Article
Biochemistry & Molecular Biology
Yi-Ming Zhang, Li-Ying Zhang, Yang-Yang Li, Heng Zhou, Zhi-Ming Miao, Zhi-Wei Liu, Gu-Cheng Zhou, Ting Zhou, Fan Niu, Jing Li, Tao Hong, Jin-Peng He, Nan Ding, Ya-Nan Zhang, Jun-Rui Hua, Ju-Fang Wang, Yong-Qi Liu
Summary: This study aims to explore the similarities and differences in the mechanism of genomic damage in tumor-associated BMSCs induced by short-term and long-term RIBE, and to provide a theoretical basis for adjuvant drugs for protection against RIBE at different clinical time periods. The results showed that both short- and long-term RIBE induced genomic instability, and this instability was associated with the activation of the HIF-1 alpha pathway mediated by TNF-alpha and TGF-beta 1. Additionally, there were differences in BMSC recruitment and genomic instability in different tissues.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Rosette N. Tamaddondoust, Alicia Wong, Megha Chandrashekhar, Edouard I. Azzam, Tommy Alain, Yi Wang
Summary: The biological impact of ionizing radiation on humans depends on both the physical properties and absorbed dose of radiation, as well as the unique susceptibility of the exposed individual. DNA is a critical target of radiation, and the damage response is important for maintaining genomic integrity. Unrepaired DNA lesions can lead to mutations and adverse health effects. Cellular sensitivity to radiation is correlated with the ability to repair DNA lesions, and recent studies have used whole-genome analysis to identify genes that impact individual sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Sharmi Mukherjee, Anindita Dutta, Anindita Chakraborty
Summary: Redox homeostasis is essential for normal physiological and metabolic functions. Radiotherapy disrupts this balance and induces genomic instability in diseased cells, affecting both targeted and non-targeted cells. The use of external modulators with radiation can enhance the therapeutic efficiency.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Review
Oncology
Haoyi Tang, Luwei Cai, Xiangyang He, Zihe Niu, Haitong Huang, Wentao Hu, Huahui Bian, Hao Huang
Summary: For many years, targeted DNA damage caused by radiation has been considered the main cause of various biological effects. However, there is increasing evidence that the linear-non-threshold model is not fully applicable to the biological effects caused by low dose radiation and requires further investigation. Additionally, non-targeted effects, such as bystander effects, genetic instability, etc., are significant effects related to low dose radiation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chuanlai Yang, Yuegang Ge, Yachen Zang, Ming Xu, Lu Jin, Yang Wang, Xinyu Xu, Boxin Xue, Zhiwei Wang, Lixia Wang
Summary: Currently, radiotherapy is a popular treatment for prostate cancer patients, but radioresistance is still a challenge. CDC20 has been shown to play a crucial role in various tumors, including prostate cancer. Higher expression of CDC20 was observed in prostate cancer tissues and cells. Knockdown of CDC20 inhibited cell proliferation, migration, tumor formation, induced cell apoptosis, and increased radiosensitivity in prostate cancer both in vitro and in vivo. CDC20 was found to regulate the Twist1 pathway, influencing cell proliferation and migration. Targeting CDC20 and Twist1 may be an effective approach to improve the radiosensitivity of prostate cancer.
Review
Biology
Ziqi Zhang, Kui Li, Mei Hong
Summary: Microbeams are useful tools for studying non-target effects and responses to cytoplasmic irradiation. This article summarizes the observations and mechanisms involved in bystander effects and cytoplasmic irradiation-related effects using different types of microbeam irradiators. These non-target effects may contribute to the biological consequences of ionizing radiation exposure, and understanding them can help better evaluate the damage caused by irradiation.
Review
Biochemistry & Molecular Biology
Nina Petrovic, Tatjana P. Stanojkovic, Marina Nikitovic
Summary: This review summarizes the miRNAs involved in the response to radiation therapy in prostate cancer (PCa) and highlights potential candidates for predicting radiation response. Let-7, miR-21, miR-34a, miR-146a, miR-155, and members of miR-17/92 cluster are identified as promising candidates for predicting radiosensitivity of PCa patients undergoing radiation treatment.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Juliette Restier-Verlet, Aurelie Joubert, Melanie L. Ferlazzo, Adeline Granzotto, Laurene Sonzogni, Joelle Al-Choboq, Laura El Nachef, Eymeric Le Reun, Michel Bourguignon, Nicolas Foray
Summary: Radiation-induced bystander effects (RIBE) refer to biological events occurring in non-targeted cells. It has been found that medium transfer-induced RIBE can result in DNA double-strand breaks, while micro-irradiation-induced RIBE shows the same temporal occurrence. The effects of RIBE on surrounding tissues can be beneficial or deleterious depending on their radiosensitivity and ability to release Ca2+ ions.
Article
Biochemistry & Molecular Biology
Mateusz Smolarz, Lukasz Skoczylas, Marta Gawin, Monika Krzyzowska, Monika Pietrowska, Piotr Widlak
Summary: Exosomes released by irradiated cells mediate the radiation-induced bystander effect, resulting in DNA breaks and replication stress in recipient cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ryan S. Alden, Mohammad Zahid Kamran, Bassel A. Bashjawish, Brittany A. Simone
Summary: Mounting evidence suggests that cancer cell metabolism plays a critical role in cancer treatment. Combining metabolism-based therapeutics with radiation therapy can overcome radioresistance. This mini-review discusses the role of glutamine metabolism in cancer growth and progression and provides data showing that inhibiting glutamine utilization can enhance radiosensitization in preclinical models. Further research is needed to determine the feasibility of combining glutamine antagonism with radiotherapy in clinical settings.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Feng Qin, Guodong Chen, Kwan Ngok Yu, Miaomiao Yang, Wei Cao, Peizhong Kong, Shengjie Peng, Mingyu Sun, Lili Nie, Wei Han
Summary: In this study, Golgi protein GOLPH3 was found to play a crucial role in the transduction of RIBE. Knocking down GOLPH3 blocked RIBE generation, while re-expression of GOLPH3 rescued the effect. The GOLPH3/ERK/EGR1 signaling axis was identified as the mechanism that regulates the transcription of TNF-alpha and determines its release level.
Article
Physics, Multidisciplinary
M. Paluch-Ferszt, U. Kazmierczak, Z. Szeflinski
Summary: This study reviews literature on radiation-induced bystander effect research, discussing in vitro experiments with various cell lines or tumor cells. The influence of nanomaterials on the radiation-induced bystander effect is analyzed, while the relationship with radiation-induced senescence, inflammatory pathways, and endothelial cells is also explored. The authors aim to explore multiple mechanisms accompanying the radiation-induced bystander effect.
ACTA PHYSICA POLONICA A
(2021)
Article
Astronomy & Astrophysics
Walter Tinganelli, Francesca Luoni, Marco Durante
Summary: Protection from cosmic radiation is crucial for the safety of long-term space missions aiming at colonizing the moon and Mars. The small size of the astronaut group makes it difficult to quantify the risk, but the experience from cancer patients treated with similar radiation could provide valuable insights. Despite the complexity, researchers should strengthen the relationship between space radiation protection and particle therapy research to exchange methods and data.
LIFE SCIENCES IN SPACE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Amparo Olivares, Miguel Alcaraz-Saura, Daniel Gyingiri Achel, Juan de Dios Berna-Mestre, Miguel Alcaraz
Summary: The research investigated the modulation effect of rosmarinic acid on radiation-induced effects and found that it could reduce micronuclei frequency and increase cell survival rate, showing a certain radioprotective capacity.
Article
Oncology
Akira Fujimori, Hirokazu Hirakawa, Cuihua Liu, Taishin Akiyama, Bevin P. Engelward, Jac A. Nickoloff, Masao Suzuki, Bing Wang, Mitsuru Nenoi, Sei Sai
Summary: This study aimed to investigate the role of homologous recombination (HR)-related genomic instability in ionizing radiation-induced thymic lymphoma in mice. The results showed that ionizing radiation induced genome instability, leading to the development of thymic lymphoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)