Article
Reproductive Biology
Susan McCoard, Neville Haack, Axel Heiser, Paul Maclean
Summary: This study found that gene expression in the placenta of sheep differs between single and twin pregnancies, as well as between different types of placentome morphology. These differences may affect fetal growth and development. The findings highlight the importance of birth rank and placentome morphology in influencing placental function, and provide insights into gene pathways for potential improvements in placental efficiency in twin pregnancies.
Article
Biochemistry & Molecular Biology
Weicheng Zhao, Fan Liu, Christina D. Marth, Mark P. Green, Hieu H. Le, Brian J. Leury, Alan W. Bell, Frank R. Dunshea, Jeremy J. Cottrell
Summary: Maternal heat stress during early to mid-gestation in pigs leads to differential gene expression in the placenta, affecting placental efficiency and nutrient transport capacity. This study indicates that altered expression of genes associated with placental metabolism and transport may contribute to heat stress-induced placental inefficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Annelieke Overbeeke, Bela Hausmann, Georgi Nikolov, Fatima C. Pereira, Craig W. Herbold, David Berry
Summary: The study found that not all gut bacteria capable of degrading chondroitin sulfate could also degrade hyaluronan, despite having lyases that act on both compounds. In the model organism Bacteroides, a lyase along with surface binding proteins may be involved in hyaluronan breakdown, and degradation of these compounds provides public goods for other bacteria. Cooperative degradation and cross-feeding may be widespread in mucosal glycan utilization.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Na Zhu, Xiaotong Ji, Xilin Geng, Huifeng Yue, Guangke Li, Nan Sang
Summary: The study found that maternal exposure to fine particulate matters during pregnancy disrupted cell proliferation and impaired nutrient transport in the placenta, with significant changes observed at E18.5. This included altered mRNA expression of nutrient transporters and changes in glycogen and triglyceride content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Amit Paporisch, Harel Bavli, Rachel J. Strickman, Rebecca B. Neumann, Nimrod Schwartz
Summary: Root exudates alter the physical properties of the rhizosphere, affecting solute transport in soil. Increased exudate concentrations lead to non-equilibrium solute transport, with more pronounced effects observed in coarser textured soil. Additionally, under unsaturated conditions, the presence of exudates results in altered solute breakthrough behavior.
WATER RESOURCES RESEARCH
(2021)
Article
Developmental Biology
Ryan C. V. Lintao, Ananth Kumar Kammala, Natasha Vora, Jerome L. Yaklic, Ramkumar Menon
Summary: This study found that nutrient transporter genes and proteins are expressed in human fetal membrane tissues and cells, with similar expression patterns to placental tissues and BeWo cells. These findings contribute to our understanding of nutrient uptake kinetics during pregnancy.
Article
Agriculture, Multidisciplinary
Lu-Min Gao, Tian-Tian Zhou, Zhong-Pin Chen, Teketay Wassie, Biao Li, Xin Wu, Yu-Long Yin
Summary: Maternal dietary supplementation with yeast-based nucleotide (YN) during late pregnancy improves reproductive performance of sows by regulating placental nutrient transport and affecting liver metabolism in neonatal piglets, leading to decreased stillbirth rate and intra-uterine growth restriction rate, as well as alterations in serum and liver profiles.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Orthopedics
Joanna L. James, Anandita Umapathy, Sonia Srinivasan, Claire N. Barker, Anna Brooks, James Hearn, Ashika Chhana, Eloise Williams, Hilary Sheppard, Sue R. McGlashan
Summary: The study found differences in chondrogenesis potential between first-trimester and term placental MSCs, with term MSCs showing significantly higher GAG content compared to BM-MSCs. Only first-trimester MSCs demonstrated significant changes in chondrogenic gene expression during induction compared to undifferentiated MSCs.
Article
Endocrinology & Metabolism
Hannah M. Kyllo, Dong Wang, Ramon A. Lorca, Colleen G. Julian, Lorna G. Moore, Randall B. Wilkening, Paul J. Rozance, Laura D. Brown, Stephanie R. Wesolowski
Summary: Glucose, lactate, and amino acids are major fetal nutrients. Placental insufficiency-induced intrauterine growth restriction (PI-IUGR) leads to decreased fetal glucose and amino acid supply and increased fetal lactate concentrations. The study suggests that the placenta adapts to PI-IUGR by altering nutrient allocation to maintain oxidative metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Rinaldo Rodrigues dos Passos Junior, Raiany Alves de Freitas, Vanessa Dela Justina, Sebastian San Martin, Victor Vitorino Lima, Fernanda Regina Giachini
Summary: This study found that insufficient protein O-GlcNAcylation caused by decreased placental nutritional apport contributes to placental dysfunction during hypertensive pregnancy, impairing fetal growth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Claire Stenhouse, Katherine M. Halloran, Makenzie G. Newton, Dana Gaddy, Larry J. Suva, Fuller W. Bazer
Summary: Components of Klotho-FGF signaling and sodium-dependent phosphate transporters are present at the ovine conceptus-maternal interface, suggesting a potential role in phosphate transport throughout gestation.
BIOLOGY OF REPRODUCTION
(2021)
Editorial Material
Biochemistry & Molecular Biology
Emily Lewkowicz, Shobini Jayaraman, Olga Gursky
Summary: Recent high-resolution structural studies have revealed parallel in-register cross-beta-sheets with periodic arrays of closely spaced identical residues in protein amyloids, shedding light on the mechanisms of common amyloid-promoting factors.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Article
Cell Biology
Kenton P. Arkill
Summary: The endothelial glycocalyx is considered the primary macromolecular filter for fluid flux out of the vasculature, but structural evidence is limited. A new interpretation suggests that the 19.5 nm spacing measured could be the proteoglycan core protein, and that syndecans are predominantly dimerized, consistent with experimental measurements. Additionally, altering the core protein lattice from hexagonal to square packing significantly changes permeability, potentially facilitated by mechanisms such as transient actin binding.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mukund Gupta, Richard G. Williams, Jonathan M. Lauderdale, Oliver Jahn, Christopher Hill, Stephanie Dutkiewicz, Michael J. Follows
Summary: The expansive gyres of the subtropical ocean play a significant role in global organic carbon export. This study examines the nutrient pathways that replenish the subeuphotic layers in the gyre interior. Using a simulation model, the researchers find that mesoscale eddies flux nutrients from the shallow flanks of the gyre into the recirculating interior, contributing to the replenishment of subeuphotic layers along density surfaces. This nutrient relay sustains the productivity of the subtropical gyre.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud
Summary: Depression is common during pregnancy and many women are prescribed antidepressants. These drugs may disrupt serotonin homeostasis in the placenta or fetus, potentially leading to adverse effects of antidepressant use during pregnancy.
Article
Reproductive Biology
Ashley F. George, Teh-Yuan Ho, Nripesh Prasad, Brittney N. Keel, Jeremy R. Miles, Jeffrey L. Vallet, Frank F. Bartol, Carol A. Bagnell
BIOLOGY OF REPRODUCTION
(2019)
Article
Agriculture, Dairy & Animal Science
Sarah C. Tenley, Renata Spuri Gomes, Shelby L. Rosasco, Emmalee J. Northrop, Jerica J. J. Rich, Anthony K. McNeel, Adam F. Summers, Jeremy R. Miles, Chadwick C. Chase, Clay A. Lents, George A. Perry, Jennifer R. Wood, Andrea S. Cupp, Robert A. Cushman
ANIMAL REPRODUCTION SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Lea A. Rempel, Megan M. Krautkramer, John J. Parrish, Jeremy R. Miles
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2019)
Article
Agriculture, Dairy & Animal Science
Robert A. Cushman, Emerson M. Soares, Hannah K. Yake, Allyson L. Patterson, Shelby L. Rosasco, Joslyn K. Beard, Emmalee J. Northrop, Jerica J. J. Rich, Jeremy R. Miles, Chadwick C. Chase, Michael G. Gonda, George A. Perry, Anthony K. McNeel, Adam F. Summers
ANIMAL REPRODUCTION SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Sophie C. Walsh, Jeremy R. Miles, Linxing Yao, Corey D. Broeckling, Lea A. Rempel, Elane C. Wright-Johnson, Angela K. Pannier
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2020)
Article
Agriculture, Dairy & Animal Science
Thomas W. Murphy, John W. Keele, Brad A. Freking
JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Genetics & Heredity
Lea A. Rempel, John J. Parrish, Jeremy R. Miles
FRONTIERS IN GENETICS
(2020)
Article
Agriculture, Dairy & Animal Science
Jeremy R. Miles, Jeffrey L. Vallet
Summary: This study aimed to evaluate placental development during late gestation in Chinese Meishan (CM) and White crossbred (WC) gilts following intrauterine crowding. The results showed that there were differences in areolae density and folded bilayer width between CM and WC gilts, indicating altered placental development in CM compared to WC gilts.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Thomas W. Murphy, Brad A. Freking
Summary: The study aimed to evaluate different sheep breeds' ability to complement Romanov germplasm in an annual lambing system. Results showed that incorporating Romanov into a crossbreeding system can improve out-of-season ewe productivity. Factors like ewe body weight and litter size were not affected by maternal grandsire breed, but birth weight of lambs and ewe weight were influenced by maternal grandsire breed.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Brad A. Freking, Tom W. Murphy
Summary: This study evaluated the effects of different breeds of wool and hair sheep on lamb growth, survival, and ewe productivity traits when crossed with Romanov sheep in two distinct production systems. The results showed that the breed of the sire had minimal impact on the first-generation crossbred lambs. In the intensive production system, lambs had higher weight and survival rates, while in the extensive production system, ewes needed to have strong rearing abilities for the lambs.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Thomas W. Murphy, Carol G. Chitko-McKown, Mike P. Heaton, Brad A. Freking
Summary: The TMEM154 gene's K35 haplotype is associated with reduced susceptibility to OPPV infection, leading to lower infection rates and higher productivity in sheep.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Brad A. A. Freking, Tom W. W. Murphy, Carol G. G. Chitko-McKown, Aspen M. M. Workman, Michael P. P. Heaton
Summary: This study compared the effects of four different TMEM154 haplotypes on ovine virus infection and ewe productivity. The study found that ewes with haplotypes 2 and 3 were more susceptible to infection, while haplotype 1 was dominant. There was no significant difference in the effect on infection between haplotypes 1 and 4. Additionally, haplotypes with two K35 amino acid substitutions were as effective as those with a frame-shift deletion mutation in reducing infection susceptibility. There was no significant difference in ewe reproductive performance between different haplotypes. The study suggests that increasing the frequency of TMEM154 haplotype K35 is recommended for producers interested in reducing their flock's genetic predisposition to ovine lentivirus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Tom W. Murphy, Brad A. Freking, Gary L. Bennett
Summary: The study compares the productivity of Composite-IV, Katahdin, and Polypay ewes in a lower-input system. The results show that the Composite-IV ewes had the highest number and weight of lambs marketed per ewe. All three breeds had better reproductive performance than the U.S. average. This highlights the importance of applying genetic tools to optimize sheep performance in specific production systems.
JOURNAL OF ANIMAL SCIENCE
(2023)
Meeting Abstract
Agriculture, Dairy & Animal Science
Madison T. Henniger, Lea A. Rempel, William T. Oliver, Jeremy R. Miles, Amanda Lindholm-Perry, Phillip R. Myer
JOURNAL OF ANIMAL SCIENCE
(2021)
Meeting Abstract
Agriculture, Dairy & Animal Science
Robert Cushman, Renata Spuri-Gomes, Sarah Tenley, Shelby Rosasco, Jerica Rich, Emmalee Northrop, Jeremy Miles, Amanda Lindhom-Perry, Brittney Keel, George Perry, Adam Summers, Andrea Cupp
JOURNAL OF ANIMAL SCIENCE
(2020)