Review
Medicine, General & Internal
Michel M. Ouellette, Sumin Zhou, Ying Yan
Summary: Radiation therapy is a common treatment for solid tumors, but radioresistance limits its effectiveness in many cancer patients. Radiation eradicates cancer cells by causing DNA damage, but it also activates multiple prosurvival signaling pathways that protect cancer cells. Targeting these pathways may improve the sensitivity of cancer cells to radiation.
Article
Genetics & Heredity
Delisa E. Clay, Donald T. Fox
Summary: Genome damage is a common threat to all organisms, and DNA damage responses (DDRs) play a crucial role in initiating cell cycle arrest, repair, and cell death. While many DDR components are conserved across different organisms, there are also adaptations to specific needs. Research on model genetic organisms has greatly advanced our understanding of DDR mechanisms and how they are influenced by the cell cycle stage. Future studies expanding beyond traditional model organisms will further enhance our knowledge of genome protection mechanisms.
Review
Biochemistry & Molecular Biology
Thomas J. Hayman, Peter M. Glazer
Summary: Research on disease treatment has focused on DNA repair pathways, with potential for enhanced efficacy with novel immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hans Liew, Stewart Mein, Thomas Tessonnier, Christian P. Karger, Amir Abdollahi, Jurgen Debus, Ivana Dokic, Andrea Mairani
Summary: Accurate knowledge of relative biological effectiveness (RBE) and its dependencies is crucial for supporting ion beam therapy. However, the influence of different dose rates of reference radiation and ion beam is rarely considered. This study investigates the impact of dose-rate effects on predicted RBE by extending the ion beam RBE-model to include DNA damage repair kinetics. The study finds that dose-rate effects increase with dose and biological effects saturate at high dose rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Torin P. Thielhelm, Stefania Goncalves, Scott M. Welford, Eric A. Mellon, Erin R. Cohen, Aida Nourbakhsh, Cristina Fernandez-Valle, Fred Telischi, Michael E. Ivan, Christine T. Dinh
Summary: Vestibular schwannomas (VS) are tumors that originate from Schwann cells of the vestibulocochlear nerve, causing hearing loss and dizziness. Though radiation therapy is common, some tumors are radioresistant, necessitating additional treatment. Understanding VS radiobiology is crucial for improving treatment outcomes.
Article
Oncology
Job-Joris Meijer, Alessandro Leonetti, Giulia Airo, Marcello Tiseo, Christian Rolfo, Elisa Giovannetti, Mahrou Vahabi
Summary: Despite poor prognosis for SCLC patients, immunotherapeutic approaches show potential. Targeting aberrant signaling pathways with new agents has shown promising results, while epigenetic alterations, gene amplifications, and mutations can act as potential biomarkers. Further research and clinical translational studies can help identify specific predictive biomarkers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mouna Mhamdi-Ghodbani, Christin Starzonek, Sarah Degenhardt, Marc Bender, Mohammed Said, Ruediger Greinert, Beate Volkmer
Summary: The study found that dermal stem cells have a similar DNA damage response to other skin cells after UVB radiation, but only fibroblasts showed significant changes in cell cycle distribution. Moreover, the UVB dose used in the experiment did not lead to UVB-induced apoptosis in any of the tested cell types.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Cell Biology
Li-Ya Chiu, Qing Sun, Frank T. Zenke, Andree Blaukat, Lyubomir T. Vassilev
Summary: More efficacious combination strategies with molecular targeted drugs are needed for cancer patients undergoing radiation therapy. Inhibiting ATM kinase, a key regulator of cellular response to DNA damage, can enhance cell death and sensitize cancer cells to radiation. Activation of the interferon response and inflammatory signaling via the cGAS/STING/TBK1 pathway is observed in irradiated cancer cells exposed to ATM inhibitors. Combining radiation, ATM inhibitors, and PD-L1 targeted therapy may provide a novel approach to radio-immunotherapy of locally advanced tumors.
Article
Biochemistry & Molecular Biology
Veronica Varzi, Emiliano Fratini, Mauro Falconieri, Daniela Giovannini, Alessia Cemmi, Jessica Scifo, Ilaria Di Sarcina, Pietro Apra, Sofia Sturari, Lorenzo Mino, Giulia Tomagra, Erminia Infusino, Valeria Landoni, Carmela Marino, Mariateresa Mancuso, Federico Picollo, Simonetta Pazzaglia
Summary: Nanodiamonds are being studied for their potential to enhance radiation effects, and this study explores the influence of their chemical and physical properties on cellular radiosensitivity. The results show that hydrogenated nanodiamonds can decrease cellular viability and increase radiosensitivity, while oxidized nanodiamonds do not. Higher energy radiation is more effective in combination with hydrogenated nanodiamonds. The molecular mechanism of nanodiamond radiosensitization involves Caspase-3-dependent apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Caroline Molinaro, Alain Martoriati, Katia Cailliau
Summary: Cells respond to genotoxic stress through complex protein pathways called DNA damage response (DDR), ensuring genomic integrity and activating processes like DNA repair, cell cycle regulation, and programmed cell death. Alterations in DDR network proteins can lead to various diseases, including cancer. Recent technological advancements have allowed for the exploitation of DDR vulnerabilities to improve cancer treatments through DNA damage strategies and combination therapies.
Article
Oncology
Lifang Pan, Qiong Wu, Yuqing Wang, Shenglin Ma, Shirong Zhang
Summary: This study aimed to establish and explore the biological characteristics of radioresistant LUSC cells. Radioresistant cells showed decreased radiosensitivity, enhanced DNA damage repair ability, and regulated double strands break through the ATM/CHK2 and DNA-PKcs/Ku70 pathways. Proteomics analysis revealed that differential genes in radioresistant cells were mainly enriched in biological pathways such as cell migration and ECM-receptor interaction.
Review
Biochemistry & Molecular Biology
Emil Mladenov, Veronika Mladenova, Martin Stuschke, George Iliakis
Summary: Radiation therapy is an essential part of cancer management, utilizing different modalities of ionizing radiation to mitigate cancer progression. This article reviews the molecular mechanisms underlying the repair pathways involved in DNA damage caused by radiation therapy. It discusses factors and processes that influence the choice of repair pathways throughout the cell cycle and highlights the preference for homologous recombination at low radiation doses. The article also explores the molecular basis of transitions from high fidelity to error-prone repair pathways and analyzes the coordination and consequences of this transition on cell viability and genomic stability. Lastly, it discusses how these advances can contribute to the development of improved cancer treatment protocols in radiation therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ankang Hu, Wanyi Zhou, Zhen Wu, Hui Zhang, Junli Li, Rui Qiu
Summary: Repair of DNA damage induced by ionizing radiation is essential for cell response, and the kinetics of repair greatly influences the cell fate and biological effects. In this study, a new repair module and a p53 system model were introduced to simulate the influences of different LET radiations on the cell response. It was found that the kinetics of double-strand break (DSB) repair plays a crucial role in determining the cell fate, with a large number of DSBs and slow repair process leading to severe biological consequences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Chaoqun Li, Dong Gao, Yijian Gao, Ran Zhang, Xiongwei Qu, Shengliang Li, Chengfen Xing
Summary: This study develops a biomimetic nanoparticle with dual-targeted properties, allowing precise modulation of ion channels at the organelle level and selective killing of malignant tumor cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Wenfeng Gou, Xiaojun Yu, Shaohua Wu, Hongying Wu, Huajie Chang, Leyuan Chen, Huiqiang Wei, Changfen Bi, Hongxin Ning, Yingliang Wu, Wenbin Hou, Daiying Zuo, Yiliang Li
Summary: This study investigated the impact of AND-1 on the radiosensitivity of non-small cell lung cancer (NSCLC) and found that AND-1 inhibition significantly increased the radiosensitivity of NSCLC cells, likely by regulating the cell cycle and enhancing DNA damage.
Article
Oncology
Lucas Basler, Aleksandra Kowalczyk, Regina Heidenreich, Mariola Fotin-Mleczek, Savas Tsitsekidis, Daniel Zips, Franziska Eckert, Stephan M. Huber
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Review
Neurosciences
Lukas Klumpp, Efe C. Sezgin, Marco Skardelly, Franziska Eckert, Stephan M. Huber
CURRENT NEUROPHARMACOLOGY
(2018)
Article
Integrative & Complementary Medicine
Sonja Schoetterl, Stephan M. Huber, Hans Lentzen, Michel Mittelbronn, Ulrike Naumann
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Oncology
Eric Neuhaus, Lisa Zirjacks, Katrin Ganser, Lukas Klumpp, Uwe Schueler, Daniel Zips, Franziska Eckert, Stephan M. Huber
Review
Oncology
Corinna J. Mohr, Friederike A. Steudel, Dominic Gross, Peter Ruth, Wing-Yee Lo, Reiner Hoppe, Werner Schroth, Hiltrud Brauch, Stephan M. Huber, Robert Lukowski
Article
Integrative & Complementary Medicine
Sonja Schoetterl, Jennifer T. Miemietz, Elena I. Ilina, Naita M. Wirsik, Ingrid Ehrlich, Andrea Gall, Stephan M. Huber, Hans Lentzen, Michel Mittelbronn, Ulrike Naumann
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Medicine, Research & Experimental
Rebecca Czolk, Niklas Schwarz, Henner Koch, Sonja Schoetterl, Thomas V. Wuttke, Per S. Holm, Stephan M. Huber, Ulrike Naumann
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2019)
Article
Cell Biology
Peter H. Neckel, Melanie Scharr, Karin Seid, Katharina Nothelfer, Joerg Fuchs, Florian Obermayr, Bernhard Hirt, Stephan M. Huber, Lothar Just
Article
Oncology
Corinna J. Mohr, Dominic Gross, Efe C. Sezgin, Friederike A. Steudel, Peter Ruth, Stephan M. Huber, Robert Lukowski
Article
Pharmacology & Pharmacy
Corinna J. Mohr, Werner Schroth, Thomas E. Muerdter, Dominic Gross, Selina Maier, Benjamin Stegen, Alice Dragoi, Friederike A. Steudel, Severine Stehling, Reiner Hoppe, Stephen Madden, Peter Ruth, Stephan M. Huber, Hiltrud Brauch, Robert Lukowski
Summary: Pore-forming alpha subunits of the BK channel play a role in promoting breast cancer, while the absence or knockdown of BK subunits attenuate the proliferation of breast cancer cells. Tamoxifen stimulates the proliferation of breast cancer cells at low concentrations.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Daniela Palme, Milan Misovic, Katrin Ganser, Lukas Klumpp, Helmut R. Salih, Daniel Zips, Stephan M. Huber
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Tatjana Vatter, Lukas Klumpp, Katrin Ganser, Nicolai Stransky, Daniel Zips, Franziska Eckert, Stephan M. Huber
Article
Cardiac & Cardiovascular Systems
Mailin-Christin Manke, Sascha Geue, Cristina Coman, Bing Peng, Ferdinand Kollotzek, Patrick Muenzer, Britta Walker, Stephan M. Huber, Dominik Rath, Albert Sickmann, David Stegner, Daniel Duerschmied, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Robert Ahrends, Oliver Borst
Summary: The study reveals the crucial role of ANXA7 in platelet signaling and metabolism during arterial thrombosis, suggesting it as a potential target for novel antiplatelet therapies. ANXA7 modulates platelet activation by affecting calcium signaling and lipid metabolism.
CIRCULATION RESEARCH
(2021)
Article
Oncology
Andreas Riedel, Lukas Klumpp, Apostolos Menegakis, Chiara De-Colle, Stephan M. Huber, Jens Schittenhelm, Manuela Neumann, Susan Noell, Marcos Tatagiba, Daniel Zips
Summary: The study evaluated radiation response in surgical specimens and gliosphere cultures from glioblastoma patients, finding that stem cell-enriched free-floating gliospheres were more resistant to radiation than specimens. There was interpatient heterogeneity, and the lack of correlation between specimens and their corresponding gliosphere cultures may impact future translational studies using gamma H2AX as a potential biomarker for personalized radiation therapy.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Immunology
Franziska Eckert, Kerstin Zwirner, Simon Boeke, Daniela Thorwarth, Daniel Zips, Stephan M. Huber
FRONTIERS IN IMMUNOLOGY
(2019)