Article
Public, Environmental & Occupational Health
Yeqing Gu, Jinhan Wang, Yan Wang, Chang Xu, Yang Liu, Liqing Du, Qin Wang, Kaihua Ji, Ningning He, Manman Zhang, Huijuan Song, Kaijun Niu, Qiang Liu
Summary: This study aimed to estimate the quantified relationships between low-dose radiation exposures and site-specific solid cancers among Chinese medical X-ray workers. The results showed a positive relationship between cumulative organ-specific dose and liver, esophagus, thyroid, and non-melanoma skin cancers, as well as a significant risk increase for liver, stomach, breast cancer (female), thyroid, and non-melanoma skin cancers.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Oncology
Elisheva R. Eisenberg, Anna Weiss, Ipshita Prakash, Sonia Skamene, Mark Basik, Jean Francois Boileau, Lissa Ajjamada, Michael N. Pollak, Stephanie M. Wong
Summary: Women with a history of chest irradiation for Hodgkin lymphoma are at increased risk of developing contralateral breast cancer. Mastectomy is the main surgical management approach, and the incidence of contralateral breast cancer increases over time.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Tianwang Guan, Zicong Qiu, Miao Su, Jinming Yang, Yongshi Tang, Yanting Jiang, Dunchen Yao, Yanxian Lai, Yanfang Li, Cheng Liu
Summary: The study found that PCNSL patients undergoing chemotherapy have a lower risk of CVD compared to those not receiving chemotherapy, as well as NCNSL patients receiving chemotherapy. The risk of CVD was reduced in PCNSL patients over 60 years old and those diagnosed between 2010 and 2015 receiving chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Sara Della Monaca, Valentina Dini, Sveva Grande, Alessandra Palma, Alan H. Tkaczyk, Rein Koch, Rein Murakas, Tanja Perko, Tatiana Duranova, Sisko Salomaa, Paivi Roivainen, Christine Willrodt, Mauro Grigioni, Simon Bouffler
Summary: The survey revealed that respondents had a high level of scientific and technical knowledge in radiation protection and generally trusted actors in the field. While most respondents were satisfied with available information on radiation risk, there is room for improvement, especially in communication and professional training gaps identified by the survey. Despite limitations in representativeness, the survey successfully provided insights into areas for improvement and building wider trust in radiation protection.
JOURNAL OF RADIOLOGICAL PROTECTION
(2021)
Article
Environmental Sciences
Kayo Togawa, Maria E. Leon, Pierre Lebailly, Laura E. Beane Freeman, Karl-Christian Nordby, Isabelle Baldi, Ewan MacFarlane, Aesun Shin, Sue Park, Robert T. Greenlee, Torben Sigsgaard, Ioannis Basinas, Jonathan N. Hofmann, Kristina Kjaerheim, Jeroen Douwes, Rachel Denholm, Gilles Ferro, Malcolm R. Sim, Hans Kromhout, Joachim Schuz
Summary: This study evaluated cancer incidence in male and female agricultural workers in an international consortium, AGRICOH, compared to their respective general populations. The results showed that agricultural workers have a lower risk of various cancers, but an elevated risk of prostate cancer, multiple myeloma (female), and melanoma of skin (female). There were significant variations in cancer risks between different cohorts.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Oncology
Olivier Laurent, Eric Samson, Sylvaine Caer-Lorho, Lucie Fournier, Dominique Laurier, Klervi Leuraud
Summary: Cohort studies of nuclear workers are crucial for studying the health effects of long-term exposures to low doses of ionizing radiation. This study found a significant association between exposure to radiation and increased risk of death from leukaemia and dementia. The association with dementia should be further investigated. Continued follow-up and pooled analyses with similar cohorts will improve the precision of risk estimates.
Review
Environmental Sciences
Mark P. Little, Richard Wakeford, Simon D. Bouffler, Kossi Abalo, Michael Hauptmann, Nobuyuki Hamada, Gerald M. Kendall
Summary: Studies show that there is a significant increase in the risk of cancer and benign neoplasms in infants and children who receive low or moderate levels of radiation. The risks are particularly higher in those exposed to radiation in utero or as children, with brain/CNS tumors, thyroid cancer, and leukemia showing particularly large excess relative risks.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Tamara V. Azizova, Evgeniya S. Grigoryeva, Nobuyuki Hamada
Summary: Research shows that there is a correlation between radiation dose rate and the risk of mortality from ischemic heart disease among occupationally chronically exposed workers. The risk increases with higher dose rates, and also with longer duration of exposure at high rates. These findings contribute to the scientific basis for recommendations on the radiation protection system.
SCIENTIFIC REPORTS
(2023)
Article
Hematology
Simone de Vries, Inge M. Krul, Michael Schaapveld, Cecile P. M. Janus, Saskia E. Rademakers, Judith M. Roesink, Marten R. Nijziel, Berthe M. P. Aleman, Flora E. van Leeuwen
Summary: Male survivors of Hodgkin lymphoma who received chest radiotherapy have a significantly increased risk of breast cancer. The risk is higher for those who received chest radiotherapy and alkylating chemotherapy compared to those who only received chest radiotherapy.
Article
Public, Environmental & Occupational Health
Ahti Anttila, Sanni Uuksulainen, Matti Rantanen, Markku Sallmen
Summary: This study aimed to assess the association between blood lead level in occupational exposure and the risk of lung cancer. The results showed that there was a positive trend between elevated blood lead levels and lung cancer risk, even at relatively low levels. The increased risk for lead exposure was not explained by other occupational carcinogens.
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
(2022)
Article
Environmental Sciences
Felix M. Onyije, Ann Olsson, Friederike Erdmann, Corrado Magnani, Eleni Petridou, Jacqueline Clavel, Lucia Miligi, Audrey Bonaventure, Daniela Ferrante, Sara Piro, Susan Peters, Roel Vermeulen, Hans Kromhout, Joachim Schuz
Summary: This study investigated the association between parental occupational exposures and the risk of childhood leukemia. The findings suggest a possible link between high paternal occupational exposure to crystalline silica and childhood leukemia. However, there were no significant associations observed for other occupational carcinogens. More research is needed to confirm these findings and explore the mechanistic pathways.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Tobias Zimmermann, Jeanne du Fay de Lavallaz, Thomas Nestelberger, Danielle M. Gualandro, Pedro Lopez-Ayala, Patrick Badertscher, Velina Widmer, Samyut Shrestha, Ivo Strebel, Noemi Glarner, Matthias Diebold, Oscar Miro, Michael Christ, Louise Cullen, Martin Than, F. Javier Martin-Sanchez, Salvatore Di Somma, W. Frank Peacock, Dagmar Keller, Murat Bilici, Juan Pablo Costabel, Michael Kuhne, Tobias Breidthardt, Venkatesh Thiruganasambandamoorthy, Christian Mueller
Summary: This international study validates the performance of the Canadian Syncope Risk Score (CSRS) in identifying low-risk syncope patients outside of Canada, showing superior performance compared to the Osservatorio Epidemiologico della Sincope nel Lazio (OESIL) score. However, clinician classification of syncope at emergency department discharge appears to have a significant impact on the performance of the CSRS, making the clinical utility of the CSRS uncertain.
ANNALS OF INTERNAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Maria Rita Fabbrizi, Jason L. Parsons
Summary: This article provides an up-to-date review on the radiobiological effects of RT in HNSCC cell models, focusing on specific cell death mechanisms, and details some of the current therapeutic strategies to enhance the radiosensitivity of HNSCC cells.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Biology
Tamara Azizova, Maria B. Moseeva, Evgeniya S. Grigoryeva, Nobuyuki Hamada
Summary: This study reports the incidence risks for cerebrovascular diseases and strokes in a cohort of Russian nuclear workers chronically exposed to ionizing radiation. The findings suggest a significant association between cumulative radiation dose and CeVD incidence, but no significant association with stroke or its types.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2022)
Article
Oncology
Tamara V. Azizova, Evgeny V. Bragin, Maria V. Bannikova, Nobuyuki Hamada, Evgeniya S. Grigoryeva
Summary: This study reports an increased risk of normal-tension glaucoma (NTG) in radiation workers exposed to chronic doses greater than 1Gy. If confirmed in other cohorts, this finding has significant implications for normal tissue complications in radiotherapy patients and ocular radiation protection in radiation workers.
Review
Oncology
Maelle Canet, Richard Harbron, Isabelle Thierry-Chef, Elisabeth Cardis
Summary: Moderate to high doses of ionizing radiation increase the risk of cancer, especially in childhood. There are concerns about the effects of lower doses of radiation and cancer-predisposing factors on radiation-induced cancer risk. A systematic review found limited evidence that cancer-predisposing factors may modify the risk of radiation-induced cancer, but further research is needed to clarify the impact.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Marijke De Saint-Hubert, Finja Suesselbeck, Fabiano Vasi, Florian Stuckmann, Miguel Rodriguez, Jeremie Dabin, Beate Timmermann, Isabelle Thierry-Chef, Uwe Schneider, Lorenzo Brualla
Summary: This study evaluated the accuracy of two computational methods for calculating out-of-the-field dose by comparing them with experimental data obtained from anthropomorphic phantom irradiations. The results showed that VMAT irradiation produces the smallest out-of-the-field dose compared to IMRT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Lydia B. Zablotska, Ljubica Zupunski, Klervi Leuraud, Julie Lopes, Joshua Hinkle, Tyler Pugeda, Thomas Delgado, John Olschowka, Jacqueline Williams, M. Kerry O'Banion, John D. Boice, Sarah S. Cohen, Michael T. Mumma, Lawrence T. Dauer, Richard A. Britten, Samuel Stephenson, Klervi Leuraud, Julie Lopes, Joshua Hinkle, Tyler Pugeda, Thomas Delgado, John Olschowka, Jacqueline Williams, M. Kerry O'Banion, John D. Boice, Sarah S. Cohen, Michael T. Mumma, Lawrence T. Dauer, Richard. A. Britten, Samuel Stephenson
Summary: This article summarizes a virtual symposium on the radiation risks of the central nervous system. It discusses the potential neurological complications and psychological consequences of repeated low-dose radiation exposure, emphasizing the need for further research in this area. The symposium highlights new directions for studying mental health disorders, neurodegenerative conditions, and cognitive impairment related to radiation exposure, including occupational exposures and exposures to galactic cosmic rays.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Oncology
Michael Hauptmann, Graham Byrnes, Elisabeth Cardis, Marie-Odile Bernier, Maria Blettner, Jeremie Dabin, Hilde Engels, Tore S. Istad, Christoffer Johansen, Magnus Kaijser, Kristina Kjaerheim, Neige Journy, Johanna M. Meulepas, Monika Moissonnier, Cecile Ronckers, Isabelle Thierry-Chef, Lucian Le Cornet, Andreas Jahnen, Roman Pokora, Magda Bosch de Basea, Jordi Figuerola, Carlo Maccia, Arvid Nordenskjold, Richard W. Harbron, Choonsik Lee, Steven L. Simon, Amy Berrington de Gonzalez, Joachim Schuz, Ausrele Kesminiene
Summary: The European EPI-CT study aims to assess the risk of brain cancer from CT examinations in children and young adults. Using data from nine European countries, the study found a significant dose-response relationship between CT-related radiation exposure and brain cancer.
Editorial Material
Public, Environmental & Occupational Health
Mary K. Schubauer-Berigan, David B. Richardson, Matthew P. Fox, Lin Fritschi, Irina Guseva Canu, Neil Pearce, Leslie Stayner, Amy Berrington de Gonzalez
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Oncology
Olivier Laurent, Eric Samson, Sylvaine Caer-Lorho, Lucie Fournier, Dominique Laurier, Klervi Leuraud
Summary: Cohort studies of nuclear workers are crucial for studying the health effects of long-term exposures to low doses of ionizing radiation. This study found a significant association between exposure to radiation and increased risk of death from leukaemia and dementia. The association with dementia should be further investigated. Continued follow-up and pooled analyses with similar cohorts will improve the precision of risk estimates.
Editorial Material
Environmental Sciences
Dominique Laurier, Yann Billarand, Dmitry Klokov, Klervi Leuraud
Summary: The use of the LNT model in radiation protection is still debated, but recent research in radiobiology and epidemiology has reinforced our scientific understanding of cancer risks at low doses. In radiobiology, early carcinogenic events show linear responses to doses as low as 10 mGy, while epidemiological studies indicate excess cancer risks at dose levels of 100 mGy or less. Overall, the LNT model does not substantially overestimate risks at low doses, and current scientific knowledge does not contradict its use in the radiological protection system.
JOURNAL OF RADIOLOGICAL PROTECTION
(2023)
Article
Public, Environmental & Occupational Health
Ankura Singh, Rachel Zeig-Owens, Madeline Cannon, Mayris P. Webber, David G. Goldfarb, Robert D. Daniels, David J. Prezant, Paolo Boffetta, Charles B. Hall
Summary: This study compared mortality rates between World Trade Center (WTC)-exposed FDNY firefighters and similarly healthy, non-WTC-exposed/non-FDNY firefighters, and compared mortality in each cohort with the general population. The results showed that both cohorts of firefighters had lower all-cause mortality compared to the general population, and WTC-exposed firefighters had lower mortality rates compared to non-WTC-exposed firefighters.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Kaitlin Kelly-Reif, Stephen J. Bertke, Estelle Rage, Paul A. Demers, Nora Fenske, Veronika Deffner, Michaela Kreuzer, Jonathan Samet, Mary K. Schubauer-Berigan, Ladislav Tomasek, Lydia B. Zablotska, Charles Wiggins, Dominique Laurier, David B. Richardson
Summary: This study is the largest and most up-to-date pooled study of uranium miners, involving 7 cohorts of male uranium miners with 7754 lung cancer deaths and 4.3 million person-years of follow-up. The study found a linear exposure-response relationship between cumulative radon exposure and lung cancer mortality, which is modified by temporal and exposure factors.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Julie Lopes, Clemence Baudin, Juliette Feuardent, Herve Roy, Sylvaine Caer-Lorho, Klervi Leuraud, Marie-Odile Bernier
Summary: Medical personnel in France are occupationally exposed to ionizing radiation, but no study has been conducted to investigate the health risks associated with this exposure. The ORICAMs cohort is a nationwide French longitudinal study that aims to assess the risk of radiation-associated cancer and non-cancer mortality in medical workers. The cohort includes workers monitored for ionizing radiation exposure from 2002 to 2012. Initial analysis shows that the mortality rate among these workers is significantly lower than the national reference rates, but further research is needed to establish a potential relationship between occupational exposure and mortality risk.
Review
Public, Environmental & Occupational Health
Nathan L. DeBono, Robert D. Daniels, Laura E. Beane Freeman, Judith M. Graber, Johnni Hansen, Lauren R. Teras, Tim Driscoll, Kristina Kjaerheim, Paul A. Demers, Deborah C. Glass, David Kriebel, Tracy L. Kirkham, Roland Wedekind, Adalberto M. Filho, Leslie Stayner, Mary K. Schubauer-Berigan
Summary: This study is a meta-analysis of the association between occupational exposure as a firefighter and cancer. The results show that there is epidemiological evidence supporting a causal relationship between being a firefighter and certain cancers, but challenges remain in exposure assessment, confounding, and medical surveillance bias.
SAFETY AND HEALTH AT WORK
(2023)
Article
Medicine, General & Internal
David B. Richardson, Klervi Leuraud, Dominique Laurier, Michael Gillies, Richard Haylock, Kaitlin Kelly-Reif, Stephen Bertke, Robert D. Daniels, Isabelle Thierry-Chef, Monika Moissonnier, Ausrele Kesminiene, Mary K. Schubauer-Berigan
Summary: This multinational study evaluated the association between protracted low dose exposure to ionising radiation and the risk of cancer. The results showed that for every 1 Gy increase in cumulative dose, the mortality rate of solid cancer increased by 52%, with the association potentially being more significant in the low dose range. These findings are of vital importance in strengthening radiation protection.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Nuclear Science & Technology
Isabelle Thierry-Chef, Beate Timmermann, Neige Journy, Marie-Odile Bernier, Richard McNally, Jeremie Dabin, Lorenzo Brualla, Siamak Haghdoost, Adelaida Sarukhan, Karin Haustermans, Inge De Wit, Sofie Isebaert, Yasmin Lassen-Ramshad, Louise Tram Henriksen, Morten Hoyer, Laura Toussaint, Guillaume Boissonnat, Juliette Thariat, Charlotte Demoor-Goldschmidt, Nadia Haddy, Stephanie Bolle, Brice Fresneau, Amel Belhout, Steffen Dreger, Hajo Zeeb, Maria Grazia Andreassi, Jonica Campolo, Eugenio Picano, Andreas Jahnen, Cecile Ronckers, John H. Maduro, Kristina Kjaerheim, Gaute Dohlen, Trude Eid Robsahm, Hilde M. Olerud, Utheya Salini Thevathas, Susmita Afroz, Bjorn Helge Osteras, Uwe Schneider, Linda Walsh, Agnes Dumas, Angela Jackson, Estelle Rage, Marijke De Saint-Hubert, Richard Hardy, Christian Baeumer, Theresa Steinmeier, Suzan Botzenhardt, Martina Wette, Rodney Ortiz, Vadim Chumak
Summary: The use of ionising radiation in medical procedures has greatly benefited paediatric patients, but the long-term health effects need to be evaluated. The HARMONIC project aims to understand the increased risk of cancer and non-cancer effects after exposure to radiation in children with cancer and cardiac defects. It investigates potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life, and risks of second primary cancers. The project also develops software tools for dose reconstruction and builds a biobank to identify biomarkers of radiation-induced adverse health effects.
EPJ NUCLEAR SCIENCES & TECHNOLOGIES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clemence Baudin, Blandine Vacquier, Guillemette Thin, Lamine Chenene, Joel Guersen, Isabelle Partarrieu, Martine Louet, Hubert Ducou Le Pointe, Stephanie Mora, Catherine Verdun-Esquer, Juliette Feuardent, Frederic Rousseau, Herve Roy, Lynda Bensefa-Colas, Louis Boyer, Marie-Odile Bernier
Summary: Health workers in France exposed to ionizing radiation account for more than 50% of all workers exposed to man-made radiation. This study aimed to evaluate and characterize the trends in radiation exposure among health workers in France between 2009 and 2019. The study found that the average exposure of health workers decreased over the past decade, but there were discrepancies in trends according to professions, departments, hospitals, and gender.
EUROPEAN RADIOLOGY
(2023)