Article
Biochemistry & Molecular Biology
Atsuko K. Kimura, Tomohiro Kimura
Summary: This article discusses the crucial role of phosphatidylserine (PS) in lipid homeostasis in cells, focusing on recent discoveries about the two enzymes involved in PS synthesis and their roles in membrane structure and PS synthesis.
Review
Cell Biology
Guillaume Lenoir, Juan Martin D'Ambrosio, Thibaud Dieudonne, Alenka Copic
Summary: The distribution of PS within cellular membranes is controlled by a variety of factors, including PS biosynthesis enzymes, lipid transfer proteins, and lipid flippases. The enrichment of PS in specific compartments requires energy input, and PS transfer may be achieved by passive flow. The presence of lateral PS nanodomains can alter the steepness or direction of PS gradients between different compartments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Suresh Velnati, Sara Centonze, Federico Girivetto, Daniela Capello, Ricardo M. Biondi, Alessandra Bertoni, Roberto Cantello, Beatrice Ragnoli, Mario Malerba, Andrea Graziani, Gianluca Baldanzi
Summary: PKC zeta and PKC iota/lambda form the atypical protein kinase C subgroup, characterized by their regulation distinct from conventional PKCs. Both PKC zeta and PKC iota interact with phosphatidic acid and phosphatidylserine, while PKC iota uniquely binds to phosphatidylinositol-monophosphates. Additionally, phosphatidylinositol 4-phosphate specifically activates PKC iota, indicating a specific regulation of PKC iota by certain membrane lipids.
Article
Cell Biology
Mitsuhiro Abe, Asami Makino, Motohide Murate, Francoise Hullin-Matsuda, Masataka Yanagawa, Yasushi Sako, Toshihide Kobayashi
Summary: The research reveals that PMP2 protein can localize on the plasma membrane and affect the distribution of sphingomyelin, which is associated with Charcot-Marie-Tooth disease. PMP2 induces membrane tubulation by binding to PI(4,5)P-2 and changes the distribution of lipids.
Article
Biochemistry & Molecular Biology
Hassan Mustafa Arif, Zhongming Qian, Rui Wang
Summary: This article summarizes the significance of the interplay between hydrogen sulfide (H2S) and iron in cellular fate and wellness. The abnormal metabolisms of both iron and H2S are associated with various diseases. Future studies should evaluate the physiological and pathophysiological importance of H2S and iron together, and expand research to other fields where the interaction between H2S and iron has not been well studied.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Priyanka Tripathi, Zhihui Zhu, Haiyan Qin, Ahmed Elsherbini, Simone M. Crivelli, Emily Roush, Guanghu Wang, Stefka D. Spassieva, Erhard Bieberich
Summary: The study reveals that ceramide stabilizes microtubules, indicating a similar function in cilia. Complex formation of ceramide with acetylated tubulin is detected in different cells, and S-palmitoylated acetylated tubulin is found to colocalize with ceramide-rich platforms in the ciliary membrane.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Chemistry, Physical
Ji Hun Wi, Cheol Ho Heo, HyeRan Gwak, Cheulhee Jung, So Yeon Kim
Summary: This study investigated the impact of cellular senescence on membrane properties through different imaging techniques. The research found that as cells undergo senescence, there is an increase in ceramide-rich lipid rafts in the membrane, highlighting the importance of membrane properties in cellular senescence.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
R. Jeitler, C. Glader, C. Tetyczka, S. Zeiringer, M. Absenger-Novak, A. Selmani, E. Froehlich, E. Roblegg
Summary: Lipid-based nanosystems can effectively deliver drugs to oral cavity cells for the treatment of local diseases. Through quality design and predictive modeling, we have demonstrated the stability of solid lipid nanoparticles and nanostructured lipid carriers, enabling reliable drug release in the oral cavity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tianyi Dou, Dmitry Kurouski
Summary: This study utilized nano-infrared imaging technique to investigate the effect of phosphatidylcholine and phosphatidylserine on the structure of alpha-synuclein oligomers. It was found that lipids can alter the secondary structure of the oligomers.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Virology
Kristen A. Johnson, Nisha Bhattarai, Melissa R. Budicini, Carolyn M. LaBonia, Sarah Catherine B. Baker, Bernard S. Gerstman, Prem P. Chapagain, Robert Stahelin
Summary: The study revealed that mutations of two highly conserved cysteine residues in VP40 can increase its affinity for membranes containing phosphatidylserine (PS), resulting in the assembly of longer virus-like particles (VLPs). These cysteine residues play a crucial role in modulating the dynamic interactions of VP40 with the plasma membrane by affecting its ability to bind PS.
Article
Biochemistry & Molecular Biology
Joel Brunner, Domitille Schvartz, Aurelie Gouiller, Alexandre Hainard, Gerrit Borchard
Summary: This study demonstrates that L-R5 interacts directly with TJ proteins, preventing the binding and phosphorylation of occludin by PKC zeta, resulting in TJ disruption and enhanced epithelial permeability.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Virology
Farhana Musarrat, Vladimir Chouljenko, Konstantin G. Kousoulas
Summary: Herpes simplex virus 1 utilizes cellular motor proteins and kinase pathways for intracellular virion transport, with Akt and kinase C inhibitors blocking virus entry and virion capsid transport. UL37 and Vp5 viral proteins are crucial for dynein-dependent transport of virion capsids, while Akt and kinase C do not directly phosphorylate or activate dynein during infection.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Bonfogo da Silveira, Camila Cristiane Pansa, Osmar Malaspina, Karen C. M. Moraes
Summary: Hepatocellular carcinoma is a common cancer with high mortality rate, and controlling fatty acid metabolism may limit its proliferation. Inhibition of miR-1914-5p has been found to change cellular metabolism and behavior, increasing energy expenditure and decreasing cell doubling time and migration rate.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Neurosciences
Oge Gozutok, Benjamin Ryan Helmold, P. Hande Ozdinler
Summary: Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases that mainly affect the upper motor neurons (UMNs) in patients. Mutations in genes coding for proteins and alterations in protein interaction domains may be key factors in causing vulnerability in UMNs, highlighting the importance of proteins involved in lipid homeostasis and cytoarchitectural dynamics for UMN health and stability.
Review
Biochemistry & Molecular Biology
Stephan L. Watkins
Summary: There has been a significant increase in the use of molecular dynamics simulations in research and industry, particularly in the study of neurological and biological membranes. This review examines both recent and older studies to assess the evolution of the field. The analysis provides an overview of current methodologies, trends, and predictions for the future of membrane molecular dynamics.