Review
Immunology
Fangzheng Guo, Jing Wei, Yamin Song, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang, Tao Xu
Summary: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. While the BCG vaccine has been widely administered, its protective rate in preventing tuberculosis is not high in some regions, especially in adults. Therefore, research on the Mtb mechanism and development of new vaccines are crucial strategies. Recent studies have highlighted the role of PE and PPE proteins in the pathogenesis and chronic infection observed in TB, leading to the development of vaccines based on Mtb antigens.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tao Xu, Chutong Wang, Minying Li, Meili Yuan, Jing Wei, Baiqing Li, Zhongqing Qian, Ting Wang, Xiaojing Wang, Hongtao Wang
Summary: Tuberculosis is a chronic and often fatal infectious disease caused by Mycobacterium tuberculosis (Mtb). The PE and PPE proteins have been identified as major factors influencing the virulence and persistence of Mtb. This study found that PE8 may be involved in stress response and inhibition of host cell apoptosis, promoting the survival of Mtb within macrophages. Targeting the PE/PPE protein family could lead to the development of more effective and safer drugs against Mtb infection.
DNA AND CELL BIOLOGY
(2023)
Article
Immunology
Christopher D'Souza, Uday Kishore, Anthony G. Tsolaki
Summary: Mycobacterium tuberculosis has been infecting a third of the world's population and the PE-PPE protein family has been identified as a key factor in its pathogenesis. Despite extensive research, many important questions about these proteins remain unanswered.
Article
Microbiology
Paula Josefina Gomez-Gonzalez, Anna D. Grabowska, Leopold D. Tientcheu, Anthony G. Tsolaki, Martin L. Hibberd, Susana Campino, Jody E. Phelan, Taane G. Clark
Summary: This study investigated the genetic diversity of the mat genes in Mycobacterium tuberculosis and found that these genes are highly conserved among different strains, although some variations were observed. Understanding the diversity and conservation of the mat genes can provide insights into the genetic pathogenesis of tuberculosis and contribute to the development of new strategies for tuberculosis control.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Cheldon Ann Alcantara, Ira Glassman, Kevin H. Nguyen, Arpitha Parthasarathy, Vishwanath Venketaraman
Summary: Mycobacterium tuberculosis (M. tb) remains a major cause of death in developing countries. The BCG vaccine is widely used in developing countries but its efficacy is still uncertain. Neutrophils play a crucial role in the immune response against M. tb, promoting clearance of the bacteria and regulating the inflammatory response. This review highlights the role of neutrophils during M. tb infection and emphasizes the need for more research on effective vaccination.
Article
Multidisciplinary Sciences
Arianne Lovey, Sheetal Verma, Vaishnavi Kaipilyawar, Rodrigo Ribeiro-Rodrigues, Seema Husain, Moises Palaci, Reynaldo Dietze, Shuyi Ma, Robert D. Morrison, David R. Sherman, Jerrold J. Ellner, Padmini Salgame
Summary: In this study, the authors found that high transmission strains of Mycobacterium tuberculosis induce rapid migration of alveolar macrophages and early dissemination of bacteria to lymph nodes, resulting in greater transmissibility. In contrast, low transmission strains impede these processes and promote Th17 immunity, leading to neutrophilic inflammation and increased bacterial replication.
NATURE COMMUNICATIONS
(2022)
Article
Parasitology
Medha, Sadhna Sharma, Monika Sharma
Summary: The PE/PPE proteins encoded by 7% of the Mtb genome are key components of the pathogen's virulence reservoir. While speculation abounds about their role at the host-pathogen interface and in disease pathogenesis, their exact function remains a mystery, highlighting the need for further research targeting these proteins. These proteins are thought to play a versatile role as host immune sensors and crucial factors in shaping the outcome of Tuberculosis infection, with the potential to pave the way for new vaccines and therapeutics.
Article
Immunology
Mariana Herrera, Yoav Keynan, Lucelly Lopez, Diana Marin, Lazaro Velez, Paul J. McLaren, Zulma Vanessa Rueda
Summary: We studied the immune changes in newly acquired tuberculosis infection in a population deprived of liberty in Colombian prisons. We found differences in immune levels between individuals with new tuberculosis infection and those incarcerated for short and long periods of time. Certain cytokines/chemokines were associated with new tuberculosis infection and tuberculosis disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Stephanie Fischinger, Deniz Cizmeci, Sally Shin, Leela Davies, Patricia S. Grace, Aida Sivro, Nonhlanhla Yende-Zuma, Hendrik Streeck, Sarah M. Fortune, Douglas A. Lauffenburger, Kogieleum Naidoo, Galit Alter
Summary: South Africa has the highest prevalence of HIV and tuberculosis co-infection globally, with HIV infected individuals having a greater likelihood of developing recurrent TB. This study investigated the humoral response in HIV co-infected individuals with and without recurrent TB, finding differences in antibody profiles, particularly decreased Mtb-antigen specific IgG3 titers in individuals with recurrent TB. These findings suggest a potential role for Mtb-specific IgG3 responses as biomarkers or mediators of protective immunity against Mtb recurrence.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Adrian Bekier, Malwina Kawka, Jakub Lach, Jaroslaw Dziadek, Agata Paneth, Justyna Gatkowska, Katarzyna Dzitko, Bozena Dziadek
Summary: The re-emergence of tuberculosis as a global pandemic due to the rapid spread of drug-resistant strains of Mycobacterium tuberculosis highlights the urgent need to develop new drugs that can inhibit its growth and biofilm formation.
Article
Biochemical Research Methods
Paula J. Gomez-Gonzalez, Susana Campino, Jody E. Phelan, Taane G. Clark
Summary: This study compared the genome sequencing of clinical isolates of Mycobacterium tuberculosis using Oxford Nanopore Technologies (ONT) sequencing and Illumina HiSeq sequencing. The analysis showed that ONT sequencing is robust for detecting single nucleotide polymorphisms and provides improved coverage in repetitive regions. It also demonstrated high concordance in variants associated with drug resistance. ONT sequencing is a promising tool for tuberculosis genomic investigations and can inform clinical and surveillance decision-making to reduce the disease burden.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Medicine, Research & Experimental
Benjamin N. Koleske, William R. Jacobs, William R. Bishai
Summary: The complete genome sequence of Mycobacterium tuberculosis, achieved in 1998, has provided invaluable insights and tools for understanding tuberculosis. Whole-genome sequencing has improved our ability to predict antibacterial susceptibility and track epidemics. It also helps in studying the effectiveness of TB vaccines and identifying targets for new treatments.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Shuping Li, Xiaohua Wang, Yuming Zhao, Juan Yang, Tianjiao Cui, Zhizhuang Joe Zhao, Yun Chen, Zhihua Zheng
Summary: The PTPN22-C1858T polymorphism is not significantly associated with higher susceptibility to M. tuberculosis infection in Caucasians and Asians, but is relevant to increased susceptibility to M. leprae infection. Further well-designed studies with sufficient populations are required to verify these conclusions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nan Wang, Yongliang Yao, Yingfen Qian, Dewen Qiu, Hui Cao, Huayuan Xiang, Jianjun Wang
Summary: Exosomes are double-membrane vesicles containing various lipids, proteins, mRNAs, and non-coding RNAs, and are involved in multiple physiological processes such as intercellular communication and immunomodulation. Studies have found that the components of exosomes released from host cells are altered following Mycobacterium tuberculosis infection. The contents of exosomes provide excellent biomarkers for the diagnosis, efficacy evaluation, and prognosis of tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Yan Guo, Yuri F. van der Heijden, Fernanda Maruri, Limin Jiang, Robert Morrison, Timothy R. Sterling
Summary: This study marks the first discovery of three RNA editing events in Mycobacterium tuberculosis, providing novel insights into gene expression regulation in this bacterium species.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Javeed Ahmad, Mohd Khubaib, Javaid Ahmad Sheikh, Rita Pancsa, Saroj Kumar, Alagiri Srinivasan, Mohan Madan Babu, Seyed E. Hasnain, Nasreen Z. Ehtesham
Editorial Material
Critical Care Medicine
Jeremiah Muhwa Chakaya, Ben Marais, Philipp du Cros, Francine Ntoumi, Sayoki Mfinanga, Nathan Kapata, Seyed Ehtesham Hasnain, Ruvandhi Nathavitharana, Alimuddin Zumla
LANCET RESPIRATORY MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Munishwar N. Gupta, Anwar Alam, Seyed E. Hasnain
Review
Infectious Diseases
Manuela Sironi, Seyed E. Hasnain, Benjamin Rosenthal, Tung Phan, Fabio Luciani, Marie-Anne Shaw, M. Anice Sallum, Marzieh Ezzaty Mirhashemi, Serge Morand, Fernando Gonzalez-Candelas
INFECTION GENETICS AND EVOLUTION
(2020)
Article
Multidisciplinary Sciences
Salma Jamal, Mohd Khubaib, Rishabh Gangwar, Sonam Grover, Abhinav Grover, Seyed E. Hasnain
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Jairo Ramos, Changwon Yoo, Quentin Felty, Zhenghua Gong, Juan P. Liuzzi, Robert Poppiti, Indu Shekhar Thakur, Ruchika Goel, Ashok Kumar Vaid, Ricardo Jorge Komotar, Nasreen Z. Ehtesham, Seyed E. Hasnain, Deodutta Roy
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Afrozul Haq, Seyed E. Hasnain, Mohammed S. Razzaque
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Neurosciences
Kaumudi Bhawe, Quentin Felty, Changwon Yoo, Nasreen Z. Ehtesham, Seyed E. Hasnain, Varindera Paul Singh, Ishani Mohapatra, Deodutta Roy
MOLECULAR NEUROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Tom L. Blundell, Munishwar N. Gupta, Seyed E. Hasnain
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2020)
Article
Immunology
Simran Kaur Arora, Anwar Alam, Nilofer Naqvi, Javeed Ahmad, Javaid Ahmad Sheikh, Syed Asad Rahman, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Infectious Diseases
Javaid Ahmad Sheikh, Jasdeep Singh, Hina Singh, Salma Jamal, Mohd Khubaib, Sunil Kohli, Ulrich Dobrindt, Syed Asad Rahman, Nasreen Zafar Ehtesham, Seyed Ehtesham Hasnain
INFECTION GENETICS AND EVOLUTION
(2020)
Editorial Material
Microbiology
Asrar Ahmad Malik, Sanjeev Sinha, Nasreen Z. Ehtesham, Seyed E. Hasnain
FUTURE MICROBIOLOGY
(2023)
Review
Virology
Mohd Shariq, Asrar A. Malik, Javaid A. Sheikh, Seyed E. Hasnain, Nasreen Z. Ehtesham
Summary: SARS-CoV-2 blocks autophagosome-lysosome fusion to regulate autophagic flux, leading to accumulation of membranous vesicles. ORF3a plays a significant role in regulating autophagy by forming a complex with UV radiation resistance associated and modulating the functions of lipid kinase complexes, thereby controlling autophagosome biogenesis. ORF3a inhibits autolysosome formation by sequestering VPS39 and preventing assembly of the SNARE complex. ORF3a also promotes reticulophagy, proinflammatory responses, and ER stress by inducing the interaction between BECN1 and HMGB1, activating PIK3CA kinases, and recruits BORCS6 and ARL8B for anterograde transport of the virus.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Microbiology
Angamuthu Selvapandiyan, Niti Puri, Pankaj Kumar, Anwar Alam, Nasreen Zafar Ehtesham, George Griffin, Seyed Ehtesham Hasnain
Summary: Intracellular pathogens such as viruses, bacteria, and parasites evade the host immune system to cause fatal diseases. They manipulate various stages of the immune response, including entry into host cells, formation and maturation of phagosomes, fusion with lysosomes to form phagolysosomes, phagolysosome acidification, and escape into the cytosol. The phagolysosome organelle plays a crucial role in degrading pathogens, and the pathogens employ different strategies to evade or manipulate the host immune system. Understanding the common targets in phagosomes and phagolysosomes can provide valuable insights for developing broad-spectrum therapeutics against infectious diseases.
FEMS MICROBIOLOGY REVIEWS
(2023)
Letter
Immunology
Hina Singh, Jasdeep Singh, Mohd Khubaib, Salma Jamal, Javaid Ahmed Sheikh, Sunil Kohli, Seyed Ehtesham Hasnain, Syed Asad Rahman
INDIAN JOURNAL OF MEDICAL RESEARCH
(2020)
