taste behaviors. Chronic nerve loss amplifies responses to salty and sour stimuli in the gustatory pons, indicating compensatory plasticity but also permanent deficits in taste signaling following early denervation.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Kristine Heiney, Ola Huse Ramstad, Vegard Fiskum, Axel Sandvig, Ioanna Sandvig, Stefano Nichele
Summary: This study investigates the interplay between dynamics and functional connectivity in networks of neurons in vitro. The results indicate that in vitro networks maintain a slightly subcritical state by striking a balance between integration and segregation.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Neurosciences
Sanna Lensu, Tomi Waselius, Elina Makinen, Heikki Kettunen, Ari Virtanen, Marja Tiirola, Markku Penttonen, Satu Pekkala, Miriam S. Nokia
Summary: Exposure of adult male rats to moderate-dose irradiation of the head did not have a significant impact on systemic inflammation, weight gain, or gut microbiota diversity, but it did reduce adult hippocampal neurogenesis and impair short-term spatial recognition memory. However, overall cognitive function was not affected.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Physiology
Tenna Bering, Henrik Hertz, Martin Fredensborg Rath
Summary: Thyroid hormone T3 plays a role in regulating the cerebellar circadian oscillator, influencing clock gene expression. However, it does not represent a systemic circadian regulatory mechanism linking the SCN to the cerebellum throughout life.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Kristina Csatlosova, Eszter Bogi, Barbora Durisova, Daniil Grinchii, Ruslan Paliokha, Lucia Moravcikova, Lubica Lacinova, Daniela Jezova, Eliyahu Dremencov
Summary: There is a higher risk of depression and schizophrenia in the descendants of mothers who experienced acute infection during pregnancy, possibly due to the altered excitability of serotonin (5-HT) and dopamine neurons. Maternal immune activation suppressed the firing rate of 5-HT neurons and stimulated the firing rate of dopamine neurons in male offspring. This alteration in neuronal excitability may contribute to the psychopathologies induced by infectious disease during pregnancy.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biology
Lea Ankri, Zoe Husson, Katarzyna Pietrajtis, Remi Proville, Clement Lena, Yosef Yarom, Stephane Dieudonne, Marylka Yoe Uusisaari
Article
Neurosciences
Marylka Uusisaari, Thomas Knopfel
Article
Neurosciences
Marylka Uusisaari, Thomas Knoepfel
Article
Neurosciences
Marylka Yoe Uusisaari, Thomas Knoepfel
Review
Neurosciences
Marylka Uusisaari, Erik De Schutter
JOURNAL OF PHYSIOLOGY-LONDON
(2011)
Article
Neurosciences
Yaara Lefler, Yosef Yarom, Marylka Yoe Uusisaari
Article
Neurosciences
M. Uusisaari, T. Knopfel
Article
Neurosciences
Shiwei Huang, Marylka Y. Uusisaari
FRONTIERS IN CELLULAR NEUROSCIENCE
(2013)
Article
Anatomy & Morphology
Nora Vrieler, Sebastian Loyola, Yasmin Yarden-Rabinowitz, Jesse Hoogendorp, Nikolay Medvedev, Tycho M. Hoogland, Chris I. De Zeeuw, Erik De Schutter, Yosef Yarom, Mario Negrello, Ben Torben-Nielsen, Marylka Yoe Uusisaari
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Neurosciences
M Uusisaaria, S Smirnov, J Voipio, K Kaila
Article
Neurosciences
K Stenkamp, JM Palva, M Uusisaari, S Schuchmann, D Schmitz, U Heinemann, K Kaila
JOURNAL OF NEUROPHYSIOLOGY
(2001)
Article
Neurosciences
Marylka Uusisaari, Kunihiko Obata, Thomas Knopfel
JOURNAL OF NEUROPHYSIOLOGY
(2007)