Article
Medical Laboratory Technology
Suwei Chen, Chenhan Zhang, Yongliang Zhong, Bing Tang, Qiang Xie, Rutao Guo, Zhiyu Qiao, Chengnan Li, Yipeng Ge, Junming Zhu
Summary: The study found a correlation between preoperative serum myoglobin concentrations and AKI after TAAD surgery, and high concentrations of serum myoglobin increased the risk of developing any-stage and severe AKI. This finding is significant for the prevention and treatment of AKI after TAAD surgery.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Chen Yang, Peng Hou, Dongxu Wang, Zhenguo Wang, Weixun Duan, Jincheng Liu, Shiqiang Yu, Feng Fu, Zhenxiao Jin
Summary: The correlation between serum myoglobin and acute kidney injury in patients who underwent total aortic arch replacement with frozen elephant trunk implantation was investigated. It was found that elevated serum myoglobin levels were associated with increased risk of severe acute kidney injury. Serum myoglobin could improve the risk classification of postoperative acute kidney injury.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jinhua Zhang, Sikang Gao
Summary: This study aimed to investigate the clinical characteristics and risk factors in aortic dissection (AD) patients with 2 Stanford subtypes. The analysis of 908 patients revealed significant differences in age, alcohol consumption, and certain blood test indicators between the two groups. Furthermore, hemoglobin, leukocytes, and neutrophils showed diagnostic value in distinguishing between the two types of patients.
Article
Cardiac & Cardiovascular Systems
Dashuai Wang, Sheng Le, Jingjing Luo, Xing Chen, Rui Li, Jia Wu, Yu Song, Fei Xie, Ximei Li, Hongfei Wang, Xiaofan Huang, Ping Ye, Xinling Du, Anchen Zhang
Summary: This study investigated the incidence, risk factors, and outcomes of postoperative headache (POH) after Stanford type A acute aortic dissection surgery (AADS) and developed two prediction models. By identifying independent predictors, nomograms predicting POH were constructed, providing clinical utility in risk evaluation, early prevention, and doctor-patient communication.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yufei Chen, Xu Xu, Zhaoran Chen, Bi Huang, Xiaojian Wang, Xiaohan Fan
Summary: This study investigated the DNA methylation patterns in acute aortic dissection (AAD) and found that DNA methylation may play a role in the progression of AAD through the regulation of gene expression.
BMC CARDIOVASCULAR DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Alyssa Elmore, Ali Almuntashiri, Xiaoyun Wang, Sultan Almuntashiri, Duo Zhang
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases. Surfactant protein-D (SP-D) has been extensively studied and found to have superior discriminatory ability for the diagnosis of ARDS. Recombinant SP-D shows potential as a drug for the treatment of ALI.
Article
Cardiac & Cardiovascular Systems
Arsalan Amin, Ravi K. Ghanta, Qianzi Zhang, Rodrigo Zea-Vera, Todd K. Rosengart, Ourania Preventza, Scott A. LeMaire, Joseph S. Coselli, Subhasis Chatterjee
Summary: This study investigated the readmission rates after surgical repair of acute Stanford type A aortic dissection (TAAD) and identified acute kidney injury and a higher Elixhauser comorbidity index as independent risk factors for readmission. Approximately 30% of patients were readmitted within 90 days, with the majority of readmissions occurring between days 31 and 90 after surgery. Targeted improvements in perioperative care and postdischarge follow-up, as well as efforts to reduce comorbidities, could help mitigate readmission rates.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Thierry Carrel, Thoralf M. Sundt, Yskert von Kodolitsch, Martin Czerny
Summary: Despite advancements in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event with high mortality and morbidity rates. Recent research has improved our understanding of the disease's pathophysiology and led to reevaluations of existing classifications. There is a shift towards a unified naming system based on morphology and function. The location and extent of the initial tear, as well as the affected aortic segments, determine the appropriate management approach - emergency surgery, endovascular intervention, or medical treatment. Ongoing scientific evidence continues to shape the management and follow-up of acute aortic dissection, the most severe form of acute aortic syndrome.
Article
Cardiac & Cardiovascular Systems
Kevin M. Harris, Christoph A. Nienaber, Mark D. Peterson, Elise M. Woznicki, Alan C. Braverman, Santi Trimarchi, Truls Myrmel, Reed Pyeritz, Stuart Hutchison, Craig Strauss, Marek P. Ehrlich, Thomas G. Gleason, Amit Korach, Daniel G. Montgomery, Eric M. Isselbacher, Kim A. Eagle
Summary: This study examined the early mortality rates for patients with TAAAD in the contemporary era and found that the mortality rate for the medical group was 0.5% per hour (23.7% at 48 hours), while for the surgical group, 48-hour mortality decreased to 4.4%.
Article
Immunology
Yubin Chen, Kaiyi Dong, Cheng Fang, Hui Shi, Wenjie Luo, Can-e Tang, Fanyan Luo
Summary: The study aimed to explore the relationship between blood count-derived inflammatory markers (BCDIMs) and postoperative acute kidney injury (pAKI), and construct a predictive model for pAKI. Results showed that monocyte-lymphocyte ratio (MLR) was an independent risk factor for pAKI. The predictive model based on BCDIMs had good discriminating ability, predictive ability, and clinical utility, and performed significantly better than the model based on white cell counts (WCCs). High MLR was significantly associated with poor short-term survival of patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Peng-fei Huang, Yun-jing Zhang, Xian-zhe Lou, Dong Ma, Yun-yan Wu, Yong-bo Zhao
Summary: Acute Stanford type A aortic dissection (ATAAD) is a life-threatening condition that requires urgent treatment. This study evaluated the prognostic value of CO2 combining power (CO2CP) combined with serum sodium levels in ATAAD patients. The combination of CO2CP and serum sodium showed a higher predictive value for death and adverse events in ATAAD patients compared to each single indicator. Patients with low CO2CP and high serum sodium had the worst prognosis. The combination of CO2CP and serum sodium can enhance the predictive value of prognosis in ATAAD patients.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren Huckaby, Ibrahim Sultan, Santi Trimarchi, Bradley Leshnower, Edward P. Chen, Derek R. Brinster, Truls Myrmel, Anthony L. Estrera, Daniel G. Montgomery, Amit Korach, Hans -Henning Eckstein, Joseph S. Coselli, Takeyoshi Ota, Clayton A. Kaiser, Kim A. Eagle, Himanshu J. Patel, Thomas G. Gleason
Summary: In-hospital mortality remains higher among women with TAAD but shows improvement in the last decade. Significant differences in presentation were noted in women, including older age and greater evidence of malperfusion. Although no distinctions in 5-year mortality or reintervention were observed, a tailored surgical approach should be considered to reduce sex disparities in early mortality rates for TAAD.
ANNALS OF THORACIC SURGERY
(2022)
Article
Anesthesiology
Xi-Sheng Shan, Hui-Rong Dai, Dan Zhao, Bi-Wen Yang, Xiao-Mei Feng, Hong Liu, Ke Peng, Fu-Hai Ji
Summary: Dexmedetomidine significantly reduced the incidence of AKI in TBAD patients undergoing EVAR procedures, indicating potential long-term benefits that warrant further investigation.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Health Care Sciences & Services
Jianjun Gu, Ziying Chen
Summary: Hybrid surgery for Stanford type A aortic dissection shows promising clinical efficacy in reducing surgical risks and postoperative complications, with successful outcomes in all cases studied. However, long-term effects remain unclear, requiring further research.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Medicine, General & Internal
Hironobu Nishiori, Hisanori Fujita, Seiichi Yamaguchi
Summary: Cardiopulmonary bypass for trauma patients carries the risk of bleeding from injured organs, while traumatic aortic dissection can progress rapidly. It is sometimes difficult to determine the optimal time for aortic repair in trauma patients. An 85-year-old woman was diagnosed with traumatic ascending aortic dissection, right clavicle and left first rib fracture, and abdominal contusions after a vehicle accident. After admission, the aortic dissection progressed, and emergent surgery was performed. Although the risk of hemorrhagic complications needs to be evaluated, prompt aortic repair is required.
CLINICAL CASE REPORTS
(2023)