Article
Immunology
Nicole M. Lane Starr, Michael D. Evans, Kristine E. Lee, James E. Gern, Loren C. Denlinger
Summary: The study found that high levels of 15-keto-PGE(2) during acute colds are associated with fewer symptoms during recovery.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Dolores Camacho-Munoz, Magdalena Kiezel-Tsugunova, Orsolya Kiss, Mohib Uddin, Mattias Sunden, Maria Ryaboshapkina, Lars Lind, Jan Oscarsson, Anna Nicolaou
Summary: In this study, the effects of Fibrates and omega-3 polyunsaturated acids on plasma levels of bioactive lipid mediators in patients with obese non-alcoholic fatty liver and hypertriglyceridemia were investigated. The results showed that these two drugs have different effects on the plasma mediator lipidome, with omega-3 promoting lipid mediators potentially affecting chronic inflammation, while Fibrates mainly reducing ceramides. These findings suggest that both treatments could alleviate chronic inflammation and possibly impact disease outcomes, independent of triglyceride reduction.
Review
Biochemistry & Molecular Biology
Liesa Salzer, Michael Witting
Summary: Metabolomics and lipidomics have gained interest in the model organism C. elegans due to its fast development, easy cultivation, and existing genetic tools. Different analytical approaches such as NMR, mass spectrometry, and chromatography have been employed for metabolomic analyses. The reviewed literature also includes application fields, bioinformatic tools, and a curated collection of metabolites and lipids for a future C. elegans-specific metabolome database.
Article
Biochemistry & Molecular Biology
Yi Lu, Finnur Freyr Eiriksson, Margret Thorsteinsdottir, Nils Cronberg, Henrik Toft Simonsen
Summary: Bryophytes, such as mosses, liverworts, and hornworts, have attracted researchers due to their diverse chemicals and potential applications in pharmaceutical, food, and cosmetic industries. They accumulate long-chain polyunsaturated fatty acids (l-PUFA) to maintain cell fluidity in cold environments. While Iceland has a rich bryophyte vegetation, the lipid profiles of these plants are largely unknown. In this study, lipidomics analysis was performed on 39 local bryophyte species in Iceland using UPLC-ESI-QTOF-MS, revealing that six moss species had abundant arachidonic acid (AA) and eicosapentaenoic acid (EPA) in their phospholipids and glycerolipids.
Article
Biotechnology & Applied Microbiology
Joao P. Monteiro, Elisabete Costa, Tania Melo, Pedro Domingues, Antoine Fort, M. Rosario Domingues, Ronan Sulpice
Summary: This study analyzed the lipid profile of three species of foliose Ulva grown in the same conditions and found important differences in fatty acid composition and sulfolipids. The study suggests that U. australis and U. rigida have higher nutritional value, while U. lacinulata has a lower n-6/n-3 ratio. Additionally, Ulva rigida contains sulfolipid species with potential bioactivity.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Yao Qian, Xiangyu Guo, Yunfang Wang, Zheng Ouyang, Xiaoxiao Ma
Summary: A mobility-modulated sequential dissociation (MMSD) strategy was developed for mass spectrometry imaging, enabling spatial lipidomics capable of multiplexed MS/MS imaging of 24 structurally distinct lipids. The method revealed a potential biomarker in a human hepatocellular carcinoma tissue.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemical Research Methods
Michael Witting, Ulrike Schmidt, Hans-Joachim Knoelker
Summary: The study utilized chromatographic and ion mobility separation combined with DIA for lipid analysis in the biomedical model organism Caenorhabditis elegans, showing that this method is effective for initial lipid identification, successfully identifying 45 marado- and lysomaradolipids.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Cell Biology
Nina Y. Yuan, Ricky Maung, Ziying Xu, Xianlin Han, Marcus Kaul
Summary: This study found that the neuroinflammation observed in HIV infection is associated with abnormal metabolism of arachidonic acid. In a transgenic mouse model, the absence of the LTC4S gene suppressed signaling activity in the inflammatory pathway in female mice. Lipidomic profiling revealed beneficial changes in brain lipids. These findings suggest that targeting the arachidonic acid cascade may have therapeutic potential for neuroinflammation in NeuroHIV and HANDs.
Article
Agriculture, Multidisciplinary
Xianlin Han, Hongping Ye
Summary: Although triglycerides play important roles in cellular growth, metabolism, and function, accurately identifying their molecular species and quantities remains a challenge.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Joao P. Monteiro, Tania Melo, Jorunn Skjermo, Silje Forbord, Ole J. Broch, Pedro Domingues, Ricardo Calado, M. Rosario Domingues
Summary: Macroalgae aquaculture, especially kelp farming, is flourishing across different production sites in Europe. The elemental and biochemical composition of Saccharina latissima is influenced significantly by the time of harvesting, with less impact from the proximity to nutrient sources like fish farm sea cages. Harvested kelp biomass in April showed differences in composition compared to those in May and June, mainly in terms of lower C, H, carbohydrates, and higher ash contents. The lipid profile analysis also revealed changes in fatty acids and lipid signatures based on the harvesting periods.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Wen-Jen Lin, Pei-Chun Shen, Hsiu-Cheng Liu, Yi-Chun Cho, Min-Kung Hsu, I-Chen Lin, Fang-Hsin Chen, Juan-Cheng Yang, Wen-Lung Ma, Wei-Chung Cheng
Summary: LipidSig is a flexible and user-friendly web server designed to help users identify significant lipid-related features and advance the field of lipid biology through efficient data analysis and exploration of lipid characteristics.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Analytical
Dain R. Brademan, Katherine A. Overmyer, Yuchen He, William D. Barshop, Jesse D. Canterbury, Brandon J. Bills, Benton J. Anderson, Paul D. Hutchins, Seema Sharma, Vlad Zabrouskov, Graeme C. McAlister, Joshua J. Coon
Summary: In mass spectrometry-based lipidomics, complex lipid mixtures are separated, ionized, and detected using tandem MS (MS(n)) for quantitative and structural analysis. The structural granularity of identified lipids depends on the analytical techniques used. Real-time identifications can trigger downstream MS(n) for improved structural characterization and analysis depth.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Manis, Antonio Murgia, Alessia Manca, Antonella Pantaleo, Giacomo Cao, Pierluigi Caboni
Summary: Our study using a hyphenated ion mobility mass spectrometric platform for lipid profiling of human erythrocytes expands the understanding of cellular processes and stress due to microgravity. We identified complex lipids associated with microgravity conditions, such as oxidized phosphocholines, phosphocholines bearing arachidonic in their moiety, as well as sphingomyelins and hexosyl ceramides. These findings provide insights into molecular alterations and erythrocyte lipidomics signatures associated with microgravity conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
James F. Markworth, Kristoffer B. Sugg, Dylan C. Sarver, Krishna Rao Maddipati, Susan V. Brooks
Summary: This study found that tendon overuse can lead to a delayed and prolonged local inflammatory response, characterized by an increase in pro-inflammatory eicosanoids and a relative lack of specialized pro-resolving lipid mediators.
Article
Biochemical Research Methods
Lauren M. Bishop, Oliver Fiehn
Summary: Large-scale lipidomic analyses have been limited by the cost and accessibility of traditional venipuncture sampling. Microsampling techniques offer a less-invasive and more accessible alternative. From a single drop of blood, plasma separation cards (PSC) deliver two volumetric dried plasma samples which are studied here for profiling endogenous blood lipids.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Editorial Material
Cell Biology
Michael A. Miller
DEVELOPMENTAL CELL
(2015)
Article
Biochemistry & Molecular Biology
Hieu D. Hoang, Michael A. Miller
Article
Biochemistry & Molecular Biology
Hiroshi Tsuda, Sung Min Han, Youfeng Yang, Chao Tong, Yong Qi Lin, Kriti Mohan, Claire Haueter, Anthony Zoghbi, Yadollah Harati, Justin Kwan, Michael A. Miller, Hugo J. Bellen
Article
Developmental Biology
Youfeng Yang, Sung Min Han, Michael A. Miller
DEVELOPMENTAL BIOLOGY
(2010)
Article
Developmental Biology
Johnathan W. Edmonds, Shauna L. McKinney, Jeevan K. Prasain, Michael A. Miller
DEVELOPMENTAL BIOLOGY
(2011)
Article
Cell Biology
Johnathan W. Edmonds, Jeevan K. Prasain, Dixon Dorand, Youfeng Yang, Hieu D. Hoang, Jack Vibbert, Homare M. Kubagawa, Michael A. Miller
DEVELOPMENTAL CELL
(2010)
Article
Cell Biology
Sung Min Han, Hiroshi Tsuda, Youfeng Yang, Jack Vibbert, Pauline Cottee, Se-Jin Lee, Jessica Winek, Claire Haueter, Hugo J. Bellen, Michael A. Miller
DEVELOPMENTAL CELL
(2012)
Review
Anatomy & Morphology
Sung Min Han, Pauline A. Cottee, Michael A. Miller
DEVELOPMENTAL DYNAMICS
(2010)
Article
Multidisciplinary Sciences
Katherine McKnight, Hieu D. Hoang, Jeevan K. Prasain, Naoko Brown, Jack Vibbert, Kyle A. Hollister, Ray Moore, Justin R. Ragains, Jeff Reese, Michael A. Miller
Article
Genetics & Heredity
Hieu D. Hoang, Jeevan K. Prasain, Dixon Dorand, Michael A. Miller
Article
Genetics & Heredity
Sung Min Han, Hajer El Oussini, Jelena Scekic-Zahirovic, Jack Vibbert, Pauline Cottee, Jeevan K. Prasain, Hugo J. Bellen, Luc Dupuis, Michael A. Miller
Article
Developmental Biology
Jessica Schultz, Se-Jin Lee, Tim Cole, Hieu D. Hoang, Jack Vibbert, Pauline A. Cottee, Michael A. Miller, Sung Min Han
Article
Developmental Biology
Pauline A. Cottee, Tim Cole, Jessica Schultz, Hieu D. Hoang, Jack Vibbert, Sung Min Han, Michael A. Miller
Article
Biochemistry & Molecular Biology
Jeevan K. Prasain, Landon Wilson, Hieu D. Hoang, Ray Moore, Michael A. Miller