期刊
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
卷 2, 期 2, 页码 77-81出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jgar.2014.01.002
关键词
Extended-spectrum beta-lactamase; ESBL; Plasmid-mediated quinolone resistance; PMQR; Integron
资金
- Comision Sectorial de Investigacion Cientifica (CSIC), Uruguay
Here we report the detection of a Leclercia adecarboxylata strain, isolated from a case of osteomyelitis, harbouring multiple antibiotic resistance genes encoded on a 450-kb IncHI1/HI2 conjugative plasmid (pLa12). The plasmid carried a complex class 1 integron with the genetic array intI1-aac(6')-Ib-cr-bla(OXA-1)-catB3-arr3-qacE Delta 1-sul1-ISCR1; in addition, a bla(DHA-1)-like allele linked to ampR-qacE Delta 1-sul1 as well as bla(SHV-12), bla(TEM)-1 and qnrB4-like genes were found. To the best of our knowledge, this is the first report of L. adecarboxylata harbouring transferable resistance genes to quinolones, chloramphenicol and rifampicin as well as a plasmidic class C beta-lactamase. (C) 2014 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
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