Review
Medicine, General & Internal
Adriana Marques, Carla Torre, Rui Pinto, Bruno Sepodes, Joao Rocha
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection, affecting over 25 million people annually. Septic shock, a severe subset of sepsis, is characterized by persistent low blood pressure, with hospital mortality rates exceeding 40%. Despite advances in early sepsis mortality, long-term complications such as secondary infection remain a significant cause of death, and there are currently no sepsis-specific therapies. Immunostimulatory therapy, including cytokines, growth factors, immune checkpoint inhibitors, and cellular therapies, holds promise in addressing this unmet medical need.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Federico Carbone, Luca Liberale, Alberto Preda, Thomas Hellmut Schindler, Fabrizio Montecucco
Summary: The onset of cardiomyopathy in sepsis is a common feature that affects its pathophysiology and clinical care. However, there is a lack of consensus in the definition of sepsis-induced cardiomyopathy, and the wide range of ultrasonographic findings may not fully reflect the understanding of the condition. This review explores the current state of research on sepsis-related cardiomyopathy, highlighting the shortcomings in its definition and discussing the dynamic changes in cardiac performance in response to different hemodynamic clusters. The review also addresses the molecular mechanisms leading to myocardial dysfunction and their similarities to myocardial hibernation.
Article
Critical Care Medicine
Laura Piccolo Serafim, Douglas A. Simonetto, Alexandra L. Anderson, Dae Hee Choi, Timothy J. Weister, Andrew C. Hanson, Patrick S. Kamath, Ognjen Gajic, Alice Gallo de Moraes
Summary: The study found that the use of systemic steroids in patients with cirrhosis and septic shock did not significantly affect mortality, length of ICU admission, or length of hospital stay, and also did not increase adverse effects. The prevalence of steroid use was higher in cirrhotic patients with higher vasopressor requirements.
Editorial Material
Cell Biology
Brianna Cyr, Juan Pablo de Rivero Vaccari
Summary: The study investigates the effect of age on brain inflammation response, finding that older individuals exhibit more exacerbated inflammatory immune responses when faced with systemic infections.
Article
Critical Care Medicine
Marta Martin-Fernandez, Maria Heredia-Rodriguez, Irene Gonzalez-Jimenez, Mario Lorenzo-Lopez, Estefania Gomez-Pesquera, Rodrigo Poves-Alvarez, F. Javier Alvarez, Pablo Jorge-Monjas, Juan Beltran-DeHeredia, Eduardo Gutierrez-Abejon, Francisco Herrera-Gomez, Gabriella Guzzo, Esther Gomez-Sanchez, Alvaro Tamayo-Velasco, Rocio Aller, Paolo Pelosi, Jesus Villar, Eduardo Tamayo
Summary: In postsurgical patients with sepsis/septic shock, arterial oxygen pressure (PaO2) above 100 mmHg is independently associated with lower 90-day mortality, shorter ICU stay, and intubation time.
Article
Immunology
Marcela Hortova-Kohoutkova, Monika Skotakova, Isaac G. Onyango, Miriam Slezakova, Roman Panovsky, Lukas Opatril, Peter Slanina, Marco De Zuani, Ondrej Mrkva, Ivana Andrejcinova, Petra Laznickova, Martina Dvoncova, Alexandra Mytnikova, Vaughn Ostland, Michal Sitina, Gorazd B. Stokin, Vladimir Sramek, Marcela Vlkova, Martin Helan, Jan Fric
Summary: This study investigated the dynamics of iron regulation in different clinical settings and determined the suitability of hepcidin and/or ferritin levels as biomarkers of inflammatory disease severity. The results showed that hepcidin levels reflect overall immune cell activation driven by intrinsic stimuli, while ferritin levels are more strongly influenced by pathogen-induced inflammation. Furthermore, the hepcidin-to-ferritin ratio has the ability to predict mortality in septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Josep Bringue, Raquel Guillamat-Prats, Maria Luisa Martinez, Eva Torrents, Marta Camprubi-Rimblas, Lluis Blanch, Antonio Artigas
Summary: The study showed that a single, low dose of MTX can protect against sepsis-induced lung damage by reducing pro-inflammatory cytokines, decreasing infiltration of inflammatory cells in the lung, and regulating adenosine receptor A2aR and metalloproteinases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Andrea Carsetti, Eva Vitali, Lucia Pesaresi, Riccardo Antolini, Erika Casarotta, Elisa Damiani, Erica Adrario, Abele Donati
Summary: Sepsis is a life-threatening condition caused by a dysfunctional response to infection, while septic shock is a severe form of sepsis characterized by persistent low blood pressure and high lactate levels despite adequate fluid resuscitation. Early identification, antibiotic therapy, and control of the infection source are crucial for patient outcomes. Anesthesiologists play a crucial role in managing these patients, evaluating organ dysfunction and optimizing hemodynamics before surgery. Anesthetic agents should be carefully chosen, and efforts should be made to maintain organ perfusion through fluids, vasoactive agents, and inotropes if necessary.
FRONTIERS IN MEDICINE
(2023)
Review
Critical Care Medicine
Tatiana Barichello, Jaqueline S. Generoso, Diogo Dominguini, Emily Corneo, Vijayasree V. Giridharan, Taha A. Sahrapour, Lutiana R. Simoes, Maria Ines da Rosa, Fabricia Petronilho, Cristiane Ritter, Tarek Sharshar, Felipe Dal-Pizzol
Summary: This systematic review identified various pathological changes in the brains of deceased sepsis patients, including edema, abscess, hemorrhagic and ischemic injuries, leading to neuronal damage and infiltration of peripheral inflammatory cells. The study highlights the detrimental effects of sepsis on brain function.
CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Gianluca Tullo, Marcello Candelli, Irene Gasparrini, Sara Micci, Francesco Franceschi
Summary: Sepsis and septic shock are leading causes of in-hospital mortality worldwide, with significant burden on healthcare systems. Ultrasound has been used as an adjunctive tool for the diagnosis and treatment of these conditions, providing valuable information for clinicians. Further research is needed to determine the impact of ultrasound on patient survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Nicole Wolfertz, Lennert Boehm, Verena Keitel, Oliver Hannappel, Philipp Kuempers, Michael Bernhard, Mark Michael
Summary: This study provides important insight into the incidence, management, and outcome of patients with infections, sepsis, and septic shock in a German emergency department. The findings have implications for quality management and optimization of treatment pathways for infectious diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.
Article
Infectious Diseases
Carlo Pietrasanta, Andrea Ronchi, Claudia Vener, Chiara Poggi, Claudia Ballerini, Lea Testa, Rosaria Maria Colombo, Elena Spada, Carlo Dani, Fabio Mosca, Lorenza Pugni
Summary: This study aimed to evaluate the accuracy of presepsin for diagnosing and early stratifying neonates with suspected sepsis. Presepsin showed potential value in diagnosing neonatal sepsis and septic shock, but had limited support in early identification of neonates with positive blood culture.
Article
Infectious Diseases
Pedro Martinez-Paz, Marta Aragon-Camino, Esther Gomez-Sanchez, Mario Lorenzo-Lopez, Estefania Gomez-Pesquera, Alejandra Fadrique-Fuentes, Pilar Liu, Alvaro Tamayo-Velasco, Christian Ortega-Loubon, Marta Martin-Fernandez, Hugo Gonzalo-Benito, Emilio Garcia-Moran, Maria Heredia-Rodriguez, Eduardo Tamayo
Summary: The study aims to distinguish between septic shock and non-septic shock in postoperative patients through gene expression signature, providing personalized treatment and avoiding unnecessary antibiotic use and increased healthcare costs.
JOURNAL OF INFECTION
(2021)
Review
Dentistry, Oral Surgery & Medicine
Saurabh Mannan, Patricia A. Tordik, Frederico C. Martinho, Noah Chivian, Craig S. Hirschberg
Summary: Sepsis is a serious and complex medical condition with a high mortality rate. Sepsis and septic shock occur as a continuum, with sepsis leading to septic shock. In the United States, the estimated incidence of severe sepsis is 300 cases per 10,000.
JOURNAL OF ENDODONTICS
(2021)
Meeting Abstract
Biotechnology & Applied Microbiology
Francisco Martin, Pilar Munoz, Marien Cobo, Almudena Sanchez-Gilabert, Pedro Real, Veronica Ramos, Philip D. Gregory, Michael C. Holmes, Miguel G. Toscano
Article
Biotechnology & Applied Microbiology
Miguel G. Toscano, Oscar Navarro-Montero, Veronica Ayllon, Veronica Ramos-Mejia, Xiomara Guerrero-Carreno, Clara Bueno, Tamara Romero, Mar Lamolda, Marien Cobo, Francisco Martin, Pablo Menendez, Pedro J. Real
Article
Biotechnology & Applied Microbiology
Miguel G. Toscano, Pilar Munoz, Almudena Sanchez-Gilabert, Marien Cobo, Karim Benabdellah, Per Anderson, Veronica Ramos-Mejia, Pedro J. Real, Olaf Neth, Agueda Molinos-Quintana, Philip D. Gregory, Michael C. Holmes, Francisco Martin
Review
Biochemistry & Molecular Biology
Diana Caballero-Hernandez, Miguel G. Toscano, Marta Cejudo-Guillen, Maria L. Garcia-Martin, Soledad Lopez, Jaime M. Franco, Francisco J. Quintana, Cintia Roodveldt, David Pozo
TRENDS IN MOLECULAR MEDICINE
(2016)
Article
Medicine, Research & Experimental
Miguel G. Toscano, Jeroen van der Velden, Sybrand van der Werf, Machteld Odijk, Ana Roque, Rafael J. Camacho-Garcia, Irene G. Herrera-Gomez, Irene Mancini, Peter de Haan
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2017)
Article
Multidisciplinary Sciences
Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia Garcia Rodriguez, Irene de Gracia Herrera Gomez, Esther Fuente-Martin, Livia Lopez-Noriega, Jose Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquie, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P. Florido, Miguel G. Toscano, Peter de Haan, Kristina Schoonjans, Luis Sanchez Palazon, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martin-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermudez-Silva, Luc St-Onge, Benoit R. Gauthier
NATURE COMMUNICATIONS
(2018)
Article
Immunology
Miguel G. Toscano, Peter de Haan
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Cell & Tissue Engineering
Ana Belen Carrillo-Galvez, Marien Cobo, Sara Cuevas-Ocana, Alejandra Gutierrez-Guerrero, Almudena Sanchez-Gilabert, Pierpaolo Bongarzone, Angelica Garcia-Perez, Pilar Munoz, Karim Benabdellah, Miguel G. Toscano, Francisco Martin, Per Anderson
Article
Multidisciplinary Sciences
Karim Benabdellah, Pilar Munoz, Marien Cobo, Alejandra Gutierrez-Guerrero, Sabina Sanchez-Hernandez, Angelica Garcia-Perez, Per Anderson, Ana Belen Carrillo-Galvez, Miguel G. Toscano, Francisco Martin
SCIENTIFIC REPORTS
(2016)
Review
Biotechnology & Applied Microbiology
Peter De Haan, Ferdy R. Van Diemen, Miguel G. Toscano
Summary: Viruses are efficient gene delivery vectors for therapies, with replication competent and defective vectors inducing strong immune responses for cancer treatments and genetic disorder therapies. Different viral vectors have applications in various disease treatments and pathogenesis studies.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Noelia Arroyo, Laura Villamayor, Irene Diaz, Rita Carmona, Mireia Ramos-Rodriguez, Ramon Munoz-Chapuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martin, David A. Cano, Anabel Rojas
Summary: GATA4 plays a crucial role in the deactivation and activation of hepatic stellate cells, and therefore in liver fibrosis. Inducing deactivation of hepatic stellate cells, GATA4 may serve as a promising therapeutic target for liver fibrosis.
Meeting Abstract
Biotechnology & Applied Microbiology
A. Gutierrez-Guerreo, S. Sanchez-Hernandez, G. Galvani, J. Pinedo-Gomez, M. G. Toscano, M. Cobo, P. D. Gregory, M. C. Holmes, K. Benabdellah, F. Martin
HUMAN GENE THERAPY
(2016)
Meeting Abstract
Biotechnology & Applied Microbiology
A. Gutierrez-Guerrero, S. Sanchez-Hernandez, G. Galvani, M. G. Toscano, M. Cobo, P. D. Gregory, M. C. Holmes, K. Benabdellah, F. Martin
HUMAN GENE THERAPY
(2015)
Meeting Abstract
Hematology
Panlo Menendez, Miguel Toscano, Oscar Navarro-Montero, Veronica Ayllon, Veronica Ramos-Mejia, Clara Bueno, Marien Cobo, Francisco Martin, Pedro Real
EXPERIMENTAL HEMATOLOGY
(2014)
Meeting Abstract
Biotechnology & Applied Microbiology
P. Munoz Fernandez, M. Garcia Toscano, M. Cobo Pulido, A. Sanchez Gilabert, K. Benabdellah, A. Gutierrez Guerrero, P. Anderson, M. Holmes, P. D. Gregory, F. Martin Molina
HUMAN GENE THERAPY
(2013)