Article
Cell Biology
Guang Wang, Tong-Xin Yang, Jiong-Ming Li, Zi-Ye Huang, Wen-Bo Yang, Pei Li, Da-Lin He
Summary: This study identifies BTK as a critical gene in IC/BPS and suggests its potential as a therapeutic target. Functional enrichment analysis indicates the involvement of innate immunity. Experimental results demonstrate increased mast cells in IC/BPS and the inhibitory effect of BTK knockdown on mast cell functions. These findings provide new insights into the molecular mechanisms of IC/BPS and offer potential avenues for treatment development.
Article
Immunology
Mostafa Jarahian, Katharina Marstaller, Nadine Banna, Roshanak Ahani, Mohammad Hossein Etemadzadeh, Lea K. Boller, Kayhan Azadmanesh, Angel Cid-Arregui, Abdolrahman Khezri, Martin R. Berger, Frank Momburg, Carsten Watzl
Summary: The extensively glycosylated Ebolavirus glycoprotein (EBOV-GP) induces physical alterations of surface molecules and plays a crucial role in viral pathogenicity. The interactions between EBOV-GP and host surface molecules reveal the involvement of NK cell receptors, selectins, DC-SIGNR/DC-SIGN, and inhibitory Siglecs, which result in a reduced NK cell-mediated lysis of EBOV-GP-expressing cells. These findings suggest potential new strategies for treating infections caused by EBOV.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Physiology
Zhinoos Taidi, Kylie J. Mansfield, Hafiz Sana-Ur-Rehman, Kate H. Moore, Lu Liu
Summary: This study investigated the role of P2X7R in acrolein-induced inflammatory damage in primary cultured porcine bladder urothelial cells. The results showed that blocking P2X7R can alleviate the damage to bladder urothelial cells and reduce the decrease in barrier function caused by acrolein, suggesting that P2X7R blockade may be a possible therapy for bladder cystitis caused by cyclophosphamide treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Jung Hyun Shin, Bosik Kang, Myung-Soo Choo
Summary: The study found that the features of HLs in IC patients were not associated with subjective symptoms, but inflammatory changes in HLs were a predictive factor for IC recurrence and associated with frequent urgency episodes and smaller bladder capacity.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Kaining Lu, Shan Wei, Zhengyi Wang, Kerong Wu, Junhui Jiang, Zejun Yan, Yue Cheng
Summary: The study identified elevated expression of Tfh cells and CD3(+) CD4(+) HLA-DR+ cells in HIC for the first time, suggesting their potential as novel diagnostic biomarkers. Six types of immune cells in HIC showed significant differences, and Gene Set Enrichment Analysis revealed altered biological processes related to autoimmune diseases and infections.
Article
Pharmacology & Pharmacy
Zhinoos Taidi, Tommy Zhou, Kate H. Moore, Kylie J. Mansfield, Lu Liu
Summary: Inflammatory conditions of the urinary bladder are associated with urothelial damage and loss of function. The purinergic P2X7 receptor plays a role in such inflammatory conditions and may be a new therapeutic target for bladder inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liao Peng, Xi Jin, Bo-ya Li, Xiao Zeng, Bang-hua Liao, Tao Jin, Jia-wei Chen, Xiao-shuai Gao, Wei Wang, Qing He, Guo Chen, Li-na Gong, Hong Shen, Kun-jie Wang, Hong Li, De-yi Luo
Summary: Interstitial cystitis is a debilitating chronic disorder with unclear etiology and pathophysiology. Immune cells in the bladders of IC patients undergo significant changes, including increased immune cell populations and a virus-related response.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Immunology
Charlotte Castenmiller, Brigitte-Carole Keumatio-Doungtsop, Ronald van Ree, Esther C. de Jong, Yvette van Kooyk
Summary: Dendritic cells play key roles in regulating immune responses by inducing either inflammatory or tolerogenic reactions. Research interest is growing in defining tolerance-inducing receptors on DCs for developing new immunotherapeutic strategies. Targeting strategies such as antigen-carbohydrate conjugates and antibody-antigen fusion proteins aim to induce a tolerogenic DC phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Pedro Abreu-Mendes, Aurora Costa, Ana Charrua, Rui Almeida Pinto, Francisco Cruz
Summary: There is a trend towards a significant association between increased VEGF levels and pain or symptom severity in BPS/IC patients. Although there are some discrepancies among the studies and the number of patients included is small, VEGF and its receptors should be considered for future studies regarding its use in BPS/IC pathophysiology, diagnosis, and prognostication.
Article
Multidisciplinary Sciences
Jung Hyun Shin, Chae-Min Ryu, Hwan Yeul Yu, Yang Soon Park, Dong-Myung Shin, Myung-Soo Choo
Summary: This study investigated the therapeutic effects of axitinib, a tyrosine kinase inhibitor, in an interstitial cystitis (IC) rat model. The results showed that axitinib improved pain, bladder function, and urothelial integrity in the IC rat model, suggesting its potential therapeutic efficacy in IC patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Robert M. Moldwin, Vishaan Nursey, Oksana Yaskiv, Siddhartha Dalvi, Eric J. Macdonald, Michael Funaro, Chengliang Zhang, William DeGouveia, Marina Ruzimovsky, Horacio R. Rilo, Edmund J. Miller, Souhel Najjar, Inna Tabansky, Joel N. H. Stern
Summary: Interstitial cystitis/bladder pain syndrome patients with Hunner lesions (HL) show local inflammatory events and increased levels of immune cells. Urinary levels of different cytokines are also elevated in HL patients, indicating different disease processes compared to patients without HL.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yuan-Ju Lee, Shang-Jen Chang, Hsiu-Ying Lin, En Meng, Jeff S. Chueh, Chi-Shin Tseng
Summary: This follow-up study assessed the long-term effects of pentosan polysulfate sodium (PPS) monotherapy on recurrent urinary tract infections (UTIs). The study found that PPS significantly reduced the recurrence of UTIs and improved the quality of life for women with recurrent UTI during the 2-year follow-up period.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Barbora Salcman, Karen Affleck, Silvia Bulfone-Paus
Summary: Localisation of mast cells at the abluminal side of blood vessels in the brain promotes their interaction with other brain cells, leading to the release of inflammatory mediators. Furthermore, activation of P2X receptors in mast cells and glial cells plays a crucial role in regulating neuroinflammation.
Article
Medicine, Research & Experimental
Yuancheng Xu, Fei Yang, Juncong Xie, Wenbiao Li, Bolong Liu, Jialiang Chen, Honglu Ding, Jiarong Cai
Summary: This study found that UC-MSCs showed potential therapeutic effects in treating IC by inhibiting mast cell degranulation. UC-MSCs could be a potential therapeutic target for alleviating inflammation in IC.
MEDICAL SCIENCE MONITOR
(2021)
Article
Biochemistry & Molecular Biology
Saleha Anwar, Taj Mohammad, Md. Khabeer Azhar, Hera Fatima, Afsar Alam, Gulam Mustafa Hasan, Asimul Islam, Punit Kaur, Md. Imtaiyaz Hassan
Summary: MARK4 is a kinase known for phosphorylating tau protein and causing Alzheimer's disease. Bacopa monnieri extracts have neuroprotective roles and have been used to treat neurological disorders. Bacopaside II shows strong binding affinity for MARK4 and inhibits its kinase activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
