Review
Geriatrics & Gerontology
Liying Zhang, Xiaofeng Zeng, Daxin Guo, Yupei Zou, Huatian Gan, Xiaoli Huang
Summary: The study found that giving probiotics within two days of antibiotic treatment can effectively reduce the incidence of AAD in elderly individuals. Therefore, it is recommended to routinely distribute probiotics to prevent the development of AAD in elderly individuals receiving antibiotic treatment.
Article
Immunology
Uday C. Ghoshal, Kok-Ann Gwee, Gerald Holtmann, Yanmei Li, Soo Jung Park, Marcellus Simadibrata, Kentaro Sugano, Henry Cohen, Eamonn M. M. Quigley
Summary: The survey conducted among physicians from seven countries in the Asia-Pacific region revealed varying rates of antibiotic prescription, with lower rates in Australia, Japan, and South Korea (11% to 19% of visits resulted in an antibiotic prescription) compared to higher rates in Indonesia, India, China, and Singapore (41% to 61%). While the majority of physicians agreed that antibiotics disrupt intestinal microbiota, rates of probiotic co-prescription remain low in many countries.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Carolyn E. Arnold, Rachel Pilla, M. Keith Chaffin, Jessica L. Leatherwood, Tryon A. Wickersham, Todd R. Callaway, Sara D. Lawhon, Jonathan A. Lidbury, Joerg M. Steiner, Jan S. Suchodolski
Summary: This study examined the influence of various factors on the fecal microbiota of healthy horses, revealing that the amount of grain in the diet and colitis had significant effects. Horses with AAD showed more severe dysbiosis compared to those with Salmonella infection.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Julie Zhu, Tyler Pitre, Carmen Ching, Dena Zeraatkar, Steven Gruchy
Summary: This study conducted a systematic review and meta-analysis to investigate the impact of probiotic supplementation on COVID-19 symptom trajectory and patient outcomes. The results showed that probiotic supplements can reduce the incidence of diarrhea, cough or dyspnea, and adverse events, and may improve the composite endpoint measured by clinical escalation or mortality.
Article
Microbiology
Jacqueline R. Phan, Dung M. Do, Minh Chau Truong, Connie Ngo, Julian H. Phan, Shiv K. Sharma, Angel Schilke, Chrisabelle C. Mefferd, Jacob V. Villarama, Dengxun Lai, Amber Consul, Brian P. Hedlund, Steven M. Firestine, Ernesto Abel-Santos
Summary: Clostridioides difficile infection (CDI) is the major cause of antibiotic-associated diarrhea. Hypervirulent strains have led to increased CDI rates, and standard treatments are becoming less effective. The bile salt analog CaPA was found to be a better antigerminant than CamSA against different C. difficile strains, and it showed efficacy in preventing CDI in mice and hamsters.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Roman Maslennikov, Andrey Svistunov, Vladimir Ivashkin, Anna Ufimtseva, Elena Poluektova, Irina Efremova, Anatoly Ulyanin, Alexey Okhlobystin, Svetlana Kardasheva, Anastasia Kurbatova, Anna Levshina, Diana Grigoriadis, Shamil Magomedov, Natiya Dzhakhaya, Oleg Shifrin, Maria Zharkova, Elena Yuryeva, Nataliya Kokina, Manana Shirtladze, Olga Kiseleva
Summary: Diarrhea in COVID-19 can manifest differently, with late antibiotic-associated diarrhea lasting longer and being more severe, and associated with an increased risk of death.
Review
Health Care Sciences & Services
Kira Kopacz, Sangita Phadtare
Summary: Probiotics have been widely used for various clinical uses, with a focus on preventing antibiotic-associated diarrhea. They have shown to support intestinal health through several mechanisms, making them an effective and affordable treatment option for gastrointestinal disorders.
Article
Microbiology
Yang Chen, Siming Lu, Zhiwei Ye, Xin Cai, Shanshan Wu, Pan Li, Bing Du
Summary: Combining probiotic beverages effectively treats antibiotic-associated diarrhea, and the S1 formula shows the best efficacy in restoring the structure of the gut and fecal microbiota.
FUTURE MICROBIOLOGY
(2022)
Article
Microbiology
Timothy J. Dallman, Saskia Neuert, Cristina Fernandez Turienzo, Michelle Berin, Emily Richardson, Pablo Fuentes-Utrilla, Nicholas Loman, Saheer Gharbia, Claire Jenkins, Ron H. Behrens, Gauri Godbole, Michael Brown
Summary: International travel is a risk factor for acquisition of resistant organisms, as shown by increased abundance and diversity of antibiotic resistance genes in fecal samples post-travel. Resistance genes for macrolides, third-generation cephalosporins, aminoglycosides, and sulfonamides were particularly increased. The study also found a significant association between diarrhea or antibiotic use and increased resistome abundance.
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Canhui Chen, Xuefang Guan, Xiaoyan Liu, Weijing Zhuang, Yiqian Xiao, Yafeng Zheng, Qi Wang
Summary: A water-soluble polysaccharide BSP extracted from bamboo shoot by-products showed significant effects on antibiotic-associated diarrhea in mice. Mice fed with BSP exhibited higher bodyweight gain, lower pH value, and higher concentrations of SCFAs in feces. BSP administration also reduced inflammation and improved the composition of gut microbiota in the mice.
Article
Plant Sciences
Qingsong Qu, Fang Yang, Chongyan Zhao, Xing Liu, Pengshuo Yang, Zhixun Li, Lu Han, Xinyuan Shi
Summary: Fermented ginseng has demonstrated efficacy in treating symptoms of antibiotic-associated diarrhea (AAD) and colon inflammation, as well as restoring the gut microbiota to its original state. Different doses of fermented ginseng exert varying influences on the gut microbiota, with excessively high or low doses being disadvantageous for resolving AAD symptoms and promoting recovery.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Maria Oana Sasaran, Cristina Oana Marginean, Heidrun Adumitrachioaiei, Lorena Elena Melit
Summary: Probiotics have strain-specific benefits in managing gastrointestinal disorders, especially acute gastroenteritis, in children. The most researched strains, such as Lactobacillus rhamnosus, L. reuteri, and S. boulardii, have proven to decrease diarrhea and hospitalization duration, particularly in rotavirus infection. Research on bacterial diarrhea and clinical trials within ambulatory care units are lacking and further investigation, including larger cohort studies, is needed.
Article
Multidisciplinary Sciences
Chiranjit Maity, Anil Kumar Gupta
Summary: The probiotic Alkalihalobacillus clausii 088AE has been clinically proven to be safe and effective in improving symptoms of antibiotic-associated diarrhea (AAD), suggesting its potential as a therapeutic agent for gastrointestinal ailments.
Article
Immunology
Alex O. Awuor, Billy Ogwel, Helen Powell, Jennifer R. Verani, Samba O. Sow, M. Jahangir Hossain, John B. Ochieng, Jane Juma, Leslie P. Jamka, Anna Roose, Sanogo Doh, Emily L. Deichsel, Uma Onwuchekwa, Adama Mamby Keita, Martin Antonio, Joquina Chiquita M. Jones, Syed M. A. Zaman, Henry Badji, Irene N. Kasumba, Dilruba Nasrin, James A. Platts-Mills, Eric R. Houpt, David M. Berendes, Ciara E. Sugerman, Marc-Alain Widdowson, Sharon M. Tennant, Eric D. Mintz, Richard Omore, Karen L. Kotloff
Summary: Inappropriate antibiotic prescribing is common for diarrheal diseases, leading to antimicrobial resistance. The VIDA study found that 77% of diarrhea cases and 41% of dysentery cases were prescribed unnecessary or incorrect antibiotics. Interventions are needed to improve adherence to international guidelines in low- and middle-income countries.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Microbiology
Wellison Amorim Pereira, Carlos Miguel N. Mendonca, Alejandro Villasante Urquiza, Viggo Por Marteinsson, Jean Guy LeBlanc, Paul D. Cotter, Elias Figueroa Villalobos, Jaime Romero, Ricardo P. S. Oliveira
Summary: In addition to human medicine, antimicrobials are used in food animals and aquaculture for therapeutic purposes against bacterial infections. However, their use in aquaculture can lead to environmental consequences and the spread of bacterial resistance genes. Probiotics and bacteriocins derived from lactic acid bacteria offer potential alternatives to antibiotics for controlling bacterial infections.
