Review
Immunology
Sjoerd T. T. Schetters, Martijn J. Schuijs
Summary: Eosinophils play multiple roles in immune responses, including defense against parasites, promoting allergic inflammation, and regulatory functions. They possess both homeostatic and pro-resolving capacity, but their function is influenced by time and space.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Nina Li, Hoomann Mirzakhani, Alexander Kiefer, Julia Koelle, Tytti Vuorinen, Manfred Rauh, Zuqin Yang, Susanne Krammer, Paraskevi Xepapadaki, Anna Lewandowska-Polak, Heikki Lukkarinen, Nan Zhang, Barbara Stanic, Theodor Zimmermann, Marek L. Kowalski, Tuomas Jartti, Claus Bachert, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto
Summary: RANTES plays a critical role in allergic asthma and infection clearance by transitioning effector T cells and increasing IL-10 production, thus showing a therapeutic potential in resolving allergen-induced asthma.
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Thayse R. Brueggemann, Hadas Pahima, David Mankuta, Bruce D. Levy, Francesca Levi-Schaffer
Summary: The study found that Cromolyn Sodium has immunomodulatory actions in allergic inflammation that go beyond just stabilizing mast cells, indicating broader mechanisms at play.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Laercia K. D. Paiva Ferreira, Larissa A. M. Paiva Ferreira, Grasiela C. Bezerra Barros, Talissa Mozzini Monteiro, Luiz A. de Araujo Silva, Ramon de A. Pereira, Pedro T. R. Figueiredo, Adriano Francisco Alves, Luis Cezar Rodrigues, Marcia Regina Piuvezam
Summary: MHTP shows therapeutic effects in the experimental model of CARAS, including reducing symptoms, inhibiting eosinophil migration, decreasing tissue inflammation, and regulating immune cytokines. These effects are mediated through the p38/ERK1/2 MAP kinase signaling pathway axis and the shutdown of intracellular transduction signals underlying cytokine gene transcription.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Guojun Qian, Wenxia Jiang, Donglin Sun, Zhun Sun, Anning Chen, Hongwei Fang, Jingyao Wang, Yongzhong Liu, Zhinan Yin, Haiming Wei, Hao Fang, Xiaoren Zhang
Summary: This study reveals that IL-10 derived from B cells, regulated by Bcl-3, promotes the development of allergic asthma. Inhibition of the Bcl-3/IL-10 axis may serve as a potential therapeutic approach for treating allergic asthma.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Eva Knuplez, Melanie Kienzl, Athina Trakaki, Rudolf Schicho, Akos Heinemann, Eva M. Sturm, Gunther Marsche
Summary: Miltefosine has a strong modulatory activity in regulating eosinophilic inflammation both in vitro and in vivo, showing potential efficacy in treating allergic diseases and other eosinophil-associated disorders. This may lead to important questions regarding the immunomodulatory effect of miltefosine in patients treated for leishmania infections.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiao-Juno Chiu, Chien-Chia Liao, Yu-Hsiang Hsu, Bor-Luen Chiang
Summary: Endogenous adult lung SSEA-1(+) cells almost disappear in asthmatic mice, but a unique population of circulating SSEA-1(+) cells is enriched after the challenge phase. These cells play a beneficial role in lung inflammation and structural damage by homing to the lung and inhibiting inflammatory cell infiltration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fei Fei, Mingfeng Zhang, Somayeh S. Tarighat, Eun Ji Joo, Lu Yang, Nora Heisterkamp
Summary: Galectin-1 and Galectin-3 have a complicated joint contribution to BCP-ALL survival, with stromal Galectin-3 playing an important role in maintaining BCP-ALL fitness during chemotherapy exposure, while stromal Galectin-1 does not significantly contribute to drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Layla A. Al-Kharashi, Saleh A. Alqarni, Sheikh F. Ahmad, Naif O. Al-Harbi, Sary Alsanea, Khalid E. Ibrahim, Mohammad M. Algahtani, Khalid Alhazzani, Gamal A. Shazly, Mohammad M. Al-Harbi, Ahmed Nadeem
Summary: Asthma is a complex and heterogeneous disease influenced by various molecular mechanisms, including the presence of antioxidant and oxidant enzymes in immune cells. The interaction between epithelial cells and immune cells plays a crucial role in the pathogenesis of asthma. The oxidant-antioxidant balance is important in the chronic phase of the disease. Genetic variability in immune cells may affect the development of airway inflammation, and different mouse strains show different responses to allergens. This study found that C57BL/6 mice had a better antioxidant system and developed mostly eosinophilic airway inflammation, while BALB/c mice developed mixed granulocytic airway inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Stefan Wirtz, Anja Schulz-Kuhnt, Markus F. Neurath, Imke Atreya
Summary: ILC2 has been established as a crucial mediator in lung diseases, influenced by the local pulmonary environment. Research indicates that ILCs have context-dependent migration capacity, with potential for innovative therapeutic targeting in inflammatory lung diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Tongqian Wu, Lan Ma, Xiaoqian Jin, Jingjing He, Ke Chen, Dingshan Zhang, Rui Yuan, Jun Yang, Qin Zhong, Haiyan Zhou, Zou Xiang, Yu Fang
Summary: The study demonstrated that S100A4 plays a critical role in regulating mast cell activation and allergic responses. S100A4(-/-) mice showed reduced symptoms in allergic models, indicating that S100A4 is required for mast cell activation and may be involved in the regulation of allergic diseases through this mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hanh Hong Chu, Yoshiki Kobayashi, Dan Van Bui, Yasutaka Yun, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Akira Kanda, Hiroshi Iwai
Summary: Eosinophilic chronic rhinosinusitis (ECRS) is a refractory airway disease accompanied by eosinophilic inflammation. In this study, researchers investigated the role of CCL4, a specific ligand for CCR5 receptors, in eosinophil activation and recruitment in ECRS patients. The findings suggest that CCL4, derived from airway epithelial cells, plays a crucial role in the accumulation and activation of eosinophils at inflammatory sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Susanne Krammer, Zuqin Yang, Theodor Zimmermann, Paraskevi Xepapadaki, Carol I. Geppert, Nikolaos G. Papadopoulos, Susetta Finotto
Summary: IL-3 plays an important regulatory role in pediatric asthma, and its association with steroid therapy needs further investigation; rIL-3 treatment can ameliorate airway eosinophilia and mucus production, providing a new strategy for treating allergic asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Adel Abo Mansour, Federica Raucci, Mustafa Sevim, Anella Saviano, Jenefa Begum, Zhaogong Zhi, Laleh Pezhman, Samantha Tull, Francesco Maione, Asif Jilani Iqbal
Summary: This study investigates the role of Gal-9 in the migration and adhesion of CD4+ and CD8+ T cells and reveals its potential therapeutic significance in inflammatory-based diseases. The findings suggest that Gal-9 supports T cell adhesion and transmigration in a glycan dependent manner and inhibits the chemotactic function of CXCL12 through direct binding.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Dermatology
Yuan-Hsin Lo, Chi-Shan Li, Hung-Lin Chen, Cho-Ying Chiang, Chi-Chun Huang, Ting-Jui Tu, Tzu-Han Lo, David F. Choy, Joseph R. Arron, Huan-Yuan Chen, Fu-Tong Liu
Summary: The study demonstrates the upregulation of galectin-8 in psoriatic skin lesions and mouse models of psoriasis. Knocking out galectin-8 leads to reduced keratinocyte proliferation and delayed cell cycle progression. Galectin-8 interacts with alpha-tubulin to maintain centrosome integrity, facilitating keratinocyte hyperproliferation in psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Musin Kelel, Ruey-Bing Yang, Tsen-Fang Tsai, Pi-Hui Liang, Fu-Yu Wu, Yu-Tien Huang, Ming-Fong Yang, Yu-Ping Hsiao, Li-Fang Wang, Chen-Fen Tu, Fu-Tong Liu, Yungling L. Lee
Summary: The study reveals that FUT8 remodeling of EGFR plays a critical role in the development of psoriasis phenotypes and is associated with disease severity. FUT8 gain of function promotes cell proliferation, while short hairpin FUT8 reduces proliferation and alters the cell cycle.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Hung-Lin Chen, Chia-Hui Lo, Chi-Chun Huang, Meng-Ping Lu, Po-Yuan Hu, Chang-Shan Chen, Di-Yen Chueh, Peilin Chen, Teng-Nan Lin, Yuan-Hsin Lo, Yu-Ping Hsiao, Daniel K. Hsu, Fu-Tong Liu
Summary: The study found that the expression of galectin-7 is reduced in skin lesions of psoriasis patients, and IL-17A and TNF-alpha suppress galectin-7 expression in human keratinocytes. Galectin-7 attenuates the production of inflammatory mediators by keratinocytes via the microRNA-146a/ERK pathway when cells are stimulated with IL-17A. Fluvastatin was identified as an inducer of galectin-7 expression and showed potential in reducing IL-6 and IL-8 production induced by IL-17A.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Tao Lei, Sandra M. Blois, Nancy Freitag, Martin Bergmann, Sudhanshu Bhushan, Eva Wahle, Annie Chi-Chun Huang, Hung-Lin Chen, Michaela F. Hartmann, Stefan A. Wudy, Fu-Tong Liu, Andreas Meinhardt, Monika Fijak
Summary: Galectin 3 plays a crucial role in testicular physiology by regulating spermatogenesis initiation and testosterone biosynthesis, which ultimately affects testicular weight and reproductive function. Through its involvement in preventing germ cell apoptosis and controlling testosterone production, Galectin 3 serves as a key factor in the development of germ cells and steroidogenesis, offering potential biomarkers for testicular function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Genetics & Heredity
Chun-Yu Wei, Jenn-Hwai Yang, Erh-Chan Yeh, Ming-Fang Tsai, Hsiao-Jung Kao, Chen-Zen Lo, Lung-Pao Chang, Wan-Jia Lin, Feng-Jen Hsieh, Saurabh Belsare, Anand Bhaskar, Ming-Wei Su, Te-Chang Lee, Yi-Ling Lin, Fu-Tong Liu, Chen-Yang Shen, Ling-Hui Li, Chien-Hsiun Chen, Jeffrey D. Wall, Jer-Yuarn Wu, Pui-Yan Kwok
Summary: The Taiwan Biobank has collected genetic information from both high-coverage whole-genome sequencing and genome-wide SNP data of individuals with Han Chinese ancestry, revealing the full range of genetic variation in this population. The study found that some individuals carry mutations related to autosomal recessive diseases, cancer-predisposing genes, and variants affecting drug response, highlighting the potential for genetic testing to improve clinical care.
NPJ GENOMIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han-Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu-Tong Liu, Nobuyuki Takakura
Summary: This study demonstrates that Gal-3 expression in long-term repopulating HSCs is induced in response to Tie2 and Mpl, and plays a crucial role in maintaining HSC quiescence through regulation of p21.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Lei Wan, Yu-An Hsu, Chang-Ching Wei, Fu-Tong Liu
Summary: Allergic inflammatory diseases are a global public health concern. Galectins, a group of beta-galactoside-binding proteins, have been identified as important factors in modulating inflammatory reactions, but there may be potential issues in understanding their exact biological functions.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Tzu-Han Lo, Hung-Lin Chen, Cheng- Yao, I-Chun Weng, Chi-Shan Li, Chi-Chun Huang, Nien-Jung Chen, Chun-Hung Lin, Fu-Tong Liu
Summary: The study demonstrates that galectin-3 enhances caspase-4/11 activation and oligomerization through binding with LPS, resulting in intensified pyroptosis. This finding provides potential opportunities for new therapeutic interventions in host resistance against bacterial infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Medicinal
Chih-Yen Lin, Zih-Syuan Yang, Wen-Hung Wang, Aspiro Nayim Urbina, Yu-Ting Lin, Jason C. Huang, Fu-Tong Liu, Sheng-Fan Wang
Summary: Currently, only Galectin-1, Galectin-3, and Galectin-9 have been reported to play a regulatory role in IAV infection. They inhibit IAV infection through multiple mechanisms, including blocking virus-host receptor interaction, activating inflammasome, and increasing expression of antiviral genes and cytokines.
Article
Dermatology
Ching-Han Tsao, Wei-Chen Hsieh, Feng-Jen Lin, Ri-Yao Yang, Meng-Ting Chang, Maria Karmella Apaya, Lie -Fen Shyur, Liang-Yin Ke, Christos C. Zouboulis, Fu-Tong Liu
Summary: Sebaceous glands produce lipids that are crucial for maintaining the skin barrier. Galectin-12 protein has been found to regulate sebocyte differentiation and lipid production, playing a positive role in sebaceous lipid metabolism.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Feng-Jen Lin, Yun-Hsi Huang, Ching-Han Tsao, Wei-Chen Hsieh, Yuan-Hsin Lo, Christos C. Zouboulis, Hung-Lin Chen, Fu-Tong Liu
Summary: Sebaceous glands play a role in skin immune response and dysregulated lipid production may contribute to the progression of certain skin diseases. Galectin-12 is a factor that affects the immune response and regulates IL-4 signaling and endoplasmic reticulum stress in sebaceous glands.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Immunology
Fu-Tong Liu, Sean R. Stowell
Summary: Galectins can modulate immune cells by binding to glycosylated proteins and lipids on the cell surface, or intracellularly via carbohydrate-dependent or carbohydrate-independent interactions. This Review explores the diverse ways in which galectins affect immunity and discusses the opportunities and challenges in the field.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peng Peng Ip, Qiongyu Li, Wei-Han Lin, Chien-Ching Chang, Cathy Shen-Jang Fann, Huan-Yuan Chen, Fu-Tong Liu, Carlito B. Lebrilla, Chih-Chao Yang, Fang Liao
Summary: Glycosylation plays a key role in protein biological functions and can be used to understand disease etiology, differentiate diseases, and develop therapeutics. Differences in glycosylation profiles of serum proteins between patients with remitting multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) were observed. Site-specific N-glycans on certain proteins were identified as potential markers to differentiate between MS and NMOSD. Monitoring serum protein glycan profiles using high-throughput analysis may provide additional diagnostic criteria for differentiating diseases and assessing treatment effects.
Review
Cell Biology
Ming-Hsiang Hong, I-Chun Weng, Fang-Yen Li, Wei-Han Lin, Fu-Tong Liu
Summary: Galectins are animal lectins that recognize carbohydrates and play important roles in cellular homeostasis. Recent studies have shown that galectins accumulate around damaged endocytic vesicles and control cellular responses by interacting with cellular proteins, such as autophagy. The differential regulatory effects among galectins are also highlighted in this review.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Hematology
Ming-Tsai Chiang, I-Ming Chen, Fu-Fei Hsu, Yen-Hui Chen, Min-Shao Tsai, Yaw-Wen Hsu, Hsin-Bang Leu, Po-Hsun Huang, Jaw-Wen Chen, Fu-Tong Liu, Ying-Hwa Chen, Lee-Young Chau
Summary: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease with high mortality in elders, lacking prognostic and therapeutic targets. Gal-1, a lectin expressed in vasculature, has been identified as a key player in the progression of AAA. Experimental and clinical studies suggest that Gal-1 may serve as a potential disease biomarker and therapeutic target for AAA.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)