Article
Agriculture, Multidisciplinary
Zhi Qiao, Wen Fu, Yongchao Zhang, Ruijia Chen, Zhiping Xu, Zhong Li, Xusheng Shao
Summary: This study reported several photochromic ligands of metaflumizone, with one ligand, ABM04, showing larvicidal and insecticidal activity while enabling real-time photoregulation of mosquito larval behavior. This marks the first successful attempt at precise regulation of invertebrate sodium channels, offering a new strategy for accurate research in this area.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Johannes Morstein, Anna C. Impastato, Dirk Trauner
Summary: Photoswitchable lipids are emerging tools for precise manipulation and study of lipid function, modulating various aspects of membrane biophysics and enabling optical control of lipid receptors in physiology. They complement other functionalized lipids used in lipid chemical biology.
Article
Biochemistry & Molecular Biology
Daniil M. Strashkov, Vladimir N. Mironov, Dmitrii M. Nikolaev, Maxim S. Panov, Stanislav A. Linnik, Andrey S. Mereshchenko, Vladimir A. Kochemirovsky, Andrey V. Vasin, Mikhail N. Ryazantsev
Summary: ATPLs are photoactive compounds with various photopharmacological applications, and their spectral and kinetic properties can be adjusted by introducing para substituents. The study obtained correlations between the electronic effects of substituents and the structural and optical properties of ATPLs, which can be used for optimal design for photopharmacological applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Albert M. Schulte, Dusan Kolarski, Vidya Sundaram, Ashutosh Srivastava, Florence Tama, Ben L. Feringa, Wiktor Szymanski
Summary: Protein kinases play a crucial role in cellular processes and signaling pathways, and their dysfunction is associated with various diseases. Photopharmacology, as an unconventional approach, uses light-controlled bioactive molecules to selectively activate drugs for kinase inhibition. This study presents the discovery and optimization of a photoswitchable inhibitor targeting casein kinase 1 delta (CK1 delta), which is involved in important signaling processes such as cell differentiation, circadian rhythm, DNA repair, and apoptosis. The optimized photoswitchable inhibitor showed improved properties, including high photostationary state distributions and solubility, as well as a 10-fold difference in activity between irradiated and thermally adapted samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Emma E. Watson, Francesco Russo, Dimitri Moreau, Nicolas Winssinger
Summary: A Ru(bpy)(3)Cl-2 photocatalyst is used to convert a range of alkene-containing pharmacological agents from inactive substances to potent cytotoxic agents. The selective in cellulo activation of a CA-4 analog, Res-3M, is demonstrated, showing potent cytotoxicity and inhibition of microtubule dynamics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Filip Borys, Piotr Tobiasz, Hanna Fabczak, Ewa Joachimiak, Hanna Krawczyk
Summary: In this paper, researchers report the synthesis and anticancer activity of 12 new visible light photoswitchable colchicine-based microtubule inhibitors. Two of the fluorescent switchable colchicine derivatives showed light-dependent cytotoxicity in cancer cells, with one compound displaying nearly twofold increase in potency. The findings provide a foundation for the synthesis and development of a novel class of photoswitchable colchicine-based microtubule polymerization inhibitors.
Article
Pharmacology & Pharmacy
Maxim Nikolaev, Daniil M. Strashkov, Mikhail N. Ryazantsev, Denis B. Tikhonov
Summary: NMDA receptors are crucial in various physiological and pathological processes in the CNS, and photoswitchable compounds have proven to be valuable for studying receptor contributions. In this study, light-sensitive compounds based on the DENAQ structure were developed and their effects on glutamate receptors were investigated. The compound PyrAQ showed the most activity in inhibiting NMDA receptors and can be used as a useful tool for photo-pharmacological studies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Maximilian Sacherer, Frank Hampel, Henry Dube
Summary: Researchers have successfully synthesized modified Hemiindigo (HI) derivatives that have additional aromatic residues, allowing for more functionalization and structural modification possibilities. These new chromophores exhibit red-light responsiveness, high thermal bistability, strong isomer accumulations, photochromism, tunable acid responsiveness, and acid gating. This progress expands the structural realm for HI photoswitches, enabling advanced applications in molecular machines and switches, photoisomerization mechanisms, and smart materials.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Simon M. Buellmann, Theresa Kolmar, Philip Slawetzky, Simon Wald, Andres Jaeschke
Summary: A high-performance photoswitch suitable for photochromic DNA synthesis was identified out of nine different 7-deaza-adenosine diarylethenes. Using solid phase synthesis, a photoresponsive T7 promotor was generated to reversibly modulate the rate of enzymatic RNA synthesis in vitro.
CHEMICAL COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Johannes Broichhagen, Joshua Levitz
Summary: This article introduces the core concept and recent advances in tethered photopharmacology, as well as its applications in various fields. Tethered photopharmacology leverages the use of light to provide high spatiotemporal control over drug action on specific protein subtypes, offering a new approach for drug research.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Anurag Mukherjee, Maximilian D. Seyfried, Bart Jan Ravoo
Summary: Aromatic units tethered with an azo functionality are molecular photoswitches that can reversibly transform between E- and Z-isomers in response to light. These photoswitches have been widely used in the preparation of dynamic self-assembled materials, optoelectronic devices, and responsive biomaterials. Recently, azoheteroarenes and cyclic azobenzenes have emerged as second generation molecular photoswitches with distinct photoswitching behavior and responsive properties, making them promising candidates for various applications. This minireview introduces the structural refinement and photoresponsive properties of azoheteroarenes and cyclic azobenzenes, and summarizes their applications in supramolecular assembly, material science, and photopharmacology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Yuri Saeki, Megumi Kayanuma, Aki Nitta, Yasuteru Shigeta, Izuru Kawamura, Tetsuya Nakagawa, Takashi Ubukata, Yasushi Yokoyama
Summary: The photochromic ring-closing reactions of a specific molecule incorporated in human serum albumin showed high enantioselectivity upon light irradiation. Through simulation, molecular dynamics calculations, and comparison of CD spectra, the absolute stereochemistry of the major ring-closed forms were determined.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Vladimir L. Bondarev, Alexey A. Festa, Olga A. Storozhenko, Nikita E. Golantsov, Venkatanarayana Pappula, Alexander G. Tskhovrebov, Alexey V. Varlamov, Leonid G. Voskressensky
Summary: A pseudo-three-component reaction has been discovered when azo coupling of aryldiazonium salts with indoles is conducted in aprotic nonpolar solvent on air. The reaction involves the nucleophilic addition of a second indole unit to the indolium intermediate after azo coupling, followed by aromatization and oxidation under air.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yaoyao Du, Zhongli Shao, Qi Xu, Zhong Li, Xusheng Shao
Summary: Photoswitchable azobenzene-avermectin derivatives have been developed, which can be activated by ultraviolet irradiation and show enhanced insecticidal activity towards insects and their larvae. These compounds allow for optical modulation of neuron membrane potential and behavioral response upon illumination.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Organic
Brian P. Corbet, J. Malte Schlueter, Elena R. Cotroneo, Stefano Crespi, Nadja A. Simeth
Summary: Light-responsive molecules, particularly photoswitches, have shown great potential in modulating biological functions due to their reversible light-mediated reactivity. However, the use of photochromic couples in a biological context is still limited, and this study focuses on exploring the photochemical and thermal properties of the dihydroazulene/vinylheptafulvene photochromic couple as peptide conjugates in an aqueous environment.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
N. Torquet, F. Marti, C. Campart, S. Tolu, C. Nguyen, V Oberto, M. Benallaoua, J. Naude, S. Didienne, N. Debray, S. Jezequel, L. Le Gouestre, B. Hannesse, J. Mariani, A. Mourot, P. Faure
NATURE COMMUNICATIONS
(2018)
Article
Biology
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jeremie Naude, Thibaut d'Izarny-Gargas, Stephanie Pons, Uwe Maskos, Dirk Trauner, Richard H. Kramer, Philippe Faure, Alexandre Mourot
Article
Biochemistry & Molecular Biology
Benoit Forget, Petra Scholze, Francina Langa, Carole Morel, Stephanie Pons, Sarah Mondoloni, Morgane Besson, Romain Durand-de Cuttoli, Audrey Hay, Ludovic Tricoire, Bertrand Lambolez, Alexandre Mourot, Philippe Faure, Uwe Maskos
Review
Neurosciences
Pierre Paoletti, Graham C. R. Ellis-Davies, Alexandre Mourot
NATURE REVIEWS NEUROSCIENCE
(2019)
Review
Pharmacology & Pharmacy
Sarah Mondoloni, Romain Durand-de Cuttoli, Alexandre Mourot
TRENDS IN PHARMACOLOGICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Romain Durand-de Cuttoli, Pradeep S. Chauhan, Adriana Petriz Reyes, Philippe Faure, Alexandre Mourot, Graham C. R. Ellis-Davies
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Neurosciences
William Renthal, Ivan Tochitsky, Lite Yang, Yung-Chih Cheng, Emmy Li, Riki Kawaguchi, Daniel H. Geschwind, Clifford J. Woolf
Editorial Material
Medicine, Research & Experimental
Romain Durand-de Cuttoli, Alexandre Mourot
M S-MEDECINE SCIENCES
(2021)
Article
Neurosciences
Claire Nguyen, Sarah Mondoloni, Tinaig Le Borgne, Ines Centeno, Maxime Come, Joachim Jehl, Clement Solie, Lauren M. Reynolds, Romain Durand-de Cuttoli, Stefania Tolu, Sebastien Valverde, Steve Didienne, Bernadette Hannesse, Jean-Francois Fiancette, Stephanie Pons, Uwe Maskos, Veronique Deroche-Gamonet, Deniz Dalkara, Jean-Pierre Hardelin, Alexandre Mourot, Fabio Marti, Philippe Faure
Summary: Nicotine affects dopamine neurons in the ventral tegmental area, eliciting opposite functional responses in different populations of neurons projecting to different brain regions, leading to anxiety-like behavior.
Article
Multidisciplinary Sciences
Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne K. Durante, Damien Lemoine, Raphael Britto, Tarek Ahmed Yahia, Sarah Mondoloni, Steve Didienne, Elise Bousseyrol, Bernadette Hannesse, Lauren M. Reynolds, Nicolas Torquet, Deniz Dalkara, Fabio Marti, Alexandre Mourot, Jeremie Naude, Philippe Faure
Summary: Chronic nicotine exposure affects decision-making processes, including exploratory behaviors, by increasing the tonic activity of VTA dopaminergic neurons and reducing exploration in mice. Long-term nicotine exposure alters brain circuits and leads to significant changes in decision-making strategies, impacting behaviors related and unrelated to drug seeking and consumption. The study also shows that optogenetically stimulating mice mimics the effects of chronic nicotine on dopamine neuron activity, highlighting a potential mechanism by which nicotine influences decision-making processes.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Sergei Nikonov, Natalia Dolgova, Raghavi Sudharsan, Ivan Tochitsky, Simone Iwabe, Jose-Manuel Guzman, Russell N. N. Van Gelder, Richard H. H. Kramer, Gustavo D. D. Aguirre, William A. A. Beltran
Summary: This study reports the effects of DENAQ, a second-generation azobenzene-based photoswitch, on retinal ganglion cells in canine retinas. DENAQ treatment increases light sensitivity in degenerated canine retinas and induces responses in previously non-responsive cells. However, limited solubility and ocular toxicity hinder the therapeutic potential of DENAQ.
Article
Biology
Damien Lemoine, Sarah Mondoloni, Jerome Tange, Bertrand Lambolez, Philippe Faure, Antoine Taly, Ludovic Tricoire, Alexandre Mourot
Correction
Biology
Marwen Belkaid, Elise Bousseyrol, Romain Durand-de Cuttoli, Malou Dongelmans, Etienne K. Durante, Tarek Ahmed Yahia, Steve Didienne, Bernadette Hanesse, Maxime Come, Alexandre Mourot, Jeremie Naude, Olivier Sigaud, Philippe Faure
COMMUNICATIONS BIOLOGY
(2020)
Article
Biology
Marwen Belkaid, Elise Bousseyrol, Romain Durand-de Cuttoli, Malou Dongelmans, Etienne K. Durante, Tarek Ahmed Yahia, Steve Didienne, Bernadette Hanesse, Maxime Come, Alex Mourot, Jeremie Naude, Olivier Sigaud, Philippe Faure
COMMUNICATIONS BIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Alexandre Mourot, Christian Herold, Michael A. Kienzler, Richard H. Kramer
BRITISH JOURNAL OF PHARMACOLOGY
(2018)