Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Cardiac & Cardiovascular Systems
Anne M. Kerola, Anne Grete Semb, Markus Juonala, Antti Palomaki, Paivi Rautava, Ville Kyto
Summary: This study found that patients with type 1 diabetes have significantly poorer long-term cardiovascular prognosis after myocardial infarction compared to patients without diabetes, with a higher incidence of major adverse cardiovascular events. The results highlight the importance of effective secondary prevention after myocardial infarction in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Sanjay Kinra, Shi Wu Wen, Hongying Liu, Xinrui Tan, Aizhong Liu
Summary: This study summarized the associations of different chemokines with T1DM, revealing that circulating concentrations of CCL5 and CXCL1 were significantly higher in T1DM patients compared to controls. Circulating CCL5 ranked highest among all the chemokines investigated in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Bruce A. Perkins, Ionut Bebu, Ian H. de Boer, Mark Molitch, Bernard Zinman, John Bantle, Gayle M. Lorenzi, David M. Nathan, John M. Lachin
Summary: This study aimed to determine a simple screening schedule based on risk factors that optimizes early detection and testing frequency. The results showed that personalized screening can significantly reduce the time with undetected kidney disease and the frequency of urine testing, improving treatment outcomes.
Article
Medicine, General & Internal
Mohamad Habes, Alan M. Jacobson, Barbara H. Braffett, Tanweer Rashid, Christopher M. Ryan, Haochang Shou, Yuhan Cui, Christos Davatzikos, Jose A. Luchsinger, Geert J. Biessels, Ionut Bebu, Rose A. Gubitosi-Klug, R. Nick Bryan, Ilya M. Nasrallah
Summary: This study found that individuals with type 1 diabetes experience accelerated brain aging but without early signs of Alzheimer's disease-related neurodegeneration. The study also discovered that brain aging is associated with reduced cognitive performance.
Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Article
Medicine, General & Internal
Anthony J. Pease, Sofianos Andrikopoulos, Mary B. Abraham, Maria E. Craig, Brett Fenton, Jane Overland, Sarah Price, David Simmons, Glynis P. Ross
Summary: Type 1 diabetes management faces challenges, and technological advancements play a crucial role in reducing the impact of the disease. In Australia, a consensus statement outlines a national framework for optimal technology implementation for individuals with type 1 diabetes, addressing various issues.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Review
Endocrinology & Metabolism
Jessica L. Harding, Pandora L. Wander, Xinge Zhang, Xia Li, Suvi Karuranga, Hongzhi Chen, Hong Sun, Yuting Xie, Richard A. Oram, Dianna J. Magliano, Zhiguang Zhou, Alicia J. Jenkins, Ronald C. W. Ma
Summary: The incidence of adult-onset type 1 diabetes is lowest in Asian countries and highest in Nordic countries, with higher rates in men than women. It is unclear whether the incidence decreases with increasing age or changes over time. This study highlights the need to better distinguish type 1 diabetes from type 2 diabetes in adults to address the true burden of type 1 diabetes in adults.
Review
Endocrinology & Metabolism
Jessica L. Harding, Pandora L. Wander, Xinge Zhang, Xia Li, Suvi Karuranga, Hongzhi Chen, Hong Sun, Yuting Xie, Richard A. Oram, Dianna J. Magliano, Zhiguang Zhou, Alicia J. Jenkins, Ronald C. W. Ma
Summary: This systematic review demonstrates that the incidence of adult-onset type 1 diabetes (T1D) is significant and emphasizes the urgent need to distinguish T1D from T2D in adults to better understand and address the true burden of T1D in adults.
Article
Pediatrics
Amanda McKenna, Myra O'Regan, Kerry Ryder, Helen Fitzgerald, Hilary Hoey, Edna Roche
Summary: The study found that Ireland has a high incidence of type 1 diabetes mellitus, with a slight reduction in incidence rates seen in recent years. The highest incidence remains in the 10- to 14-year-old age group, with higher diagnosis rates in autumn and winter. Ongoing monitoring of incidence rates is crucial for informing healthcare services and research related to pediatric diabetes management.
Article
Endocrinology & Metabolism
Rose Gubitosi-Klug, Xiaoyu Gao, Rodica Pop-Busui, Ian H. de Boer, Neill White, Lloyd P. Aiello, Ryan Miller, Jerry Palmer, William Tamborlane, Amisha Wallia, Mikhail Kosiborod, John M. Lachin, Ionut Bebu
Summary: The study found that the presence of microvascular disease in type 1 diabetes patients was associated with an increased risk of subsequent cardiovascular disease and major adverse cardiovascular events (MACE) in the DCCT/EDIC cohort. These associations remained significant even after adjusting for age and HbA(1c).
Article
Endocrinology & Metabolism
Robert French, Dylan Kneale, Justin T. Warner, Holly Robinson, James Rafferty, Adrian Sayers, Peter Taylor, John W. Gregory, Colin M. Dayan
Summary: There is no strong evidence to suggest a significant association between type 1 diabetes and educational outcomes. However, the level of blood glucose control (HbA(1c)) is related to academic achievements.
Article
Public, Environmental & Occupational Health
Jack Wang, Sarah H. Wild
Summary: The study revealed that socioeconomic inequalities in the prevalence of type 2 diabetes in Scotland have increased between 2001-2007 and 2021. Further research is needed to investigate potential medium-term effects of the COVID-19 pandemic.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Pediatrics
Ahmed Megahed, Nanees Salem, Abeer Fathy, Tarik Barakat, Mona Abd El Latif Alsayed, Suzy Abd El Mabood, Khaled R. Zalata, Ahmed F. Abdalla
WORLD JOURNAL OF PEDIATRICS
(2017)
Article
Endocrinology & Metabolism
Nanees Abdel-Badie Salem, Rania Mostafa El Helaly, Ibrahim Maroof Ali, Hala Abd Alem Ebrahim, Mostafa Mahmoud Alayooti, Huda Ahmed El Domiaty, Hadil Mohamed Aboelenin
PEDIATRIC DIABETES
(2020)
Article
Pediatrics
Maha Abd Elmoneim, Heba Azmy Mohamed, Amal Awad, Amany El-Hawary, Nanees Salem, Rania El Helaly, Nehad Nasef, Hesham Abdel-Hady
Summary: The study demonstrated that massage therapy has a positive impact on growth and body composition parameters in preterm infants, showing significant increases in daily weight gain, growth velocity, total and regional lean mass, and bone mineral density compared to routine care.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Wafaa Laimon, Amany El-Hawary, Hadil Aboelenin, Mohamed Elzohiri, Sherif Abdelmaksoud, Nirmeen Megahed, Nanees Salem
Summary: This article reports four cases of pathological causes of prepubertal gynecomastia, including Sertoli cell tumor, trauma, mammary duct ectasia, and hyperprolactinemia secondary to congenital hypothyroidism. It emphasizes the need for thorough investigations to exclude pathology and differentiate idiopathic gynecomastia from pathological causes.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Rania Mostafa El Helaly, Rasha Rizk Elzehery, Ola Ali El-Emam, Huda Ahmed El Domiaty, Wesam Reda Elbohy, Hadil Mohamed Aboelenin, Nanees Abdel-Badie Salem
Summary: The study found that IL-10 gene rs1518111 and rs3021094 SNPs are associated with the risk of type 1 diabetes and diabetic nephropathy. The AA genotype and A allele of rs1518111 may be linked to increased risk for T1DM and DN among Egyptian children, while rs3021094 genotypes and alleles did not show significant association with DN. Haplotypes GA and AC may be protective against T1DM and DN susceptibility.
PEDIATRIC DIABETES
(2021)
Article
Endocrinology & Metabolism
Wafaa Laimon, Magdy El-Ziny, Amany El-Hawary, Ashraf Elsharkawy, Nanees Abdel-Badie Salem, Hadil Mohamed Aboelenin, Mohammad Hosny Awad, Sarah E. Flanagan, Elisa De Franco
Summary: This study aimed to define the genetic aetiology and clinical phenotypes of permanent neonatal diabetes mellitus (PNDM) in a large Egyptian cohort from a single center. The results showed that PNDM is a heterogenous disease with variable genotypes and clinical phenotypes among Egyptian patients, with EIF2AK3, INS, ABCC8, and KCNJ11 mutations being the commonest causes. The study also highlighted the importance of genetic testing for diagnosis, treatment plan, and prognosis of patients with neonatal diabetes mellitus.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Nanees Salem, Ashraf Bakr
Summary: In children with kidney failure on maintenance hemodialysis, size-adjusted techniques of lumber-spine DXA measurements were evaluated for bone mineralization assessment. The study found that in short-for-age CKD patients, aBMD(Z-CA) was significantly lower than vBMD(Z-score), while aBMD(Z-HA) was significantly higher than aBMD(Z-CA), and vBMD(Z-score).
Overall, estimated vBMD appears to be a convenient size-adjustment approach for assessing BMD, especially in older short-for-age children with CKD.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Sohier Yahia, Reham El-Farahaty, Abdel-Hady EL-Gilany, Rasha Shoaib, Rowayda Ramadan, Nanees Salem
Summary: The study found that prepubertal children with Down syndrome who are obese have a higher risk of obesity and more pronounced metabolic syndrome manifestations compared to matched obese controls. These children also have lower levels of adiponectin and show a potential biomarker role for adiponectin.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Parasitology
Doaa A. Salem, Nanees A. Salem, Shimaa R. Hendawy
Summary: The study results suggest that T. gondii infection may exert an immune-metabolic effect that may have a potential role in the development of MetS among obese adolescents.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Nanees A. Salem, Nihal M. Batouty, Ahmed M. Tawfik, Donia M. Sobh, Basma Gadelhak, Shimaa R. Hendawy, Wafaa Laimon
Summary: The study found that TS girls have adverse cardiometabolic profiles during late childhood and adolescence, with EFT and PHFT emerging as cardiometabolic risk predictors in TS patients. Excess EFT, rather than total body adiposity, may contribute to altered metabolic profiles among lean-Turner patients.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Shaimaa Rakha, Nanees Salem, Ahmed Abdel Khalek Abdel Razek, Donia M. Sobh, Farahat El-Moslemany, Hala Elmarsafawy
Summary: This study evaluated left ventricular functions in prepubertal obese children and identified correlations with obesity-related clinical and metabolic parameters. The results showed that obese children had impaired left ventricular functions, which were associated with body mass index, fat mass index, and trunk fat mass. The study emphasizes the importance of early and strict management of childhood obesity.
CARDIOLOGY IN THE YOUNG
(2022)
Meeting Abstract
Endocrinology & Metabolism
Amany El-Hawary, Nanees Salem, Hossam Abdel Twab, Evan Badrous
HORMONE RESEARCH IN PAEDIATRICS
(2021)
Article
Allergy
Magdy M. Zedan, Nanees A. Salem, Mohammad M. Zedan, Hoda Nasser, Layla M. Saleh
EGYPTIAN JOURNAL OF PEDIATRIC ALLERGY AND IMMUNOLOGY
(2020)
Article
Clinical Neurology
Bothina Hasaneen, Riad Moustafa Elsayed, Nanees Salem, Ashraf Elsharkawy, Noha Tharwat, Khaled Fathy, Amany El-Hawary, Hadil M. Aboelenin
JOURNAL OF PEDIATRIC NEUROSCIENCES
(2017)
Meeting Abstract
Endocrinology & Metabolism
Wafaa N. Laymoun, Amany El-Hawary, Nanees Salem, Hadil Aboelenin, Nirmeen Megahed, Sherif Abdelaziz
HORMONE RESEARCH IN PAEDIATRICS
(2017)