The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light

Spherulites in Human Brain Tissue are Composed of Beta Sheets of Amyloid and Resemble Senile Plaques

(2018) Emily House et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Burdens of Aluminum, Iron, and Copper and their Relationships with Amyloid-β Pathology in 60 Human Brains

(2018) Christopher Exley et al.   JOURNAL OF ALZHEIMERS DISEASE

Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress

(2018) Joseph J. Gallagher et al.   JOURNAL OF ALZHEIMERS DISEASE

Copper Abolishes the β-Sheet Secondary Structure of Preformed Amyloid Fibrils of Amyloid-β42

(2017) Emily House et al.   JOURNAL OF ALZHEIMERS DISEASE

Spherulites of Amyloid-β42 In Vitro and in Alzheimer's Disease

(2017) Christopher Exley et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

(2017) Mark A. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimer’s Disease Peptide β-Amyloid

(2014) James Everett et al.   INORGANIC CHEMISTRY

A novel calibration strategy for the quantitative imaging of iron in biological tissues by LA-ICP-MS using matrix-matched standards and internal standardisation

(2014) Jennifer O'Reilly et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide  -amyloid (1-42)

(2014) J. Everett et al.   Journal of the Royal Society Interface

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Visualization of nigrosome 1 and its loss in PD: Pathoanatomical correlation and in vivo 7 T MRI

(2013) A. I. Blazejewska et al.   NEUROLOGY

X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples

(2012) Graham N. George et al.   JOURNAL OF SYNCHROTRON RADIATION

Concentration of various trace elements in the rat retina and their distribution in different structures

(2012) Marta Ugarte et al.   Metallomics

Fibrillation of transferrin

(2011) Claire Booyjz̈sen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

pH-Dependent Structures of Ferritin and Apoferritin in Solution: Disassembly and Reassembly

(2011) Mihee Kim et al.   BIOMACROMOLECULES

Combined use of hard X-ray phase contrast imaging and X-ray fluorescence microscopy for sub-cellular metal quantification

(2011) Ewelina Kosior et al.   JOURNAL OF STRUCTURAL BIOLOGY

High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron

(2011) Vijay Antharam et al.   NEUROIMAGE

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

A high-repetition rate scheme for synchrotron-based picosecond laser pump/x-ray probe experiments on chemical and biological systems in solution

(2011) Frederico A. Lima et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Brain iron detected by SWI high pass filtered phase calibrated with synchrotron X-ray fluorescence

(2010) Karla Hopp et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Brain iron metabolism and its perturbation in neurological diseases

(2010) Robert R. Crichton et al.   JOURNAL OF NEURAL TRANSMISSION

Trace metal imaging with high spatial resolution: Applications in biomedicine

(2010) Zhenyu Qin et al.   Metallomics

Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells

(2010) Elizabeth A. Carter et al.   Molecular BioSystems

Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

(2010) Andreana C. Leskovjan et al.   NEUROIMAGE

Pigmented creatine deposits in Amyotrophic Lateral Sclerosis central nervous system tissues identified by synchrotron Fourier Transform Infrared microspectroscopy and X-ray fluorescence spectromicroscopy

(2010) M.Z. Kastyak et al.   NEUROSCIENCE

Macromolecular crystallography at synchrotron radiation sources: current status and future developments

(2010) E. M. H. Duke et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Metallomics: Guidelines for terminology and critical evaluation of analytical chemistry approaches (IUPAC Technical Report)

(2010) Ryszard Lobinski et al.   PURE AND APPLIED CHEMISTRY

Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging

(2009) Asunción Carmona et al.   ACS Chemical Neuroscience

Synchrotron X-ray Fluorescence Reveals Abnormal Metal Distributions in Brain and Spinal Cord in Spinocerebellar Ataxia: A Case Report

(2009) Bogdan F. Gh. Popescu et al.   CEREBELLUM

In Situ Imaging of Metals in Cells and Tissues

(2009) Reagan McRae et al.   CHEMICAL REVIEWS

MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice

(2009) Mark D. Meadowcroft et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Biological X-ray absorption spectroscopy and metalloproteomics

(2009) Isabella Ascone et al.   JOURNAL OF SYNCHROTRON RADIATION

Identification of L-ferritin in Neuromelanin Granules of the Human Substantia Nigra

(2009) Florian Tribl et al.   MOLECULAR & CELLULAR PROTEOMICS

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

(2009) Andreana C. Leskovjan et al.   NEUROIMAGE

Iron as a cause of Parkinson disease – a myth or a well established hypothesis?

(2009) Andrzej Friedman et al.   PARKINSONISM & RELATED DISORDERS

Mapping metals in Parkinson's and normal brain using rapid-scanning x-ray fluorescence

(2009) Bogdan F Gh Popescu et al.   PHYSICS IN MEDICINE AND BIOLOGY

P2-001: High-resolution magnetic resonance imaging to quantify relaxation parameters in Alzheimer's brain tissue

(2008) Joanna F. Collingwood et al.   Alzheimers & Dementia

Intracellular Chemical Imaging of the Developmental Phases of Human Neuromelanin Using Synchrotron X-ray Microspectroscopy

(2008) Sylvain Bohic et al.   ANALYTICAL CHEMISTRY

Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia

(2008) A. Campanella et al.   HUMAN MOLECULAR GENETICS

1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue

(2008) Michael J. House et al.   MAGNETIC RESONANCE IN MEDICINE