期刊
FRONTIERS IN PHYSIOLOGY
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2012.00468
关键词
myocyte; peroxynitrite; nitric oxide synthase; Ca2+; cAMP-dependent protein kinase; protein phosphatase 2a
类别
资金
- American Heart Association [0715159B]
- National Institutes of Health [K02HL094692, R01HL079283]
- [R01HL38324]
- [HL63744]
- [HL65608]
Peroxynitri e is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca2+ handling, proposed signaling pathways, and protein end-targets.
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