Article
Materials Science, Multidisciplinary
Tanveer A. Tabish, Roger J. Narayan
Summary: The article discusses the potential of graphene as a drug delivery system to cross the blood-brain barrier, and how it can improve, protect, or rescue brain energetics, with a specific focus on how graphene alters neuronal cell function.
Review
Pharmacology & Pharmacy
Erica A. Power, Julian S. Rechberger, Sumit Gupta, Jonathan D. Schwartz, David J. Daniels, Soumen Khatua
Summary: Although there has been a surge in the identification of molecular targets and targeted therapies in pediatric brain tumors in the last decade, the blood brain barrier (BBB) remains a significant challenge for systemic drug delivery. Recent efforts have identified strategies to enhance drug delivery into pediatric brain tumors, including invasive and non-invasive technologies.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Yong-Jiang Li, Jun-Yong Wu, Jihua Liu, Xiaohan Qiu, Wenjie Xu, Tiantian Tang, Da-Xiong Xiang
Summary: Biomimetic drug delivery systems based on blood cells for brain drug delivery have rapidly grown, showcasing their engineering feasibility and versatile delivery ability, but face translational challenges in the future.
Review
Biochemistry & Molecular Biology
Andrew M. Hersh, Safwan Alomari, Betty M. Tyler
Summary: This article provides a review of the potential of nanoparticles (NPs) in improving drug delivery to brain tumors. The unique physical and chemical properties of NPs and the mechanisms of NP transport across the blood-brain barrier are discussed, along with the major types of NPs investigated for brain tumor treatment. In addition, the use of NPs as imaging contrast agents and their conjugation with imaging probes for visualization and treatment monitoring are explored. Finally, the limitations of NPs for brain tumor treatment are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Article
Chemistry, Multidisciplinary
Jianping Lu, Jiali Ding, Binbin Chu, Chen Ji, Qian Zhang, Yanan Xu, Bin Song, Houyu Wang, Yao He
Summary: We found that dead Escherichia coli K1 (EC-K1) can safely penetrate the blood-brain barrier (BBB), and developed a drug delivery system using dead EC-K1, which retain the intact structure and chemotaxis of live EC-K1 but lose their pathogenicity. The dead bacteria carry therapeutics and bypass the BBB, delivering higher doses into the brain than free therapeutics. This strategy enables the therapy of bacterial meningitis and glioblastoma in mice.
Article
Chemistry, Multidisciplinary
Suyeong Seo, Seung-Yeol Nah, Kangwon Lee, Nakwon Choi, Hong Nam Kim
Summary: The study introduced an engineered 3D human glioblastoma in vitro platform integrated with a tricultured BBB, allowing for mimicking the physiological environment of brain tumors. The platform showed potential for studying the physiology of the BBB and monitoring drug responses based on the interaction between brain tumor cells and the BBB.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Joelle P. Straehla, Cynthia Hajal, Hannah C. Safford, Giovanni S. Offeddu, Natalie Boehnke, Tamara G. Dacoba, Jeffrey Wyckoff, Roger D. Kamm, Paula T. Hammond
Summary: In this study, a vascularized human glioblastoma multiforme (GBM) model in a microfluidic device was established to accurately recapitulate brain tumor vasculature and investigate the transport of targeted nanotherapeutics across the blood-brain barrier and into GBM cells. The surface of nanoparticles was functionalized with GBM-targeting motifs to improve their trafficking to tumors. The therapeutic potential of functionalized nanoparticles was demonstrated both in vitro and in an in vivo orthotopic xenograft model. This vascularized GBM model represents a significant biomaterials advance, enabling in-depth investigation of brain tumor vasculature and accelerating the development of targeted nanotherapeutics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Medicine, General & Internal
Sneha Rathi, Jessica Griffith, Wenjuan Zhang, Wenqiu Zhang, Ju-Hee Oh, Surabhi Talele, Jann N. Sarkaria, William F. Elmquist
Summary: Brain tumours have a poor prognosis due to the challenges posed by the blood-brain barrier (BBB) in drug delivery. The heterogeneity of the blood-brain tumour barrier (BBTB) limits the success of relying on its disruption for effective drug concentrations in tumours. Therefore, designing drugs and delivery strategies to overcome the 'normal' BBB is crucial for treating brain tumours effectively.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Apostolos A. Gkountas, Nickolas D. Polychronopoulos, George N. Sofiadis, Evangelos G. Karvelas, Leonidas A. Spyrou, Ioannis E. Sarris
Summary: This study numerically investigates the delivery of magnetic nanoparticles through the blood-brain barrier, showing that an external magnetic field can significantly enhance drug delivery to the central nervous system. Factors such as the size of MNPs, external magnetic field, and blood flow affect the permeability of the barrier.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Joji Ishida, Saira Alli, Andrew Bondoc, Brian Golbourn, Nesrin Sabha, Kristina Mikloska, Stacey Krumholtz, Dilakshan Srikanthan, Naohide Fujita, Amanda Luck, Colin Maslink, Christian Smith, Kullervo Hynynen, James Rutka
Summary: Diffuse intrinsic pontine glioma (DIPG) is a devastating tumor in children that cannot be surgically removed, and MRI-guided focused ultrasound (MRgFUS) shows promise in enhancing drug delivery for DIPG treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Fatemeh Madani, Seyedeh Sara Esnaashari, Thomas J. Webster, Masood Khosravani, Mahdi Adabi
Summary: This review discusses the challenges of delivering drugs through the blood-brain barrier (BBB) in glioblastoma (GBM) treatment and introduces the latest advances in using nanoparticles for this purpose. It also describes the development of drug delivery and combination modalities using natural and synthetic polymer nanoparticles, as well as adjuvant therapies for GBM treatment. Additionally, it explains the receptor-mediated endocytosis agents that exist in brain endothelial capillary cells and emphasizes future research directions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Anna Froelich, Tomasz Osmalek, Barbara Jadach, Vinam Puri, Bozena Michniak-Kohn
Summary: Nose-to-brain drug delivery has gained significant attention as a route to deliver drugs directly to the central nervous system, bypassing the blood-brain barrier. Challenges include the small volume of the nasal cavity and limited drug absorption, which can be addressed by using drug carriers to enhance delivery efficiency.
Review
Chemistry, Multidisciplinary
Alireza Poustforoosh, Mohammad Hadi Nematollahi, Hassan Hashemipour, Abbas Pardakhty
Summary: This review discusses the challenges and barriers in drug delivery to the brain, as well as strategies and pathways to overcome the blood-brain barrier. The application of bioconjugated vesicles as nanocarriers for enhancing drug loading into the brain is emphasized.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Kibeom Kim, Jungmin Lee, Myoung-Hwan Park
Summary: The blood-brain barrier is an important barrier that protects the brain and maintains homeostasis. Traditional drug delivery methods face limitations such as low diversity and efficiency. Microbubble-based drug delivery systems, which utilize ultrasound-induced physical changes, have gained attention in recent years for their ability to enhance drug delivery by disrupting the blood-brain barrier.