Article
Oncology
Ann H. Rosendahl, Sofie Bjorner, Maria Ygland Rodstrom, Karin Jirstrom, Signe Borgquist, Christian Ingvar, Michael N. Pollak, Helena Jernstrom
Summary: The study found that circulating levels of IGF-I and IGFBP-3 in breast cancer patients are significantly associated with recurrence-risk, while the correlation with IGFBP-7 levels is weaker. There is a significant interaction between IGFBP-7 levels and recurrence-risk in patients with IGF-IRm positivity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Jennifer M. Mongiovi, Jo L. Freudenheim, Kirsten B. Moysich, Susan E. McCann
Summary: This study found an association between higher glycemic index and glycemic load with a lower risk of ovarian cancer, but caution should be taken in interpreting the results as they may have been influenced by limitations such as lack of variability in dietary intake. Additional studies are needed to better understand the driving factors behind these associations.
JOURNAL OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Oncology
Qian Wang, Meng Ru, Yaning Zhang, Tamara Kurbanova, Paolo Boffetta
Summary: The study suggests that higher dietary intake of phytoestrogens may reduce the risk of lung cancer in a Caucasian-dominant population, particularly among smokers, non-small cell histology, males, and females, with no significant linear trend observed. Further research is needed to confirm these findings and investigate the mechanisms of action and interactions with smoking and endogenous estrogens.
Article
Oncology
Santino S. Butler, Brandon A. Mahal, Javid J. Moslehi, Anju Nohria, Edward C. Dee, Rishi Makkar, Amanda Whitbeck, Janet Wangoe, Kent W. Mouw, Paul L. Nguyen, Vinayak Muralidhar
Summary: This study found that the use of ADT plus RT, compared with RT alone, does not increase the risk of cardiovascular mortality in men with radiation-managed prostate cancer, even among those with preexisting comorbidities and cardiovascular disease.
Article
Endocrinology & Metabolism
Anne Mette Frobert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Frobert, Cheryl A. Conover, Michael T. Overgaard
Summary: Brown bears shift from circulating ternary IGF/IGFBP/ALS complexes in the active state to binary IGF/IGFBP complexes during hibernation, indicating increased tissue IGF-bioactivity. Furthermore, brown bears use a splice variant of IGF-2, suggesting increased bone-specific targeting of IGF anabolic signaling.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Oncology
Susan R. Sturgeon, David A. Sela, Eva P. Browne, Jonah Einson, Asha Rani, Mohamed Halabi, Thomas Kania, Andrew Keezer, Raji Balasubramanian, Regina G. Ziegler, Catherine Schairer, Karl T. Kelsey, Kathleen F. Arcaro
Summary: Analysis of WBC DNA methylation in breast cancer cases and noncases revealed potential associations with breast cancer risk, although the specific patterns were not conclusively identified. Further research is needed to better understand the link between prediagnostic WBC DNA methylation marks and breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Endocrinology & Metabolism
Vita Birzniece, Teresa Lam, Mark McLean, Navneeta Reddy, Haleh Shahidipour, Amy Hayden, Howard Gurney, Glenn Stone, Rikke Hjortebjerg, Jan Frystyk
Summary: This study investigates the effects of metformin on the circulating insulin-like growth factor system in prostate cancer patients undergoing androgen deprivation therapy. The results show that metformin improves insulin sensitivity, reduces circulating IGF-2 and IGFBP-3 levels, and increases IGF bioactivity. Additionally, metformin administration leads to a decrease in STC2 levels. These findings suggest that the modulation of the IGF system and STC2 may contribute to the potential anti-cancer effects of metformin.
ENDOCRINE CONNECTIONS
(2022)
Review
Biochemistry & Molecular Biology
Aldona Kasprzak
Summary: Colorectal cancer is a common aggressive carcinoma with poor prognosis, often associated with metabolic syndrome and high blood sugar levels. The role of IGF-1 in glucose metabolism in colorectal carcinogenesis and its potential link to the Warburg effect require further investigation. Current therapeutic strategies targeting impaired glucose metabolism in CRC are being explored to improve treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Wei Wang, Kang Yu, Shou-Yong Zhao, De-Gang Mo, Jia-Hui Liu, Li-Jinn Han, Tai Li, Heng-Chen Yao
Summary: This study aimed to evaluate the relationship between levels of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 2 (IGFBP-2) at admission and the risk of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS). In patients with acute myocardial infarction, IGF-1 levels were lower and IGFBP-2 levels were higher compared to healthy controls. Follow-up results showed that low levels of IGFBP-2 were associated with a decreased incidence of MACEs. Multivariable Cox regression analysis revealed that IGFBP-2, but not IGF-1, was a positive predictor of MACEs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Christos Charalambous, James C. Moon, Jeff M. P. Holly, Nishi Chaturvedi, Alun D. Hughes, Gabriella Captur
Summary: The study found that decreasing levels and bioavailability of IGF-I are associated with prolongation of the QTc interval in older individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Vicky C. C. Chang, Jongeun Rhee, Sonja I. I. Berndt, Steven C. C. Moore, Neal D. D. Freedman, Rena R. R. Jones, Debra T. T. Silverman, Gretchen L. L. Gierach, Jonathan N. N. Hofmann, Mark P. P. Purdue
Summary: In this nested case-control study, prediagnostic serum levels of PFOS and PFOA were found to be associated with breast cancer risk, particularly for hormone receptor-positive tumors, providing evidence of a possible positive association.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Cody Z. Watling, Rebecca K. Kelly, Yashvee Dunneram, Anika Knuppel, Carmen Piernas, Julie A. Schmidt, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago
Summary: This study found that there were inverse associations between intake of total dairy protein, protein from milk, and dietary calcium and the incidence of colorectal cancer. However, positive associations were observed between milk protein, dietary calcium, and prostate cancer risk. No significant associations were found between dairy protein intake and breast cancer risk.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Kenechukwu Chudy-Onwugaje, Wen-Yi Huang, L. Joseph Su, Mark P. Purdue, Christine C. Johnson, Lingxiao Wang, Hormuzd A. Katki, Kathryn Hughes Barry, Sonja I. Berndt
Summary: In this study, a beneficial role for both aspirin and ibuprofen in preventing advanced adenoma and curbing progression to recurrence and cancer among older adults was observed during long-term follow-up.
Article
Cardiac & Cardiovascular Systems
Wei Wang, Ying Sun, De-Gang Mo, Tai Li, Heng-Chen Yao
Summary: The study found that levels of IGF-1 and IGFBP-2 are associated with risk stratification in ACS patients and can be used as predictive biomarkers. IGF-1 is negatively correlated with TIMI risk levels, while IGFBP-2 is positively correlated with TIMI risk levels.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
