Article
Oncology
Chika Iwamoto, Kenoki Ohuchida, Tomohiko Shinkawa, Sho Okuda, Yoshiki Otsubo, Takashi Okumura, Akiko Sagara, Kazuhiro Koikawa, Yohei Ando, Koji Shindo, Naoki Ikenaga, Kohei Nakata, Taiki Moriyama, Yoshihiro Miyasaka, Takao Ohtsuka, Masatoshi Eto, Koichi Akashi, Masafumi Nakamura
Summary: This study found that in PDAC, macrophages derived from bone marrow can partially convert into CAF-like cells, acting as a specific subtype that promotes pancreatic cancer growth and invasion. This conversion may represent a novel therapeutic strategy.
Article
Biochemistry & Molecular Biology
Chongbiao Huang, Hui Li, Yang Xu, Chao Xu, Huizhi Sun, Zengxun Li, Yi Ge, Hongwei Wang, Tiansuo Zhao, Song Gao, Xiuchao Wang, Shengyu Yang, Peiqing Sun, Zhe Liu, Jing Liu, Antao Chang, Jihui Hao
Summary: VEGF inhibitors have been successful in treating solid tumors, but pancreatic adenocarcinoma (PAAD) cells can activate VEGF-independent pathways to reinstate tumor angiogenesis, leading to resistance to VEGF inhibitors. BICC1 is a top gene involved in PAAD-specific angiogenesis. Overexpression of BICC1 in human PAAD tissues is associated with increased microvessel density, tumor growth, and worse prognosis. BICC1 promotes angiogenesis in pancreatic cancer through a VEGF-independent mechanism. Its binding to LCN2 mRNA up-regulates LCN2 expression, leading to the activation of the JAK2/STAT3 signal pathway and increased production of the angiogenic factor CXCL1. Blocking the BICC1/LCN2 signaling reduces microvessel density and tumor volume, and enhances the suppressive effect of gemcitabine. BICC1/LCN2 signaling may be a promising therapeutic target for anti-angiogenesis in pancreatic cancer patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Oncology
Xinyao Chang, Xingchen Liu, Haoze Wang, Xuan Yang, Yan Gu
Summary: Metabolic reprogramming, specifically the switch from oxidative phosphorylation to glycolysis, promotes the malignant behavior of pancreatic cancer and affects tumor microenvironments. Glycolysis is critical for cancer cells to maintain biosynthesis and promotes tumor initiation, invasion, angiogenesis, and metastasis to distant organs.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Si Liu, Haiyan Jiang, Li Min, Tingting Ning, Junxuan Xu, Tiange Wang, Xingyu Wang, Qian Zhang, Ruizhen Cao, Shutian Zhang, Shengtao Zhu
Summary: The study revealed the close relationship between LPA and ESCC, with Lpar1 identified as a potential therapeutic target for ESCC. LPA was found to promote proliferation and migration of ESCC cells through the PI3K/Akt pathway.
Article
Oncology
Yang Long, Yuqin Wang, Mengxia Qu, Di Zhang, Xiaotian Zhang, Junjie Zhang
Summary: Autotaxin (ATX) is a key enzyme in lysophosphatidic acid (LPA) production, and the ATX-LPA axis plays a critical role in tumorigenesis. Clinical data analysis revealed a negative correlation between ATX and EZH2 expression in colon cancer. Our study identified ATX as a novel PRC2 target gene silenced by EZH2, and cotargeting EZH2 and the ATX-LPA-LPA2 axis may be a potential combination therapy strategy for colon cancer.
Review
Oncology
Yutong Zhao, Cheng Qin, Bangbo Zhao, Yuanyang Wang, Zeru Li, Tianyu Li, Xiaoying Yang, Weibin Wang
Summary: Pancreatic cancer is a highly aggressive malignancy with self-renewal and proliferation capacity of pancreatic cancer stem cells playing a crucial role in metastasis and therapy resistance. This review focuses on the regulation of pancreatic cancer stem cells, including stemness-related signaling pathways, stimuli in tumor cells and the tumor microenvironment, and the development of innovative stemness-targeted therapies. Understanding the plasticity and molecular mechanisms of PCSCs will help identify new treatment strategies for this devastating disease.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Yawen Geng, Jie Fan, Lianyu Chen, Chenyue Zhang, Chao Qu, Ling Qian, Kun Chen, Zhiqiang Meng, Zhen Chen, Peng Wang
Summary: This study uncovered a Notch-dependent feedback circuit between pancreatic cancer cells and macrophages, which promotes PDAC metastasis through miR-124, IL6, and STAT3 signaling pathways. Disrupting this circuit could potentially be a therapeutic approach for treating PDAC metastasis.
Article
Oncology
Margaret A. Nagai-Singer, Holly A. Morrison, Mackenzie K. Woolls, Katerina Leedy, Khan Mohammad Imran, Juselyn D. Tupik, Irving C. Allen
Summary: Pancreatic cancer is a deadly malignancy with limited treatment options. NLRX1, an understudied member of the NLR family, plays a role in regulating various biological processes relevant to pancreatic cancer. Its function in cancer remains enigmatic, with contradictory findings on whether it promotes or suppresses tumor growth.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Kirby P. Gardner, Susan Tsai, Mohammed Aldakkak, Stephen Gironda, Daniel L. Adams
Summary: This study aimed to investigate the expression of CXCR4 in tumor-associated cells in the blood of pancreatic cancer patients and explore its relationship with cell migration and patient clinical outcomes. The results showed that high expression of CXCR4 in circulating tumor cells, cancer-associated macrophage-like cells, and epithelial-to-mesenchymal transition cells was significantly associated with increased numbers in circulation, and higher expression of CXCR4 in cancer-associated macrophage-like cells and epithelial-to-mesenchymal transition cells was significantly related to faster progression and worse survival.
Article
Biochemistry & Molecular Biology
Justin Thomas, Molly A. Torok, Kriti Agrawal, Timothy Pfau, Trang T. Vu, Justin Lyberger, Hsiaochi Chang, Alyssa Marie M. Castillo, Min Chen, Bryan Remaily, Kyeongmin Kim, Zhiliang Xie, Mary E. Dillhoff, Samuel K. Kulp, Gregory K. Behbehani, Zobeida Cruz-Monserrate, Latha P. Ganesan, Dwight H. Owen, Mitch A. Phelps, Christopher C. Coss, Thomas A. Mace
Summary: The neonatal Fc receptor (FcRn) is responsible for recycling antibodies and albumin in the body. However, little is known about its expression in circulating immune cells. In this study, FcRn expression was found to be elevated in immune cells of pancreatic ductal adenocarcinoma (PDAC) patients and mice with PDAC. These findings may contribute to understanding the mechanisms behind poor efficacy of antibody immunotherapies in PDAC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ning-Ning Liu, Cheng-Xiang Yi, Lu-Qi Wei, Jin-An Zhou, Tong Jiang, Cong-Cong Hu, Lu Wang, Yuan-Yuan Wang, Yun Zou, Yi-Kai Zhao, Le-Le Zhang, Ya-Ting Nie, Yi-Jing Zhu, Xin-Yao Yi, Ling-Bing Zeng, Jing-Quan Li, Xiao-Tian Huang, Hong-Bin Ji, Zisis Kozlakidis, Lin Zhong, Christopher Heeschen, Xiao-Qi Zheng, Changbin Chen, Peng Zhang, Hui Wang
Summary: Enriched tumor-resident Aspergillus sydowii is associated with immunosuppression and poor patient outcome in lung adenocarcinoma (LUAD), promoting tumor progression by promoting MDSC expansion and activation, suppressing cytotoxic T lymphocyte activity, and accumulating PD-1+ CD8+ T cells through IL-10 secretion via the 0-glucan/Dectin-1/CARD9 pathway.
Review
Cell Biology
Chao-Hui Chang, Siim Pauklin
Summary: Pancreatic cancer is a leading cause of cancer-related deaths worldwide due to delayed diagnosis and limited treatments. Pancreatic ductal adenocarcinoma accounts for more than 90% of all pancreatic cancers, with extracellular vesicles playing a crucial role in regulating tumor growth and metastasis. Understanding the factors in EVs derived from pancreatic ductal adenocarcinoma can provide insights into potential early diagnosis and therapeutic strategies against this deadly cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Hongkai Zhuang, Zixuan Zhou, Zedan Zhang, Xinming Chen, Zuyi Ma, Shanzhou Huang, Yuanfeng Gong, Chuanzhao Zhang, Baohua Hou
Summary: B3GNT3 overexpression in pancreatic cancer is associated with tumor progression, poor clinical outcomes, and immunosuppression, making it a potential therapeutic target.
Review
Medicine, Research & Experimental
Hong Xiang, Runjuan Yang, Jiaxin Tu, Yan Xi, Shilei Yang, Linlin Lv, Xiaohan Zhai, Yanna Zhu, Deshi Dong, Xufeng Tao
Summary: Abnormal intracellular metabolism in pancreatic cancer not only provides nutrition for tumor development, but also affects the function of immune cells in the immune microenvironment, promoting immune escape. This review discusses the emerging role of immune cells in pancreatic cancer, focusing on metabolic reprogramming and key metabolic pathways. The hotspots of immune cell metabolic reprogramming in pancreatic cancer mainly involve glucose metabolism, lipid metabolism, tricarboxylic acid cycle, and amino acid metabolism, which impact the function of anti-tumor immune cells and immunosuppressive cells through key metabolic signaling pathways. The review also elaborates on drugs targeting tumor metabolism pathways for clinical treatment of pancreatic cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Feng Guo, Yingke Zhou, Hui Guo, Dianyun Ren, Xin Jin, Heshui Wu
Summary: NR5A2 acts as a negative prognostic biomarker in pancreatic ductal adenocarcinoma (PDAC), being transcriptionally upregulated by BRD4 and promoting pancreatic cancer progression through inducing the transcription of GDF15.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)