Article
Engineering, Biomedical
Kunal Sahasrabuddhe, Aamir A. Khan, Aditya P. Singh, Tyler M. Stern, Yeena Ng, Aleksandar Tadic, Peter Orel, Chris LaReau, Daniel Pouzzner, Kurtis Nishimura, Kevin M. Boergens, Sashank Shivakumar, Matthew S. Hopper, Bryan Kerr, Mina-Elraheb S. Hanna, Robert J. Edgington, Ingrid McNamara, Devin Fell, Peng Gao, Amir Babaie-Fishani, Sampsa Veijalainen, Alexander Klekachev, Alison M. Stuckey, Bert Luyssaert, Takashi D. Y. Kozai, Chong Xie, Vikash Gilja, Bart Dierickx, Yifan Kong, Malgorzata Straka, Harbaljit S. Sohal, Matthew R. Angle
Summary: The Argo system developed in this study allows for high-speed recording of neural activity in the cortex, with the highest channel count in vivo recording system currently available. Through bench testing and in vivo experiments, neural activities in the rat and sheep cortex were successfully recorded. This system has potential for clinical translation in the future.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Szu-Ying Li, Hsin-Yi Tseng, Bo-Wei Chen, Yu-Chun Lo, Huai-Hsuan Shao, Yen-Ting Wu, Ssu-Ju Li, Ching-Wen Chang, Ta-Chung Liu, Fu-Yu Hsieh, Yi Yang, Yan-Bo Lai, Po-Chun Chen, You-Yin Chen
Summary: Increasing requirements for neural implantation have led to advancements in semiconductor technologies, allowing for high-density electrode arrays to improve neural recordings. However, there are technological challenges, such as complex manufacturing processes and environmental concerns. A new eco-fabrication process for neural electrode arrays reduces carbon emissions and offers customization.
Article
Automation & Control Systems
Han Wang, Yang Li, Xiang Chen, Yuchao Jia, Guanxin Chi, Yukui Wang, Zhenlong Wang
Summary: An integrated method of micro-milling and micro electrical discharge machining is proposed for manufacturing micro-structures array, ensuring high accuracy and consistency. This method improves the machining performance of the array micro-structures and shows good prospects in micro-fabrication through in-situ machining, parameter study, and workpiece lifting control.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Koji Yamashita, Hirohito Sawahata, Shota Yamagiwa, Shohei Yokoyama, Rika Numano, Kowa Koida, Takeshi Kawano
Summary: This study presents an approach using a 5 μm-diameter needle electrode for stable and long-term recording by reducing tissue damage and implementing a floating electrode architecture.
Article
Biology
Nicolette Driscoll, Richard E. Rosch, Brendan B. Murphy, Arian Ashourvan, Ramya Vishnubhotla, Olivia O. Dickens, A. T. Charlie Johnson, Kathryn A. Davis, Brian Litt, Danielle S. Bassett, Hajime Takano, Flavia Vitale
Summary: The study presents a technique to map the onset and spatiotemporal spread of acute epileptic seizures in vivo by recording high bandwidth microelectrocorticography and calcium fluorescence simultaneously. By integrating dynamic data features from both modalities, sequential spatiotemporal patterns of seizure onset and evolution were identified, revealing the link between the temporal progression of ictal electrophysiology and the spatial evolution of the recruited seizure core. This integrated analysis of multimodal data enables future targeted therapeutic interventions and novel spatially embedded models of local circuit dynamics during seizure onset and evolution.
COMMUNICATIONS BIOLOGY
(2021)
Article
Instruments & Instrumentation
Daeban Seo, Youngsuk Ryu, Jinnil Choi, Jongkwang Lee
Summary: This paper describes a micro-load cell used for thrust measurement of a micro-resistojet. The load cell utilizes piezoresistive sensing method and is designed to have linear characteristics within the measurement range. The sensor shows high sensitivity and accuracy in measuring thrust-induced membrane deflection.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2021)
Article
Materials Science, Multidisciplinary
Ricardo G. Poeira, Ana Perez-Rodriguez, Aubin J. C. M. Prot, Marina Alves, Phillip J. Dale, Sascha Sadewasser
Summary: Micro-concentrator photovoltaics combine light concentration and low electrical losses to improve efficiency. A novel approach to produce arrays of Cu(In,Ga)Se2 micro absorber layers is demonstrated in this work, with a proof of principle of micro solar cells achieving an efficiency of 1.2% under 1 Sun. This presents a new material-efficient synthesis route for the fabrication of micro solar cells.
MATERIALS & DESIGN
(2023)
Article
Optics
Sun Xuhui, Wang Zhiwen, Tian Wentao, Liu Weicheng, Wei Juan, Zheng Hongyu
Summary: This paper proposes a method for preparing a multi-directional polarization filter using one-dimensional nano-grating polarizers. The effects of laser processing parameters on ablation morphology and optical transmittance are studied. Experimental results demonstrate the high measurement accuracy and flexibility and cost-effectiveness of the proposed filter.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Chiara Rinoldi, Yasamin Ziai, Seyed Shahrooz Zargarian, Pawel Nakielski, Krzysztof Zembrzycki, Mohammad Ali Haghighat Bayan, Anna Beata Zakrzewska, Roberto Fiorelli, Massimiliano Lanzi, Agnieszka Kostrzewska-Ksiezyk, Rafal Czajkowski, Ewa Kublik, Leszek Kaczmarek, Filippo Pierini
Summary: Neural interface design is important in neuroscience for analyzing brain processes and detecting neurological disorders. This study presents a novel soft neural biointerface made of polyacrylamide hydrogels loaded with plasmonic silver nanocubes. The hydrogels, surrounded by a silicon-based template, enable stable recordings from specific sites in the brain cortex, showing superior electroconductivity and mimicking the mechanical characteristics of brain tissue. In vitro and in vivo tests demonstrate the biocompatibility of the hydrogels and their suitability as a chronic neural biointerface.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Jae-Won Jang, Yoo Na Kang, Hee Won Seo, Boil Kim, Han Kyoung Choe, Sang Hyun Park, Maan-Gee Lee, Sohee Kim
Summary: This study investigated the electrical functionality of flexible penetrating microelectrode arrays (FPMAs) implanted in vivo for up to 3 months. The results demonstrated successful recording of neuronal signals by FPMAs for 12 weeks with consistently maintained signal-to-noise ratios.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Biochemical Research Methods
Anton Guimera-Brunet, Eduard Masvidal-Codina, Jose Cisneros-Fernajndez, Francesc Serra-Graells, Jose A. Garrido
Summary: Neuroelectronic interfaces play a crucial role in uncovering the working mechanisms of the brain, with multichannel neural probes and acquisition systems enabling recording of brain signals using thousands of channels.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yang Wang, Qifan Wang, Ruichen Zheng, Xinxiu Xu, Xinze Yang, Qiang Gui, Xiaowei Yang, Yijun Wang, He Cui, Weihua Pei
Summary: Flexible electrodes have shown better compatibility and functionality compared to rigid electrodes. Nonhuman primates, which have similar brain structures and functions to humans, are more suitable as animal models for potential clinical usage than rodents. However, there are limited studies regarding the application of flexible electrodes on nonhuman primates.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Hong Wang, Florian Fontein, Yandong Wang, Zhifang Wang, Harald Fuchs, Liqiang Li, Wenping Hu, Lifeng Chi, Wenchong Wang
Summary: This study presents an in situ observation of organic single crystal formation via solvent vapor annealing on both bare and Au patterned SiO2 surfaces, revealing that micro-sized organic islands absorb solvent to form droplets which then nucleate to form single crystals. The technique allows for positional control of single crystal array fabrication and improved light absorption and detectability in organic single crystal device arrays, such as photon-detectors, through area selective growth on Au electrodes.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Physics, Applied
Maximilian T. Becker, Poppy Oldroyd, Nives Strkalj, Moritz L. Mueller, George G. Malliaras, Judith L. MacManus-Driscoll
Summary: We demonstrate ferroelectric and bipolar impedance switching behavior in 18-nm-thick epitaxial BaTiO3 (BTO) films and explore its potential as a ferroelectric microelectrode in bioelectronics. Cyclic voltammetry measurements show characteristic ferroelectric switching peaks in the bipolar current-voltage loop. Small-signal electrochemical impedance spectroscopy measurements indicate bipolar impedance switching behavior with a maximum impedance ratio of 1.5 at 100 Hz frequency. This research represents a key step towards neural recordings with ferroelectric microelectrodes.
APPLIED PHYSICS LETTERS
(2023)
Review
Polymer Science
Jeong Eun Park, Sukyoung Won, Woongbi Cho, Jae Gwang Kim, Saebohm Jhang, Jae Gyeong Lee, Jeong Jae Wie
Summary: The text discusses various fabrication processes to mimic the performance of natural features in living creatures through periodic micro/nanoscale structures. It explores the shape-reconfiguration of stimuli-responsive micro/nanopillar arrays using capillary force, light, magnetic field, and heat. Applications of these pillar arrays in adhesives, omniphobicity, optics, and biomedical technologies are also examined.
JOURNAL OF POLYMER SCIENCE
(2021)