Article
Surgery
Xu-Feng Zhang, Feng Xue, Ding-Hui Dong, Alexandra G. Lopez-Aguiar, George Poultsides, Eleftherios Makris, Flavio Rocha, Zaheer Kanji, Sharon Weber, Alexander Fisher, Ryan Fields, Bradley A. Krasnick, Kamran Idrees, Paula M. Smith, Cliff Cho, Megan Beems, Yi Lv, Shishir K. Maithel, Timothy M. Pawlik
Summary: The study found that both the number of metastatic lymph nodes and the minimum number of lymph nodes necessary for accurate staging play a crucial role in the prognosis of patients with pancreatic neuroendocrine tumors. Particularly for patients with lymph node metastasis, regional lymphadenectomy of at least 8 lymph nodes was necessary for accurate staging.
Review
Oncology
Megan L. Sulciner, Thomas E. Clancy
Summary: Pancreatic neuroendocrine tumors (PNETs) are rare malignancies characterized by secretion of hormones. Tumor grade, determined by Ki67 proliferation index and mitotic index, is the primary prognostic indicator. Surgery is the main treatment for PNETs, with functional PNETs requiring resection for symptom control and potential cure, while nonfunctional PNETs are increasingly managed nonoperatively. Evidence supports surgical management of metastatic disease and primary tumor in the presence of widespread metastases. In this review, we discuss the evolving surgical management of local and metastatic PNETs.
Article
Oncology
Alexander R. Siebenhuener, Melanie Langheinrich, Juliane Friemel, Niklaus Schafer, Dilmurodjon Eshmuminov, Kuno Lehmann
Summary: This review provides an updated view on treatment options for metastatic pancreatic neuroendocrine tumors (pNETs) and emphasizes the importance of selecting the right timing for surgery in the context of multimodal treatment.
Article
Oncology
Jordan M. Cloyd, George A. Poultsides
Summary: PNETs are a rare type of tumor originating from pancreatic islet cells, with surgical resection being the standard treatment for most patients and pancreas-preserving approaches being acceptable for smaller tumors. Observation is recommended for small, low-grade PNETs.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Ammar Javed, Alessandra Pulvirenti, Samrah Razi, Jian Zheng, Theodoros Michelakos, Yurie Sekigami, Elizabeth S. Thompson, David Klimstra, Vikram D. Deshpande, Aatur J. Singhi, Matthew L. Weiss, Christopher L. Wolfgang, John C. Cameron, Alice C. H. Wei, Amer R. Zureikat, Cristina Ferrone, Jin He
Summary: A multicenter retrospective study found that the concordance between cytological grade (c-grade) and histopathological grade (h-grade) in PanNETs patients was 80.4%, and it was associated with tumor size, with the highest concordance observed in PanNETs smaller than 2cm.
Review
Oncology
Ugo Marchese, Martin Gaillard, Anna Pellat, Stylianos Tzedakis, Einas Abou Ali, Anthony Dohan, Maxime Barat, Philippe Soyer, David Fuks, Romain Coriat
Summary: This review focuses on the classification and treatment options for pancreatic neuroendocrine tumors (pNETs), with a special emphasis on benign tumors. The article discusses different treatment approaches from the perspectives of oncologists and surgeons, and highlights the advantages of minimally invasive surgery.
Article
Surgery
Xu-Feng Zhang, Feng Xue, Zheng Wu, Alexandra G. Lopez-Aguiar, George Poultsides, Eleftherios Makris, Flavio Rocha, Zaheer Kanji, Sharon Weber, Alexander Fisher, Ryan Fields, Bradley A. Krasnick, Kamran Idrees, Paula M. Smith, Cliff Cho, Megan Beems, Yi Lyu, Shishir K. Maithel, Timothy M. Pawlik
Summary: This study aimed to improve the prognostic accuracy of pNETs by establishing and validating a new staging system. The eighth edition of AJCC staging system for pNETs failed to stratify patients effectively, while the proposed mTNM staging system showed better stratification based on long-term overall survival. This research has important implications for the treatment and prognosis evaluation of pNETs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei-Xia Li, Fei Miao, Xue-Qin Xu, Jing Zhang, Zhi-Yuan Wu, Ke-Min Chen, Fu-Hua Yan, Xiao-Zhu Lin
Summary: There are significant differences in CT spectral imaging parameters between non-LG and LG PNENs. Tumor size is the most promising independent parameter, and the combination of quantitative parameters with qualitative parameters is the best predictor in differentiating non-LG PNENs from LG PNENs. CT spectral imaging can help determine the malignancy of PNENs and assist in surgical planning.
ACADEMIC RADIOLOGY
(2021)
Article
Oncology
Mu-Xing Li, Alexandra G. Lopez-Aguiar, George Poultsides, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, Cliff Cho, Shishir K. Maithel, Xu-Feng Zhang, Timothy M. Pawlik
Summary: The study aimed to define surgical outcomes of patients with GEP-NEN G3. The results showed that patients with NEC had worse survival outcomes compared to patients with NET G3 among those who underwent surgical resection.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Wentong Mei, Feng Cao, Jiongdi Lu, Chang Qu, Zhen Fang, Jia Li, Fei Li
Summary: This study aimed to explore the treatment strategies for small pNETs with a diameter ≤ 2 cm. The results showed that surgery could improve patient survival, and factors such as age, tumor location, and differentiation degree affected patient survival. Patients need to pay attention to the characteristics of invasive tumors to improve survival.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Min Yang, Lin Zeng, Shengzhong Hou, Bole Tian, Shuguang Jin, Yi Zhang
Summary: This study found that surgical resection is an independent predictor for a favorable prognosis in patients with G3 pancreatic neuroendocrine tumors (p-NETs). The new modified tumor-node-metastasis (mTNM) staging system is more suitable and practical for stratifying G3 p-NETs into prognostic groups compared to the current American Joint Committee on Cancer (AJCC) system.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Hallbera Gudmundsdottir, Ron Pery, Rondell P. Graham, Cornelius A. Thiels, Susanne G. Warner, Rory L. Smoot, Mark J. Truty, Michael L. Kendrick, Thorvardur R. Halfdanarson, Elizabeth B. Habermann, David M. Nagorney, Sean P. Cleary
Summary: For patients with metastatic pancreatic neuroendocrine tumors (pNETs), combined pancreatic and hepatic resections can be performed with acceptable morbidity and mortality in selected patients at high-volume institutions.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Clara Zhu, Georgianna Sandilos, John Williamson, Robert Emery, Rebecca Platoff, Upasana Joneja, Nimish K. Acharya, Andrew Lin, Jeremy Badach, Brian Zilberman, Jozef Madzo, Jaroslav Jelinek, Ping Zhang, Young Ki Hong
Summary: This study reveals that the aberrant expression of DNA methyltransferase 1 (DNMT1) is associated with the malignancy of pancreatic neuroendocrine tumors. Treatment with DNMT1 inhibitor 5-azacytidine and chemotherapy drugs can inhibit tumor cell proliferation, upregulate tumor suppressor genes, and reduce tumor volume.
Article
Oncology
Rihong Zhang, Yu Guo, Youliang Wang, Li Hu, Cheng Fang, Yujie Yang, Xianqi Yang, Luohai Chen, Jie Chen, Wei Wang, Xiaowei Sun
Summary: The proposed TNMG staging system can more accurately predict the 3- and 5-year OS rate of gNENs patients than the 8th AJCC TNM staging system.
Article
Genetics & Heredity
Tincy Simon, Pamela Riemer, Armin Jarosch, Katharina Detjen, Annunziata Di Domenico, Felix Bormann, Andrea Menne, Slim Khouja, Nanna Monje, Liam H. Childs, Dido Lenze, Ulf Leser, Florian Rossner, Markus Morkel, Nils Bluethgen, Marianne Pavel, David Horst, David Capper, Ilaria Marinoni, Aurel Perren, Soulafa Mamlouk, Christine Sers
Summary: Pancreatic neuroendocrine neoplasms (PanNENs) can be classified into two subclasses: well-differentiated PanNETs and poorly-differentiated high-grade PanNECs. Recent studies have shown that high-grade PanNECs originate from exocrine cells, distinguishing them in cell lineage from other endocrine-origin PanNETs. This study provides a method to clearly distinguish PanNECs from G3 PanNETs, improving patient stratification.
Article
Surgery
Niccolo Napoli, Emanuele Kauffmann, Concetta Cacace, Francesca Menonna, Davide Caramella, Carla Cappelli, Daniela Campani, Andrea Cacciato Insilla, Enrico Vasile, Caterina Vivaldi, Lorenzo Fornaro, Gabriella Amorese, Fabio Vistoli, Ugo Boggi
Summary: This study identified pre-operative prognostic factors that can predict cancer-specific survival in patients undergoing pancreatectomy with arterial resection. Factors such as metabolic deterioration of diabetes, platelet count, serum levels of Ca 15.3 and Ca 125, neutrophils-to-lymphocytes ratio were found to be associated with survival outcomes. The development of a prognostic score and identification of three risk groups allows for better risk stratification in these patients.
UPDATES IN SURGERY
(2021)
Article
Cell Biology
Claudio Urbani, Alessandro Mattiello, Gianmarco Ferri, Francesco Raggi, Dania Russo, Giulia Marconcini, Daniele Cappellani, Luca Manetti, Claudio Marcocci, Francesco Cardarelli, Fausto Bogazzi
Summary: This study demonstrated that PCB153 reduces apoptosis in pituitary cells through activation of the PI3K/Akt-mediated NF-κB pathway, while also inhibiting the expression of pro-apoptotic proteins like p38-MAPK, P53, and P21.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Carlo Lombardo, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Antonella Romanini, Daniela Campani, Davide Caramella, Ugo Boggi
Article
Oncology
Gennaro Nappo, Domenico Borzomati, Alessandro Zerbi, Paola Spaggiari, Ugo Boggi, Daniela Campani, Slawomir Mrowiec, Lukasz Liszka, Alessandro Coppola, Michela Amato, Tommasangelo Petitti, Fabio Vistoli, Marco Montorsi, Giuseppe Perrone, Roberto Coppola, Damiano Caputo
Summary: There is no clear evidence on the most effective method of pathological analysis and clearance definition for defining R1 resection after PD. The 1 mm clearance is the most effective factor in determining the R1 rate after PD, but the pathological method is crucial in accurately evaluating its prognostic role.
Article
Endocrinology & Metabolism
Daniele Cappellani, Giuseppina De Marco, Eleonora Ferrarini, Liborio Torregrossa, Agostino Maria Di Certo, Giada Cosentino, Claudio Urbani, Giulia Marconcini, Alessandro Mattiello, Luca Manetti, Patrizia Agretti, Fulvio Basolo, Massimo Tonacchera, Luigi Bartalena, Fausto Bogazzi
Summary: The study found that in AIT patients, having TRAb-positive does not necessarily mean having GD and AIT1, with approximately 60% of TRAb-positive patients exhibiting destructive thyroiditis. The response to methimazole and glucocorticoids also varied among TRAb1 and TRAb2 patients.
Article
Chemistry, Physical
Ozlem Ipek Kalaoglu-Altan, Havva Baskan, Timo Meireman, Pooja Basnett, Bahareh Azimi, Alessandra Fusco, Niccola Funel, Giovanna Donnarumma, Andrea Lazzeri, Ipsita Roy, Serena Danti, Karen De Clerck
Summary: This study aims to improve wound dressings by using nanofiber materials made of Polyhydroxyalkanoates (PHAs) and incorporating silver nanoparticles for enhanced biocompatibility and immunomodulatory properties. The modified nanofibers show promise for wound dressing applications by stimulating human beta defensin 2 and cytokeratin expression in vitro.
Article
Oncology
Alice Usai, Gregorio Di Franco, Margherita Piccardi, Perla Cateni, Luca Emanuele Pollina, Caterina Vivaldi, Enrico Vasile, Niccola Funel, Matteo Palmeri, Luciana Dente, Alfredo Falcone, Dimitri Giunchi, Alessandro Massolo, Vittoria Raffa, Luca Morelli
Summary: The study demonstrates that the zPDX model may predict patient outcomes in PDAC, dividing them into responders and non-responders. The non-responder group showed a significantly higher cancer recurrence rate at 1 year after surgery. The findings suggest that zPDX could potentially be a promising tool for personalized oncological treatment of PDAC patients.
Article
Oncology
Laura Crocetti, Paola Scalise, Elena Bozzi, Daniela Campani, Piercarlo Rossi, Rosa Cervelli, Irene Bargellini, Davide Ghinolfi, Paolo De Simone, Roberto Cioni
Summary: This study aimed to evaluate the efficacy of Microwave (MW) ablation by correlating with histology in excised liver samples at the time of liver transplantation. The results showed a high rate of complete necrosis with MW ablation for hepatocellular carcinoma nodules, indicating its effectiveness in percutaneous treatment.
Review
Oncology
Laura Crocetti, Elena Bozzi, Paola Scalise, Irene Bargellini, Giulia Lorenzoni, Davide Ghinolfi, Daniela Campani, Emanuele Balzano, Paolo De Simone, Roberto Cioni
Summary: Liver transplantation is the primary treatment for patients with unresectable early-stage hepatocellular carcinoma and cirrhosis. While traditional Milan criteria are restrictive, there is a trend towards expanding inclusion criteria due to a limited organ supply. Locoregional therapies play a crucial role in selecting patients who will benefit the most from transplantation and meet the criteria for transplantation.
Article
Biochemistry & Molecular Biology
Federica La Rosa, Letizia Guiducci, Maria Angela Guzzardi, Andrea Cacciato Insilla, Silvia Burchielli, Maurizia Rossana Brunetto, Ferruccio Bonino, Daniela Campani, Patricia Iozzo
Summary: The study shows that maternal high-fat diet during pregnancy can affect the metabolic and immune development of offspring, but normalization of the mother's diet during a second pregnancy can reverse most of the adverse effects.
Article
Biochemistry & Molecular Biology
Maria Angela Guzzardi, Federica La Rosa, Daniela Campani, Andrea Cacciato Insilla, Monica Nannipieri, Maurizia Rossana Brunetto, Ferruccio Bonino, Patricia Iozzo
Summary: This study validated the use of PET with oral FDG administration in mice to examine the role of the gastrointestinal tract in glucose metabolism. The results showed that the GI tract can selectively suppress glucose metabolism in organs responsible for energy intake and storage, and this effect is blunted by lipid ingestion. Furthermore, modulation of gut and liver inflammation may be involved in the acute signaling of the energy status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Angela Guzzardi, Federica La Rosa, Daniela Campani, Maria Carmen Collado, Daniel Monleon, Andrea Cacciato Insilla, Maria Tripodi, Alessandro Zega, Alessia Dattilo, Maurizia Rossana Brunetto, Margherita Maffei, Ferruccio Bonino, Patricia Iozzo
Summary: Metabolic impairments and alterations in liver and adipose depots were observed in subjects with Alzheimer's disease (AD), and the gut microbiota may play a modulating role. In a mouse model of AD, we investigated the changes in liver and white/brown adipose tissues and their associations with serum and gut metabolites and gut bacteria. The findings showed impaired lipid accumulation in liver and adipose tissues, along with disrupted gut microbiota profiles.
Article
Endocrinology & Metabolism
Lars Krogvold, Angelo Genoni, Anna Puggioni, Daniela Campani, Sarah J. Richardson, Christine S. Flaxman, Bjorn Edwin, Trond Buanes, Knut Dahl-Jorgensen, Antonio Toniolo
Summary: This study has found the presence of enterovirus genomes in the pancreas of type 1 diabetes patients, suggesting a potential link between enterovirus infection and the development of type 1 diabetes.
Article
Endocrinology & Metabolism
Rosario Pivonello, Renata Simona Auriemma, Alessandra Delli Veneri, Francesca Dassie, Riccardina Lorusso, Marta Ragonese, Marco Liotta, Elisa Sala, Barbara Zarino, Elisa Lai, Claudio Urbani, Fausto Bogazzi, Giovanna Mantovani, Salvatore Cannavo, Pietro Maffei, Paolo Chiodini, Annamaria Colao
Summary: Acromegaly is associated with significant impairments in psychological profile, sleep quality, sexual function, cognitive functions, and quality of life. Female patients experience more discomfort in body image, while both male and female patients experience worsened sexual function. These psychopathological conditions are mainly determined by disease duration, patient's age, and gender.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
N. Viola, C. Urbani, M. Cosottini, A. Abruzzese, L. Manetti, G. Cosentino, G. Marconcini, C. Marcocci, F. Bogazzi, I Lupi
Summary: Pituitary apoplexy is a complex medical emergency that is difficult to diagnose and manage. This study presents a case of pituitary apoplexy in a 63-year-old male with atrial fibrillation treated with oral anticoagulant therapy. The patient presented with asthenia and severe headache that did not respond to common analgesics. Further evaluation revealed a haemorrhagic pituitary macroadenoma compressing the optic chiasm. Treatment with intravenous fluids and high-dose hydrocortisone resulted in rapid improvement of the patient's health and visual field abnormalities.
ENDOCRINOLOGY DIABETES & METABOLISM
(2022)