Review
Biochemistry & Molecular Biology
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Summary: Mitochondria play a crucial role in providing energy and participating in metabolism and signaling processes. However, mitochondrial dysfunction in critical illness can lead to organ failure and muscle wasting. This review aims to discuss the molecular mechanisms underlying mitochondrial dysfunction in intensive care unit-acquired weakness and critical illness myopathy, and its implications for muscle function and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Bernhard Wernly, Michael Beil, Raphael Romano Bruno, Stephan Binneboessel, Malte Kelm, Sviri Sigal, Peter Vernon van Heerden, Ariane Boumendil, Antonio Artigas, Maurizio Cecconi, Brian Marsh, Rui Moreno, Sandra Oeyen, Bernardo Bollen Pinto, Wojciech Szczeklik, Susannah Leaver, Sten Mikael Walther, Joerg C. Schefold, Michael Joannidis, Jesper Fjolner, Tilemachos Zafeiridis, Dylan de Lange, Bertrand Guidet, Hans Flaatten, Christian Jung
Summary: In Europe, there are two different healthcare organisation systems: tax-based healthcare system (THS) and social health insurance system (SHI). The characteristics, treatment, and mortality of critically ill older patients in the intensive care unit (ICU) differ between THS and SHI. Patients in SHI are older, sicker, and frailer, with higher ICU mortality but similar 30-day mortality compared to THS. The trend towards ICU excess mortality in SHI may result from a more liberal admission policy and increased treatment limitations.
Article
Health Care Sciences & Services
Pattharawin Pattharanitima, Charat Thongprayoon, Tananchai Petnak, Narat Srivali, Guido Gembillo, Wisit Kaewput, Supavit Chesdachai, Saraschandra Vallabhajosyula, Oisin A. O'Corragain, Michael A. Mao, Vesna D. Garovic, Fawad Qureshi, John J. Dillon, Wisit Cheungpasitporn
Summary: Consensus clustering analysis identified clinically distinct lactic acidosis subgroups with different outcomes by synthesizing patterns of clinical and laboratory data.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Critical Care Medicine
Ilse Vanhorebeek, An Jacobs, Liese Mebis, Karolijn Dulfer, Renate Eveleens, Hanna Van Cleemput, Pieter J. Wouters, Ines Verlinden, Koen Joosten, Sascha Verbruggen, Greet Van den Berghe
Summary: The PEPaNIC trial found that early use of parenteral nutrition (early-PN) in the PICU can result in long-term developmental impairments. This follow-up study showed that former critically ill children had worse physical performance compared to healthy children four years after PICU admission, but the timing of PN initiation did not significantly affect these outcomes. These findings provide further support for de-implementing the early use of PN in the PICU.
Article
Anesthesiology
F. Huq, E. Manners, D. O'Callaghan, L. Thakuria, C. Weaver, U. Waheed, R. Stumpfle, S. J. Brett, P. Patel, S. Soni
Summary: We investigated the transfers of critically ill patients with COVID-19 between three different hospital ICUs. Our findings indicate that patients may experience short-term physiological deterioration after transfer, but this resolves within 24 hours.
Review
Critical Care Medicine
Sira M. Baumann, Natalie J. Kruse, Paulina S. C. Kliem, Simon A. Amacher, Sabina Hunziker, Tolga D. Dittrich, Fabienne Renetseder, Pascale Grzonka, Raoul Sutter
Summary: This review examines the challenges and obstacles in implementing and translating patients' advance directives (ADs) in intensive care units (ICUs). The study reveals variations in the prevalence of ADs across different regions and significant effects of ADs on intensive care provision, do-not-resuscitate orders, and treatment costs. However, insufficient knowledge, lack of awareness, communication issues, and ethical/legal concerns hinder the implementation of ADs.
JOURNAL OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
Christian Waydhas, Reimer Riessen, Andreas Markewitz, Florian Hoffmann, Lorenz Frey, Bernd W. W. Boettiger, Sebastian Brenner, Thorsten Brenner, Teresa Deffner, Matthias M. M. Deininger, Uwe Janssens, Stefan Kluge, Gernot Marx, Stefan Schwab, Andreas W. W. Unterberg, Felix Walcher, Thomas van den Hooven
Summary: This article provides guidance and recommendations for the requirements of infrastructure, personnel, and organization of intensive care units (ICUs). The recommendations were developed based on a systematic literature search and a formal consensus process involving a group of multidisciplinary specialists. The document offers a detailed framework for organizing and planning the operation and construction/renovation of ICUs.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Christian Waydhas, Reimer Riessen, Andreas Markewitz, Florian Hoffmann, Lorenz Frey, Bernd W. Boettiger, Sebastian Brenner, Thorsten Brenner, Teresa Deffner, Matthias M. Deininger, Uwe Janssens, Stefan Kluge, Gernot Marx, Stefan Schwab, Andreas W. Unterberg, Felix Walcher, Thomas van den Hooven
Summary: This article provides guidance and recommendations for the requirements of infrastructure, personal, and organization of intensive care units (ICU). It covers the levels and severity of illness, qualitative and quantitative requirements of physicians and nurses, as well as staffing with other specialists. Furthermore, it proposes suggestions for ICU equipment and construction.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Pieter-Jan Herten, Erika Vlieghe, Emmanuel Bottieau, Eric Florence, Philippe G. Jorens
Summary: In the management of organ failure in the intensive care unit (ICU), it is important for physicians to be aware of and able to differentiate various tropical diseases. These diseases can present with similar organ failure symptoms, making clinical differentiation difficult. Physicians should consider specific symptoms, travel history, geographic distribution, and incubation period to aid in diagnosis.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Ru-Yu Lien, Chien-Ying Wang, Shih-Hsin Hung, Shu-Fen Lu, Wen-Ju Yang, Shu- Chin, Dung-Hung Chiang, Hui-Chen Lin, Chun-Gu Cheng, Chun-An Cheng
Summary: This study investigated the efficacy of a systemic targeted intervention protocol in preventing pressure injuries (PrIs) in the Chinese population. The results showed that targeted interventions significantly reduced the incidence of PrIs. This highlights the importance of implementing targeted interventions in intensive care units for improving healthcare quality and promoting patient health.
Review
Genetics & Heredity
Stephen F. Kingsmore, F. Sessions Cole
Summary: Genetic diseases are a leading cause of neonatal and infant mortality in the United States. Rapid genome sequencing has been developed to improve diagnosis and treatment of these diseases in neonatal intensive care units. It identifies pathogenic genomic variants, changes medical management, and predicts genetic risks.
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
(2022)
Article
Endocrinology & Metabolism
Jianying Guo, Yanyan Hong, Zhiyong Wang, Yukun Li
Summary: A low concentration of plasma triiodothyronine (T3) indicates euthyroid sick syndrome (ESS), which could be associated with a poor outcome in patients in intensive care units (ICUs). This study found that the incidence of ESS in the comprehensive ICU was 38.7%, with a cut-off value of FT3 for 28-day mortality being 2.88 pmol/L.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Critical Care Medicine
Marie Smedberg, Johan Helleberg, Ake Norberg, Inga Tjader, Olav Rooyackers, Jan Wernerman
Summary: A study on 269 patients found that hyperglutaminemia was associated with increased six-month mortality, indicating it is an independent mortality predictor. The study suggests further investigation into the mechanism of hyperglutaminemia and the prognostic value of repeated measurements for ICU patients.
Article
Critical Care Medicine
Alexander Avidan, Charles L. Sprung, Joerg C. Schefold, Bara Ricou, Christiane S. Hartog, Joseph L. Nates, Ulrich Jaschinski, Suzana M. Lobo, Gavin M. Joynt, Olivier Lesieur, Manfred Weiss, Massimo Antonelli, Hans-Henrik Bulow, Maria G. Bocci, Annette Robertsen, Matthew H. Anstey, Belen Estebanez-Montiel, Alexandre Lautrette, Anastasiia Gruber, Angel Estella, Sudakshina Mullick, Roshni Sreedharan, Andrej Michalsen, Charles Feldman, Kai Tisljar, Martin Posch, Steven Ovu, Barbara Tamowicz, Alexandre Demoule, Freda DeKeyser Ganz, Hans Pargger, Alberto Noto, Philipp Metnitz, Laszlo Zubek, Veronica de la Guardia, Christopher M. Danbury, Orsolya Szucs, Alessandro Protti, Mario Filipe, Steven Q. Simpson, Cameron Green, Alberto M. Giannini, Ivo W. Soliman, Claudio Piras, Eliana B. Caser, Manuel Hache-Marliere, Spyros Mentzelopoulos
Summary: This study revealed global disparities in end-of-life practices among ICU patients. Limitation of life-sustaining treatment is common worldwide with regional variability, and recognizing these differences may help improve end-of-life care globally.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Psychology, Applied
Yue Zhu, Tingting Chen, Jie Wang, Mo Wang, Russell E. Johnson, Yanghua Jin
Summary: This study discovered that during the COVID-19 pandemic, the occupational calling of ICU nurses may increase due to the daily code blue events, and individual differences in prosocial motivation can impact the level and variability of occupational calling, which in turn affects job performance.
JOURNAL OF APPLIED PSYCHOLOGY
(2021)
Review
Critical Care Medicine
Shannon M. Fernando, Alexandre Tran, Wei Cheng, Behnam Sadeghirad, Yaseen M. Arabi, Deborah J. Cook, Morten Hylander Moller, Sangeeta Mehta, Robert A. Fowler, Karen E. A. Burns, Philip S. Wells, Marc Carrier, Mark A. Crowther, Damon C. Scales, Shane W. English, Kwadwo Kyeremanteng, Salmaan Kanji, Michelle E. Kho, Bram Rochwerg
Summary: In critically ill adults, low-molecular-weight heparin (LMWH) reduces the incidence of deep vein thrombosis (DVT) compared to control treatment, and unfractionated heparin (UFH) may also reduce the risk of DVT. LMWH is likely more effective in reducing DVT compared to UFH. Mechanical compressive devices may decrease the risk of DVT, but the evidence is limited. The efficacy and safety of combination pharmacologic therapy and mechanical compressive devices are still unclear.
Article
Rehabilitation
Anastasia N. L. Newman, Michelle E. Kho, Jocelyn E. Harris, Alison Fox-Robichaud, Patricia Solomon
Summary: The study explored clinicians' experiences and perceptions of using in-bed cycling for rehabilitation in the intensive care unit. Results indicated that teamwork, confidence in the method, and appropriate patient selection are key factors for successful cycling, while barriers include inadequate staffing, bike size, and time for cycling.
DISABILITY AND REHABILITATION
(2022)
Review
Rehabilitation
Julia (Shi-Peng) Xiong, Sarah E. Reedman, Michelle E. Kho, Brian W. Timmons, Olaf Verschuren, Jan Willem Gorter
Summary: This study aimed to explore the operationalization and measurement of sedentary behavior in individuals with cerebral palsy. Results showed that sitting and lying are considered sedentary postures in individuals with CP, defined as <= 1.5 METs. There is variability in the tools used to measure SB in this population, highlighting the need for consensus on the definition and reporting of sedentary behavior.
DISABILITY AND REHABILITATION
(2022)
Article
Rehabilitation
Anastasia N. L. Newman, Michelle E. Kho, Jocelyn E. Harris, Alison Fox-Robichaud, Patricia Solomon
Summary: This article investigates the current physiotherapy practice for critically ill adult patients who require prolonged stays in critical care after complicated cardiac surgery in Ontario. The study found that physiotherapists provide a variety of interventions for these patients, but the use of outcome measures is limited.
PHYSIOTHERAPY CANADA
(2022)
Article
Medicine, Research & Experimental
Julie C. Reid, Alex Molloy, Geoff Strong, Laurel Kelly, Heather O'Grady, Deborah Cook, Patrick M. Archambault, Ian Ball, Sue Berney, Karen E. A. Burns, Frederick D'Aragon, Erick Duan, Shane W. English, Francois Lamontagne, Amy M. Pastva, Bram Rochwerg, Andrew J. E. Seely, Karim Serri, Jennifer L. Y. Tsang, Avelino C. Verceles, Brenda Reeve, Alison Fox-Robichaud, John Muscedere, Margaret Herridge, Lehana Thabane, Michelle E. Kho
Summary: The COVID-19 pandemic has disrupted non-COVID critical care trials. This study uses the CONSERVE statement to report the impact of the pandemic on the CYCLE trial and describes the mitigation approaches.
Article
Respiratory System
Ana Maria Ilicic, Dina Brooks, Michelle Kho, Roger Goldstein, Ana Oliveira
Summary: Pulmonary rehabilitation is an important intervention for controlling respiratory symptoms in people with chronic respiratory diseases. However, this study found that chronic cough is rarely assessed and managed in pulmonary rehabilitation. Education and standardized strategies were suggested as important factors for improving the assessment and management of chronic cough.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Editorial Material
Critical Care Medicine
Oleksa G. Rewa, Michelle Kho
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Michelle E. Kho, Sue Berney, Bronwen Connolly
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Carol L. Hodgson, Michelle E. Kho, Vinicius Maldaner da Silva
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Michelle E. Kho, Julie Reid, Alexander J. Molloy, Margaret S. Herridge, Andrew J. Seely, Jill C. Rudkowski, Lisa Buckingham, Diane Heels-Ansdell, Tim Karachi, Alison Fox-Robichaud, Ian M. Ball, Karen E. A. Burns, Joseph R. Pellizzari, Christopher Farley, Sue Berney, Amy M. Pastva, Bram Rochwerg, Frederick D'Aragon, Francois Lamontagne, Erick H. Duan, Jennifer L. Y. Tsang, Patrick Archambault, Shane W. English, John Muscedere, Karim Serri, Jean-Eric Tarride, Sangeeta Mehta, Avelino C. Verceles, Brenda Reeve, Heather O'Grady, Laurel Kelly, Geoff Strong, Abby H. Hurd, Lehana Thabane, Deborah J. Cook
Summary: This article describes the protocol for an international, multicentre randomised controlled trial (RCT) to determine the effectiveness of early in-bed cycling versus routine physiotherapy (PT) in critically ill, mechanically ventilated adults. The primary outcome is the Physical Function ICU Test-scored (PFIT-s) at 3 days post-ICU discharge.
Article
Critical Care Medicine
Michelle E. Kho, Bronwen Connolly
CRITICAL CARE CLINICS
(2023)
Article
Critical Care Medicine
Heather K. O'Grady, Lara Edbrooke, Christopher Farley, Sue Berney, Linda Denehy, Zudin Puthucheary, Michelle E. Kho
Summary: Among three progressive outcome measures evaluated in this study, the 30 s STS test appears to have the most favorable clinimetric properties to assess function at ICU and hospital discharge in moderate to severely ill participants.
Review
Rehabilitation
Ana Maria Ilicic, Ana Oliveira, Razanne Habash, Yejin Kang, Michelle Kho, Roger Goldstein, Dina Brooks
Summary: The evidence of non-pharmacological therapies for non-productive chronic cough is limited. Existing studies reflect the heterogeneity in study design, sample size, and outcome measures.
FRONTIERS IN REHABILITATION SCIENCES
(2022)
Article
Rehabilitation
Kenneth S. Noguchi, Linda Nguyen, Ava Mehdipour, Elise Wiley, Stephanie Saunders, Kevin Moncion, Julie C. Reid, Nora Bakaa, Laura Garcia Diaz, Jill Van Damme, Cassandra D'Amore, Anne Kumurenzi, Ze Lu, Erin Knobl, Marla K. Beauchamp, Luciana G. Macedo, Brenda Vrkljan, Sandra E. Moll, Lisa C. Carlesso, Lori J. Letts, Michelle E. Kho, Julie Richardson
Summary: Rehabilitation researchers faced challenges during the COVID-19 pandemic including protocol adjustments, participant accessibility, and knowledge dissemination. They suggested strategies such as implementing virtual approaches, engaging community stakeholders, and revisiting timeframes for knowledge dissemination.
FRONTIERS IN REHABILITATION SCIENCES
(2022)
Article
Respiratory System
Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Mike Irvine, Laura Merson, Ignacio Martin-Loeches, Jordi Rello, Fabio S. Taccone, Robert A. Fowler, Annemarie B. Docherty, Christiana Kartsonaki, Irene Aragao, Peter W. Barrett, Abigail Beane, Aidan Burrell, Matthew Pellan Cheng, Michael D. Christian, Jose Pedro Cidade, Barbara Wanjiru Citarella, Christl A. Donnelly, Susana M. Fernandes, Craig French, Rashan Haniffa, Ewen M. Harrison, Antonia Ying Wai Ho, Mark Joseph, Irfan Khan, Michelle E. Kho, Anders Benjamin Kildal, Demetrios Kutsogiannis, Francois Lamontagne, Todd C. Lee, Gianluigi Li Bassi, Jose Wagner Lopez Revilla, Catherine Marquis, Jonathan Millar, Raul Neto, Alistair Nichol, Rachael Parke, Rui Pereira, Sergio Poli, Pedro Povoa, Kollengode Ramanathan, Oleksa Rewa, Jordi Riera, Sally Shrapnel, Maria Joao Silva, Andrew Udy, Timothy Uyeki, Steve A. Webb, Evert-Jan Wils, Amanda Rojek, Piero L. Olliaro
Summary: This study investigated the clinical outcomes of severe COVID-19 patients treated outside the ICU, compared to those treated in the ICU. It found that patients admitted to an ICU had a longer hospital stay and a lower 28-day fatality ratio.