Review
Plant Sciences
Barkha Ravi, Christine H. Foyer, Girdhar K. Pandey
Summary: Reactive oxygen species (ROS) and calcium (Ca2+) signalling play important roles in plant growth, development, and defense. They function together with electric signals in directional cell-to-cell systemic signalling and even plant-to-plant communication. However, there is still limited understanding of the molecular mechanisms underlying the management of ROS and Ca2+ signals, as well as the synchronous and independent signaling in different cellular compartments. This review focuses on the proteins that may connect different pathways during abiotic stress responses, and highlights the crosstalk between ROS and Ca2+ pathways in cell signaling.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Francesca Aglialoro, Asena Abay, Nurcan Yagci, Minke A. E. Rab, Lars Kaestner, Richard van Wijk, Marieke von Lindern, Emile van den Akker
Summary: In this study, we found that PIEZO1 acts as a mechanosensor that, when transferred to orbital shaking, activates signaling cascades that are Ca2+-dependent, regulating various aspects of erythropoiesis. This suggests that there are direct physiological outcomes of mechanical stress on erythroblasts, as shown by the comparable activation of some Ca2+-dependent pathways induced by Yoda1 treatment and mechanical stress via orbital shaking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yoona Jung, Jooseong Kim, Sukyoung Kim, Shin Hye Chung, Jinhong Wie
Summary: Bioceramics, such as calcium-phosphate-based materials, are used in medical and dental implants for bone tissue replacement or repair. The effect of bioceramic sintering on intracellular signaling pathways is still unknown. This study analyzed the impact of sintering on osteoblast cell signaling pathways using sintered and non-sintered hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP). The findings showed that sintering affects multiple signaling pathways, providing insights into bioceramic function and expanding their application scope in clinical settings.
Article
Biochemistry & Molecular Biology
Egor A. Turovsky, Maria V. Turovskaya, Evgeniya I. Fedotova, Alexey A. Babaev, Victor S. Tarabykin, Elena G. Varlamova
Summary: Transcription factors Satb1 and Satb2 are involved in regulating genes encoding NMDA, AMPA, and KA receptor subunits, impacting neurotransmission and neuronal network inhibition. Their deletion alters gene expression and calcium signaling, affecting neuron maturation processes and switching GABAergic responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Ludmila Zylinska
Summary: The activity of specific populations of neurons in different brain areas plays a critical role in decision-making processes related to synaptic transmission, adaptations to external signals, and the maintenance of neural function. The endocannabinoid system (ECS) is identified as a vital control system in the central nervous system (CNS), allowing for rapid responses to synaptic processes and inducing long-term changes. Endocannabinoids are bioactive lipid mediators that act primarily through two receptors, CB1R and CB2R, which can regulate downstream Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Kyle Symonds, Howard Teresinski, Bryan Hau, David Chiasson, Kirsten Benidickson, William Plaxton, Wayne A. Snedden
Summary: Calmodulin-like proteins (CMLs) are the largest family of calcium-binding proteins in plants. The study found that CML13 and CML14 play important roles in plant development, regulating development and morphological features through interactions with other proteins. Inhibition of CML13 or CML14 transcript levels leads to abnormal plant development, including difficulties in germination, chlorosis, and leaf senescence.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Xiaotong Shi, Jinyu Bao, Xu Lu, Lei Ma, Yi Zhao, Shimin Lan, Jie Cao, Shaoying Ma, Sheng Li
Summary: Ca2+ is an essential metal ion for plant growth and development, playing important roles in plant signal transduction and metabolic processes. This review summarizes the mechanisms of Ca2+ response to stress signals, the regulation of ion transport, the interaction with phytohormones, and the role of calcium-dependent proteins in stress response.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Brendan Elsworth, Manoj T. Duraisingh
Summary: Babesia species are tick-borne parasites that infect mammalian red blood cells, causing severe diseases. They have complex life cycles involving multiple stages in both ticks and mammalian hosts, utilizing intricate signaling pathways for replication, egress, and invasion. Understanding the signaling pathways and environmental stimuli used by Babesia species during transmission is crucial for further biological and translational studies of these parasites.
MOLECULAR MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Moriah Gildart Turcotte, Hrishikesh Thakur, Michael S. Kapiloff, Kimberly L. Dodge-Kafka
Summary: Pathological cardiac myocyte hypertrophy, which is a condition characterized by the enlargement of heart cells, is regulated by the pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin. This study reveals that the scaffold protein muscle A-Kinase Anchoring Protein beta (mAKAP beta/AKAP6 beta) organizes perinuclear signalosomes, which are responsible for localized calcium transients and the subsequent activation of calcineurin-dependent NFATc nuclear localization, leading to myocyte hypertrophy upon beta-adrenergic receptor activation. These findings demonstrate the existence of a functionally independent calcium signaling compartment in cardiac myocytes that regulates hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Plant Sciences
Maria Stolarz, Kazimierz Trebacz
Summary: This study observed the movements and action potentials of Mimosa pudica L. plants, revealing spontaneous rapid leaf movements and action potentials in intact plants, with a delay between the appearance of action potential and leaf movement, suggesting that action potentials may trigger the rapid leaf movements.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Cell Biology
Patricia Kasowanjete, Heidi Abrahamse, Nicolette N. Houreld
Summary: This study evaluated the effect of photobiomodulation (PBM) at 660 nm on wound healing in diabetic patients, and found that PBM can stimulate diabetic wound healing through activation of the Ras/MAPK pathway. This indicates that PBM has the potential to be an effective treatment for diabetic foot ulcers.
Review
Immunology
Nicholas Manolios, John Papaemmanouil, David Adams
Summary: T lymphocytes are crucial cells in the immune system, and ion channels play a critical role in regulating their function. This review summarizes the impact of ion channels on T cell function and disease, emphasizing their potential as drug targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Rodrigo G. Mira, Waldo Cerpa
Summary: Glutamate, as a major excitatory neurotransmitter in the brain, is involved in synaptic plasticity and excitotoxicity through NMDAR receptors. Mitochondria also play a crucial role in calcium homeostasis, and disruption of this homeostasis can lead to neuronal death.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biology
Eider Nunez, Frederick Jones, Arantza Muguruza-Montero, Janire Urrutia, Alejandra Aguado, Covadonga Malo, Ganeko Bernardo-Seisdedos, Carmen Domene, Oscar Millet, Nikita Gamper, Alvaro Villarroel, Henry M. Colecraft
Summary: Neuronal K(V)7 channels are highly sensitive to reactive oxygen species, and the S2S3 linker of the voltage sensor plays a crucial role in redox modulation of the channels. Recent structural studies have revealed interactions between this linker and the Ca2+-binding loop of calmodulin, specifically the EF3 hand, which is essential for the signaling. Disrupting Ca2+ binding to EF3 abolishes the oxidation-induced enhancement of K(V)7.4 currents. Furthermore, the loading of EF3 with Ca2+ is critical for the reorientation of the AB fork, which translates the Ca2+ signals.
Review
Pharmacology & Pharmacy
Emma R. R. Carruthers, Natasha L. L. Grimsey
Summary: Cannabinoid CB2 receptor agonists have potential therapeutic applications for immune modulation and pain relief, but their efficacy in human clinical trials has been limited. Differences in ligand engagement and signaling responses between the human CB2 receptor and animal models may contribute to this discrepancy. This review summarizes the gene and protein structure of CB2 receptors, compares their pharmacology in different species, and discusses the challenges in translating preclinical studies to clinical success for CB2 receptor-targeted drugs.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
