Review
Biochemistry & Molecular Biology
Andrea Capucciati, Fabio A. Zucca, Enrico Monzani, Luigi Zecca, Luigi Casella, Tim Hofer
Summary: Neuromelanin (NM) is a complex substance found in long-lived brain neurons and plays a potential role in age-related neurodegenerative diseases. Understanding NM formation and function is crucial for identifying potential toxic mechanisms and modulators, and using suitable animal models and stem cell-based models could provide valuable insights in this area.
Article
Multidisciplinary Sciences
Theodoros Tsetsenis, Julia K. Badyna, Julianne A. Wilson, Xiaowen Zhang, Elizabeth N. Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A. Thomas, John A. Dani
Summary: This study identifies a cluster of midbrain dopamine neurons near the hippocampus that send direct projections and play a crucial role in aversive memory formation. The neuromodulation of midbrain dopamine in the hippocampus is sufficient to maintain aversive memory formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Sooyeon Ji, Eun-Jung Choi, Beomseok Sohn, Kyoungwon Baik, Na-Young Shin, Won-Jin Moon, Seongbeom Park, Soohwa Song, Phil Hyu Lee, Dong Hoon Shin, Se-Hong Oh, Eung Yeop Kim, Jongho Lee
Summary: This study proposes a new NM-sensitive imaging method called sandwichNM, which utilizes the incidental MT effects of spatial saturation RF pulses to generate high-quality NM images using product sequences. Compared to conventional NM-sensitive imaging methods, sandwichNM provides higher NM contrast and consistent contrasts across vendors in a multi-vendor experiment.
Article
Multidisciplinary Sciences
Dipshay Avi Chand, Miriam Scadeng, Birger Victor Dieriks
Summary: Parkinson's disease is characterized by selective degeneration of pigmented neurons in the substantia nigra. Neuromelanin, which is difficult to study and quantify, plays an unclear role in the disease. A new quantification protocol has been developed to measure the absolute concentration of neuromelanin in formalin-fixed tissue, providing insights for biomarker development and further research into neuromelanin's role in Parkinson's disease.
Article
Neurosciences
Michal Rafal Zareba, Wiktoria Furman, Marek Binder
Summary: Aging is associated with changes in brain structure and function, leading to a decline in cognitive function. Dopamine and noradrenaline are likely to play a key role in mediating these effects, but the underlying mechanisms are not well understood.
Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Neurosciences
Martin Martinez, Mikel Ariz, Ignacio Alvarez, Gabriel Castellanos, Miquel Aguilar, Jorge Hernandez-Vara, Nuria Caballol, Alicia Garrido, Angels Bayes, Dolores Vilas, Maria Jose Marti, Pau A. Pastor, Carlos Ortiz de Solorzano, Maria Pastor
Summary: Quantifying and locating brainstem NM and iron through MRI can reveal specific patterns linked to LRRK2-PD or iPD. PD patients had lower NM CR and nVol in ventral-caudal SNc, while iron increased in lateral, medial-rostral, and caudal SNc. LC CR and nVol were better discriminators among subgroups, with LRRK2-PD showing similar LC NM CR and nVol as controls and larger LC NM nVol and RN iron CR than iPD. SNc NM was the best discriminator between HC and PD according to ROC analysis.
NPJ PARKINSONS DISEASE
(2023)
Article
Neuroimaging
Xinhui Wang, Pei Huang, Ewart Mark Haacke, Yu Liu, Youmin Zhang, Zhijia Jin, Yan Li, Qiuyun Xu, Peng Liu, Shengdi Chen, Naying He, Fuhua Yan
Summary: Neuromelanin measures of the substantia nigra and locus coeruleus can improve the differential diagnosis of essential tremor and Parkinson's disease. There are significant differences in neuromelanin measures between patients with Parkinson's disease and those with essential tremor or healthy controls. Utilizing these measures for differential diagnosis can achieve high accuracy.
NEUROIMAGE-CLINICAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rami Al Haddad, Mira Chamoun, Christine L. Tardif, Synthia Guimond, Guillermo Horga, Pedro Rosa-Neto, Clifford M. Cassidy
Summary: This study aims to support the use of NM-MRI as a clinical biomarker by establishing the normal range of NM-MRI signal and volume metrics in cognitively normal older adults. The results indicate that the only significant change in NM-MRI metrics in older adults is a decrease in left substantia nigra volume.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Ziying Yu, Lishuang Huang, Yinyin Xia, Shuqun Cheng, Cantao Yang, Chengzhi Chen, Zhen Zou, Xiaoliang Wang, Xin Tian, Xuejun Jiang, Lixiao Zhou
Summary: Parkinson's disease (PD) is a neurodegenerative disorder in which m6A modification may play a role. By establishing a PD mouse model, researchers found abnormalities in m6A regulators in learning, memory, and motor functions, as well as significant loss of TH+ neurons in the substantia nigra and striatum.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Alexander Pilski, Steven M. Graves
Summary: Methamphetamine (meth) is a neurotoxic psychostimulant that affects axonal and somatic compartments of neurons in the brain, leading to degeneration of substantia nigra pars compacta (SNc) and locus coeruleus (LC) neurons. This study found that chronic meth use results in axonal deficits in SNc and LC neurons in male mice before somatic loss occurs, while female mice are resistant to these effects. MAO inhibition showed neuroprotective effects, suggesting a potential therapeutic approach for meth-induced degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Marina Yu. Kopaeva, Anton B. Cherepov, Mikhail V. Nesterenko, Irina Yu. Zarayskaya
Summary: The study showed that pretreatment with human lactoferrin significantly alleviated MPTP toxicity in mice, improving motor functions and exploratory behavior, as well as partially recovering the number of TH-positive cells in the substantia nigra and TH-positive fibers in the striatum. This suggests a neuroprotective effect and potential for neuroregeneration with lactoferrin in the treatment of neurodegenerative diseases.
Article
Multidisciplinary Sciences
Donovan K. Galvez-Marquez, Mildred Salgado-Menez, Perla Moreno-Castilla, Luis Rodriguez-Duran, Martha L. Escobar, Fatuel Tecuapetla, Federico Bermudez-Rattoni
Summary: This study found that decreasing catecholamine release from the locus coeruleus terminals in the hippocampus can impact the updating of spatial contextual memory. Photoinhibtion of these terminals impaired the consolidation of object location memory and led to a decrease in both dopamine and noradrenaline levels. This data suggests that dopamine plays a role in the mechanisms of spatial contextual memory updating.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Geriatrics & Gerontology
Shangpei Wang, Tong Wu, Yajie Cai, Yongqiang Yu, Xianwen Chen, Longsheng Wang
Summary: The downregulation of monoamines, particularly dopamine and norepinephrine, is associated with freezing of gait in Parkinson's disease. NM-MRI revealed decreased volume, surface area, and CNR of SN and LC in PD-FOG patients. The measurements of SN and LC showed correlations with clinical symptoms and freezing of gait questionnaire scores, and CNR had good sensitivity and specificity for distinguishing PD from HC.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu
Summary: Parkinson's disease is an aging-related neurodegenerative disease characterized by movement disorders and deficiency of dopamine. Lewy bodies and abnormal accumulation of neuromelanin are the histopathological hallmarks of Parkinson's disease, leading to cell death of dopamine neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Endocrinology & Metabolism
Charles W. Wilkinson
ENDOCRINE PRACTICE
(2015)
Article
Neurosciences
Patricia Szot, Allyn Franklin, Cristina Miguelez, Yangqing Wang, Igor Vidaurrazaga, Luisa Ugedo, Carl Sikkema, Charles W. Wilkinson, Murray A. Raskind
Article
Neurosciences
A. G. Schindler, J. S. Meabon, K. F. Pagulayan, R. C. Hendrickson, K. D. Meeker, M. Cline, G. Li, C. Sikkema, C. W. Wilkinson, D. P. Perl, M. R. Raskind, E. R. Peskind, J. J. Clark, D. G. Cook
NEUROBIOLOGY OF DISEASE
(2017)
Article
Clinical Neurology
Ge Li, Jane B. Shofer, Eric C. Petrie, Chang-En Yu, Charles W. Wilkinson, Dianne P. Figlewicz, Andrew Shutes-David, Jing Zhang, Thomas J. Montine, Murray A. Raskind, Joseph F. Quinn, Douglas R. Galasko, Elaine R. Peskind
ALZHEIMERS RESEARCH & THERAPY
(2017)
Article
Neurosciences
Rebecca L. Kow, Carl Sikkema, Jeanna M. Wheeler, Charles W. Wilkinson, Brian C. Kraemer
BIOLOGICAL PSYCHIATRY
(2018)
Article
Geriatrics & Gerontology
Lucy Y. Wang, Murray A. Raskind, Charles W. Wilkinson, Jane B. Shofer, Carl Sikkema, Patricia Szot, Joseph F. Quinn, Douglas R. Galasko, Elaine R. Peskind
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2018)
Article
Clinical Neurology
Arundhati Undurti, Elizabeth A. Colasurdo, Carl L. Sikkema, Jaclyn S. Schultz, Elaine R. Peskind, Kathleen F. Pagulayan, Charles W. Wilkinson
FRONTIERS IN NEUROLOGY
(2018)
Article
Neurosciences
Amy Claxton, Laura D. Baker, Charles W. Wilkinson, Emily H. Trittschuh, Darla Chapman, G. Stennis Watson, Brenna Cholerton, Stephen R. Plymate, Matthew Arbuckle, Suzanne Craft
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Article
Geriatrics & Gerontology
Lucy Y. Wang, Richard R. Murphy, Brett Hanscom, Ge Li, Steven P. Millard, Eric C. Petrie, Douglas R. Galasko, Carl Sikkema, Murray A. Raskind, Charles W. Wilkinson, Elaine R. Peskind
NEUROBIOLOGY OF AGING
(2013)
Article
Clinical Neurology
Angela J. Hanson, Jennifer L. Bayer-Carter, Pattie S. Green, Thomas J. Montine, Charles W. Wilkinson, Laura D. Baker, Stennis Watson, Laura M. Bonner, Maureen Callaghan, James B. Leverenz, Elaine Tsai, Nadia Postupna, Jing Zhang, Johanna Lampe, Suzanne Craft
Article
Neurosciences
Miriam Ben-Hamo, Tracy A. Larson, Leanne S. Duge, Carl Sikkema, Charles W. Wilkinson, Horacio O. de la Iglesia, Monica M. C. Gonzalez
Article
Psychology, Clinical
Karen B. Schmaling, Joan M. Romano, Mark P. Jensen, Charles W. Wilkinson, Sterling McPherson
JOURNAL OF FAMILY PSYCHOLOGY
(2015)
Meeting Abstract
Biochemistry & Molecular Biology
Charles W. Wilkinson, Elizabeth A. Colasurdo, Kathleen F. Pagulayan, Jane B. Shofer, Elaine R. Peskind
Meeting Abstract
Neurosciences
Charles W. Wilkinson, Elaine R. Peskind, Elizabeth A. Colasurdo, Kathleen F. Pagulayan, Jane B. Shofer