Article
Neurosciences
Can Sun, Jian Fu, Zhenzhen Qu, Lijing Jia, Dongxiao Li, Junli Zhen, Weiping Wang
Summary: The study found that chronic intermittent hypobaric hypoxia treatment can rescue cognitive deficits in epileptic rats by activating the Wnt/β-catenin pathway, providing a potential therapeutic approach for epilepsy-induced cognitive impairments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Evan A. Hutcheon, Vasily A. Vakorin, Adonay Nunes, Urs Ribary, Sherri Ferguson, Victoria E. Claydon, Sam M. Doesburg
Summary: This study aimed to explore the correlations between oxygen saturation (SpO(2)) and neural responses in normobaric (NH) and hypobaric (HH) hypoxia. Resting-state electroencephalogram (EEG) and SpO(2) were recorded during control, NH, and HH conditions from 13 participants. The results showed significant correlations between EEG measures and SpO(2) in the desaturating phase of NH, but no significant differences between NH and HH once steady desaturation occurred. The findings highlight the importance of developing strategies to mitigate the hypoxic stimulus during the desaturating phase of high-altitude training courses.
HUMAN BRAIN MAPPING
(2023)
Article
Biochemistry & Molecular Biology
Pavel Pchelin, Daria Shkarupa, Nadezhda Smetanina, Tatiana Grigorieva, Roman Lapshin, Natalia Schelchkova, Tatiana Machneva, Anna Bavrina
Summary: Low-level laser therapy using red or near-infrared light can improve mitochondrial dysfunction in the brain caused by hypoxia. The therapy was effective in improving respiration and membrane polarization, but had no significant effect on Complex IV activity. This research provides valuable insights for the development of non-invasive phototherapy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Emergency Medicine
Lothar A. Schwarte, Huub J. van der Werf, Milan L. Ridderikhof, Jan Fraessdorf, Daphne van Embden, Robert P. Weenink
Summary: We report a rare case of a successful treatment and full recovery of a stowaway found in the wheelwell of an airplane. The stowaway experienced neurological deficits due to hypoxia or altitude decompression sickness, but was treated with hyperbaric oxygen therapy and achieved complete neurological recovery.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Julie Vinkel, Bjoern Arenkiel, Ole Hyldegaard
Summary: The perception of sepsis has changed, recognizing it as an imbalance in host cellular functions triggered by invading pathogens. Hyperbaric oxygen (HBO2) treatment has shown improvement in survival for patients with necrotizing soft tissue infections and sepsis models, possibly by affecting oxidative phosphorylation and cellular processes. This article argues for the protective effects of HBO2 treatment on tissue damage and the upregulation of anti-inflammatory measures in sepsis.
Review
Integrative & Complementary Medicine
Dorota Olex-Zarychta
Summary: Psychomotor performance is the coordination of a sensory or ideational (cognitive) process and a motor activity. This paper reviews the effects of hyperbaric oxygen therapy on different aspects of human psychomotor function, including musculoskeletal properties, motor abilities, cognitive function, and myocardial and pulmonary functions.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Neurosciences
Valerian Tanner, Raphael Faiss, Jonas Saugy, Nicolas Bourdillon, Laurent Schmitt, Gregoire P. Millet
Summary: The study found that the changes in supine HRV parameters during a 24-hour exposure were similar between normobaric and hypobaric hypoxia, indicating a similar decrease in parasympathetic activity.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Oncology
Pei Wang, Xiao-Yan Wang, Chang-Feng Man, Dan-Dan Gong, Yu Fan
Summary: Hyperbaric oxygen therapy can influence immunotherapy by regulating the tumor microenvironment, providing a direction for the future development of immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Metallurgy & Metallurgical Engineering
Duan Guan-nan, Song Cong, Liu Yan-feng, Wang Deng-jia, Cao Rui-xuan
Summary: Hypobaric hypoxia in the Tibetan plateau affects thermal comfort by causing a decrease in thermal sensation and mean skin temperature. Oxygen partial pressure has a significant impact on thermal sensation, exacerbating discomfort in a hypoxic environment.
JOURNAL OF CENTRAL SOUTH UNIVERSITY
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshihito Morimoto, Hideo Ohuchi, Kenichi Kurosaki, Michikazu Nakai
Summary: Fontan patients showed lower oxygen saturation levels during flight compared to volunteers, and exercise-induced oxygen saturation decline was strongly correlated with oxygen saturation dynamics during flight.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Li Zhang, Lin Jin, Jialiang Guo, Kai Bao, Jinglue Hu, Yingze Zhang, Zhiyong Hou, Liping Zhang
Summary: The study demonstrated that CIHH treatment improves fracture healing, increases bone mineral density, and enhances bone strength through the activation of HIF-1 alpha and bone production-related genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Clinical Neurology
Diogo Alpuim Costa, Mafalda Sampaio-Alves, Eduardo Netto, Goncalo Fernandez, Edson Oliveira, Andreia Teixeira, Pedro Modas Daniel, Guilherme Silva Bernardo, Carla Amaro
Summary: Glioblastoma (GBM) is a common and aggressive brain tumor with poor treatment outcomes. Recent studies suggest that hyperbaric oxygen therapy (HBOT) may enhance the sensitivity of anticancer therapies by increasing oxygen tension within the tumor tissue, potentially improving the treatment outcomes for GBM.
FRONTIERS IN NEUROLOGY
(2022)
Article
Physiology
Hannes Gatterer, Simon Rauch, Ivo B. Regli, Simon Woyke, Maja Schlittler, Rachel Turner, Giacomo Strapazzon, Hermann Brugger, Jens P. Goetze, Eric Feraille, Christoph Siebenmann
Summary: This study suggests that the reduction of atrial natriuretic peptide (ANP) after prolonged hypoxic exposure is at least partially due to plasma volume contraction, while the decreased arterial oxygen tension (Pa-O2) does not seem to contribute significantly.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Physiology
Thomas Rupp, Jonas J. Saugy, Nicolas Bourdillon, Gregoire P. Millet
Summary: This study examined the differences in cerebral and muscular regulation during self-paced aerobic exercise under hypobaric and normobaric hypoxia conditions. The results showed that performance and pacing were more down-regulated in hypobaric hypoxia, accompanied by impaired systemic and prefrontal cortex oxygenation during exercise.
FRONTIERS IN PHYSIOLOGY
(2022)