期刊
FRONTIERS IN NEUROSCIENCE
卷 8, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fnins.2014.00053
关键词
adult neurogenesis; ventricular-subventricular zone; neural stem cell; neuronal migration; blood vessel; brain injury; ischemia; brain regeneration
资金
- Funding Program for the Next Generation World-Leading Researchers
- Takeda Science Foundation
- Terumo Life Science Foundation
- JSPS KAKENHI [22122004, 25890017]
- Grants-in-Aid for Scientific Research [22122004, 25890017] Funding Source: KAKEN
Neural stem cells in the mammalian adult brain continuously produce new neurons throughout life. Accumulating evidence in rodents suggests that various aspects of adult neurogenesis, including the genesis, migration, and maturation of new neurons, are regulated by factors derived from blood vessels and their microenvironment. Brain injury enhances both neurogenesis and angiogenesis, thereby promoting the cooperative regeneration of neurons and blood vessels. In this paper, we briefly review the mechanisms for the vascular regulation of adult neurogenesis in the ventricular-subventricular zone under physiological and pathological conditions, and discuss their clinical potential for brain regeneration strategies.
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