Article
Neurosciences
Karolina Bogaj, Roksana Kaplon, Joanna Urban-Ciecko
Summary: This study investigated the inhibitory effects of GABAA receptors on different types of interneurons in mouse brain slices. The results showed that different types of interneurons have varying sensitivity to inhibition, and GABAA inhibition can decrease the excitability of one type of interneuron while not affecting another type.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Hirofumi Ochiai, Taiji Shimoda, Kazuhiro Fukae, Masatoshi Maeda, Kazuyuki Ishii, Kenta Yoshida, Katsunari Tezuka, Keisuke Tazuru, Hayato Saijo, Hiroaki Asai, Akio Kanatani, Yuji Nishiuchi
Summary: Somatostatin, a growth hormone inhibitory factor, can affect physiological functions through its action on five distinct receptor subtypes. By attaching human complex-type oligosaccharides, we have developed glycosylated somatostatin analogues that have improved metabolic stability and high affinity to all receptor subtypes. These analogues have the potential to be novel therapeutic drugs for somatostatin-related diseases and can provide insights into new indications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Cell Biology
Heng Kang Yao, Alexandre Guet-McCreight, Frank Mazza, Homeira Moradi Chameh, Thomas D. Prevot, John D. Griffiths, Shreejoy J. Tripathy, Taufik A. Valiante, Etienne Sibille, Etay Hay
Summary: This study investigated the impact of reduced somatostatin interneuron-mediated inhibition on cortical processing in human neuronal microcircuits using a data-driven computational approach. The findings demonstrate a decreased signal-to-noise ratio and increased false detection of stimuli in depression due to higher baseline activity. Ultimately, this research provides mechanistic insights into how reduced inhibition impairs cortical processing in depression and its quantitative links to cognitive deficits.
Article
Neurosciences
Ivan Banovac, Dora Sedmak, Monique Esclapez, Zdravko Petanjek
Summary: In this study, the molecular expression, morphological features, and laminar distribution of somatostatin cells in the human prefrontal cortex were comprehensively analyzed. The results showed that somatostatin neurons comprise around 7% of neocortical neurons, with different molecular and morphological characteristics in different cortical layers.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Psychiatry
Urvakhsh Meherwan Mehta, Aboli Ektare, Jitender Jakhar, Rakshathi Basavaraju, Tarasingh N. Sanjay, Shalini S. Naik, Farooq Ali Syed, Praerna Hemant Bhargav, Preethi Reddy, Radhika Suneel Kelkar, Shyam Sundar Arumugham, Muralidharan Kesavan, Jagadisha Thirthalli, Bangalore N. Gangadhar
Summary: Research suggests that cortical inhibition aberrations play a central role in severe mental disorders. Through Transcranial Magnetic Stimulation combined with electromyography, researchers examined inhibitory processes in the motor cortex in individuals with different mental disorders compared to healthy subjects. The study found that long-interval intracortical inhibition was significantly increased in mania and schizophrenia, but reduced in OCD, while cortical silent period was decreased in OCD and depression groups compared to healthy individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Yun Fei Feng, Yin Yong Zhou, Kai Ming Duan
Summary: Postpartum depression is a serious disease that has a high incidence and severe impact on pregnant women and infants. However, the mechanism of this condition is still unclear. Recent studies have shown that GABA receptors, especially extrasynaptic receptors, are closely associated with postpartum depression. This review focuses on the function of GABA receptors, particularly extrasynaptic receptors, and their association with postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Cristina Donato, Daniella Balduino Victorino, Carolina Cabezas, Andrea Aguirre, Joana Lourenco, Marie -Claude Potier, Javier Zorrilla de San Martin, Alberto Bacci
Summary: In the neocortex, somatostatin-positive interneurons called Martinotti cells (MCs) inhibit pyramidal neurons (PNs) directly and also connect with other interneurons. These connections contribute to cortical network balance and play important roles in cognitive functions. This study found that MCs primarily connect with PNs, but also connect with other interneurons. Interestingly, the synapses between MCs and different targets exhibited specific short-term plasticity and used different GABAAR subunits. These findings provide new insights into the connectivity and molecular mechanisms of MCs in the cortical circuits.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Manoela V. Fogaca, Min Wu, Chan Li, Xiao-Yuan Li, Marina R. Picciotto, Ronald S. Duman
Summary: Major depressive disorder is associated with alterations of GABAergic interneurons in cortical brain areas, and the antidepressant effects of rapid-acting drugs may occur through inhibition of these neurons. It has been found that transient inhibition of GABA interneurons promotes synaptic plasticity that underlies rapid antidepressant responses.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Rhiannan H. Williams, Therese Riedemann
Summary: Researchers are extensively studying cortical interneurons to understand their specific functions in the brain and potentially target them for therapeutic purposes. Among the different classes of interneurons, this review focuses on parvalbumin or somatostatin-containing cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Tzu-Hsuan Huang, Yi-Sian Lin, Chiao-Wan Hsiao, Liang-Yun Wang, Musa Iyiola Ajibola, Wahab Imam Abdulmajeed, Yu-Ling Lin, Yu-Jui Li, Cho-Yi Chen, Cheng-Chang Lien, Cheng-Di Chiu, Irene Han-Juo Cheng
Summary: This study compared the transcriptomic differences between PV and SST inhibitory interneurons in the hippocampus and identified distinct gene expressions related to voltage-gated ion channels and GABA(A) receptor subunits. Additionally, some differentially expressed genes were associated with schizophrenia and epilepsy. These results provide molecular insights into the distinct roles of PV and SST interneurons in health and disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wei Shao, Hang Zheng, Jingwen Zhu, Wenhao Li, Yifan Li, Wenjie Hu, Juanjuan Zhang, Liang Jing, Kai Wang, Xiao Jiang
Summary: Autism spectrum disorder (ASD) is a highly inherited neurodevelopmental disorder, and loss-of-function mutations in the CACNA2D3 gene are associated with ASD. Dysfunction of cortical interneurons (INs), specifically Parvalbumin-expressing (PV) INs, may underlie the abnormal social behavior observed in ASD. Knockout mouse models were used to investigate the role of Cacna2d3 insufficiency in PV neurons, and it was found that these mice exhibited deficits in core ASD behaviors, anxiety-like behavior, and improved spatial memory. On the other hand, mice with Cacna2d3 insufficiency in somatostatin-expressing (SOM) neurons did not show obvious deficits in social, cognitive, or emotional phenotypes.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
G. Dobrzanski, A. Lukomska, R. Zakrzewska, A. Posluszny, D. Kanigowski, J. Urban-Ciecko, M. Liguz-Lecznar, M. Kossut
Summary: In this study, the role of cortical SOM-INs and VIP-INs in a Pavlovian conditioning were examined, revealing the crucial involvement of L4 SOM-INs activity in learning-induced plastic changes. It is suggested that L4 SOM-INs may provide disinhibition by blocking L4 parvalbumin interneurons, allowing information flow into upper cortical layers during learning.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Computer Science, Cybernetics
Marije Ter Wal, Paul H. E. Tiesinga
Summary: This study analyzed circuit motifs and dynamics of neural circuits composed of excitatory cells, PV-like fast-spiking interneurons, and SOM-like low-threshold spiking interneurons. Through simulation and clustering, the study identified unique oscillatory behaviors specific to circuits with the three cell types, providing insights into experimental activity patterns and suggesting potential validation approaches using pharmacological or optogenetic techniques.
BIOLOGICAL CYBERNETICS
(2021)
Article
Neurosciences
Kimberly L. Kraus, Arihant P. Chordia, Austin W. Drake, James P. Herman, Steve C. Danzer
Summary: This study found that under baseline conditions, glucocorticoid receptors (GR) expression in parvalbumin-positive (PV+) interneurons in the hippocampus showed considerable subregion variability, while somatostatin-positive (SST+) interneurons expressed GR ubiquitously. These findings suggest anatomical diversity in the regulation of stress-dependent hippocampal responses, which may imply functional differences.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Marcin Wyroslak, Grzegorz Dobrzanski, Jerzy W. Mozrzymas
Summary: In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and parvalbumin-containing interneurons. Our results showed that NMDA application enhanced tonic conductance in somatostatin-containing interneurons, while reducing tonic inhibition in both fast-spiking and non-fast-spiking parvalbumin-positive cells. These changes were associated with alterations in the content of α5 and δ-subunit-containing GABA(A) receptors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
L. C. Lin, E. Sibille
MOLECULAR PSYCHIATRY
(2015)
Article
Neurosciences
Anke A. Dijkstra, Li-Chun Lin, Alissa L. Nana, Stephanie E. Gaus, William W. Seeley
Article
Behavioral Sciences
Hsiun-Ing Chen, Li-Chun Lin, Lung Yu, Yu-Fan Liu, Yu-Min Kuo, A-Min Huang, Jih-Ing Chuang, Fong-Sen Wu, Pao-Chi Liao, Chauying J. Jen
NEUROBIOLOGY OF LEARNING AND MEMORY
(2008)
Article
Endocrinology & Metabolism
Ling-Ling Hwang, Chien-Hua Wang, Tzu-Ling Li, Shih-Dar Chang, Li-Chun Lin, Ching-Ping Chen, Chiung-Tong Chen, Keng-Chen Liang, Ing-Kang Ho, Wei-Shiung Yang, Lih-Chu Chiou
Article
Neurosciences
Li-Chun Lin, David A. Lewis, Etienne Sibille
Article
Neurosciences
Li-Chun Lin, Alissa L. Nana, Mackenzie Hepker, Ji-Hye Lee Hwang, Stephanie E. Gaus, Salvatore Spina, Celica G. Cosme, Li Gan, Lea T. Grinberg, Daniel H. Geschwind, Giovanni Coppola, Howard J. Rosen, Bruce L. Miller, William W. Seeley
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2019)
Editorial Material
Clinical Neurology
Kimberly L. Fiock, Li-Chun Lin, Stacie Colwell, Marco M. Hefti
Review
Pathology
Li-Chun Lin, Bailey Hollis, Marco M. Hefti
Summary: The COVID-19 pandemic has put global healthcare systems under immense pressure, but it has also provided an opportunity for pathologists to study the effects of the virus on patient care. Current knowledge about the neuropathology of COVID-19 is limited, but it has been observed that the virus can infect both the central and peripheral nervous systems. Neuroinflammation and vascular injury are common manifestations of COVID-19 in the brain, and there may be a complex relationship between the virus and neurodegenerative diseases. Further research is needed to fully understand these findings.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2022)
Article
Cell Biology
Jessica E. Rexach, Damon Polioudakis, Anna Yin, Vivek Swarup, Timothy S. Chang, Tam Nguyen, Arjun Sarkar, Lawrence Chen, Jerry Huang, Li-Chun Lin, William Seeley, John Q. Trojanowski, Dheeraj Malhotra, Daniel H. Geschwind