期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 460, 期 3, 页码 543-548出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2015.03.066
关键词
Lymph node resection; Distant metastasis; Metastatic mouse model; Latent tumor cells
资金
- JSPS KAKENHI Grant [26293425, 26670856, 25293382, 24659834, 26242051, 24650286]
- JSPS Dissertation PhD Program
- Grants-in-Aid for Scientific Research [26670856, 26242051, 24659834, 24650286, 25293382, 26293425] Funding Source: KAKEN
latrogenic induction of regional and distant cancer metastases is a risk associated with clinical resection of tumor-positive sentinel lymph nodes. However, there have been no studies of this risk in a mouse model of cancer metastasis. Here, we report that resection of a tumor-bearing subiliac lymph node (SiLN) enhanced lung metastasis in a mouse model of lymph node metastasis. Bioluminescence imaging revealed that metastatic tumor cells in the secondary lymph node continued to grow after resection of the SiLN, and that the probability of metastasis to the lungs was increased when the interval between SiLN inoculation and resection was reduced. Futhermore, histological analysis demonstrated that latents in the lung were stimulated to grow after resection of the SiLN. Fluorescence imaging indicated that the route of tumor cell dissemination from SiLN to the lung was the venous system located over the SiLN. We speculate that our mouse model will be useful for studying the mechanisms of tumor cell latency, with a view to improving the detection and treatment of latent metastases. (C) 2015 Elsevier Inc. All rights reserved.
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