Article
Engineering, Multidisciplinary
Sherif M. Sharroush, Yasser S. Abdalla
Summary: This paper proposes three ultra-low current sources suitable for biomedical and implantable applications, with currents in the range of nanoamperes. One of the sources utilizes a modified version of the conventional Widlar MOS current source, employing a tunable subthreshold-region operated transistor as a controlled resistance. This current source is suitable for low-voltage and low-power applications. Additionally, two digitally controlled current sources (DCCSs)are proposed, which find wide-ranging applications in digital-to-analog converters, implantable microstimulators, and charge pumps. The three proposed current sources are quantitatively analyzed and verified through simulation using the 45 nm CMOS Predictive Technology Model (PTM) with a power-supply voltage, VDD, equal to 1 V.
AIN SHAMS ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shanshan Guo, Baomin Wang, Daniel Wolf, Axel Lubk, Weixing Xia, Mingkun Wang, Yao Xiao, Junfeng Cui, Dhanapal Pravarthana, Zehua Dou, Karin Leistner, Run-Wei Li, Ruben Huehne, Kornelius Nielsch
Summary: This study successfully achieved hierarchical La0.7Sr0.3MnO3 thin films with well-defined crystallographic orientations, which significantly broadened the temperature range of the magnetic transition and extended the working window of colossal magnetoresistance. The findings suggest a promising approach for altering magnetic transitions and enhancing phase-transition-related effects in functional oxides.
Article
Chemistry, Analytical
Haoming Bao, Kenta Motobayashi, Katsuyoshi Ikeda
Summary: The efficient detection of sulfide ions (S2-), especially in a wide quantitative range, has been achieved using Au@CuO nanoparticles for surface-enhanced Raman spectroscopy (SERS). The detection range spans from 5 ppb to 64,000 ppm, demonstrating the high potential and practicality of this method.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Tim Thielemans, Filip Tavernier
Summary: This article presents dynamic voltage-domain stacking, which combines the efficiency benefits of voltage-domain stacking into a wide-input-range conversion system. By incorporating two novel switched-capacitor converter topologies and an integrated finite-state machine, a highly reconfigurable system is achieved. Experimental results show that the system has excellent average and peak efficiency.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Engineering, Biomedical
Hamed Osouli Tabrizi, Omid Farhanieh, Qiao Owen, Sebastian Magierowski, Ebrahim Ghafar-Zadeh
Summary: This paper presents a new fully integrated CMOS capacitance sensor chip with a wider input dynamic range, high-resolution measurement capability, and fast measurement speed.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2021)
Article
Materials Science, Multidisciplinary
Xia Guo, Yukuan Wang, Fangzhi Mou, Qi Xie, Shu Su, Chuanrui Chen, Jianguo Guan
Summary: This research demonstrates the ability of phototactic micromotor assemblies to manipulate large cargoes in dynamic line formations. By using light and a magnetic field as stimuli, the micromotors can self-organize into groups with emergent behaviors and perform cooperative manipulation of cargoes in various environments.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Engineering, Electrical & Electronic
Pavel Vybornov, Nikolay Filatov
Summary: This paper presents a high-accuracy Ti-Ni bolometer-based uncooled detection system with a wide dynamic range of optical power measurements for optoelectronic devices and nuclear electronics. A high-precision method for measuring the noise equivalent power (NEP), responsivity, thermal time constant, thermal conductance, and temperature coefficient of resistance (TCR) is studied in detail. The paper also describes and tests an adaptive module that provides high-precision voltage measurements for bolometer systems over a wide temperature range. The proposed uncooled bolometer system's performance is evaluated using calculations and measurements of uncooled Ti-Ni bolometers and adaptive module parameters.
IEEE SENSORS JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Qianling Chen, Jing Yang, Bin Chen, Jiansong Feng, Songhua Xiao, Quan Yue, Xu Zhang, Taihong Wang
Summary: In this study, a capacitive pressure sensor with an asymmetric structure was fabricated by stacking a layer of mixed ionic nanofiber membrane and a layer of pure nanofiber membrane. The sensor showed a wide dynamic range, high sensitivity, fast response time, and ultra-low pressure detection limit. It also demonstrated potential applications in the detection of human physiological signals.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemical Research Methods
Yun-Nam Choi, Ye Rim Shin, Jong Moon Park, Jeong Wook Lee
Summary: This study developed a CRISPR/Cas12a-based assay coupled with cyanobacteria cell-free systems for rapid prototyping of promoter characteristics. It demonstrated cyanobacteria cell-free transcription for the first time, confirming a positive correlation between in vitro and in vivo transcription performance. By generating a synthetic promoter library and evaluating promoter subregions, varied promoter strengths derived from random mutations were rapidly and effectively measured in a high-throughput manner. The study offers an easily applicable and rapid prototyping platform for characterizing promoters in cyanobacterial engineering.
ACS SYNTHETIC BIOLOGY
(2021)
Review
Plant Sciences
Jacob Sebesta, Wei Xiong, Michael T. Guarnieri, Jianping Yu
Summary: Genetically engineered algae can convert light and carbon dioxide into industrially and commercially relevant chemicals. However, there is a need to address the potential risks of releasing these engineered algae into the natural environment, and develop effective biocontainment strategies.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Venkata Ramesh Naganaboina, Mariappan Anandkumar, Atul Suresh Deshpande, Shiv Govind Singh
Summary: This article presents a CO2 gas detection method using Y-HEC-based sensors, which exhibit excellent sensing performance at room temperature, including wide-range detection, fast response and recovery times, high repeatability and selectivity, and good long-term stability.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
P. Ratheesh, Priyanka Anbarasu, Pankaj Bhujbal, Lalit Gaikwad, Sahil Saini, Sakshi Dubey, Praveen Kumar Gond, Samruddhi Meshram, A. N. Viswanatha Rao, Devnath Dhirhe
Summary: A novel wide dynamic range of temperature sensors based on a Fiber Bragg Grating (FBG) is developed and demonstrated. The FBG sensor head is reinforced with borosilicate glass wool fiber (BGWF) and enclosed in a 4 mm quartz tube. The BGWF-reinforced FBG sensors exhibit a dynamic temperature range of 1270°C from -170°C to 1100°C. The experimental results indicate that the BGWF-reinforced FBG sensors possess excellent stability, comparable to thermocouples. This paper is expected to lay a foundation for further research and design of new FBG sensors for measuring extreme temperature conditions.
OPTICAL FIBER TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Andres Diaz Lantada, Jan G. Korvink, Monsur Islam
Summary: Engineered living materials (ELMs) are a revolutionary innovation in materials science and engineering, with unique properties such as autonomy, intelligent responses, self-repair, and even self-replication. This study presents the first complete proposal of taxonomy for ELMs, illustrating its applicability and utility in guiding research in this field.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Qiangwei Xu, Shitao Yan, Huafeng Liu, Jinquan Liu, Wenjie Wu, Liangcheng Tu
Summary: This article proposes a metal flexure electromagnetic rebalance accelerometer with both low noise and wide dynamic range for gravity gradient instrumentation. The detailed noise analysis of the proposed accelerometer is conducted to ensure its self-noise can meet the target level. The evaluation and calibration results show that the proposed accelerometer meets the current requirement of high precision applications.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Clemens Muehlenhoff, Christoph Vogler, Wolfgang Raberg, Dieter Suess, Manfred Albrecht
Summary: Magnetoresistive sensors are widely used in low field environments, but Hall sensors dominate high field applications due to their wider linear range. Utilizing a perpendicularly magnetized reference system and in-plane free layer overcomes this disadvantage, allowing for investigation of spin-canting effects in interlayer exchange coupled perpendicular synthetic antiferromagnets (p-SAF).
IEEE SENSORS JOURNAL
(2021)
Article
Multidisciplinary Sciences
Kamonchanock Eungrasamee, Aran Incharoensakdi, Peter Lindblad, Saowarath Jantaro
SCIENTIFIC REPORTS
(2020)
Review
Chemistry, Medicinal
Xiang Gao, Xin Jing, Xufeng Liu, Peter Lindblad
Summary: Scytonemin is a valuable UV-screen and antioxidant molecule primarily biosynthesized in certain cyanobacteria, with its biosynthesis mechanism elucidated in a model cyanobacterium. Metabolic engineering is an important approach for achieving high-efficiency production of scytonemin.
Article
Biotechnology & Applied Microbiology
Claudia Durall, Kateryna Kukil, Jeffrey A. Hawkes, Alessia Albergati, Peter Lindblad, Pia Lindberg
Summary: This study successfully introduced the glyoxylate shunt into Synechocystis PCC 6803 and found that complete expression of the glyoxylate shunt can increase succinate accumulation. Supplementation with succinate dehydrogenase enzyme inhibitor and acetate can further enhance succinate accumulation in the presence of nitrate.
MICROBIAL CELL FACTORIES
(2021)
Article
Plant Sciences
Yagut Allahverdiyeva, Eva-Mari Aro, Bert van Bavel, Carlos Escudero, Christiane Funk, Jarna Heinonen, Lars Herfindal, Peter Lindblad, Sari Makinen, Merja Penttila, Kaarina Sivonen, Matilde Skogen Chauton, Hanne Skomedal, Jorunn Skjermo
Summary: NordAqua is a Nordic Center of Excellence focused on promoting Blue Bioeconomy and reforming the use of natural resources sustainably. Their key research includes improving photosynthesis, developing novel photosynthetic cell factories, promoting diversity of Nordic cyanobacteria and algae, and improving bio-based wastewater purification technologies.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Plant Sciences
Sergey Kosourov, Maximilian Bohm, Moritz Senger, Gustav Berggren, Karin Stensjo, Fikret Mamedov, Peter Lindblad, Yagut Allahverdiyeva
Summary: Photosynthetic production of molecular hydrogen is a potential source of renewable energy, but current efficiency levels are too low for industrial applications due to physiological, biochemical, and engineering barriers. Researchers have some understanding of the metabolic pathways and enzymes involved in H-2 production in cyanobacteria and green algae, and have made progress in engineering photosynthetic cell factories to overcome major obstacles to efficient and sustainable H-2 production.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Plant Sciences
Pauli Kallio, Amit Kugler, Samuli Pyytovaara, Karin Stensjo, Yagut Allahverdiyeva, Xiang Gao, Peter Lindblad, Pia Lindberg
Summary: Ethylene, a volatile hydrocarbon with a massive global market in the plastic industry, is currently produced exclusively from nonrenewable petroleum sources as biotechnological production systems are not yet competitive. Research focuses on developing photoautotrophic bioproduction strategies that enable direct solar-driven conversion of CO2 into ethylene using genetically engineered cyanobacteria expressing heterologous EFE.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Plant Sciences
Konstantinos Vavitsas, Amit Kugler, Alessandro Satta, Dimitris G. Hatzinikolaou, Peter Lindblad, David P. Fewer, Pia Lindberg, Mervi Toivari, Karin Stensjo
Summary: The use of photosynthetic microbes in synthetic biology for sustainable production has garnered increasing attention. While there have been advancements in research and resources for microalgae, genetic engineering tools for these organisms still lag behind. The review provides an overview of commonly used photosynthetic microbes, outlines techniques and tools available, and emphasizes the importance of CRISPR technology in advancing the field.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Multidisciplinary Sciences
Hsin-Ho Huang, Massimo Bellato, Yili Qian, Pablo Cardenas, Lorenzo Pasotti, Paolo Magni, Domitilla Del Vecchio
Summary: CRISPRi allows for the simultaneous control of many genes, however the sgRNAs compete for binding to dCas9. Here the authors design a dCas9 concentration regulator to allow independent regulation of multiple genes.
NATURE COMMUNICATIONS
(2021)
Review
Biochemical Research Methods
Xufeng Liu, Hao Xie, Stamatina Roussou, Peter Lindblad
Summary: This review summarizes the recent progress in engineering cyanobacteria and discusses the achieved and potential utilization of these advancements for the production of the bulk chemical butanol, specifically isobutanol and 1-butanol.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kamonchanock Eungrasamee, Aran Incharoensakdi, Peter Lindblad, Saowarath Jantaro
Summary: Engineering engineered cyanobacteria for increased production of free fatty acids, the KAOL strain achieved the highest level of FFAs secretion with morphological changes compared to the wild type, showing promising potential for sustainable growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Hao Xie, Peter Lindblad
Summary: This study successfully expressed heterologous genes and synthesized isobutanol in cyanobacteria cells. By optimizing gene copy numbers and region composition, isobutanol production was significantly increased. This research provides a foundation for further investigation of continuous photosynthetic isobutanol production from solar energy and carbon dioxide.
MICROBIAL CELL FACTORIES
(2022)
Review
Green & Sustainable Science & Technology
Balasubramani Ramprakash, Peter Lindblad, Julian J. Eaton-Rye, Aran Incharoensakdi
Summary: This review focuses on the production of hydrogen by biological methods, highlighting various fermentation processes, the role of enzymes, and different pretreatment methods. It identifies lignocellulosic waste and dynamic membrane bioreactor as the best choices for biomass and bioreactor in biohydrogen production, and emphasizes the importance of developing hybrid fermentation technologies and novel engineered strains for commercial-scale production in the future.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Maturin Natesungnoen, Varisa Pongrakhananon, Peter Lindblad, Saowarath Jantaro
Summary: In this study, five strains of Synechocystis sp. PCC 6803 overexpressing native genes related to the carotenoid biosynthetic pathway were successfully constructed, leading to increased carotenoid production and antioxidant activity. Specifically, OX_CrtR and OX_CrtQ strains showed promising effects in treating lung cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Anup Rana, Leandro Cid Gomes, Joao S. Rodrigues, Dalia M. M. Yacout, Hugo Arrou-Vignod, Johan Sjolander, Nathalie Proos Vedin, Ouissam El Bakouri, Karin Stensjo, Peter Lindblad, Leena Andersson, Cecilia Sundberg, Mathias Berglund, Pia Lindberg, Henrik Ottosson
Summary: This study explores the direct production of bio-isoprene from carbon dioxide using engineered photosynthetic cyanobacteria. The researchers successfully converted isoprene into limonene and other hydrocarbons through photochemical processes. The resulting isoprene dimers can be used as drop-in jet fuels that meet the criteria for energy density, flashpoint, viscosity, density, and freezing point. Life-cycle assessment indicates the potential for environmentally sustainable fuel production.
Article
Biotechnology & Applied Microbiology
Stamatina Roussou, Alessia Albergati, Feiyan Liang, Peter Lindblad
Summary: The study demonstrated that overexpression of two selected CBB enzymes significantly increased ethanol production in cyanobacteria, especially the co-overexpression of FBA and TK showing the most pronounced effect.
METABOLIC ENGINEERING COMMUNICATIONS
(2021)
