Review
Dentistry, Oral Surgery & Medicine
Anita Aminoshariae, James C. Kulild
Summary: The study identified five different mechanisms of dentinal sensitivity and suggested that these mechanisms may interact. Pulpal responses to tissue injury may alter the relative contribution of these mechanisms, for example, pulpal inflammation may lead to neuronal sprouting and peripheral sensitization.
JOURNAL OF ENDODONTICS
(2021)
Article
Chemistry, Multidisciplinary
Zhuo Chen, Yuyan Duan, Songzhe Shan, Kaida Sun, Gang Wang, Changyu Shao, Zhenhang Tang, Zekai Xu, Yanyan Zhou, Zhi Chen, Ruikang Tang, Haihua Pan, Zhijian Xie
Summary: Combining biomimetic mineralization and mineral overgrowth effectively occludes dentinal tubules, forming a compact and deep mineral layer with mechanical and acid resistance, demonstrating the potential for treating dentin hypersensitivity with inexpensive, long-term, and efficient therapy.
Article
Polymer Science
Saad Mohammed AlQahtani, Raghavendra Reddy Nagate, Manae Musa Musleh Al-Ahmari, Mohammad Al. Magbol, Shankar T. T. Gokhale, Shreyas Tikare, Saurabh Chaturvedi
Summary: This study aimed to compare and evaluate the effects of a 10% propolis hydrogel, 2% sodium fluoride, and 1.23% acidulated phosphate fluoride in conjunction with iontophoresis for the treatment of cervical dentin hypersensitivity. The results showed that all three desensitizers were effective when used with iontophoresis, with 2% sodium fluoride demonstrating the most significant reduction in dentin hypersensitivity compared to 1.23% acidulated phosphate fluoride and 10% propolis hydrogel.
Article
Multidisciplinary Sciences
Matthias Menzel, Andreas Kiesow, Juliana Martins de Souza E. Silva
Summary: Dentin hypersensitivity is a common oral health concern, and occlusion of exposed dentinal tubules is a treatment option. Current microscopic techniques have limitations in evaluating the occluding effects of desensitizing agents. This study used high-resolution X-ray computed tomography (nano-CT) to investigate human dentin treated with silver diammine fluoride (SDF). Nano-CT provided comparable resolution to scanning electron microscopy (SEM) and produced three-dimensional images of the occluded tubules.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shenglong Tan, Shangsi Chen, Qian Lei, Dandan Ma
Summary: In this study, a novel rapidly mineralized biphasic calcium phosphate (RMBCP) was successfully synthesized, which could quickly induce mineralization to form hydroxyapatite (HA) and exhibit excellent acid-resistant stability. This material effectively blocked exposed dental tubules and protected them from acid attack.
Article
Chemistry, Physical
Nuo Chen, Jingjing Deng, Shengjie Jiang, Xiang-Yu Kong, Teng Zhou, Kai Zhao, Zuohui Xiao, Huimin Zheng, Weipeng Chen, Congcong Zhu, Xinyu Liu, Liping Wen, Yan Wei, Xuliang Deng, Lei Jiang
Summary: This study demonstrates that stimuli-induced directional cation transport, rather than fluid-flow, through dentinal tubules actually leads to dentine hypersensitivity. The research provides evidence that external stimuli (pressure, pH, and temperature) can induce ion currents through negatively charged dentinal tubules, triggering nerve impulses and causing dentine hypersensitivity. Blocking these tubules with cationic hydrogels can significantly reduce nerve action potentials, while anionic hydrogels enhance them, supporting the role of cation-flow in dentine hypersensitivity.
Article
Biotechnology & Applied Microbiology
Yanhong Yan, Yun Guan, Linjuan Luo, Bingqiang Lu, Feng Chen, Beizhan Jiang
Summary: This study evaluated the effects of IgY-loaded amorphous calcium phosphate (IgY@ACP) on dentinal tubule occlusion and antibacterial activity. The results showed that IgY@ACP effectively occluded dentinal tubules with acid-resistant stability and had prominent anti-Streptococcus mutans effects. It also demonstrated good biocompatibility, acid and abrasion resistance. The study suggests that IgY@ACP has the potential to be a suitable desensitization material in dental clinics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Xiu Peng, Sili Han, Kun Wang, Longjiang Ding, Zhenqi Liu, Linglin Zhang
Summary: The study demonstrates that TVH-19 is effective in promoting dentin sealing by binding to periodontal dentin, promoting mineral deposition, and reducing the space between dentin tubules.
Article
Chemistry, Multidisciplinary
Eleonora Fambrini, Marco Miceli, Marco Pasini, Maria Rita Giuca
Summary: Dentin hypersensitivity is a common global dental problem that affects the oral health-related quality of life of a large population. A longitudinal study was conducted to measure dentinal hypersensitivity in adult patients after using domiciliary desensitizing devices. The study found that both desensitizing agents were effective in reducing DH for different stimuli.
APPLIED SCIENCES-BASEL
(2022)
Article
Nanoscience & Nanotechnology
Bolin Li, Chunyan Liu, Ze-hui Fang, Ying Cao, Zheng Zhou, Haiyan Lu
Summary: The mineralizing complex paste can effectively occlude dentinal tubules in-depth, induce the growth of inorganic crystals on the dentin surface, and provide a bleaching effect. The paste has a fine texture, is injectable, and contains 2.6% H2O2 concentration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Emilia Bologa, Simona Stoleriu, Irina Nica, Ionut Taraboanta, Andrei Georgescu, Ruxandra Ilinca Matei, Sorin Andrian
Summary: This study evaluated the efficacy of three toothpastes on dentinal tubule occlusion, mineral acquisition, and dentin hardness. The results showed that all three toothpastes effectively occluded dentinal tubules, but only Dontodent Sensitive and Sensodyne Repair and Protect toothpastes increased the calcium and phosphorus content on the dentin surface, without increasing dentin hardness through mineral acquisition.
Article
Engineering, Biomedical
Zihuai Zhou, Jiachen Li, Zhe Wang, Hongli Zhang, Yiru Wang, Dongni Shen, Zhifang Wu, Minjuan Shen, Haihua Pan, Qi Wang, Ruikang Tang, Matthias Hannig, Baiping Fu
Summary: In this study, a polyelectrolyte-calcium complex pre-precursor (PCCP) process was proposed for managing dentin hypersensitivity (DH). The PCCP process achieved heavy remineralization of demineralized dentin and compact occlusion of dentinal tubules (DTs) over 200 μm depth. This process relies on the pH-dependent electrostatic attraction between polyelectrolyte-calcium complexes and the inwalls of DTs under alkaline conditions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Dentistry, Oral Surgery & Medicine
S. Behzadi, Y. Mohammadi, L. Rezaei-Soufi, A. Farmany
Summary: This study evaluated the occlusion effects of bioactive glass and hydroxyapatite on dental tubules. The results showed that both bioactive glass and hydroxyapatite had the potential efficacy in dentin tubule occlusion compared to the control.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Biotechnology & Applied Microbiology
Melanie Maillard, Octave Nadile Bandiaky, Suzanne Maunoury, Charles Alliot, Brigitte Alliot-Licht, Samuel Serisier, Emmanuelle Renard
Summary: This systematic review evaluates the ability of different formulations of calcium phosphate to reduce dentin hypersensitivity pain level in clinical studies. The results show that calcium phosphates have properties that reduce dentin hypersensitivity pain. The biomimetic and non-toxic characteristics of these materials make them a major asset in treating dentin hypersensitivity.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Medicinal
Jung-Chang Kung, Wei-Hsun Wang, Yu-Ching Chiang, Yuan-Ting Yang-Wang, Yueh-Ching Wang, Wen-Cheng Chen, Chi-Jen Shih
Summary: The study aimed to evaluate the remineralization and antibacterial effect of silver-containing mesoporous bioactive glass (MBG-Ag) sealing combined with Er:YAG laser irradiation on human demineralized dentin. Results showed that both MBG-Ag and Er:YAG laser have the ability to enhance remineralization and hydroxyapatite crystal precipitation, with superior treatment outcomes when combined.